The DOI matches its Crossref record; 41 of the 44 references it cites were found in a registry or an index.
Insulin-like growth factor-1 and interleukin 6 predict sarcopenia in very old community-living men and women: the Framingham Heart Study
Abstract
Objectives To assess the prognostic role of the inflammatory cytokine, interleukin 6 (IL-6), and insulin-like growth factor-1 (IGF-1) in predicting 2-year changes in fat-free mass (FFM) while controlling for potential confounders. Design Population-based cohort, the Framingham Heart Study, examined in 1992-93 and 1994-95. Setting General community. Participants Two hundred thirty-two men and 326 women aged 72 to 92. Measurements IGF-1 was measured using radio-immunoassay and cellular IL-6 production using non-cross-reacting radioimmunoassays. FFM was estimated using population-specific equations for predicting FFM from bioelectrical impedance analysis developed separately for men and women. Results Higher IGF-1 predicted smaller loss of FFM in men than lower IGF-1 did (P=.002), after adjusting for age, baseline FFM, fat mass, and 2-year weight changes, whereas cellular IL-6 was a significant predictor of sarcopenia in women (P=.02). Weight change was a strong determinant of change in FFM in both sexes (P Conclusion Predictors of sarcopenia include body composition characteristics that are common to men and women and sex-specific metabolic predictors. Sarcopenia appears to reflect a withdrawal of anabolic stimuli, such as growth hormone, in men but an increase in catabolic stimuli, such as cellular IL-6, in women.
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“Inflammation is associated with anorexia and catabolism of skeletal muscle and adipose tissue, which may contribute to the nutritional compromise, muscle weakness and weight loss that characterise frailty (41, 61, 62).”
From Frailty in elderly people (2013) · cites this paper as [41]
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“a series of observational studies have reported inconsistent associations (37-41)”
From Frailty in elderly people (2013) · cites this paper as [41]
Citations
Cites
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267
Assessment of older people: self-maintaining and instrumental activities of daily living.
Lawton, M., & Brody, E. M. (1969) · The gerontologist · doi:10.1097/00006199-197005000-00029 · Cited by 18,276
Reproducibility and validity of a semiquantitative food frequency questionnaire
WILLETT, W. C., SAMPSON, L., STAMPFER, M. J., ROSNER, B., BAIN, C., WITSCHI, J., HENNEKENS, C. H., & SPEIZER, F. E. (1985) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114086 · Cited by 4,274
Epidemiology of Sarcopenia among the Elderly in New Mexico
Baumgartner, R. N., Koehler, K. M., Gallagher, D., Romero, L., Heymsfield, S. B., Ross, R. R., Garry, P. J., & Lindeman, R. D. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009520 · Cited by 4,004
How we should measure "change": Or should we?
Cronbach, L. J., & Furby, L. (1970) · Psychological Bulletin · doi:10.1037/h0029382 · Cited by 2,456
Sarcopenia: origins and clinical relevance
Rosenberg, I. H. (1997) · The Journal of Nutrition · doi:10.1093/jn/127.5.990s · Cited by 2,399
(1993) · Archives of Internal Medicine · doi:10.1001/archinte.1993.00410020010002 · Cited by 1,974
An epidemiology of disability among adults in the United States.
