Real-time targeted genome profile analysis of pancreatic ductal adenocarcinomas identifies genetic alterations that might be targeted with existing drugs or used as biomarkers
Open accessAbstract
BACKGROUND & AIMS: It has been a challenge to select treatment for patients with pancreatic ductal adenocarcinomas (PDACs) based on genome alterations. We performed targeted genomic profile analyses of a large number of PDACs to assess the full spectrum of actionable genomic alterations. METHODS: We performed targeted genomic profile analyses of 3594 PDAC samples from an international cohort, including capture-based targeted genomic profiling of as many as 315 cancer-associated genes and intron regions of 28 genes that are rearranged in cancer cells. Tumor mutation burden (TMB) and microsatellite instability (MSI) status were also assessed. TMB was calculated across a 1.14-megabase region; TMB-high was defined as ≥20 mutations/megabase. MSI-high status was assigned based on analysis of 114 intron homopolymer loci. RESULTS: KRAS, TP53, CDKN2A, and SMAD4 were the most frequently altered genes in PDAC. We found KRAS mutations in 88% of samples. Among PDACs without mutations in KRAS, we found alterations in genes whose products are in the mitogen-activated protein kinase signaling pathway and are candidate drug targets (actionable targets, n = 132; 4%), as well as gene fusions (n = 51), gene amplifications (n = 35), genes with missense mutations (n = 30), and genes that contain deletions (n = 16). Many of these encode proteins in receptor tyrosine kinase, RAS, or mitogen-activated protein kinase signaling pathways. Aside from TP53, alterations in genes encoding DNA damage repair proteins (BRCA and FANC) were detected in 14% of PDACs. Among PDACs evaluated for MSI (n = 2563) and TMB (n = 1021), MSI-high and/or TMB-high phenotypes were detected in 0.5% of samples. Alterations in FGF23, CCND2, PIK3CA, and FGF6 were more commonly detected in intraductal papillary mucinous neoplasm-associated PDACs. CONCLUSIONS: In targeted genomic profile analyses of 3594 PDACs, we found 17% to contain genomic alterations that might make the tumor cells susceptible to currently used anticancer agents. We identified mutations in genes that could contribute to progression of intraductal papillary mucinous neoplasms into malignancies. These alterations might be used as biomarkers for early detection.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Alternative drivers are found in 8-10% of PDAC cases that are KRAS wild type.
“there are also so-called “alternative drivers” found in the 8–10% of cases that are KRAS wild type104,105.”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [104]
Cites
A global reference for human genetic variation
The 1000 Genomes Project Consortium, authors, C., Auton, A., Abecasis, G. R., Steering committee, Altshuler, D. M., Durbin, R. M., Abecasis, G. R., Bentley, D. R., Chakravarti, A., et al. (2015) · Nature · doi:10.1038/nature15393 · Cited by 18,247 · see citing works
Siegel, R. L., Miller, K. D., & Jemal, A. (2018) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21442 · Cited by 16,632 · see citing works
Signatures of mutational processes in human cancer
Initiative, A. P. C. G., Alexandrov, L. B., ICGC Breast Cancer Consortium, ICGC MMML-Seq Consortium, PedBrain, I., Nik-Zainal, S., Wedge, D. C., Aparicio, S. A. J. R., Behjati, S., Biankin, A. V., et al. (2013) · Nature · doi:10.1038/nature12477 · Cited by 9,660 · see citing works
Analysis of protein-coding genetic variation in 60,706 humans
Exome Aggregation Consortium, Lek, M., Karczewski, K. J., Minikel, E. V., Samocha, K. E., Banks, E., Fennell, T., O’Donnell-Luria, A. H., Ware, J. S., Hill, A. J., et al. (2016) · Nature · doi:10.1038/nature19057 · Cited by 9,587 · see citing works
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
Le, D. T., Uram, J. N., Wang, H., Bartlett, B. R., Kemberling, H., Eyring, A. D., Skora, A. D., Luber, B. S., Azad, N. S., Laheru, D., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1500596 · Cited by 9,377 · see citing works
FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer
Conroy, T., Desseigne, F., Ychou, M., Bouché, O., Guimbaud, R., Bécouarn, Y., Adenis, A., Raoul, J.-L., Gourgou-Bourgade, S., de la Fouchardière, C., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1011923 · Cited by 7,810 · see citing works
