The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Protective effects of idebenone and α‐tocopherol on β‐amyloid‐(1–42)‐induced learning and memory deficits in rats: implication of oxidative stress in β‐amyloid‐induced neurotoxicity in vivo
Abstract
Amyloid β‐peptide (Aβ), the major constituent of the senile plaques in the brains of patients with Alzheimer's disease, is cytotoxic to neurons and has a central role in the pathogenesis of the disease. Previous studies have suggested that oxidative stress is involved in the mechanisms of Aβ‐induced neurotoxicity in vitro. In the present study, we examined whether oxidative stress contributes to learning and memory deficits caused by continuous intracerebroventricular infusion of Aβ‐(1–42). In the Aβ‐(1–42)‐infused rats, spontaneous alternation behaviour in a Y‐maze and spatial memory in a water maze task were significantly impaired, as compared with Aβ‐(40–1)‐infused control rats. The retention of passive avoidance learning was also significantly impaired by treatment with Aβ‐(1–42). Potent antioxidants idebenone and α‐tocopherol prevented the behavioural deficits in Y‐maze and water maze, but not passive avoidance, tasks in Aβ‐(1–42)‐infused rats when they were repeatedly administered by mouth once a day from 3 days before the start of Aβ infusion to the end of behavioural experiments. Lipid peroxide levels in the hippocampus and cerebral cortex of Aβ‐(1–42)‐infused rats did not differ from those in control animals, and neither idebenone nor α‐tocopherol affected the lipid peroxide levels. These results suggest that treatment with antioxidants such as idebenone and α‐tocopherol prevents learning and memory deficits caused by Aβ.
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“Similarly, when used in combination with α-tocopherol, it alleviates β-amyloid induced learning and memory deficits in rats165.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [165]
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Oxidative stress hypothesis in Alzheimer’s disease
Markesbery, W. R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00629-6 · Cited by 2,383
MIND diet slows cognitive decline with aging
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Metadata
- Authors
- Yamada, K., Tanaka, T., Han, D., Senzaki, K., Kameyama, T., & Nabeshima, T.
- Affiliations
- Nagoya University Hospital (JP)
- Meijo University (JP)
- Nagoya University (JP)
- Corresponding author
- Nabeshima, Toshitaka
- ORCID
- Tanaka, Tomoko
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 1999-01
- Volume
- 11
- Issue
- 1
- Pages
- 83-90
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2038415004
- Cited by
- 238
- References
- 67
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 4 · 2017: 9 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 11 · 2012: 9
- FWCI
- 9.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Keywords
- idebenone, alpha-tocopherol, amyloid-beta 42, Alzheimer's disease, oxidative stress, learning and memory impairment, neuroprotection, antioxidants, lipid peroxidation, hippocampus, cerebral cortex, spatial memory, passive avoidance learning, intracerebroventricular infusion
- MeSH terms
- Alzheimer Disease, Animals, Antioxidants, Avoidance Learning, Brain Chemistry, Drug Interactions, Injections, Intraventricular, Locomotion, Male, Memory, Nerve Degeneration, Neurotoxins, Peptide Fragments, Ubiquinone, Vitamin E, Lipid Peroxidation, Benzoquinones, Amyloid beta-Peptides, Rats, Wistar, Oxidative Stress, Maze Learning, Rats
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