Nagi, S. Z. (1976) · The Milbank Memorial Fund Quarterly. Health and Society · doi:10.2307/3349677 · Cited by 1,431
Visser, M., Pahor, M., Taaffe, D. R., Goodpaster, B. H., Simonsick, E. M., Newman, A. B., Nevitt, M., & Harris, T. B. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.5.m326 · Cited by 1,294
Self-citationA Guttman Health Scale for the Aged
Rosow, I., & Breslau, N. (1966) · Journal of Gerontology · doi:10.1093/geronj/21.4.556 · Cited by 1,132
Research works printed but not linked: 11
- Holloszy JO., 1995, Workshop on sarcopenia, Muscle atrophy in old age, 50, 1
- Poehlman E, 1995, Exercise, substrate utilisation and energy requirements in the elderly, Int J Obes Relat Metab Disord, 19, S93
- Harris TB, 1997, Association of insulin‐like growth factor‐I with body composition, weight history, and past health behaviors in the very old, The Framingham Heart Study, 45, 133
- 10.1210/jc.80.6.1845 · DOI
- Roubenoff R, 1994, Rheumatoid cachexia, Cytokine-driven hypermetabolism accompanying reduced body cell mass in chronic inflammation, 93, 2379
- Cohen HJ., 2000, Editorial, In search of the underlying mechanisms of frailty, 55, M706
- Ellis KJ, 1999, Bioelectrical impedance methods in clinical research, A follow-up to the NIH Technology Assessment Conference, 15, 874
- Jette AM, 1981, The Framingham disability study, II. Physical disability among the aging, 71, 1211
- Beekman AT, 1997, Criterion validity of the Center for Epidemiologic Studies Depression scale (CES‐D), Results from a community based sample of older adults in the Netherlands, 27, 231
- Kehayias JJ, 1997, Total body potassium and body fat, Relevance to aging, 66, 904
- Manolagas SC, 1995, New insights into the cellular, biochemical, and molecular basis of postmenopausal and senile osteoporosis, roles of IL-6 and gp130, 17, 109
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Sieber, C. C. (2005) · Zeitschrift für Gerontologie und Geriatrie · Cited by 2
The relationship between follistatin and sarcopenia in elderly
Aryana, I. G. P. S., Putrawan, I. B. P., Purnami, N. K. R., Kuswardhani, R. T., & Astika, I. N. (2022) · Indonesia Journal of Biomedical Science · doi:10.15562/ijbs.v16i2.382 · Cited by 2
Carlsson, M. (2011) · DiVA at Umeå University (Umeå University) · Cited by 2
Association of nut consumption and sarcopenia in Chinese older adults
Xu, J., Pu, K., Sun, W., Pang, C., Li, D., & Zang, S. (2025) · Scientific Reports · doi:10.1038/s41598-025-02389-x · Cited by 2
Zhu, L.-Y., Chen, B., Lu, X., Xia, J., & Sun, J. (2025) · Current Problems in Surgery · doi:10.1016/j.cpsurg.2025.101902 · Cited by 1
Coronado‐Zarco, R., Diez-García, M. D. P., Arias, D. D. C., León-Hernández, S. R., Cruz‐Medina, E., & Arellano‐Hernández, A. (2005) · PubMed · Cited by 1
Sarcopenia and Myopathies in the Elderly
O’Rourke, K. S. (2011) · Springer eBooks · doi:10.1007/978-1-4419-5792-4_27 · Cited by 2
Kim, K. (2008) · Exercise Science · doi:10.15857/ksep.2008.17.2.119 · Cited by 1
Jackson, T., Wilson, D. V., & Greig, C. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-43365-3_9 · Cited by 1
Salutondok, W., Riviati, N., Kusnadi, Y., Bahar, E., Kuniati, N., & Indra, S. (2021) · Bioscientia Medicina Journal of Biomedicine and Translational Research · doi:10.32539/bsm.v5i3.220 · Cited by 1
Sex and the Aging Immune System
Gibson, D. C., & Bupp, M. G. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00059-2 · Cited by 1
Allen, S., & Tiwari, D. (2019) · SM Gerontology and Geriatric Research · doi:10.36876/smggr.1020 · Cited by 1
Oral health status as a predictor of changes in general health among elderly people
Hämäläinen, P. (2005) · Työväentutkimus Vuosikirja · Cited by 1
Stanescu, C. I. (2005) · UA Campus Repository (The University of Arizona) · Cited by 1
Treatment of Sarcopenia and Cachexia in the Elderly
Lambert, C. P., Evans, W. J., & Sullivan, D. H. (2007) · Springer eBooks · doi:10.1007/978-88-470-0552-5_69 · Cited by 1
Diekmann, R., Kaiser, M. J., Modreker, M. K., Wirth, R., & Bauer, J. M. (2014) · e Curriculum Geriatrie · doi:10.1007/s40407-014-0007-5 · Cited by 1
Efeito da suplementação de simbióticos sobre a inflamação sistêmica de idosos
Neto, J. V. (2015) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.89.2015.tde-15052015-113025
The interrelationship of sex steroid levels, body composition and bone characteristics in men
Lapauw, B. (2009) · Ghent University Academic Bibliography (Ghent University)
Testosterone and frailty in elderly men
