Cited by 245Nutrition and Health in AgingMuscle Physiology and DisordersBody Composition Measurement Techniques

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Insulin-like growth factor-1 and interleukin 6 predict sarcopenia in very old community-living men and women: the Framingham Heart Study

Payette, Hélène, Roubenoff, Ronenn, Jacques, Paul F., Dinarello, Charles A., Wilson, Peter W. F., Abad, Leslie W., Harris, Tamara·2003·Journal of the American Geriatrics Society

DOI 10.1046/j.1532-5415.2003.51407.x

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Abstract

Objectives To assess the prognostic role of the inflammatory cytokine, interleukin 6 (IL-6), and insulin-like growth factor-1 (IGF-1) in predicting 2-year changes in fat-free mass (FFM) while controlling for potential confounders. Design Population-based cohort, the Framingham Heart Study, examined in 1992-93 and 1994-95. Setting General community. Participants Two hundred thirty-two men and 326 women aged 72 to 92. Measurements IGF-1 was measured using radio-immunoassay and cellular IL-6 production using non-cross-reacting radioimmunoassays. FFM was estimated using population-specific equations for predicting FFM from bioelectrical impedance analysis developed separately for men and women. Results Higher IGF-1 predicted smaller loss of FFM in men than lower IGF-1 did (P=.002), after adjusting for age, baseline FFM, fat mass, and 2-year weight changes, whereas cellular IL-6 was a significant predictor of sarcopenia in women (P=.02). Weight change was a strong determinant of change in FFM in both sexes (P Conclusion Predictors of sarcopenia include body composition characteristics that are common to men and women and sex-specific metabolic predictors. Sarcopenia appears to reflect a withdrawal of anabolic stimuli, such as growth hormone, in men but an increase in catabolic stimuli, such as cellular IL-6, in women.

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Authors: Payette, H., Roubenoff, R., Jacques, P. F., Dinarello, C. A., Wilson, P. W. F., Abad, L. W., & Harris, T.
Affiliations: Tufts University (US)
Corresponding author: Payette, Hélène
ORCID: Roubenoff, Ronenn
Jacques, Paul F.
Dinarello, Charles A.
Wilson, Peter W. F.
Harris, Tamara
Venue: Journal of the American Geriatrics Society
Publisher: Wiley
Published: 2003-08-15
Volume: 51
Issue: 9
Pages: 1237-1243
ISSN: 0002-8614 (ISSN-L)
1532-5415
DOI: 10.1046/j.1532-5415.2003.51407.x
OpenAlex: W1584397506
Cited by: 245
References: 44
Citations by year: 2026: 3 · 2025: 7 · 2024: 11 · 2023: 4 · 2022: 18 · 2021: 18 · 2020: 11 · 2019: 9 · 2018: 9 · 2017: 5 · 2016: 8 · 2015: 5 · 2014: 11 · 2013: 9 · 2012: 6
FWCI: 7.09
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of the American Geriatrics Society (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k08dk002120-02, 5r21ag015797-02)
National Institute on Aging (AG-15797, Y01-AG-4-0245)
National Heart, Lung, and Blood Institute (N01-HC-Z5195)
National Institute of Diabetes and Digestive and Kidney Diseases (DK02120)
Topics: Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology (medical) › Body Composition Measurement Techniques
Keywords: sarcopenia, insulin-like growth factor I, interleukin-6, fat-free mass, weight change, oldest old, community-dwelling older adults, sex differences, inflammation, body composition, growth hormone, catabolism
MeSH terms: Adipose Tissue, Age Factors, Aged, Aged, 80 and over, Body Composition, Body Weight, Female, Humans, Insulin-Like Growth Factor I, Male, Prognosis, Radioimmunoassay, Residence Characteristics, Sex Factors, Time Factors, Cohort Studies, Interleukin-6, Body Mass Index, Linear Models, Electric Impedance

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Insulin-like growth factor-1 and interleukin 6 predict sarcopenia in very old community-living men and women: the Framingham Heart Study

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