Rahib, L., Smith, B. D., Aizenberg, R., Rosenzweig, A. B., Fleshman, J. M., & Matrisian, L. M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0155 · Cited by 7,094 · see citing works
Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine
Von Hoff, D. D., Ervin, T., Arena, F. P., Chiorean, E. G., Infante, J., Moore, M., Seay, T., Tjulandin, S. A., Ma, W. W., Saleh, M. N., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1304369 · Cited by 6,712 · see citing works
Self-citationMismatch repair deficiency predicts response of solid tumors to PD-1 blockade
Le, D. T., Durham, J. N., Smith, K. N., Wang, H., Bartlett, B. R., Aulakh, L. K., Lu, S., Kemberling, H., Wilt, C., Luber, B. S., et al. (2017) · Science · doi:10.1126/science.aan6733 · Cited by 6,645 · see citing works
SIFT: predicting amino acid changes that affect protein function
Ng, P. C. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg509 · Cited by 6,601 · see citing works
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969 · see citing works
Self-citationPredicting Functional Effect of Human Missense Mutations Using PolyPhen‐2
Adzhubei, I., Jordan, D. M., & Sunyaev, S. R. (2013) · Current Protocols in Human Genetics · doi:10.1002/0471142905.hg0720s76 · Cited by 3,705 · see citing works
Genomic analyses identify molecular subtypes of pancreatic cancer
Bailey, P., Chang, D. K., Nones, K., Johns, A. L., Patch, A.-M., Gingras, M.-C., Miller, D. K., Christ, A. N., Bruxner, T. J. C., Quinn, M. C., et al. (2016) · Nature · doi:10.1038/nature16965 · Cited by 3,621 · see citing works
Self-citationAnalysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden
Chalmers, Z. R., Connelly, C. F., Fabrizio, D., Gay, L., Ali, S. M., Ennis, R., Schrock, A., Campbell, B., Shlien, A., Chmielecki, J., et al. (2017) · Genome Medicine · doi:10.1186/s13073-017-0424-2 · Cited by 3,519 · see citing works
Self-citationClinVar: public archive of relationships among sequence variation and human phenotype
Landrum, M. J., Lee, J. M., Riley, G. R., Jang, W., Rubinstein, W. S., Church, D. M., & Maglott, D. R. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1113 · Cited by 3,516 · see citing works
Discovery and saturation analysis of cancer genes across 21 tumour types
Lawrence, M. S., Stojanov, P., Mermel, C. H., Robinson, J. T., Garraway, L. A., Golub, T. R., Meyerson, M., Gabriel, S. B., Lander, E. S., & Getz, G. (2014) · Nature · doi:10.1038/nature12912 · Cited by 3,096 · see citing works
Whole genomes redefine the mutational landscape of pancreatic cancer
Initiative, A. P. C. G., Waddell, N., Pajic, M., Patch, A.-M., Chang, D. K., Kassahn, K. S., Bailey, P., Johns, A. L., Miller, D., Nones, K., et al. (2015) · Nature · doi:10.1038/nature14169 · Cited by 2,642 · see citing works
Self-citationTumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers
Goodman, A. M., Kato, S., Bazhenova, L., Patel, S. P., Frampton, G. M., Miller, V., Stephens, P. J., Daniels, G. A., & Kurzrock, R. (2017) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-0386 · Cited by 2,264 · see citing works
Self-citationCOSMIC: exploring the world's knowledge of somatic mutations in human cancer
Forbes, S. A., Beare, D. M., Gunasekaran, P., Leung, K., Bindal, N., Boutselakis, H., Ding, M., Bamford, S., Cole, C. G., Ward, S. A., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1075 · Cited by 2,261 · see citing works
Frampton, G. M., Fichtenholtz, A., Otto, G. A., Wang, K., Downing, S. R., He, J., Schnall-Levin, M., White, J., Sanford, E. M., An, P., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2696 · Cited by 2,157 · see citing works
Self-citationPancreatic cancer genomes reveal aberrations in axon guidance pathway genes
Initiative, A. P. C. G., Biankin, A. V., Waddell, N., Kassahn, K. S., Gingras, M.-C., Muthuswamy, L. B., Johns, A. L., Miller, D. K., Wilson, P. J., Patch, A.-M., et al. (2012) · Nature · doi:10.1038/nature11547 · Cited by 2,058 · see citing works
Self-citationStandards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer
Li, M. M., Datto, M., Duncavage, E. J., Kulkarni, S., Lindeman, N. I., Roy, S., Tsimberidou, A. M., Vnencak‐Jones, C. L., Wolff, D. J., Younes, A., et al. (2016) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2016.10.002 · Cited by 2,054 · see citing works
Self-citationIntegrated genomic characterization of pancreatic ductal adenocarcinoma
