Role of the Intestinal Microbiota in Resistance to Colonization by Clostridium difficile

Britton, Robert A.; Young, Vincent B.

doi:10.1053/j.gastro.2014.01.059

Cited by 446Clostridium difficile and Clostridium perfringens researchGut microbiota and healthGastrointestinal motility and disorders

Role of the Intestinal Microbiota in Resistance to Colonization by Clostridium difficile

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Britton, Robert A., Young, Vincent B.·2014·Gastroenterology

DOI 10.1053/j.gastro.2014.01.059PMC PMC3995857

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Abstract

Antibiotic-associated infection with the bacterial pathogen Clostridium difficile is a major cause of morbidity and increased health care costs. C difficile infection follows disruption of the indigenous gut microbiota by antibiotics. Antibiotics create an environment within the intestine that promotes C difficile spore germination, vegetative growth, and toxin production, leading to epithelial damage and colitis. Studies of patients with C difficile infection and animal models have shown that the indigenous microbiota can inhibit expansion and persistence of C difficile. Although the specific mechanisms of these processes are not known, they are likely to interfere with key aspects of the pathogen's physiology, including spore germination and competitive growth. Increasing our understanding of how the intestinal microbiota manage C difficile could lead to better means of controlling this important nosocomial pathogen.

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Susceptibility to CDI is predominantly driven by antibiotic-induced perturbations to the intestinal microbiota resulting in a loss of colonization resistance.
“Susceptibility to CDI is predominantly driven by antibiotic-induced perturbations to the intestinal microbiota resulting in a loss of colonization resistance”
From Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut (2023) · cites this paper as [24]

