Cited by 239Alzheimer's disease research and treatmentsMedicinal Plants and NeuroprotectionAntioxidants, Aging, Portulaca oleracea

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Protective effects of idebenone and α‐tocopherol on β‐amyloid‐(1–42)‐induced learning and memory deficits in rats: implication of oxidative stress in β‐amyloid‐induced neurotoxicity in vivo

Yamada, Kiyofumi, Tanaka, Tomoko, Han, Daiken, Senzaki, Kouji, Kameyama, Tsutomu, Nabeshima, Toshitaka·1999·European Journal of Neuroscience

DOI 10.1046/j.1460-9568.1999.00408.x

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Abstract

Amyloid β‐peptide (Aβ), the major constituent of the senile plaques in the brains of patients with Alzheimer's disease, is cytotoxic to neurons and has a central role in the pathogenesis of the disease. Previous studies have suggested that oxidative stress is involved in the mechanisms of Aβ‐induced neurotoxicity in vitro. In the present study, we examined whether oxidative stress contributes to learning and memory deficits caused by continuous intracerebroventricular infusion of Aβ‐(1–42). In the Aβ‐(1–42)‐infused rats, spontaneous alternation behaviour in a Y‐maze and spatial memory in a water maze task were significantly impaired, as compared with Aβ‐(40–1)‐infused control rats. The retention of passive avoidance learning was also significantly impaired by treatment with Aβ‐(1–42). Potent antioxidants idebenone and α‐tocopherol prevented the behavioural deficits in Y‐maze and water maze, but not passive avoidance, tasks in Aβ‐(1–42)‐infused rats when they were repeatedly administered by mouth once a day from 3 days before the start of Aβ infusion to the end of behavioural experiments. Lipid peroxide levels in the hippocampus and cerebral cortex of Aβ‐(1–42)‐infused rats did not differ from those in control animals, and neither idebenone nor α‐tocopherol affected the lipid peroxide levels. These results suggest that treatment with antioxidants such as idebenone and α‐tocopherol prevents learning and memory deficits caused by Aβ.

