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Electrophysiological properties of microglial cells in normal and pathologic rat brain slices
Abstract
UNLABELLED: Microglial cells serve as pathologic sensors of the brain. They are highly abundant in all regions of the central nervous system (CNS) and are characterized by a ramified morphology within the normal tissue. In the present study, we have developed a procedure to study the membrane properties of identified, in situ microglia in acutely isolated brain slices from rat cortex, striatum and facial nucleus. Unlike the well characterized cultured microglial cells, ramified microglia of the slice are characterized by little, if any, voltage-gated membrane currents and a very low membrane potential. They are thus distinct from neurons, other glial cells and nonbrain macrophages. To study the consequences of microglial activation on the membrane channel pattern, we compared cells in the normal facial nucleus and at defined times after facial nerve axotomy. Within 12 h of axotomy, microglial cells expressed a prominent inward rectifier current and thus acquired the physiological properties of cultured microglia. Within 24 h of the lesion, the cells expressed an additional outward current, which is typical for lipopolysaccharide (LPS)-activated microglia in vitro. Seven days after the lesion, at a time of major regenerative processes in the facial nucleus, the physiological properties of microglial cells had reverted to those present prior to the pathological event. IN CONCLUSION: (i) ramified microglial cells represent a physiologically unique population of cells in the brain; (ii) are distinct from their cultured counterparts; and (iii), undergo a defined pattern of physiological states in the course of pathologic events.
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“Development of outward K+ current in microglia is associated with an advanced microglial activation status (Boucsein et al., 2000; Wendt et al., 2017)”
From Overexpressing low‐density lipoprotein receptor reduces tau‐associated neurodegeneration in relation to apoE‐linked mechanisms (2021) · cites this paper as Boucsein et al., 2000
In the citing paper
“VTA and SNc microglia exhibited resting potentials similar to those reported for cortical microglia (Boucsein et al., 2000; Boucsein et al., 2003)”
From Local cues establish and maintain region-specific phenotypes of basal ganglia microglia (2017) · cites this paper as Boucsein et al., 2000
In the citing paper
“microglia filled with biocytin during recording exhibited ramified morphology comparable to that reported previously (Boucsein et al., 2000; Boucsein et al., 2003)”
From Local cues establish and maintain region-specific phenotypes of basal ganglia microglia (2017) · cites this paper as Boucsein et al., 2000
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Metadata
- Authors
- Boucsein, C., Kettenmann, H., & Nolte, C.
- Affiliations
- Max Delbrück Center (DE)
- ORCID
- Kettenmann, Helmut
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2000-06
- Volume
- 12
- Issue
- 6
- Pages
- 2049-2058
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W1992967280
- Cited by
- 166
- References
- 34
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 13 · 2020: 7 · 2019: 8 · 2018: 8 · 2017: 10 · 2016: 5 · 2015: 5 · 2014: 10 · 2013: 4 · 2012: 8
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- microglia, voltage-gated currents, inward rectifier potassium current, lipopolysaccharide stimulation, facial nerve axotomy, facial nucleus, microglial activation, rat brain slices, cortical microglia, membrane potential
- MeSH terms
- Animals, Animals, Newborn, Cells, Cultured, Cerebral Cortex, Facial Nerve, Female, Lipopolysaccharides, Membrane Potentials, Potassium Channels, Rats, Wistar, Microglia, Patch-Clamp Techniques, Axotomy, Lectins, Plant Lectins, Cell Size, Rats
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