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Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548 · see citing works
A framework for human microbiome research
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11209 · Cited by 2,650 · see citing works
The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing
Dethlefsen, L., Huse, S., Sogin, M. L., & Relman, D. A. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060280 · Cited by 2,361 · see citing works
An Epidemic, Toxin Gene–Variant Strain of Clostridium difficile
McDonald, L. C., Killgore, G., Thompson, A. D., Owens, R. C., Kazakova, S. V., Sambol, S. P., Johnson, S., & Gerding, D. N. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051590 · Cited by 1,997 · see citing works
Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity
Pépin, J. (2004) · Canadian Medical Association Journal · doi:10.1503/cmaj.1041104 · Cited by 1,130 · see citing works
Clostridium difficile Toxins: Mechanism of Action and Role in Disease
Voth, D. E., & Ballard, J. D. (2005) · Clinical Microbiology Reviews · doi:10.1128/cmr.18.2.247-263.2005 · Cited by 1,103 · see citing works
Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens
Ng, K. M., Ferreyra, J. A., Higginbottom, S. K., Lynch, J. B., Kashyap, P. C., Gopinath, S., Naidu, N., Choudhury, B., Weimer, B. C., Monack, D. M., et al. (2013) · Nature · doi:10.1038/nature12503 · Cited by 1,035 · see citing works
Decreased Diversity of the Fecal Microbiome in RecurrentClostridium difficile–Associated Diarrhea
Chang, J. Y., Antonopoulos, D. A., Kalra, A., Tonelli, A., Khalife, W. T., Schmidt, T. M., & Young, V. B. (2008) · The Journal of Infectious Diseases · doi:10.1086/525047 · Cited by 1,010 · see citing works
Self-citation
The Changing Epidemiology of Clostridium difficile Infections
Freeman, J., Bauer, M. P., Baines, S. D., Corver, J., Fawley, W. N., Goorhuis, A., Kuijper, E. J., & Wilcox, M. H. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00082-09 · Cited by 825 · see citing works
INTESTINAL FLORA IN NEW-BORN INFANTS
Hall, I. C. (1935) · American journal of diseases of children · doi:10.1001/archpedi.1935.01970020105010 · Cited by 766 · see citing works
Stool substitute transplant therapy for the eradication of Clostridium difficile infection: ‘RePOOPulating’ the gut
Petrof, E. O., Gloor, G. B., Vanner, S. J., Weese, S. J., Carter, D., Daigneault, M. C., Brown, E. M., Schroeter, K., & Allen-Vercoe, E. (2013) · Microbiome · doi:10.1186/2049-2618-1-3 · Cited by 731 · see citing works
Bile Salts and Glycine as Cogerminants for Clostridium difficile Spores
Sorg, J. A., & Sonenshein, A. L. (2008) · Journal of Bacteriology · doi:10.1128/jb.01765-07 · Cited by 711 · see citing works
Emergence ofClostridium difficileInfection Due to a New Hypervirulent Strain, Polymerase Chain Reaction Ribotype 078
Goorhuis, A., Bakker, D., Corver, J., Debast, S. B., Harmanus, C., Notermans, D. W., Bergwerff, A. A., Dekker, F. W., & Kuijper, E. J. (2008) · Clinical Infectious Diseases · doi:10.1086/592257 · Cited by 633 · see citing works
Profound alterations of intestinal microbiota following a single dose of clindamycin results in sustained susceptibility to Clostridium difficile-induced colitis
Buffie, C. G., Jarchum, I., Equinda, M., Lipuma, L., Gobourne, A., Viale, A., Ubeda, C., Xavier, J., & Pamer, E. G. (2012) · Infection and Immunity · doi:10.1128/iai.05496-11 · Cited by 596 · see citing works
BACTERIOTHERAPY FOR CHRONIC RELAPSING CLOSTRIDIUM DIFFICILE DIARRHOEA IN SIX PATIENTS
Tvede, M., & Rask-Madsen, J. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92749-9 · Cited by 595 · see citing works
Reproducible Community Dynamics of the Gastrointestinal Microbiota following Antibiotic Perturbation
Antonopoulos, D. A., Huse, S. M., Morrison, H. G., Schmidt, T. M., Sogin, M. L., & Young, V. B. (2009) · Infection and Immunity · doi:10.1128/iai.01520-08 · Cited by 545 · see citing works
Self-citation
Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice
Lawley, T. D., Clare, S., Walker, A. W., Stares, M. D., Connor, T. R., Raisen, C., Goulding, D., Rad, R., Schreiber, F., Brandt, C., et al. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002995 · Cited by 540 · see citing works
A mouse model of clostridium difficile-associated disease
Chen, X., Katchar, K., Goldsmith, J. D., Nanthakumar, N., Cheknis, A., Gerding, D. N., & Kelly, C. P. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.09.002 · Cited by 510 · see citing works
Clindamycin-Associated Colitis Due to a Toxin-Producing Species of Clostridium in Hamsters
Bartlett, J. G., Onderdonk, A. B., Cisneros, R. L., & Kasper, D. L. (1977) · The Journal of Infectious Diseases · doi:10.1093/infdis/136.5.701 · Cited by 471 · see citing works
From Structure to Function: the Ecology of Host-Associated Microbial Communities
Robinson, C. J., Bohannan, B. J. M., & Young, V. B. (2010) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00014-10 · Cited by 454 · see citing works
Self-citation
Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers.
Hecht, G. A., Pothoulakis, C., LaMont, J. T., et al. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113760 · Cited by 392 · see citing works
Effect of Streptomycin on Susceptibility of Intestinal Tract to Experimental Salmonella Infection.