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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
Ohkawa, H., Ohishi, N., & Yagi, K. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90738-3 · Cited by 29,746
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959
Developments of a water-maze procedure for studying spatial learning in the rat
Morris, R. (1984) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(84)90007-4 · Cited by 7,180
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516
Oxidative stress hypothesis in Alzheimer’s disease
Markesbery, W. R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00629-6 · Cited by 2,383
Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
Jarrett, J. T., & Lansbury, P. T. (1993) · Cell · doi:10.1016/0092-8674(93)90635-4 · Cited by 2,178
Hydrogen peroxide mediates amyloid β protein toxicity
Behl, C. (1994) · Cell · doi:10.1016/0092-8674(94)90131-7 · Cited by 2,074
Hippocampus, space, and memory
Olton, D. S., Becker, J. T., & Handelmann, G. E. (1979) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00062713 · Cited by 2,018
Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides
Yankner, B. A., Duffy, L. K., & Kirschner, D. A. (1990) · Science · doi:10.1126/science.2218531 · Cited by 1,975
Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)
Iwatsubo, T., Odaka, A., Suzuki, N., Mizusawa, H., Nukina, N., & Ihara, Y. (1994) · Neuron · doi:10.1016/0896-6273(94)90458-8 · Cited by 1,774
beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
Mattson, M. P., Cheng, B., Davis, D. G., Bryant, K., Lieberburg, I. M., & Rydel, R. E. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00376.1992 · Cited by 1,633
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.-H., Mistl, C., Rothacher, S., Ledermann, B., Bürki, K., Frey, P., Paganetti, P. A., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13287 · Cited by 1,507
Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.
Smith, C. D., Carney, J. M., Starke-Reed, P. E., Oliver, C. N., Stadtman, E. R., Floyd, R. A., & Markesbery, W. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10540 · Cited by 1,296
Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease
Tanzi, R. E., McClatchey, A. I., Lamperti, E. D., Villa‐Komaroff, L., Gusella, J. F., & Neve, R. L. (1988) · Nature · doi:10.1038/331528a0 · Cited by 1,093
Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity
Kitaguchi, N., Takahashi, Y., Tokushima, Y., Shiojiri, S., & Ito, H. (1988) · Nature · doi:10.1038/331530a0 · Cited by 1,083
Oxidative damage to mitochondrial DNA is increased in Alzheimer’s disease
Mecocci, P., MacGarvey, U., & Beal, M. F. (1994) · Annals of Neurology · doi:10.1002/ana.410360510 · Cited by 1,037
Mechanisms of Neuronal Degeneration in Alzheimer's Disease
Yankner, B. A. (1996) · Neuron · doi:10.1016/s0896-6273(00)80115-4 · Cited by 953
Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.
Carney, J. M., Starke-Reed, P. E., Oliver, C., Landum, R. W., Cheng, M. S., Wu, J., & Floyd, R. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3633 · Cited by 724
Ibotenate Lesions of Hippocampus and/or Subiculum: Dissociating Components of Allocentric Spatial Learning
Morris, R., Schenk, F., Tweedie, F., & Jarrard, L. E. (1990) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1990.tb00014.x · Cited by 666
β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage
Koh, J., Yang, L. L., & Cotman, C. W. (1990) · Brain Research · doi:10.1016/0006-8993(90)91355-k · Cited by 617
Vitamin E protects nerve cells from amyloid βprotein toxicity
Behl, C., Davis, J. B., Cole, G. M., & Schubert, D. A. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)90837-b · Cited by 582
Amyloid β-Peptide Impairs Glucose Transport in Hippocampal and Cortical Neurons: Involvement of Membrane Lipid Peroxidation
Mark, R. J., Pang, Z., Geddes, J. W., Uchida, K., & Mattson, M. P. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-03-01046.1997 · Cited by 551
Untitled work
(1997) · doi:10.1073/pnas.94.4.1550 · Cited by 535
Amnesia induced in mice by centrally administered β-amyloid peptides involves cholinergic dysfunction
Maurice, T., Lockhart, B. P., & Privat, A. (1996) · Brain Research · doi:10.1016/0006-8993(95)01032-7 · Cited by 530
An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.
Kowall, N. W., Beal, M. F., Busciglio, J. A., Duffy, L. K., & Yankner, B. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.7247 · Cited by 529
Autopsy Samples of Alzheimer's Cortex Show Increased Peroxidation In Vitro
Subbarao, K. V., Richardson, J. S., & Ang, L. C. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb08858.x · Cited by 463
β-Amyloid Peptide Free Radical Fragments Initiate Synaptosomal Lipoperoxidation in a Sequence-Specific Fashion: Implications to Alzheimer′s Disease
Butterfield, D. A., Hensley, K., Harris‐White, M. E., Mattson, M. P., & Carney, J. M. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1508 · Cited by 404
Amyloid peptides are toxic via a common oxidative mechanism.
Schubert, D. A., Behl, C., Lesley, R., Brack, A., Dargusch, R., Sagara, Y., & Kimura, H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.6.1989 · Cited by 382
Psychological stress impairs spatial working memory: Relevance to electrophysiological studies of hippocampal function.
