Cited by 245Nutrition and Health in AgingMuscle Physiology and DisordersBody Composition Measurement Techniques

The DOI matches its Crossref record; 41 of the 44 references it cites were found in a registry or an index.

Insulin-like growth factor-1 and interleukin 6 predict sarcopenia in very old community-living men and women: the Framingham Heart Study

Abstract

Objectives To assess the prognostic role of the inflammatory cytokine, interleukin 6 (IL-6), and insulin-like growth factor-1 (IGF-1) in predicting 2-year changes in fat-free mass (FFM) while controlling for potential confounders. Design Population-based cohort, the Framingham Heart Study, examined in 1992-93 and 1994-95. Setting General community. Participants Two hundred thirty-two men and 326 women aged 72 to 92. Measurements IGF-1 was measured using radio-immunoassay and cellular IL-6 production using non-cross-reacting radioimmunoassays. FFM was estimated using population-specific equations for predicting FFM from bioelectrical impedance analysis developed separately for men and women. Results Higher IGF-1 predicted smaller loss of FFM in men than lower IGF-1 did (P=.002), after adjusting for age, baseline FFM, fat mass, and 2-year weight changes, whereas cellular IL-6 was a significant predictor of sarcopenia in women (P=.02). Weight change was a strong determinant of change in FFM in both sexes (P Conclusion Predictors of sarcopenia include body composition characteristics that are common to men and women and sex-specific metabolic predictors. Sarcopenia appears to reflect a withdrawal of anabolic stimuli, such as growth hormone, in men but an increase in catabolic stimuli, such as cellular IL-6, in women.

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Crossref · 10.1046/j.1532-5415.2003.51407.x

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Citations

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Research works printed but not linked: 11

  1. Holloszy JO., 1995, Workshop on sarcopenia, Muscle atrophy in old age, 50, 1
  2. Poehlman E, 1995, Exercise, substrate utilisation and energy requirements in the elderly, Int J Obes Relat Metab Disord, 19, S93
  3. Harris TB, 1997, Association of insulin‐like growth factor‐I with body composition, weight history, and past health behaviors in the very old, The Framingham Heart Study, 45, 133
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  5. Roubenoff R, 1994, Rheumatoid cachexia, Cytokine-driven hypermetabolism accompanying reduced body cell mass in chronic inflammation, 93, 2379
  6. Cohen HJ., 2000, Editorial, In search of the underlying mechanisms of frailty, 55, M706
  7. Ellis KJ, 1999, Bioelectrical impedance methods in clinical research, A follow-up to the NIH Technology Assessment Conference, 15, 874
  8. Jette AM, 1981, The Framingham disability study, II. Physical disability among the aging, 71, 1211
  9. Beekman AT, 1997, Criterion validity of the Center for Epidemiologic Studies Depression scale (CES‐D), Results from a community based sample of older adults in the Netherlands, 27, 231
  10. Kehayias JJ, 1997, Total body potassium and body fat, Relevance to aging, 66, 904
  11. Manolagas SC, 1995, New insights into the cellular, biochemical, and molecular basis of postmenopausal and senile osteoporosis, roles of IL-6 and gp130, 17, 109

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Metadata

Authors
Payette, H., Roubenoff, R., Jacques, P. F., Dinarello, C. A., Wilson, P. W. F., Abad, L. W., & Harris, T.
Affiliations
Tufts University (US)
Corresponding author
Payette, Hélène
Venue
Journal of the American Geriatrics Society
Publisher
Wiley
Published
2003-08-15
Volume
51
Issue
9
Pages
1237-1243
ISSN
  • 0002-8614 (ISSN-L)
  • 1532-5415
OpenAlex
W1584397506
Cited by
245
References
44
Citations by year
2026: 3 · 2025: 7 · 2024: 11 · 2023: 4 · 2022: 18 · 2021: 18 · 2020: 11 · 2019: 9 · 2018: 9 · 2017: 5 · 2016: 8 · 2015: 5 · 2014: 11 · 2013: 9 · 2012: 6
FWCI
7.09
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of the American Geriatrics Society (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5k08dk002120-02, 5r21ag015797-02)
  • National Institute on Aging (AG-15797, Y01-AG-4-0245)
  • National Heart, Lung, and Blood Institute (N01-HC-Z5195)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK02120)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Physiology (medical) › Body Composition Measurement Techniques
Keywords
sarcopenia, insulin-like growth factor I, interleukin-6, fat-free mass, weight change, oldest old, community-dwelling older adults, sex differences, inflammation, body composition, growth hormone, catabolism
MeSH terms
Adipose Tissue, Age Factors, Aged, Aged, 80 and over, Body Composition, Body Weight, Female, Humans, Insulin-Like Growth Factor I, Male, Prognosis, Radioimmunoassay, Residence Characteristics, Sex Factors, Time Factors, Cohort Studies, Interleukin-6, Body Mass Index, Linear Models, Electric Impedance

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