Cited by 107Advanced Glycation End Products researchPotato Plant ResearchFood and Agricultural Sciences

Comparison of Free and Bound Advanced Glycation End Products in Food: A Review on the Possible Influence on Human Health

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Zhao, Di, Sheng, Bulei, Wu, Yi, Li, Hao, Xu, Dan, Nian, Yingqun, Mao, Shengyong, Li, Chunbao +2 more·2019·Journal of Agricultural and Food Chemistry

Abstract

Debate on the hazards of advanced glycation end products (AGEs) in food has continued for many years as a result of their uncertain bioavailability and ability to bind to their receptors (RAGEs) in vivo . There are increasing evidence that free and bound AGEs have many differences in gastrointestinal digestion, intestinal absorption, binding with RAGEs, in vivo circulation, and renal clearance. Therefore, this paper compares these aspects between free and bound AGEs by summarizing the available knowledge. On the basis of the current knowledge, we conclude that it is time to differentiate free AGEs from bound AGEs in food in future studies, because they vary in many aspects that are closely related to their influence on human health. Several perspectives were proposed at the end of this review for further exploring the difference between free and bound AGEs in food.

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Crossref · 10.1021/acs.jafc.9b05891

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Authors
Zhao, D., Sheng, B., Wu, Y., Li, H., Xu, D., Nian, Y., Mao, S., Li, C., Xu, X., & Zhou, G.
Affiliations
  • Nanjing Agricultural University (CN)
  • Aarhus University (DK)
  • South China University of Technology (CN)
Corresponding author
Li, Chunbao
Venue
Journal of Agricultural and Food Chemistry
Published
2019-12-01
Volume
67
Issue
51
Pages
14007-14018
ISSN
  • 0021-8561 (ISSN-L)
  • 1520-5118
OpenAlex
W2989727899
Cited by
107
References
115
Citations by year
2026: 10 · 2025: 18 · 2024: 17 · 2023: 21 · 2022: 19 · 2021: 14 · 2020: 8
FWCI
1.34
Type
journal article
Language
en
Open access
Locations
  • Journal of Agricultural and Food Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Nanjing Agricultural University (JCQY201905)
  • National Natural Science Foundation of China (31530054)
  • Ministry of Agriculture and Rural Affairs of the People's Republic of China (CARS35)
  • Priority Academic Program Development of Jiangsu Higher Education Institutions
  • Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology (KL-2018-10)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Food and Agricultural Sciences
Keywords
advanced glycation end products, receptor for advanced glycation end products, bioavailability, gastrointestinal digestion, intestinal absorption, renal clearance, food safety, human health effects
MeSH terms
Digestion, Food Analysis, Health, Humans, Glycation End Products, Advanced

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