Interaction between flavonoids and the blood–brain barrier: in vitro studies

Structure-antioxidant activity relationships of flavonoids and phenolic acids

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Oxidative Stress, Glutamate, and Neurodegenerative Disorders

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Flavonoid Antioxidants

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Physicochemical Profiling (Solubility, Permeability and Charge State)

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A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: a multiplicity of effects

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Flavonoids: A class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein

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Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3

Schroeter, H., Spencer, J. P. E., Rice-Evans, C. A., & WILLIAMS, R. J. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3580547 · Cited by 373

Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults ☆ ☆Mention of trade name, proprietary product, or specific equipment does not constitute a guarantee by the US Department of Agriculture and does not imply its approval to the exclusion of other products that may be suitable.

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Inhibition of Peroxynitrite-Mediated Tyrosine Nitration by Catechin Polyphenols

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Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress

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Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression.

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Drug Transfer Across the Blood‐Brain Barrier: Correlation Between In Vitro and In Vivo Models

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Decomposition of Cocoa Procyanidins in the Gastric Milieu

Spencer, J. P. E., Chaudry, F., Pannala, A. S., Srai, S. K., Debnam, E. S., & Rice-Evans, C. A. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2749 · Cited by 283

Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3

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Neurobehavioral aspects of antioxidants in aging

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Dietary Flavonoids as Potential Neuroprotectants

Youdim, K. A., Spencer, J. P. E., Schroeter, H., & Rice-Evans, C. A. (2002) · Biological Chemistry · doi:10.1515/bc.2002.052 · Cited by 210

Epicatechin and its in vivo metabolite, 3′-O-methyl epicatechin, protect human fibroblasts from oxidative-stress-induced cell death involving caspase-3 activation

Spencer, J. P. E., Schroeter, H., Kuhnle, G., Srai, S. K., Tyrrell, R. M., Hahn, U., & Rice-Evans, C. A. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3540493 · Cited by 194

Blood-Spinal Cord and Brain Barriers in Health and Disease

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Modulation of adriamycin® accumulation and efflux by flavonoids in HCT-15 colon cells

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Saint John's wort: An in vitro analysis of P‐glycoprotein induction due to extended exposure

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Effect of bioflavonoids on vincristine transport across blood–brain barrier

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Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts

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Age-related changes in the blood-brain barrier

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Inhibition of Peroxynitrite‐Mediated Oxidation of Dopamine by Flavonoid and Phenolic Antioxidants and Their Structural Relationships

Kerry, N. L., & Rice-Evans, C. A. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0730247.x · Cited by 113

Determination of naringenin and its glucuronide conjugate in rat plasma and brain tissue by high-performance liquid chromatography

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Functional Expression of P‐Glycoprotein in an Immortalised Cell Line of Rat Brain Endothelial Cells, RBE4

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Epicatechin and its in vivo metabolite, 3′-O-methyl epicatechin, protect human fibroblasts from oxidative-stress-induced cell death involving caspase-3 activation

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Distribution of morphine 6-glucuronide and morphine across the blood-brain barrier in awake, freely moving rats investigated by in vivo microdialysis sampling.

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Inhibition of P-glycoprotein activity and reversal of multidrug resistance in vitro by rosemary extract

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Bioavailability of Flavonoids and Potential Bioactive Forms in Vivo

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Inhibition of Nitrous Acid-Dependent Tyrosine Nitration and DNA Base Deamination by Flavonoids and Other Phenolic Compounds

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Effects of flavonols on P-glycoprotein activity in cultured rat hepatocytes

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The effects of aging and oxidative stress on psychomotor and cognitive behavior

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Procyanidins extracted from pine bark protect α‐tocopherol in ECV 304 endothelial cells challenged by activated RAW 264.7 macrophages: role of nitric oxide and peroxynitrite

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Increased Lipophilicity and Subsequent Cell Partitioning Decrease Passive Transcellular Diffusion of Novel, Highly Lipophilic Antioxidants

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A comparison of the induction of immortalized endothelial cell impermeability by astrocytes

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Rat olfactory bulb and epithelium UDP-glucuronosyltransferase 2A1 (UGT2A1) expression: in situ mRNA localization and quantitative analysis

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Drug transport to the brain: comparison between in vitro and in vivo models of the blood-brain barrier

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In Vivo Study of the Elimination from Rat Brain of an Intracerebrally Formed Xenobiotic Metabolite, 1‐Naphthyl‐β‐D‐Glucuronide

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Nitric oxide-induced perturbations in a cell culture model of the blood-brain barrier

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Comparative protection against oxyradicals by three flavonoids on cultured endothelial cells

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Determination of unbound hesperetin in rat blood and brain by microdialysis coupled to microbore liquid chromatography

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Expression of multiple thyroid hormone receptor isoforms in rat femoral and vertebral bone and in bone marrow osteogenic cultures

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A Unique Multifunctional Transporter Translocates Estradiol-17β-Glucuronide in Rat Liver Microsomal Vesicles

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Aortic endothelial cells damaged by a nitric oxide donor and protected by flavonoids

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Action of anthocyanosides of Vaccinium myrtillis on the permeability of the blood brain barrier.

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Effect of procyanidolic oligomers on the permeability of the blood-brain barrier

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Effect of flavonoids on arachidonic acid metabolism and prostacyclin (PGI2) formation in human vascular endothelial cells

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Polyphenols: Food sources and bioavailability

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Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not?

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Permeability Studies on In Vitro Blood–Brain Barrier Models: Physiology, Pathology, and Pharmacology

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Flavonoid permeability across an in situ model of the blood–brain barrier

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Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory

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Flavonoid permeability across an in situ model of the blood–brain barrier

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Flavonoid metabolites transport across a human BBB model

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Transport of active flavonoids, based on cytotoxicity and lipophilicity: An evaluation using the blood–brain barrier cell and Caco-2 cell models

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Flavan‐3‐ols Transport Across Blood‐Brain Barrier

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Flavonoid transport across RBE4 cells: A blood-brain barrier model

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