Bohnhoff, M., Drake, B. L., & Miller, C. P. (1954) · Experimental Biology and Medicine · doi:10.3181/00379727-86-21030 · Cited by 354 · see citing works
Mechanisms That Control Bacterial Populations in Continuous-Flow Culture Models of Mouse Large Intestinal Flora
Freter, R., Brickner, H., Botney, M. D., Cleven, D., & Aranki, A. (1983) · Infection and Immunity · doi:10.1128/iai.39.2.676-685.1983 · Cited by 340 · see citing works
Characterization of the kinetics of the passive and active transport mechanisms for bile acid absorption in the small intestine and colon of the rat
Schiff, E. R., Small, N. C., & Dietschy, J. M. (1972) · Journal of Clinical Investigation · doi:10.1172/jci106931 · Cited by 303 · see citing works
Role of competition for nutrients in suppression of Clostridium difficile by the colonic microflora
Wilson, K. H., & Perini, F. (1988) · Infection and Immunity · doi:10.1128/iai.56.10.2610-2614.1988 · Cited by 297 · see citing works
Suppression of Clostridium difficile in the Gastrointestinal Tracts of Germfree Mice Inoculated with a Murine Isolate from the Family Lachnospiraceae
Reeves, A. E., Koenigsknecht, M. J., Bergin, I. L., & Young, V. B. (2012) · Infection and Immunity · doi:10.1128/iai.00647-12 · Cited by 292 · see citing works
Self-citation
Bacteriotherapy for chronic relapsing Clostridium difficile in six patients
Tvede, M. (1989) · The Lancet · Cited by 290 · see citing works
Bile Acid Recognition by the Clostridium difficile Germinant Receptor, CspC, Is Important for Establishing Infection
Francis, M. B., Allen, C. A., Shrestha, R., & Sorg, J. A. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003356 · Cited by 284 · see citing works
The interplay between microbiome dynamics and pathogen dynamics in a murine model ofClostridium difficileInfection
Reeves, A. E., Theriot, C. M., Bergin, I. L., Huffnagle, G. B., Schloss, P. D., & Young, V. B. (2011) · Gut Microbes · doi:10.4161/gmic.2.3.16333 · Cited by 270 · see citing works
Self-citation
The Human Microbiome Project in 2011 and Beyond
Proctor, L. M. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.10.001 · Cited by 269 · see citing works
Active and Passive Bile Acid Absorption in Man. PERFUSION STUDIES OF THE ILEUM AND JEJUNUM
KRAG, E., & Phillips, S. F. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107720 · Cited by 248 · see citing works
Mouse model for colonization and disease caused by enterohemorrhagic Escherichia coli O157:H7
Wadolkowski, E. A., Burris, J. A., & O’Brien, A. D. (1990) · Infection and Immunity · doi:10.1128/iai.58.8.2438-2445.1990 · Cited by 239 · see citing works
Interaction between the intestinal microbiota and host in Clostridium difficile colonization resistance
Britton, R. A., & Young, V. B. (2012) · Trends in Microbiology · doi:10.1016/j.tim.2012.04.001 · Cited by 236 · see citing works
Self-citation
Clostridium difficile Carriage in Elderly Subjects and Associated Changes in the Intestinal Microbiota
Rea, M. C., O’Sullivan, Ó., Shanahan, F., O’Toole, P. W., Stanton, C., Ross, R. P., & Hill, C. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.05176-11 · Cited by 224 · see citing works
Clostridium difficile infection
Vedantam, G., Clark, A. E., Chu, M., McQuade, R., Mallozzi, M., & Viswanathan, V. K. (2012) · Gut Microbes · doi:10.4161/gmic.19399 · Cited by 210 · see citing works
Clostridium difficile toxin B acts on the GTP-binding protein Rho.
Just, I., Fritz, G., Aktories, K., et al. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34116-9 · Cited by 200 · see citing works
Neutrophil recruitment in Clostridium difficile toxin A enteritis in the rabbit.
Kelly, C. P., Becker, S., Linevsky, J. K., Joshi, M. A., O’Keane, J. C., Dickey, B. F., LaMont, J. T., & Pothoulakis, C. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117080 · Cited by 200 · see citing works
Chenodeoxycholate Is an Inhibitor of Clostridium difficile Spore Germination
Sorg, J. A., & Sonenshein, A. L. (2009) · Journal of Bacteriology · doi:10.1128/jb.01260-08 · Cited by 199 · see citing works
Metabolism of Bile Salts in Mice Influences Spore Germination in Clostridium difficile
Giel, J. L., Sorg, J. A., Sonenshein, A. L., & Zhu, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008740 · Cited by 195 · see citing works
The Fatal Enteric Cholera Infection in the Guinea Pig, Achieved by Inhibition of Normal Enteric Flora
Freter, R. (1955) · The Journal of Infectious Diseases · doi:10.1093/infdis/97.1.57 · Cited by 194 · see citing works
Clostridium difficile Carriage in Healthy Infants in the Community: A Potential Reservoir for Pathogenic Strains
Rousseau, C., Poilane, I., de Pontual, L., Maherault, A.-C., Monnier, A. L., & Collignon, A. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis637 · Cited by 192 · see citing works
Cefoperazone-treated mice as an experimental platform to assess differential virulence ofClostridium difficilestrains
Theriot, C. M., Koumpouras, C. C., Carlson, P. E., Bergin, I. L., Aronoff, D. M., & Young, V. B. (2011) · Gut Microbes · doi:10.4161/gmic.19142 · Cited by 190 · see citing works
Self-citation
Efficiency of various bile salt preparations for stimulation of Clostridium difficile spore germination
Wilson, K. H. (1983) · Journal of Clinical Microbiology · doi:10.1128/jcm.18.4.1017-1019.1983 · Cited by 188 · see citing works
