Comparison of Free and Bound Advanced Glycation End Products in Food: A Review on the Possible Influence on Human Health
Open accessAbstract
Debate on the hazards of advanced glycation end products (AGEs) in food has continued for many years as a result of their uncertain bioavailability and ability to bind to their receptors (RAGEs) in vivo . There are increasing evidence that free and bound AGEs have many differences in gastrointestinal digestion, intestinal absorption, binding with RAGEs, in vivo circulation, and renal clearance. Therefore, this paper compares these aspects between free and bound AGEs by summarizing the available knowledge. On the basis of the current knowledge, we conclude that it is time to differentiate free AGEs from bound AGEs in food in future studies, because they vary in many aspects that are closely related to their influence on human health. Several perspectives were proposed at the end of this review for further exploring the difference between free and bound AGEs in food.
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Sorted by citations
Rungratanawanich, W., Qu, Y., Wang, X., Essa, M. M., & Song, B.-J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00561-7 · Cited by 411 · see citing works
- Authors
- Zhao, D., Sheng, B., Wu, Y., Li, H., Xu, D., Nian, Y., Mao, S., Li, C., Xu, X., & Zhou, G.
- Affiliations
- Nanjing Agricultural University (CN)
- Aarhus University (DK)
- South China University of Technology (CN)
- Corresponding author
- Li, Chunbao
- ORCID
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-12-01
- Volume
- 67
- Issue
- 51
- Pages
- 14007-14018
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2989727899
- Cited by
- 107
- References
- 115
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 17 · 2023: 21 · 2022: 19 · 2021: 14 · 2020: 8
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- green
- pure.au.dk
- Licence
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Nanjing Agricultural University (JCQY201905)
- National Natural Science Foundation of China (31530054)
- Ministry of Agriculture and Rural Affairs of the People's Republic of China (CARS35)
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology (KL-2018-10)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Food and Agricultural Sciences
- Keywords
- advanced glycation end products, receptor for advanced glycation end products, bioavailability, gastrointestinal digestion, intestinal absorption, renal clearance, food safety, human health effects
- MeSH terms
- Digestion, Food Analysis, Health, Humans, Glycation End Products, Advanced
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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