Ligands of peroxisome proliferator-activated receptor γ modulate profibrogenic and proinflammatory actions in hepatic stellate cells
Open accessAbstract
Background & aims Proliferation and migration of hepatic stellate cells (HSCs) and expression of chemokines are involved in the pathogenesis of liver inflammation and fibrogenesis. Peroxisome proliferator-activated receptor (PPAR)-gamma is a receptor transcription factor that controls growth and differentiation in different tissues. We explored the effects of PPAR-gamma agonists on the biological actions of cultured human HSCs.Methods HSCs were isolated from normal human liver tissue and used in their myofibroblast-like phenotype or immediately after isolation. Activation of PPAR-gamma was induced with 15-deoxy-Delta(12, 14)-prostaglandin J(2) or with troglitazone.Results PPAR-gamma agonists dose-dependently inhibited HSC proliferation and chemotaxis induced by platelet-derived growth factor. This effect was independent of changes in postreceptor signaling or expression of c-fos and c-myc and was associated with inhibition of cell cycle progression beyond the G(1) phase. Activation of PPAR-gamma also resulted in a complete inhibition of the expression of monocyte chemotactic protein 1 at the gene and protein levels. Comparison of quiescent and culture-activated HSCs revealed a marked decrease in PPAR-gamma expression in activated cells.Conclusions Activation of PPAR-gamma modulates profibrogenic and proinflammatory actions in HSCs. Reduced PPAR-gamma expression may contribute to confer an activated phenotype to HSCs.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In vitro studies investigating PPAR-γ activation in hepatic stellate cells showed an additional decrease of hepatic stellate cell proliferation after PDGF induction.
“Interestingly, in vitro studies investigating PPAR-γ activation in HSCs showed an additional decrease of HSC proliferation after PDGFinduction.[129,134]”
From Nuclear receptors in liver fibrosis (2021) · cites this paper as [129]
PPAR-γ prevents the TGF-β/SMAD pathway in pro-fibrotic myofibroblasts.
“Furthermore, PPAR-γ prevents the TGF-β/SMAD pathway in pro-fibrotic MFs.[128,129]”
From Nuclear receptors in liver fibrosis (2021) · cites this paper as [129]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961 · see citing works
The Steroid and Thyroid Hormone Receptor Superfamily
Evans, R. M. (1988) · Science · doi:10.1126/science.3283939 · Cited by 7,442 · see citing works
Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., & Kliewer, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12953 · Cited by 3,626 · see citing works
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature · doi:10.1038/34178 · Cited by 3,525 · see citing works
PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
Jiang, C., Ting, A. T., & Seed, B. (1998) · Nature · doi:10.1038/34184 · Cited by 2,899 · see citing works
15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
FORMAN, B. M., Tontonoz, P., Chen, J., Brun, R. P., Spiegelman, B. M., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90193-0 · Cited by 2,858 · see citing works
Andrews, N. C., & Faller, D. V. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.9.2499 · Cited by 2,337 · see citing works
Kliewer, S. A., Lenhard, J. M., Willson, T. M., Patel, I., Morris, D. C., & Lehmann, J. M. (1995) · Cell · doi:10.1016/0092-8674(95)90194-9 · Cited by 2,028 · see citing works
Roles of PPARs in health and disease
Kersten, S., Desvergne, B., & Wahli, W. (2000) · Nature · doi:10.1038/35013000 · Cited by 1,956 · see citing works
Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ
Nagy, L., Tontonoz, P., Alvarez, J. G. A., Chen, H.-W., & Evans, R. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81574-3 · Cited by 1,861 · see citing works
PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL
Tontonoz, P., Nagy, L., Alvarez, J. G. A., Thomázy, V. A., & Evans, R. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81575-5 · Cited by 1,800 · see citing works
Kliewer, S. A., Umesono, K., Noonan, D. J., Heyman, R. A., & Evans, R. M. (1992) · Nature · doi:10.1038/358771a0 · Cited by 1,741 · see citing works
Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
Jiang, J., & Struhl, G. (1998) · Nature · doi:10.1038/35154 · Cited by 1,735 · see citing works
The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies
Flier, J. S., Underhill, L. H., & Friedman, S. L. (1993) · New England Journal of Medicine · doi:10.1056/nejm199306243282508 · Cited by 1,433 · see citing works
Adipogenesis and Obesity: Rounding Out the Big Picture
Spiegelman, B. M., & Flier, J. S. (1996) · Cell · doi:10.1016/s0092-8674(00)81359-8 · Cited by 1,254 · see citing works
Inducible cyclooxygenase may have anti-inflammatory properties
Gilroy, D. W., Colville‐Nash, P., Willis, D., Chivers, J. E., Paul‐Clark, M. J., & Willoughby, D. A. (1999) · Nature Medicine · doi:10.1038/9550 · Cited by 1,243 · see citing works
A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas
Basset, P., Bellocq, J., Wolf, C., Stoll, I., Hutin, P., Limacher, J. M., Podhajcer, O. L., Chenard, M., Rio, M., & Chambon, P. (1990) · Nature · doi:10.1038/348699a0 · Cited by 1,125 · see citing works
Lehmann, J. M., Lenhard, J. M., Oliver, B. B., Ringold, G. M., & Kliewer, S. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3406 · Cited by 1,110 · see citing works
Differentiation and reversal of malignant changes in colon cancer through PPARγ
Sarraf, P., Mueller, E., Jones, D. M., King, F. J., DeAngelo, D. J., Partridge, J. B., Holden, S. A., Chen, L. B., Singer, S., Fletcher, C. D. �., et al. (1998) · Nature Medicine · doi:10.1038/2030 · Cited by 987 · see citing works
Improvement in Glucose Tolerance and Insulin Resistance in Obese Subjects Treated with Troglitazone
Nolan, J. J., Ludvik, B. H., Beerdsen, P., Joyce, M., & Olefsky, J. M. (1994) · New England Journal of Medicine · doi:10.1056/nejm199411033311803 · Cited by 925 · see citing works
Elstner, E., Müller‐Tidow, C., Koshizuka, K., Williamson, E. A., Park, D. J., Asou, H., Shintaku, P. I., SAID, J. W., Heber, D., & Koeffler, H. P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8806 · Cited by 805 · see citing works
Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists
Mukherjee, R., Davies, P. J., Crombie, D. L., Bischoff, E. D., Cesario, R. M., Jow, L., Hamann, L. G., Boehm, M. F., Mondon, C. E., Nadzan, A. M., et al. (1997) · Nature · doi:10.1038/386407a0 · Cited by 598 · see citing works
Platelet-derived growth factor receptor signals.
Claesson, L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31591-6 · Cited by 561 · see citing works
Lee, K. S., Buck, M., Houglum, K., & Chojkier, M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118304 · Cited by 537 · see citing works
NF- kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene.
Ueda, A., Okuda, K., Ohno, S., Shirai, A., IGARASHI, T., Matsunaga, K., Fukushima, J., Kawamoto, S., Ishigatsubo, Y., & Okubo, T. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.5.2052 · Cited by 523 · see citing works
Pinzani, M., Gesualdo, L., Sabbah, G. M., & Abboud, H. E. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114363 · Cited by 477 · see citing works
Self-citationTroglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia.
Law, R. E., Meehan, W. P., Xi, X. P., Graf, K., Wuthrich, D. A., Coats, W. D., Faxon, D. P., & Hsueh, W. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118991 · Cited by 476 · see citing works
Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation.