Diamond, D. M., Fleshner, M., Ingersoll, N., & Rose, G. M. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.4.661 · Cited by 340
On the role of hippocampal connections in the performance of place and cue tasks: Comparisons with damage to hippocampus.
Jarrard, L. E., Okaichi, H., Steward, O., & Goldschmidt, R. B. (1984) · Behavioral Neuroscience · doi:10.1037//0735-7044.98.6.946 · Cited by 334
Age-related spatial reference and working memory deficits assessed in the water maze
Frick, K. M., Baxter, M. G., Markowska, A. L., Olton, D. S., & Price, D. L. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(94)00155-3 · Cited by 322
β-Amyloid protein-induced Alzheimer's disease animal model
Nitta, A., Itoh, A., Hasegawa, T., & Nabeshima, T. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90239-9 · Cited by 269
Self-citation
Alzheimer's disease: a re-examination of the amyloid hypothesis
Neve, R. L., & Robakis, N. K. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01168-5 · Cited by 255
Antioxidants protect against glutamate-induced cytotoxicity in a neuronal cell line.
Miyamoto, M., Murphy, T. H., Schnaar, R. L., & Coyle, J. T. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22783-5 · Cited by 247
Behavioral evidence for a modulating role of σ ligands in memory processes. I. Attenuation of dizocilpine (MK-801)-induced amnesia
Maurice, T., Hiramatsu, M., Itoh, J., Kameyama, T., Hasegawa, T., & Nabeshima, T. (1994) · Brain Research · doi:10.1016/0006-8993(94)91397-8 · Cited by 214
Self-citation
Alzheimer's Disease: Biology, Diagnosis and Therapeutics
Hier, D. B. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-128-3-199802010-00025 · Cited by 197
Chronic cerebral hypoperfusion by permanent internal carotid ligation produces learning impairment without brain damage in rats
Ohta, H., Nishikawa, H., Kimura, H., Anayama, H., & Miyamoto, M. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00037-7 · Cited by 193
Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium
Mattson, M. P., & Goodman, Y. (1995) · Brain Research · doi:10.1016/0006-8993(95)00148-j · Cited by 190
Membrane damage due to lipid oxidation
Niki, E., Yamamoto, Y., Komuro, E., & Sato, K. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.1.201s · Cited by 179
Differential effects of amyloid peptides β-(1–40) and β-(25–35) injections into the rat nucleus basalis
Giovannelli, L., Casamenti, F., Scali, C., Bartolini, L., & Pepeu, G. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00610-h · Cited by 170
Alzheimer's disease: Its proteins and genes
Glenner, G. G. (1988) · Cell · doi:10.1016/s0092-8674(88)80021-7 · Cited by 149
Continuous Infusion of .BETA.-Amyloid Protein into the Rat Cerebral Ventricle Induces Learning Impairment and Neuronal and Morphological Degeneration.
Nitta, A., Fukuta, T., Hasegawa, T., & Nabeshima, T. (1997) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.73.51 · Cited by 142
Self-citation
Dysfunction of Cholinergic and Dopaminergic Neuronal Systems in β‐Amyloid Protein‐Infused Rats
Itoh, A., Nitta, A., Nadai, M., Kyoko, N., Hirose, M., Hasegawa, T., & NABESHIMA, T. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66031113.x · Cited by 134
Self-citation
Nitric oxide synthase inhibitors impair reference memory formation in a radial arm maze task in rats
Zou, L., Yamada, K., Tanaka, T., Kameyama, T., & NABESHIMA, T. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00042-2 · Cited by 115
Self-citation
The role of nitric oxide in dizocilpine-induced impairment of spontaneous alternation behavior in mice.
Yamada, K., Noda, Y., Hasegawa, T., Komori, Y., Nikai, T., Sugihara, H., & NABESHIMA, T. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12295-7 · Cited by 113
Self-citation
Memory Impairment and Neuronal Dysfunction Induced by .BETA.-Amyloid Protein in Rats.
Nabeshima, T., & Nitta, A. (1994) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.174.241 · Cited by 95
Self-citation
Inhibition of lipid peroxidation by a novel compound (CV-2619) in brain mitochondria and mode of action of the inhibition
Suno, M., & Nagaoka, A. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)91389-5 · Cited by 91
Damage to ceruleo-cortical noradrenergic projections impairs locally cued but enhances spatially cued water maze acquisition
Selden, N. R. W., Cole, B. J., Everitt, B. J., & Robbins, T. W. (1990) · Behavioural Brain Research · doi:10.1016/0166-4328(90)90119-y · Cited by 81
Idebenone attenuates neuronal degeneration induced by intrastriatal injection of excitotoxins
Miyamoto, M., & Coyle, J. T. (1990) · Experimental Neurology · doi:10.1016/0014-4886(90)90005-d · Cited by 80
Hippocampal long-term potentiation and spatial learning in the rat: effects of GABAB receptor blockade
Brucato, F. H., Levin, E. D., Mott, D. D., Lewis, D. V., Wilson, W. A., & Swartzelder, H. S. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00131-5 · Cited by 77
Implants containing β-amyloid protein are not neurotoxic to young and old rat brain
Clemens, J. A., & Stephenson, D. T. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90059-7 · Cited by 71
High levels of circulating beta-amyloid peptide do not cause cerebral beta-amyloidosis in transgenic mice.