Raphael, B. J., Hruban, R. H., Aguirre, A. J., Moffitt, R. A., Yeh, J. J., Stewart, C., Robertson, A. G., Cherniack, A. D., Gupta, M., Getz, G., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.07.007 · Cited by 2,019 · see citing works
Self-citationNeoptolemos, J. P., Palmer, D. H., Ghaneh, P., Psarelli, E. E., Valle, J. W., Halloran, C. M., Faluyi, O. O., O'Reilly, D. A., Cunningham, D., Wadsley, J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(16)32409-6 · Cited by 1,941 · see citing works
Olaparib Monotherapy in Patients With Advanced Cancer and a Germline BRCA1/2 Mutation
Kaufman, B., Shapira‐Frommer, R., Schmutzler, R. K., Audeh, M. W., Friedlander, M. L., Balmañà, J., Mitchell, G., Fried, G., Stemmer, S. M., Hubert, A., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2014.56.2728 · Cited by 1,707 · see citing works
HGVS Recommendations for the Description of Sequence Variants: 2016 Update
den Dunnen, J. T., Dalgleish, R. W. M., Maglott, D. R., Hart, R. K., Greenblatt, M. S., McGowan‐Jordan, J., Roux, A., Smith, T. D., Antonarakis, S. E., & Taschner, P. E. M. (2016) · Human Mutation · doi:10.1002/humu.22981 · Cited by 1,662 · see citing works
Hallmarks of 'BRCAness' in sporadic cancers
Turner, N. C., Tutt, A. N. J., & Ashworth, A. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1457 · Cited by 1,651 · see citing works
Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets
Witkiewicz, A. K., McMillan, E. A., Balaji, U., Baek, G., Lin, W.-C., Mansour, J., Mollaee, M., Wagner, K.-U., Koduru, P., Yopp, A., et al. (2015) · Nature Communications · doi:10.1038/ncomms7744 · Cited by 1,115 · see citing works
Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer
Tiriac, H., Belleau, P., Engle, D. D., Plenker, D., Deschênes, A., Somerville, T. D. D., Froeling, F. E. M., Burkhart, R. A., Denroche, R. E., Jang, G.-H., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0349 · Cited by 1,092 · see citing works
Pennington, K. P., Walsh, T., Harrell, M. I., Lee, M. K., Pennil, C. C., Rendi, M. H., Thornton, A., Norquist, B. M., Casadei, S., Nord, A. S., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2287 · Cited by 1,050 · see citing works
Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development
Wu, J., Matthaei, H., Maitra, A., Molin, M. D., Wood, L., Eshleman, J., Goggins, M., Canto, M., Schulick, R., Edil, B., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002543 · Cited by 786 · see citing works
Self-citationPhase II Study of BGJ398 in Patients With FGFR-Altered Advanced Cholangiocarcinoma
Javle, M. M., Lowery, M. A., Shroff, R. T., Weiss, K. H., Springfeld, C., Borad, M. J., Ramanathan, R. K., Goyal, L., Sadeghi, S., Macarulla, T. M., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2017.75.5009 · Cited by 695 · see citing works
Wu, J., Jiao, Y., Molin, M. D., Maitra, A., de Wilde, R. F., Wood, L. D., Eshleman, J. R., Goggins, M., Wolfgang, C. L., Canto, M. I., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118046108 · Cited by 640 · see citing works
Self-citationAung, K. L., Fischer, S. E., Denroche, R. E., Jang, G.-H., Dodd, A., Creighton, S., Southwood, B., Liang, S.-B., Chadwick, D., Zhang, A., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2994 · Cited by 618 · see citing works
Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma
Palanisamy, N., Ateeq, B., Sundaram, S. K., Pflueger, D., Ramnarayanan, K., Shankar, S., Han, B., Cao, Q., Cao, X., Suleman, K., et al. (2010) · Nature Medicine · doi:10.1038/nm.2166 · Cited by 460 · see citing works
Overall survival and clinical characteristics of pancreatic cancer in BRCA mutation carriers
Golan, T., Kanji, Z. S., Epelbaum, R., Devaud, N., Dagan, E., Holter, S., Aderka, D., Paluch–Shimon, S., Kaufman, B., Gershoni‐Baruch, R., et al. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.418 · Cited by 437 · see citing works
Self-citationSinghi, A. D., McGrath, K., Brand, R. E., Khalid, A., Zeh, H. J., Chennat, J. S., Fasanella, K. E., Papachristou, G. I., Slivka, A., Bartlett, D. L., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-313586 · Cited by 405 · see citing works
Self-citationReal-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine
Aguirre, A. J., Nowak, J. A., Camarda, N. D., Moffitt, R. A., Ghazani, A. A., Hazar-Rethinam, M., Raghavan, S., Kim, J., Brais, L. K., Ragon, D., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0275 · Cited by 367 · see citing works