Holt, J. T., Gopal, T. V., Moulton, A. D., & Nienhuis, A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.13.4794 · Cited by 439 · see citing works
Altiok, S., Xu, M. J., & Spiegelman, B. M. (1997) · Genes & Development · doi:10.1101/gad.11.15.1987 · Cited by 378 · see citing works
Knittel, T. E., Kobold, D., Saile, B., Grundmann, A., Neubauer, K., Piscaglia, F., & Ramadori, G. P. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70407-5 · Cited by 338 · see citing works
Alcoholic liver injury in baboons: Transformation of lipocytes to transitional cells
Mak, K. M., Leo, M. A., & Lieber, C. S. (1984) · Gastroenterology · doi:10.1016/0016-5085(84)90143-4 · Cited by 314 · see citing works
Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling.
Peraldi, P., Xu, M., & Spiegelman, B. M. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119715 · Cited by 313 · see citing works
Marra, F., DeFranco, R., Grappone, C., Milani, S., Pastacaldi, S., Pinzani, M., Romanelli, R. G., Laffi, G., & Geñtilini, P. (1998) · Europe PMC (PubMed Central) · Cited by 287 · see citing works
Self-citationKim, Y.-S., Ratziu, V., Choi, S.-G., Lalazar, A., Theiss, G., Dang, Q., Kim, S., & Friedman, S. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.50.33750 · Cited by 249 · see citing works
Molecular regulation of hepatic fibrogenesis
Olaso, E., & Friedman, S. L. (1998) · Journal of Hepatology · doi:10.1016/s0168-8278(98)80269-9 · Cited by 244 · see citing works
Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis
Ratziu, V., Lalazar, A., Wong, L., Dang, Q., Collins, C. C., Shaulian, E., Jensen, S., & Friedman, S. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9500 · Cited by 240 · see citing works
Signal transduction in hepatic stellate cells
Pinzani, M., Marra, F., & Carloni, V. (1998) · Liver International · doi:10.1111/j.1600-0676.1998.tb00120.x · Cited by 232 · see citing works
Self-citationCasini, A., Pinzani, M., Milani, S., Grappone, C., Galli, G., Jézéquel, A. M., Schuppan, D., Rotella, C. M., & Surrenti, C. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90033-9 · Cited by 225 · see citing works
Self-citationMarra, F., Gentilini, A., Pinzani, M., Choudhury, G., Parola, M., Herbst, H., Mu, D., Laffi, G., Abboud, H. E., & Geñtilini, P. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70144-6 · Cited by 195 · see citing works
Self-citationHepatic stellate cells and the regulation of liver inflammation
Marra, F. (1999) · Journal of Hepatology · doi:10.1016/s0168-8278(99)80327-4 · Cited by 187 · see citing works
Self-citationMarra, F., Arrighi, M. C., Fazi, M., Caligiuri, A., Pinzani, M., Romanelli, R. G., Efsen, E., Laffi, G., & Geñtilini, P. (1999) · Hepatology · doi:10.1002/hep.510300406 · Cited by 160 · see citing works
Self-citationGoebeler, M., Kilian, K., Gillitzer, R., et al. (1999) · Blood · doi:10.1182/blood.v93.3.857.403k03_857_865 · Cited by 155 · see citing works
Davis, B. H., Kramer, R. T., & Davidson, N. O. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114943 · Cited by 148 · see citing works
Hansen, J. B., Petersen, R. K., Larsen, B. M., Bártková, J., Alsner, J., & Kristiansen, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.2386 · Cited by 143 · see citing works
Marra, F., Grandaliano, G., Valente, A. J., & Abboud, H. E. (1995) · Hepatology · doi:10.1002/hep.1840220314 · Cited by 118 · see citing works
Self-citationDiminished retinoic acid signaling in hepatic stellate cells in cholestatic liver fibrosis
Ohata, M., Lin, M. P., Satre, M. A., & Tsukamoto, H. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.272.3.g589 · Cited by 117 · see citing works
