The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Testosterone‐mediated neuroprotection through the androgen receptor in human primary neurons
Abstract
Estrogen is an active neuroprotectant and is presently investigated as a potential therapy against Alzheimer's disease for women. To determine if male hormones could also be neuroprotective, we investigated the effect of testosterone, methyltestosterone, and epitestosterone at physiological concentrations on primary cultures of human neurons induced to undergo apoptosis by serum deprivation. Serum deprivation significantly induces neuronal apoptosis in a protracted fashion. As expected, physiological concentrations of 17‐β‐estradiol and transcriptionally inactive 17‐α‐estradiol protect neurons against apoptosis. Similar to 17‐β‐estradiol, physiological concentrations of testosterone are also neuroprotective. Androgen receptors are present at 8 ± 2 fmol/mg protein in the neuron cultures. The non‐aromatizable androgen, mibolerone, is also neuroprotective and aromatase inhibitor, 4‐androsten‐4‐OL‐3,17‐dione, does not prevent testosterone‐mediated neuroprotection. In contrast, anti‐androgen, flutamide, eliminates testosterone‐mediated neuroprotection. Testosterone analog, methyltestosterone, showed androgen receptor‐dependent neuroprotection that was delayed in time indicating that a metabolite may be the active agent. The endogenous anti‐androgen, epitestosterone, also showed a slight neuroprotective effect but not through the androgen receptor. These results indicate that androgens induce neuroprotection directly through the androgen receptor. These data suggest that androgens may also be of therapeutic value against Alzheimer's disease in aging males.
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Cites
Neuroprotective effects of estrogens: potential mechanisms of action
Green, P. S., & Simpkins, J. W. (2000) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(00)00017-4 · Cited by 523
Simard, J., Luthy, I., Guay, J., Bélanger, A., & Labrie, F. (1986) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(86)90132-2 · Cited by 256
Puy, L., MacLusky, N. J., Becker, L., Karsan, N., Trachtenberg, J., & Brown, T. J. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00165-v · Cited by 113
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Sex differences in cognitive impairment and Alzheimer’s disease
Li, R., & Singh, M. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.01.002 · Cited by 527
Non-genomic actions of androgens
Foradori, C. D., Weiser, M. J., & Handa, R. J. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.10.005 · Cited by 493
Spritzer, M. D., & Galea, L. A. M. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20457 · Cited by 277
Gender, sex steroid hormones, and Alzheimer’s disease
Vest, R. S., & Pike, C. J. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.04.006 · Cited by 260
Zhang, J., Konkle, A. T. M., Zup, S. L., & McCarthy, M. M. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06073.x · Cited by 151
Classical androgen receptors in non-classical sites in the brain
Sarkey, S., Azcoitia, I., Garcia-Segura, L. M., Garcia-Ovejero, D., & DonCarlos, L. L. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.02.015 · Cited by 146
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Datto, J. P., Bastidas, J. C., Miller, N. L., Shah, A. K., Arheart, K. L., Marcillo, A. E., Dietrich, W. D., & Pearse, D. D. (2015) · Journal of Neurotrauma · doi:10.1089/neu.2014.3702 · Cited by 96
Acute neuro-endocrine profile and prediction of outcome after severe brain injury
Olivecrona, Z., Dahlqvist, P., & Koskinen, L.-O. D. (2013) · Scandinavian Journal of Trauma Resuscitation and Emergency Medicine · doi:10.1186/1757-7241-21-33 · Cited by 93
Gamache, J., Yun, Y., & Chiba-Falek, O. (2020) · Disease Models & Mechanisms · doi:10.1242/dmm.045211 · Cited by 84
Pittman, M. E., Edwards, S. W., Ives, C., & Mortensen, H. M. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.02.006 · Cited by 78
Effects of testosterone on cognitive and brain aging in elderly men
MOFFAT, S. D. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1323.014 · Cited by 76
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Metadata
- Authors
- Hammond, J., Le, Q., Goodyer, C., Gelfand, M., Trifiro, M., & LeBlanc, A.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2001-06
- Volume
- 77
- Issue
- 5
- Pages
- 1319-1326
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1563459863
- Cited by
- 310
- References
- 3
- FWCI
- 8.28
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