Fukuchi, K., Ho, L., Younkin, S. G., Kunkel, D. D., Ogburn, C. E., LeBoeuf, R. C., Furlong, C. E., Deeb, S. S., Nochlin, D., Węgiel, J., et al. (1996) · Europe PMC (PubMed Central) · Cited by 69
Lack of long-term effects after β-amyloid protein injections in rat brain
Winkler, J., Connor, D. J., Frautschy, S. A., Behl, C., Waite, J. J., Cole, G. M., & Thal, L. J. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)00054-9 · Cited by 69
Microinjection of synthetic amyloid beta-protein in monkey cerebral cortex fails to produce acute neurotoxicity.
Podlisny, M. B., Stephenson, D. T., Frosch, M. P., Tolan, D. R., Lieberburg, I. M., Clemens, J. A., & Selkoe, D. J. (1993) · PubMed · Cited by 68
Propentofylline improves learning and memory deficits in rats induced by β-amyloid protein-(1-40)
Yamada, K., Tanaka, T., Senzaki, K., Kameyama, T., & Nabeshima, T. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00166-6 · Cited by 62
Self-citation
An amyloid β-protein fragment, Aβ[12–28], equipotently impairs post-training memory processing when injected into different limbic system structures
Flood, J. F., Morley, J. E., & Roberts, E. (1994) · Brain Research · doi:10.1016/0006-8993(94)91273-4 · Cited by 61
Stimulation of nerve growth factor synthesis/secretion by 1,4‐benzoquinone and its derivatives in cultured mouse astroglial cells
Takeuchi, R., Murase, K., Furukawa, Y., Furukawa, S., & Hayashi, K. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80637-x · Cited by 50
Orally active NGF synthesis stimulators: potential therapeutic agents in alzheimer's disease
Yamada, K., Nitta, A., Hasegawa, T., Fuji, K., Hiramatsu, M., Kameyama, T., Furukawa, Y., Hayashi, K., & Nabeshima, T. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)86054-8 · Cited by 45
Self-citation
Oral administration of idebenone induces nerve growth factor in the brain and improves learning and memory in basal forebrain-lesioned rats
Nitta, A., Murakami, Y., Furukawa, Y., Kawatsura, W., HAYASHI, K., Yamada, K., Hasegawa, T., & NABESHIMA, T. (1994) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00170887 · Cited by 41
Self-citation
Vitamin E Prevents the Place Learning Deficit and the Cholinergic Hypofunction Induced by AF64A
Wörtwein, G., Stackman, R. W., & Walsh, T. J. (1994) · Experimental Neurology · doi:10.1006/exnr.1994.1002 · Cited by 39
Effects of repeated administration of propentofylline on memory impairment produced by basal forebrain lesion in rats
Fuji, K., Hiramatsu, M., Kameyama, T., & NABESHIMA, T. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90479-2 · Cited by 38
Self-citation
Oral administration of idebenone, a stimulator of NGF synthesis, recovers reduced NGF content in aged rat brain
Nitta, A., Hasegawa, T., & Nabeshima, T. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90387-z · Cited by 38
Self-citation
Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of β-amyloid(1–40) protein
Yamada, K., Nitta, A., Saito, T., Hu, J., & Nabeshima, T. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12161-7 · Cited by 19
Self-citation
Effects of idebenone on information processing in aged Long-Evans rats
Pelleymounter, M. A., & Cullen, M. J. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90373-2 · Cited by 13
Alzheimer's disease animal models induced by continuous infusion of ß-amyloid protein and anti-nerve growth factor antibody
Nabeshima, T., & Itoh, A. (1997) · Reviews on heteroatom chemistry · Cited by 9
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Authors: Yamada, K., Tanaka, T., Han, D., Senzaki, K., Kameyama, T., & Nabeshima, T.
Affiliations: Nagoya University Hospital (JP)
Meijo University (JP)
Nagoya University (JP)
Corresponding author: Nabeshima, Toshitaka
ORCID: Tanaka, Tomoko
Venue: European Journal of Neuroscience
Publisher: Wiley
Published: 1999-01
Volume: 11
Issue: 1
Pages: 83-90
ISSN: 0953-816X (ISSN-L)
1460-9568
DOI: 10.1046/j.1460-9568.1999.00408.x
OpenAlex: W2038415004
Cited by: 238
References: 67
Citations by year: 2026: 1 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 4 · 2017: 9 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 11 · 2012: 9
FWCI: 9.25
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1088 d)
Locations: European Journal of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
Keywords: idebenone, alpha-tocopherol, amyloid-beta 42, Alzheimer's disease, oxidative stress, learning and memory impairment, neuroprotection, antioxidants, lipid peroxidation, hippocampus, cerebral cortex, spatial memory, passive avoidance learning, intracerebroventricular infusion
MeSH terms: Alzheimer Disease, Animals, Antioxidants, Avoidance Learning, Brain Chemistry, Drug Interactions, Injections, Intraventricular, Locomotion, Male, Memory, Nerve Degeneration, Neurotoxins, Peptide Fragments, Ubiquinone, Vitamin E, Lipid Peroxidation, Benzoquinones, Amyloid beta-Peptides, Rats, Wistar, Oxidative Stress, Maze Learning, Rats

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Protective effects of idebenone and α‐tocopherol on β‐amyloid‐(1–42)‐induced learning and memory deficits in rats: implication of oxidative stress in β‐amyloid‐induced neurotoxicity in vivo

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