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Cited by 1,091Wound Healing and TreatmentsTissue Engineering and Regenerative MedicineAnimal testing and alternatives

The DOI matches its Crossref record; 180 of the 182 references it cites were found in a registry or an index.

THE PIG AS A MODEL FOR HUMAN WOUND HEALING

Sullivan, Tory P, Eaglstein, William H, Davis, Stephen C, Mertz, Patricia·2001·Wound Repair and Regeneration
DOI 10.1046/j.1524-475x.2001.00066.x
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Abstract

The medical literature describes numerous in vitro and in vivo wound-healing models. The selection of an animal model depends on a number of factors including availability, cost, ease of handling, investigator familiarity, and anatomical/functional similarity to humans. Small mammals are frequently used for wound healing studies, however, these mammals differ from humans in a number of anatomical and physiological ways. Anatomically and physiologically, pig skin is more similar to human skin. The many similarities between man and pig would lead one to believe that the pig should make an excellent animal model for human wound healing. The purpose of this paper is to review the existing literature for evidence of this supposition and determine how well the various models correlate to human wound healing. Studies of wound dressings, topical antimicrobials, and growth factors are examined. Over 180 articles were utilized for this comparative review. Our conclusion is that the porcine model is an excellent tool for the evaluation of therapeutic agents destined for use in human wounds.

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Crossref · 10.1046/j.1524-475x.2001.00066.x

Cites

180 of 180 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 26

  1. Montagna W, 1964, The skin of the domestic pig, J Invest Dermatol, 43, 11
  2. Winter GD, 1966, PhD Thesis
  3. Forbes PD, 1969, Advances in the biology of skin: Hair growth, 419
  4. Nicolaides N, 1968, The skin surface lipids of man compared with those of eighteen species of animals, J Invest Derm, 51, 83
  5. Hartwell SW, 1955, The mechanism of healing in human wounds
  6. Lee KT, 1986, Swine in biomedical research, 1481
  7. Champsaur A, 1986, Use of DuoDerm on skin graft donor sites: comparative study with tulle gras, Ann Chir Plast Esthet, 31, 273
  8. Blitz H, 1985, Royal Society of Medicine International Congress and Symposium Series, No 88, 125
  9. Stair TO, 1984, Polyurethane and silver sulfadiazine dressings in treatments of partial‐thickness burns and abrasions, Am J Emerg Med, 214
  10. Mertz PM, 1988, Pulsed rhEGF treatment increased epithelialization of partial thickness wounds, J Invest Dermatol, 90, 588
  11. Pierce GF, 1992, Platelet‐derived growth factor (BB homodimer) transforming growth factor beta 1 and basic fibroblastic growth factor in dermal wound healing, Am J Path, 140, 1375
  12. Jyvasjarvi S, 1976, A model for studies of dermal surface epithelialization: with observations on the effects of dexamethasone and nandrolone deconate, Arzneim Forsch, 3, 443
  13. Mertz PM, 1986, Swine in biomedical research, 291
  14. Rives JM, 1997, Calcium alginate versus paraffin gauze in the treatment of scalp graft donor sites, Wounds, 9, 199
  15. Alvarez OM, 1984, Healing wounds: occlusion or exposure, Inf Surg, 173
  16. Gilbert EC, 1990, Hydrogel dressings II. Healing of full thickness skin wounds in swine; treatment with a new non‐occlusive hydrogel absorbent dressing, Wounds, 2, 56
  17. Bolton L, 1985, Models in dermatology, 145
  18. ConstableJ.Comparative effects of Betadine ointment (povidone‐iodine) and other topical agents on epidermal regeneration in rabbits. In:Proceedings from the Symposium Sponsored by the Department of Surgery;Durham (NC):1974.
  19. Mertz PM, 1985, Bactroban (Mupirocin) Proceedings of an International Symposium; 1984 May 21–22, 211
  20. White AR, 1985, Bactroban (Mupirocin) Proceedings of an International Symposium; 1984 May 21–22, 19
  21. Fuscher B, 1906, Organ fur amtliche und pracktische arzte Munch, Med Wochenschr, 42, 2041
  22. 10.1001/archsurg.1979.01370340094016 · DOI
  23. Danilenko DM, 1995, Growth factors in porcine full and partial thickness burn repair, Am J Pathol, 147, 1661
  24. Pierce GF, 1992, Platelet derived growth factor (BB homodimer), transforming growth fator‐beta 1 and basic fibroblast growth factor in dermal wound healing, Am J Pathol, 140, 1375
  25. Alvarez OM, 1981, Testosterone increases collagen deposition in experimentally induced granulation tissue, Fed Proc, 40, 343
  26. 10.1007/BF00412864 · DOI

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Metadata

Authors
Sullivan, T. P., Eaglstein, W. H., Davis, S. C., & Mertz, P.
Affiliations
University of Miami (US)
ORCID
Venue
Wound Repair and Regeneration
Publisher
Wiley
Published
2001-03
Volume
9
Issue
2
Pages
66-76
ISSN
  • 1067-1927 (ISSN-L)
  • 1524-475X
DOI
10.1046/j.1524-475x.2001.00066.x
OpenAlex
W2060049869
Cited by
1,091
References
182
Citations by year
2026: 69 · 2025: 47 · 2024: 65 · 2023: 54 · 2022: 67 · 2021: 72 · 2020: 63 · 2019: 62 · 2018: 65 · 2017: 56 · 2016: 72 · 2015: 63 · 2014: 49 · 2013: 48 · 2012: 43
FWCI
1.62
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 297 d)
Locations
  • Wound Repair and Regeneration (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Wound Healing and Treatments
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
Keywords
porcine model, porcine skin, wound dressings, topical antimicrobial agents, growth factors, translational validity
MeSH terms
Animals, Anti-Infective Agents, Burns, Debridement, Epidermal Growth Factor, Epidermis, Growth Substances, Homeostasis, Humans, Occlusive Dressings, Skin, Swine, Wound Healing, Fibroblast Growth Factor 2, Models, Animal

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