Differential activation of the prefrontal cortex in successful and unsuccessful memory retrieval
Open accessAbstract
Six subjects underwent PET scans while they performed three versions of a recognition memory test for words and three versions of a control task. In each memory condition, the subjects discriminated between words presented in a prescan study list and words new to the experiment. During the 30 s scanning interval, the ratio of old and new words was 0:20, 4:16 or 16:4, depending on the experimental condition. Outside this interval, the ratio was 50:50 in all three conditions. The requirement in the control task was to discriminate between two character strings, the ratios of which were also manipulated during the 30 s scanning interval. Employing the control task as a covariate, analysis with statistical parametric mapping revealed that regional cerebral blood flow (rCBF) covaried with increasing density of old items in three regions of prefrontal cortex: right dorsolateral [Brodmann area (BA) 9/46], right medial (BA 32/8) and bilateral frontopolar cortex (BA 10). It is concluded that the prefrontal cortex, especially in the right hemisphere, is more active when a retrieval attempt succeeds than when it fails. This finding is consistent with the idea that the prefrontal cortex supports processes that operate selectively on the products of memory retrieval.
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Frontal activations have consistently been observed during successful declarative retrieval.
“Frontal activations have consistently been observed during successful declarative retrieval (Rugg et al., 1996; Buckner et al., 1998; McDermott et al., 2003; Simons and Spiers, 2003; Spaniol et al., 2009; Huijbers et al., 2013).”
From Neural Correlates of Long-Term Memory Enhancement Following Retrieval Practice (2021) · cites this paper as Rugg et al., 1996
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- Authors
- Rugg, M. D., Fletcher, P. C., Frith, C. D., Frackowiak, R. S. J., & Dolan, R. J.
- Affiliations
- University of St Andrews (GB)
- The Royal Free Hospital (GB)
- Corresponding author
- Rugg, M. D.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 1996
- Volume
- 119
- Issue
- 6
- Pages
- 2073-2083
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2095422075
- Cited by
- 361
- References
- 51
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 7 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 8 · 2016: 9 · 2015: 9 · 2014: 12 · 2013: 7 · 2012: 5
- FWCI
- 19.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Brain (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- prefrontal cortex, memory retrieval, recognition memory, regional cerebral blood flow, dorsolateral prefrontal cortex, medial prefrontal cortex, frontopolar cortex, right hemisphere, word recognition, statistical parametric mapping
- MeSH terms
- Adult, Cerebrovascular Circulation, Humans, Male, Memory, Radionuclide Imaging, Prefrontal Cortex
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