Hanazawa, S., Takeshita, A., Amano, S., et al. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98383-3 · Cited by 113 · see citing works
Friedman, S. L., Wei, S., & Blaner, W. S. (1993) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1993.264.5.g947 · Cited by 110 · see citing works
Meichle, A. (1992) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(92)90011-m · Cited by 102 · see citing works
Changes in melatonin concentrations during IFN therapy
Uchimura, Y., Uchimura, N., Kumashiro, R., Hattori, A., & Sata, M. (1999) · Journal of Hepatology · doi:10.1016/s0168-8278(99)80328-6 · Cited by 95 · see citing works
Marra, F., DeFranco, R., Grappone, C., Parola, M., Milani, S., Leonarduzzi, G., Pastacaldi, S., Wenzel, U. O., Pinzani, M., Dianzani, M. U., et al. (1999) · Journal of Investigative Medicine · doi:10.1177/108155899904700110 · Cited by 95 · see citing works
Self-citationGoebeler, M., Kilian, K., Gillitzer, R., et al. (1999) · Blood · doi:10.1182/blood.v93.3.857 · Cited by 91 · see citing works
Simultaneous induction of stimulatory and inhibitory signals by PDGF
Heldin, C. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00318-9 · Cited by 87 · see citing works
Valente, A. J., Xie, J. F., Abramova, M. A., Wenzel, U. O., Abboud, H. E., & Graves, D. T. (1998) · PubMed · Cited by 74 · see citing works
Interferon-gamma-mediated activation of STAT1alpha regulates growth factor-induced mitogenesis.
Marra, F., Choudhury, G. G., & Abboud, H. E. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118905 · Cited by 74 · see citing works
Self-citationGraf, K., Xi, X.-P., Hsueh, W. A., et al. (1997) · FEBS Letters · doi:10.1016/s0014-5793(96)01371-3 · Cited by 70 · see citing works
A Complex Element Regulates IFN-γ-Stimulated Monocyte Chemoattractant Protein-1 Gene Transcription
Valente, A. J., Xie, J. F., Abramova, M. A., Wenzel, U. O., Abboud, H. E., & Graves, D. T. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.7.3719 · Cited by 68 · see citing works
All- trans and 9- cis retinoic acid alter rat hepatic stellate cell phenotype differentially
Hellemans, K., Grinko, I., Rombouts, K., Schuppan, D., & Geerts, A. E. (1999) · Gut · doi:10.1136/gut.45.1.134 · Cited by 66 · see citing works
Choudhury, G. G., Wang, L. M., Pierce, J., Harvey, S. A. K., & Sakaguchi, A. Y. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)92941-8 · Cited by 55 · see citing works
Hanazawa, S., Takeshita, A., & Kitano, S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31973-7 · Cited by 46 · see citing works
Knockout of α6β1-integrin expression reverses the transformed phenotype of hepatocarcinoma cells
Carloni, V., Romanelli, R. G., Mercurio, A. M., et al. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70210-0 · Cited by 44 · see citing works
Self-citationIntegrin‐mediated stimulation of monocyte chemotactic protein‐1 expression
Marra, F., Pastacaldi, S., Romanelli, R. G., Pinzani, M., Ticali, P., Carloni, V., Laffi, G., & Geñtilini, P. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01004-1 · Cited by 29 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- Marra F, Arrighi MC, Fazi M, Caligiuri A, Pinzani M, Romanelli RG, Efsen E, Laffi G, Gentilini P. ERK activation differentially regulates PDGF's actions in hepatic stellate cells, and is induced by in vivo liver injury in the rat. Hepatology 1999;30:951-958.
- Marra F, Ghosh Choudhury G, Abboud HE. Interferon-␥-mediated activation of STAT1␣ regulates growth factor-induced mitogene- sis. J Clin Invest 1996;98:1218 -1230.
