Cited by 754Alcohol Consumption and Health EffectsGut microbiota and healthLiver Disease and Transplantation

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Gut–Liver Axis in Alcoholic Liver Disease

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Szabo, Gyongyi·2015·Gastroenterology

DOI 10.1053/j.gastro.2014.10.042PMC PMC4274189

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Abstract

Alcoholic liver disease (ALD) has been among the leading causes of cirrhosis and liver-related death worldwide for decades. Early discoveries in alcoholic liver disease identified increased levels of bacterial endotoxin in the portal circulation, suggesting a role for gut-derived toxins in ALD. Indeed, alcohol consumption can disrupt the intestinal epithelial barrier and result in increased gut permeability that increasingly is recognized as a major factor in ALD. Bacterial endotoxin, lipopolysaccharide, is a prototypic microbe-derived inflammatory signal that contributes to inflammation in ALD through activation of the Toll-like receptor 4. Recent studies also have shown that alcohol consumption is associated with alterations in the gut microbiome, and the dysbalance of pathogenic and commensal organisms in the intestinal microbiome may contribute to the abnormal gut-liver axis in ALD. Indeed, bacterial decontamination improves ALD both in human and animal models. This short review summarizes recent findings and highlights emerging trends in the gut-liver axis relevant to ALD.

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Authors: Szabo, G.
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2015-01
Volume: 148
Issue: 1
Pages: 30-36
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2014.10.042
PMC: PMC4274189
OpenAlex: W2034801500
Cited by: 754
References: 81
Citations by year: 2026: 64 · 2025: 67 · 2024: 72 · 2023: 67 · 2022: 89 · 2021: 77 · 2020: 63 · 2019: 59 · 2018: 67 · 2017: 49 · 2016: 51 · 2015: 28
FWCI: 6.05
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (AA021907, AA017729, AA010744)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Keywords: alcoholic liver disease, gut-liver axis, bacterial endotoxin, lipopolysaccharide, intestinal permeability, intestinal epithelial barrier, TLR4, gut microbiota, bacterial decontamination, liver cirrhosis, inflammation
MeSH terms: Animals, Bacteria, Humans, Intestinal Mucosa, Intestines, Liver, Liver Diseases, Alcoholic, Permeability, Prognosis, Signal Transduction, Microbiota

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