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Cited by 247Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsHistorical and Modern Theater Studies

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

The course of neuropsychiatric symptoms in dementia. Part I: findings from the two‐year longitudinal Maasbed study

Aalten, Pauline, de Vugt, Marjolein E., Jaspers, Niek, Jolles, Jaspers, Verhey, Frans R. J.·2005·International Journal of Geriatric Psychiatry
DOI 10.1002/gps.1316
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Abstract

Background: Although neuropsychiatric symptoms in dementia are common, there have been few large long‐term prospective studies assessing the course of a broad range of neuropsychiatric symptoms in dementia. Objectives: To investigate the course of neuropsychiatric symptoms in patients with dementia, including data about prevalence, incidence and persistence. Methods: One hundred and ninety‐nine patients with dementia were assessed every six months for two‐years, using the Neuropsychiatric Inventory (NPI) to evaluate neuropsychiatric symptoms. Results: Nearly all patients (95%) developed one or more neuropsychiatric symptoms in the two‐year study period. Mood disorders were the most common problem. The severity of depression decreased, whereas the severity of apathy and aberrant motor behaviour increased during follow‐up. The cumulative incidence was highest for hyperactive behaviours and apathy. Overall behavioral problems were relatively persistent, but most symptoms were intermittent, with apathy and aberrant motor behaviour being persistent for longer consecutive periods. Conclusions: Neuropsychiatric symptoms in dementia are a common and major problem. Different symptoms have their own specific course, most of the time show a intermittent course, but behavioural problems overall are chronically present. The data have implications for developing treatment strategies. Copyright © 2005 John Wiley & Sons, Ltd.

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Crossref · 10.1002/gps.1316

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  • Agitation is common, persistent, difficult to treat, costly, and associated with severe adverse consequences for patients and caregivers.

    “Agitation is common, persistent, difficult to treat, costly, and associated with severe adverse consequences for patients and caregivers1–5.”

    From Effect of Citalopram on Agitation in Alzheimer Disease: The CitAD Randomized Clinical Trial (2014) · cites this paper as [4]

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Metadata

Authors
Aalten, P., de Vugt, M. E., Jaspers, N., Jolles, J., & Verhey, F. R. J.
Affiliations
  • Maastricht University (NL)
  • Maastricht University Medical Centre (NL)
Corresponding author
Verhey, Frans R. J.
ORCID
Venue
International Journal of Geriatric Psychiatry
Publisher
Wiley
Published
2005-05-26
Volume
20
Issue
6
Pages
523-530
ISSN
  • 0885-6230 (ISSN-L)
  • 1099-1166
DOI
10.1002/gps.1316
OpenAlex
W2126418649
Cited by
247
References
2
Citations by year
2026: 6 · 2025: 9 · 2024: 7 · 2023: 11 · 2022: 10 · 2021: 7 · 2020: 7 · 2019: 9 · 2018: 11 · 2017: 11 · 2016: 25 · 2015: 13 · 2014: 13 · 2013: 19 · 2012: 18
FWCI
5.36
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • International Journal of Geriatric Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (publishedVersion)
  • Research Publications (Maastricht University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords
neuropsychiatric symptoms, dementia, symptom course, mood disorders, depression, apathy, prevalence, incidence, persistence, Neuropsychiatric Inventory
MeSH terms
Aged, Aged, 80 and over, Dementia, Depression, Epidemiologic Methods, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Psychomotor Agitation, Disease Progression, Mood Disorders

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