Cited by
Sorted by citations
Bataller, R., & Brenner, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24282 · Cited by 4,958 · see citing works
Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
Friedman, S. L. (2008) · Physiological Reviews · doi:10.1152/physrev.00013.2007 · Cited by 2,842 · see citing works
Liver fibrosis – from bench to bedside
Friedman, S. L. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00429-4 · Cited by 1,780 · see citing works
Liver inflammation and fibrosis
Koyama, Y., & Brenner, D. A. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88881 · Cited by 1,295 · see citing works
Fiorucci, S., Antonelli, E., Rizzo, G., Renga, B., Mencarelli, A., Riccardi, L., Orlandi, S., Pellicciari, R., & Morelli, A. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.08.001 · Cited by 472 · see citing works
Galli, A., Crabb, D. W., Ceni, E., Salzano, R., Mello, T., Svegliati–Baroni, G., Ridolfi, F., Trozzi, L., Surrenti, C., & Casini, A. (2002) · Gastroenterology · doi:10.1053/gast.2002.33666 · Cited by 440 · see citing works
Hepatic fibrosis: molecular mechanisms and drug targets
Lotersztajn, S., Julien, B., Teixeira-Clerc, F., Grenard, P., & Mallat, A. (2005) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.45.120403.095906 · Cited by 325 · see citing works
Hazra, S., Xiong, S., Wang, J., Rippe, R. A., Krishna, V., Chatterjee, K., & Tsukamoto, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310284200 · Cited by 320 · see citing works
Povero, D., Panera, N., Eguchi, A., Johnson, C. D., Papouchado, B. G., de Araujo Horcel, L., Pinatel, E. M., Alisi, A., Nobili, V., & Feldstein, A. E. (2015) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2015.07.007 · Cited by 221 · see citing works
Patterson, E., O' Doherty, R. M., Murphy, E. F., Wall, R., O' Sullivan, O., Nilaweera, K., Fitzgerald, G. F., Cotter, P. D., Ross, R. P., & Stanton, C. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514000117 · Cited by 211 · see citing works
Fiorucci, S., Rizzo, G., Antonelli, E., Renga, B., Mencarelli, A., Riccardi, L., Morelli, A., Pruzanski, M., & Pellicciari, R. (2005) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.085597 · Cited by 177 · see citing works
Boyer-Diaz, Z., Aristu-Zabalza, P., Andrés-Rozas, M., Robert, C., Ortega-Ribera, M., Fernández-Iglesias, A., Broqua, P., Junien, J.-L., Wettstein, G., Bosch, J., et al. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2020.11.045 · Cited by 168 · see citing works
Fickert, P., Fuchsbichler, A., Moustafa, T., Wagner, M., Zollner, G., Halilbasic, E., Stöger, U., Arrese, M., Pizarro, M., Solís, N., et al. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.090114 · Cited by 169 · see citing works
Self-citationPathophysiology of NASH: perspectives for a targeted treatment
Marra, F., & Lotersztajn, S. (2013) · Current Pharmaceutical Design · doi:10.2174/13816128113199990344 · Cited by 163 · see citing works
Self-citationKawaguchi, K., Sakaida, I., Tsuchiya, M., Omori, K., Takami, T., & Okita, K. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.01.038 · Cited by 160 · see citing works
Alcohol induced hepatic fibrosis: Role of acetaldehyde
Mello, T., Ceni, E., Surrenti, C., & Galli, A. (2008) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2007.10.001 · Cited by 160 · see citing works
Hellemans, K., Michalik, L., Dittie, A., Knorr, A., Rombouts, K., de Jong, J., Heirman, C., Quartier, E., Schuit, F., Wahli, W., et al. (2003) · Gastroenterology · doi:10.1053/gast.2003.50015 · Cited by 137 · see citing works