Emmelot‐Vonk, M. H. (2009) · Utrecht University Repository (Utrecht University)
A Nonlinear Model for Health Outcomes in Nursing Research
Lin, F. V., & Kitzman, H. J. (2014)
Kim, K., 박주식, & Hong, C. (2008) · Exercise Science · doi:10.15857/ksep.2008.17.1.39
Bautmans, I. (2017) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-368-1350-1_4
Frailty and anabolic hormones in ageing men
O’Connell, M. D. L. (2011) · Research Explorer (The University of Manchester)
Rolland, Y., & Vellas, B. J. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6231-8.10073-x
McIntosh, E. I. (2020) · The Atrium (University of Guelph)
Salutondok, W., Riviati, N., Kusnadi, Y., Bahar, E., Kuniati, N., & Indra, S. (2021) · Bioscientia Medicina Journal of Biomedicine and Translational Research · doi:10.32539/bsm.v5i2.220
Crocco, P., Iannone, F., Dato, S., Rose, G., & Passarino, G. (2021) · Elsevier eBooks · doi:10.1016/c2019-0-04856-x
Galvis, J. C., M., J. A. V., & V., J. F. C. (2018) · Archivos de la Sociedad Chilena de Medicina del Deporte · doi:10.59856/arch.soc.chil.med.deporte.v63i2.32
Bucci, L., Ostan, R., Capri, M., Salvioli, S., Cevenini, E., Celani, L., Monti, D., & Franceschi, C. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_45
Different components of frailty in the aging subjects—The role of sarcopenia
Crocco, P., Dato, S., Iannone, F., Passarino, G., & Rose, G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822569-1.00011-1
Bautmans, I. (2022) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-368-2783-6_5
Lee, S.-Y., Gim, J., Kim, S. C., Baek, K., & Yoo, J. (2022) · Research Square · doi:10.21203/rs.3.rs-2103290/v1
Body Composition in Geriatric Patients
Gómez, M. P. A., Aparisi, F., Guglielmi, G., & Bazzocchi, A. (2023) · Practical issues in geriatrics · doi:10.1007/978-3-031-14877-4_15
Wolfram, S., & Bauer, R. (2024) · Springer eBooks · doi:10.1007/978-3-662-69586-9_3
Wolfram, S., & Bauer, R. (2025) · Springer eBooks · doi:10.1007/978-3-662-70774-6_3
Kim, J., Byon, H. D., Platz, K., Toledo, G., & Howie‐Esquivel, J. (2025) · Heart & Lung · doi:10.1016/j.hrtlng.2025.09.003
Kang, S. H., Lee, K. H., Chang, Y., Choe, Y. S., Kim, J. P., Jang, H., Shin, H. Y., Kim, H. J., Koh, S.-B., Na, D. L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21273939
Sarcopenia and sepsis fuel a self-perpetuating cycle of immunometabolism decline
Gutman, E. G., Muniz‐Santos, R., da Silva, A. M., Costa, G. L. A., da Cunha, C. M. C., de Moraes, B. P. T., & Gonçalves-de-Albuquerque, C. F. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1867909
Gou, X., Zhu, J., Feng, X., Li, D., Gao, Q., & Ruan, B. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1938860
Frailty in Older Adults: Pathogenesis, Treatment and Prevention
Lema‐Arranz, C., Fernández‐Bertólez, N., Lorenzo‐López, L., Valdiglesias, V., & Laffón, B. (2026) · Current Epidemiology Reports · doi:10.1007/s40471-026-00406-9
Metadata
- Authors
- Payette, H., Roubenoff, R., Jacques, P. F., Dinarello, C. A., Wilson, P. W. F., Abad, L. W., & Harris, T.
- Affiliations
- Tufts University (US)
- Corresponding author
- Payette, Hélène
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2003-08-15
- Volume
- 51
- Issue
- 9
- Pages
- 1237-1243
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- OpenAlex
- W1584397506
- Cited by
- 245
- References
- 44
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 11 · 2023: 4 · 2022: 18 · 2021: 18 · 2020: 11 · 2019: 9 · 2018: 9 · 2017: 5 · 2016: 8 · 2015: 5 · 2014: 11 · 2013: 9 · 2012: 6
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Geriatrics Society (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k08dk002120-02, 5r21ag015797-02)
- National Institute on Aging (AG-15797, Y01-AG-4-0245)
- National Heart, Lung, and Blood Institute (N01-HC-Z5195)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK02120)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Body Composition Measurement Techniques
- Keywords
- sarcopenia, insulin-like growth factor I, interleukin-6, fat-free mass, weight change, oldest old, community-dwelling older adults, sex differences, inflammation, body composition, growth hormone, catabolism
- MeSH terms
- Adipose Tissue, Age Factors, Aged, Aged, 80 and over, Body Composition, Body Weight, Female, Humans, Insulin-Like Growth Factor I, Male, Prognosis, Radioimmunoassay, Residence Characteristics, Sex Factors, Time Factors, Cohort Studies, Interleukin-6, Body Mass Index, Linear Models, Electric Impedance
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