Toward a structural understanding of Clostridium difficile toxins A and B
Pruitt, R. N., & Lacy, D. B. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00028 · Cited by 186 · see citing works
From Stool Transplants to Next-Generation Microbiota Therapeutics
Petrof, E. O., & Khoruts, A. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.004 · Cited by 184 · see citing works
Clostridium difficile Ribotype Does Not Predict Severe Infection
Walk, S. T., Micić, D., Jain, R., et al. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis786 · Cited by 184 · see citing works
Proline-Dependent Regulation of Clostridium difficile Stickland Metabolism
Bouillaut, L., Self, W. T., & Sonenshein, A. L. (2012) · Journal of Bacteriology · doi:10.1128/jb.01492-12 · Cited by 180 · see citing works
Clostridium difficile Toxins: Mediators of Inflammation
Shen, A. (2012) · Journal of Innate Immunity · doi:10.1159/000332946 · Cited by 171 · see citing works
A defined growth medium for Clostridium difficile
Karasawa, T., Ikoma, S., Yamakawa, K., & Nakamura, S. (1995) · Microbiology · doi:10.1099/13500872-141-2-371 · Cited by 168 · see citing works
Colonization for the Prevention of Clostridium difficile Disease in Hamsters
Sambol, S. P., Merrigan, M. M., Tang, J. K., Johnson, S., & Gerding, D. N. (2002) · The Journal of Infectious Diseases · doi:10.1086/345676 · Cited by 165 · see citing works
Antibiotic administration alters the community structure of the gastrointestinal microbiota
Robinson, C. J., & Young, V. B. (2010) · Gut Microbes · doi:10.4161/gmic.1.4.12614 · Cited by 161 · see citing works
Self-citation
The Microecology of Clostridium difficile
Wilson, K. H. (1993) · Clinical Infectious Diseases · doi:10.1093/clinids/16.supplement_4.s214 · Cited by 142 · see citing works
Colonic absorption of unconjugated bile acids
Mekhjian, H. S., Phillips, S. F., & Hofmann, A. F. (1979) · Digestive Diseases and Sciences · doi:10.1007/bf01489324 · Cited by 139 · see citing works
Colonization of the streptomycin-treated mouse large intestine by a human fecal Escherichia coli strain: role of growth in mucus
Wadolkowski, E. A., Laux, D. C., & Cohen, P. S. (1988) · Infection and Immunity · doi:10.1128/iai.56.5.1030-1035.1988 · Cited by 132 · see citing works
Analysis of Proline Reduction in the Nosocomial Pathogen Clostridium difficile
Jackson, S., Calos, M., Myers, A. G., & Self, W. T. (2006) · Journal of Bacteriology · doi:10.1128/jb.01370-06 · Cited by 123 · see citing works
Reductions in intestinal Clostridiales precede the development of nosocomial Clostridium difficile infection
Vincent, C., Stephens, D. A., Loo, V. G., Edens, T. J., Behr, M. A., Dewar, K., & Manges, A. R. (2013) · Microbiome · doi:10.1186/2049-2618-1-18 · Cited by 123 · see citing works
Clindamycin-Induced Enterocolitis in Hamsters
Lusk, R. H., Fekety, R., Silva, J., et al. (1978) · The Journal of Infectious Diseases · doi:10.1093/infdis/137.4.464 · Cited by 120 · see citing works
Mapping Interactions between Germinants and Clostridium difficile Spores
Howerton, A., Ramírez, N. R., & Abel‐Santos, E. (2010) · Journal of Bacteriology · doi:10.1128/jb.00980-10 · Cited by 118 · see citing works
A New Strategy for the Prevention of Clostridium difficile Infection
Howerton, A., Patra, M., & Abel‐Santos, E. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit068 · Cited by 104 · see citing works
Binary toxin producing Clostridium difficile strains
Rupnik, M., Grabnar, M., & Stare, B. G. (2003) · Anaerobe · doi:10.1016/j.anaerobe.2003.09.002 · Cited by 91 · see citing works
Succession in the Gut Microbiome following Antibiotic and Antibody Therapies for Clostridium difficile
Peterfreund, G. L., Vandivier, L. E., Sinha, R., Marozsan, A. J., Olson, W. C., Zhu, J., & Bushman, F. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046966 · Cited by 89 · see citing works
Identification of Clostridium difficile toxin B cardiotoxicity using a zebrafish embryo model of intoxication
Hamm, E. E., Voth, D. E., & Ballard, J. D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604725103 · Cited by 80 · see citing works
Clostridial Binary Toxins: Iota and C2 Family Portraits
Stiles, B. G., Wigelsworth, D. J., Popoff, M. R., & Barth, H. (2011) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2011.00011 · Cited by 60 · see citing works
Clostridium difficile Cytotoxin in a Pediatric Population
Thompson, C. M. (1983) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1983.02140290057015 · Cited by 56 · see citing works
Clostridium difficile infection: The scope of the problem
Dubberke, E. R. (2012) · Journal of Hospital Medicine · doi:10.1002/jhm.1916 · Cited by 45 · see citing works
Carbohydrate Fermentation by Clostridium difficile
Nakamura, S., Nakashio, S., Yamakawa, K., et al. (1982) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1982.tb00159.x · Cited by 36 · see citing works
A comparative analysis of the effect of antibiotic treatment and enteric infection on intestinal homeostasis
Antunes, L. C. M., & Finlay, B. B. (2011) · Gut Microbes · doi:10.4161/gmic.2.2.15610 · Cited by 35 · see citing works
Susceptibility of hamsters to human pathogenic Clostridium difficile strain B1 following clindamycin, ampicillin or ceftriaxone administration
Merrigan, M. M. (2003) · Anaerobe · doi:10.1016/s1075-9964(03)00063-5 · Cited by 25 · see citing works

