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Cited by 34Memory Processes and InfluencesMemory and Neural MechanismsFace Recognition and Perception

Regional brain activity during shape recognition impaired by a scopolamine challenge to encoding

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Rosier, Anne‐Marie, Cornette, Luc, Dupont, Patrick, Bormans, Guy, Mortelmans, Luc, Orban, Guy A.·1999·European Journal of Neuroscience
DOI 10.1046/j.1460-9568.1999.00784.x
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Abstract

In the present positron emission tomography (PET) study, we examine the effect of a scopolamine‐induced challenge to encoding upon the pattern of regional cerebral blood flow during recognition of a list of abstract visual shapes 3 days after encoding of these shapes. This study was conducted to test hypotheses concerning the fusiform and thalamic contributions to object recognition arising from a previous imaging study of impaired recognition. In that study, we demonstrated that activity in the fusiform cortex and the thalamus during shape recognition was modulated by memory challenges. These memory challenges included, on one hand, impaired storage as a consequence of diazepam administration during encoding, and, on the other hand, impaired retrieval caused by a perceptual challenge. Activation in the fusiform cortex decreased during impaired recognition, irrespective of the type of challenge. In contrast, thalamic activation increased only when the recognition deficit resulted from impaired memory storage. Based on these results, we hypothesized that fusiform activation during recognition reflects the matching of an incoming stimulus with a stored one, whereas thalamic activation reflects retrieval attempts. These hypotheses would receive considerable support if scopolamine, which also impairs memory storage, induced similar modulations of fusiform and thalamic activation. In the present study, we observed that a scopolamine challenge to encoding does indeed modulate the activity in the very same regions that were previously modulated by a diazepam challenge. Hence, a similar memory deficit, although primarily effected through different neurochemical pathways, was paralleled by a similar modulation of activity in the same set of nodes in the shape recognition network. In the fusiform cortex, scopolamine decreased recognition‐related activity, as did the sensory challenge of retrieval. Furthermore, covariate analysis demonstrated that the level of fusiform activity linearly correlates with behavioural performance. In the thalamus, activation increased following impaired encoding. This is in accordance with the idea that enhanced thalamic activity reflects increased effort expended in retrieval. In addition, in the intraparietal sulcus, differential activation also increased following impaired memory storage, possibly reflecting enhanced visuospatial attention in an effort to compensate for impaired performance.

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  • Several studies demonstrated disruption of encoding-evoked neuronal activity in hippocampal, para-hippocampal and entorhinal regions and resulting impairments in recognition memory after scopolamine.

    “several studies demonstrated disruption of encoding-evoked neuronal activity in these regions and resulting impairments in recognition memory (Rosier et al, 1999; Schon et al, 2005).”

    From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Rosier et al, 1999

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Research works printed but not linked: 3

  1. Amaral, D.G. (1987) Memory: anatomical organization of candidate brain regions. In Mountcastle, V. B. (ed.) Handbook of Physiology, Sections 1 and 5. American Physiological Society, Bethesda, MA, USA, pp. 211±294.
  2. Clark, W.G., Brater, D.C. & Johnson, A.R. (1988) In Bircher, S. (ed.) Goth's Medical Pharmacology, 12th edn.
  3. C. V. Mosby, Washington DC, Toronto.

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Authors
Rosier, A., Cornette, L., Dupont, P., Bormans, G., Mortelmans, L., & Orban, G. A.
Affiliations
  • KU Leuven (BE)
  • Universitair Ziekenhuis Leuven (BE)
ORCID
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
1999-10
Volume
11
Issue
10
Pages
3701-3714
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
DOI
10.1046/j.1460-9568.1999.00784.x
OpenAlex
W2011442470
Cited by
34
References
95
Citations by year
2023: 1 · 2020: 2 · 2018: 1 · 2016: 1 · 2013: 1
FWCI
1.67
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3252 d)
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
Vlaamse regering
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
Keywords
scopolamine, object recognition, shape recognition, fusiform cortex, thalamus, regional cerebral blood flow, memory retrieval, visuospatial attention, intraparietal sulcus, diazepam
MeSH terms
Administration, Oral, Adult, Cerebrovascular Circulation, Conditioning, Psychological, Diazepam, Humans, Magnetic Resonance Imaging, Male, Memory, Parietal Lobe, Pattern Recognition, Visual, Scopolamine, Tomography, Emission-Computed, Visual Cortex, Muscarinic Antagonists, GABA Modulators, Posterior Thalamic Nuclei

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