MAREK, C. J., TUCKER, S. J., KONSTANTINOU, D. K., ELRICK, L. J., HAEFNER, D., SIGALAS, C., MURRAY, G. I., GOODWIN, B., & WRIGHT, M. C. (2005) · Biochemical Journal · doi:10.1042/bj20041598 · Cited by 89 · see citing works
A critical review of endpoints for non-cirrhotic NASH therapeutic trials
Ratziu, V. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2017.12.001 · Cited by 74 · see citing works
Limited therapeutic efficacy of pioglitazone on progression of hepatic fibrosis in rats
Leclercq, I. A. (2006) · Gut · doi:10.1136/gut.2005.079194 · Cited by 67 · see citing works
Hellemans, K., Rombouts, K., Quartier, E., Dittié, A. S., Knorr, A., Michalik, L., Rogiers, V., Schuit, F., Wahli, W., & Geerts, A. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200376-jlr200 · Cited by 64 · see citing works
PPAR Gamma and Hepatic Stellate Cells
Hazra, S., Miyahara, T., Rippe, R. A., & Tsukamoto, H. (2004) · Comparative Hepatology · doi:10.1186/1476-5926-2-s1-s7 · Cited by 66 · see citing works
Sung, C. K., She, H., Xiong, S., & Tsukamoto, H. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00411.2003 · Cited by 63 · see citing works
Renga, B., Mencarelli, A., Migliorati, M., Cipriani, S., D’Amore, C., Distrutti, E., & Fiorucci, S. (2011) · Inflammation Research · doi:10.1007/s00011-010-0306-1 · Cited by 53 · see citing works
Nuclear receptors in liver fibrosis
Königshofer, P., Brusilovskaya, K., Petrenko, O., Hofer, B. S., Schwabl, P., Trauner, M., & Reiberger, T. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166235 · Cited by 45 · see citing works
Glucocorticoids have opposing effects on liver fibrosis in hepatic stellate and immune cells
Kim, K. H., Lee, J. M., Zhou, Y., Harpavat, S., & Moore, D. D. (2016) · Molecular Endocrinology · doi:10.1210/me.2016-1029 · Cited by 41 · see citing works
The new therapeutic frontier--nuclear receptors and the liver
Karpen, S. J., & Trauner, M. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2009.12.002 · Cited by 29 · see citing works
- Authors
- Marra, F., Efsen, E., Romanelli, R. G., Caligiuri, A., Pastacaldi, S., Batignani, G., Bonacchi, A., Caporale, R., Laffi, G., Pinzani, M., & Gentilini, P.
- Affiliations
- University of Florence (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- ORCID
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2000-08
- Volume
- 119
- Issue
- 2
- Pages
- 466-478
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2163207725
- Cited by
- 409
- References
- 62
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 5 · 2023: 10 · 2022: 5 · 2021: 14 · 2020: 11 · 2019: 10 · 2018: 9 · 2017: 20 · 2016: 16 · 2015: 20 · 2014: 14 · 2013: 17 · 2012: 16
- FWCI
- 10.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- PPARγ, hepatic stellate cells, PPARγ agonists, liver fibrosis, liver inflammation, cell proliferation, chemotaxis, platelet-derived growth factor, MCP-1, troglitazone, 15-deoxy-Δ12,14-prostaglandin J2, cell cycle progression, G1 phase, myofibroblast activation
- MeSH terms
- Troglitazone, Antineoplastic Agents, Biological Transport, Cell Division, Cell Movement, Cell Survival, Cells, Cultured, Chromans, Cytotoxins, Hepatitis, Humans, Interleukin-1, Ligands, Liver, Liver Cirrhosis, Phosphorylation, Platelet-Derived Growth Factor, Proto-Oncogenes, RNA, Messenger, Thiazoles, Transcription Factors, Tyrosine, Wound Healing, Prostaglandin D2, Gene Expression, NF-kappa B, Receptors, Cytoplasmic and Nuclear, Transcription Factor AP-1, Chemokine CCL2, Mitogen-Activated Protein Kinases, Thiazolidinediones, p38 Mitogen-Activated Protein Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