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Asnicar, F., Manara, S., Zolfo, M., Truong, D. T., Scholz, M., Armanini, F., Ferretti, P., Gorfer, V., Pedrotti, A., Tett, A., et al. (2017) · mSystems · doi:10.1128/msystems.00164-16 · Cited by 445 · see citing works
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Authors: Britton, R. A., & Young, V. B.
Affiliations: Michigan State University (US)
University of Michigan (US)
Corresponding author: Young, Vincent B.
ORCID: Britton, Robert A.
Young, Vincent B.
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2014-05
Volume: 146
Issue: 6
Pages: 1547-1553
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2014.01.059
PMC: PMC3995857
OpenAlex: W2025786976
Cited by: 446
References: 68
Citations by year: 2026: 13 · 2025: 27 · 2024: 34 · 2023: 38 · 2022: 30 · 2021: 40 · 2020: 44 · 2019: 39 · 2018: 37 · 2017: 35 · 2016: 44 · 2015: 46 · 2014: 19
FWCI: 6.66
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Public Health Service (U19090872)
National Institute of Allergy and Infectious Diseases (U19AI090871, U19AI090872)
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK034933)
Topics: Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: Clostridium difficile, gut microbiota, antibiotic-associated diarrhea, Clostridium difficile infection, spore germination, toxin production, competitive exclusion, colitis, nosocomial infections, gut dysbiosis
MeSH terms: Animals, Anti-Bacterial Agents, Bile Acids and Salts, Biological Therapy, Disease Models, Animal, Enterocolitis, Pseudomembranous, Feces, Humans, Intestinal Mucosa, Intestines, Clostridioides difficile, Probiotics, Host-Pathogen Interactions, Microbiota, Dysbiosis

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Role of the Intestinal Microbiota in Resistance to Colonization by Clostridium difficile

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