The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Apathy in Alzheimer's Disease
Abstract
Apathy, or loss of motivation, is arguably the most common change in behavior in Alzheimer's disease (AD) but is underrecognized. Apathy represents a form of executive cognitive dysfunction. Patients with apathy suffer from decreased daily function and specific cognitive deficits and rely on families to provide more care, which results in increased stress for families. Apathy is one of the primary syndromes associated with frontal and subcortical pathology, and apathy in AD appears to have multiple neuroanatomical correlates that implicate components of frontal subcortical networks. Despite the profound effects of this common syndrome, only a few instruments have been designed to specifically assess apathy, and these instruments have not been directly compared. Assessment of apathy in AD requires clinicians to distinguish loss of motivation from loss of ability due to cognitive decline. Although apathy may be misdiagnosed as depression because of an overlap in symptoms, current research has shown apathy to be a discrete syndrome. Distinguishing apathy from depression has important treatment implications, because these disorders respond to different interventions. Further research is required to clarify the specific neuroanatomical and neuropsychological correlates of apathy and to determine how correct diagnosis and treatment of apathy may improve patient functioning and ease caregiver burden.
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Social brain, social dysfunction and social withdrawal
Porcelli, S., Van Der Wee, N., van der Werff, S., Aghajani, M., Glennon, J. C., van Heukelum, S., Mogavero, F., Lobo, A., Olivera, F. J., Lobo, E., et al. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.012 · Cited by 391
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Structural correlates of apathy in Alzheimer's disease
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Metadata
- Authors
- Landes, A. M., Sperry, S. D., Strauss, M. E., & Geldmacher, D. S.
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2001-12
- Volume
- 49
- Issue
- 12
- Pages
- 1700-1707
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- OpenAlex
- W2030689331
- Cited by
- 379
- References
- 68
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Landes, A. M., Sperry, S. D., Strauss, M. E., & Geldmacher, D. S. (2001). Apathy in Alzheimer's Disease. Journal of the American Geriatrics Society. https://doi.org/10.1046/j.1532-5415.2001.49282.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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