Amato, E., Molin, M. D., Mafficini, A., Yu, J. Q., Malleo, G., Rusev, B. C., Fassan, M., Antonello, D., Sadakari, Y., Castelli, P., et al. (2014) · The Journal of Pathology · doi:10.1002/path.4344 · Cited by 349 · see citing works
Self-citationYoh, K., Seto, T., Satouchi, M., Nishio, M., Yamamoto, N., Murakami, H., Nogami, N., Matsumoto, S., Kohno, T., Tsuta, K., et al. (2016) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(16)30322-8 · Cited by 298 · see citing works
Sun, J., He, Y., Sanford, E. M., Montesion, M., Frampton, G. M., Vignot, S., Soria, J., Ross, J. S., Miller, V. A., Stephens, P. J., et al. (2018) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005965 · Cited by 273 · see citing works
Self-citationTargeting HER2 for the Treatment of Breast Cancer
Rimawi, M. F., Schiff, R., & Osborne, C. K. (2015) · Annual Review of Medicine · doi:10.1146/annurev-med-042513-015127 · Cited by 268 · see citing works
Chantrill, L. A., Nagrial, A. M., Watson, C., Johns, A. L., Martyn-Smith, M., Simpson, S. H., Mead, S., Jones, M. D., Samra, J. S., Gill, A. J., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-0426 · Cited by 238 · see citing works
HER2/neu-directed therapy for biliary tract cancer
Javle, M. M., Churi, C. R., Kang, H. C., Shroff, R. T., Jankú, F., Surapaneni, R., Zuo, M., Barrera, C., Al-Shamsi, H. O., Krishnan, S., et al. (2015) · Journal of Hematology & Oncology · doi:10.1186/s13045-015-0155-z · Cited by 227 · see citing works
Prospective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms
Lowery, M. A., Wong, W., Jordan, E. J., Lee, J. W., Kemel, Y., Vijai, J., Mandelker, D., Zehir, A., Capanu, M., Salo-Mullen, E., et al. (2018) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djy024 · Cited by 224 · see citing works
Lowery, M. A., Jordan, E., Baştürk, O., Ptashkin, R. N., Zehir, A., Berger, M. F., Leach, T., Herbst, B. T., Askan, G., Maynard, H., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-0899 · Cited by 212 · see citing works
Hypermutation In Pancreatic Cancer
Humphris, J. L., Patch, A., Nones, K., Bailey, P. J., Johns, A. L., McKay, S., Chang, D. K.-F., Miller, D. K., Pajic, M., Kassahn, K. S., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.09.060 · Cited by 209 · see citing works
Self-citationCystic precursors to invasive pancreatic cancer
Matthaei, H., Schulick, R. D., Hruban, R. H., & Maitra, A. (2011) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2011.2 · Cited by 193 · see citing works
Self-citationChmielecki, J., Hutchinson, K. E., Frampton, G. M., Chalmers, Z. R., Johnson, A., Shi, C., Elvin, J. A., Ali, S. M., Ross, J. S., Baştürk, O., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0617 · Cited by 188 · see citing works
Self-citationKanda, M., Sadakari, Y., Borges, M., Topazian, M., Farrell, J., Syngal, S., Lee, J., Kamel, I., Lennon, A. M., Knight, S., et al. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.11.016 · Cited by 181 · see citing works
Chen, S.-H., Zhang, Y., Van Horn, R. D., Yin, T., Buchanan, S., Yadav, V., Mochalkin, I., Wong, S. S., Yue, Y. G., Huber, L., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0896 · Cited by 171 · see citing works
PIK3CA Mutations in Intraductal Papillary Mucinous Neoplasm/Carcinoma of the Pancreas
Schönleben, F., Qiu, W., Ciau, N. T., Ho, D. J., Li, X., Allendorf, J., Remotti, H. E., & Su, G. H. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0292 · Cited by 164 · see citing works
Identification of Targetable ALK Rearrangements in Pancreatic Ductal Adenocarcinoma
Singhi, A. D., Ali, S. M., Lacy, J., Hendifar, A. E., Nguyen, K., Koo, J., Chung, J., Greenbowe, J. R., Ross, J. S., Nikiforova, M. N., et al. (2017) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2017.0058 · Cited by 106 · see citing works
Self-citationTargeted Therapies for Lung Cancer
Larsen, J. E., Cascone, T., Gerber, D. E., Heymach, J. V., & Minna, J. D. (2011) · The Cancer Journal · doi:10.1097/ppo.0b013e31823e701a · Cited by 103 · see citing works
Biomarker-Based Therapy in Pancreatic Ductal Adenocarcinoma: An Emerging Reality?
Krantz, B. A., & O'Reilly, E. M. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-3169 · Cited by 43 · see citing works
Pishvaian, M. J., Rolfo, C. D., Liu, S. V., Multani, P. S., Maneval, E. C., & Garrido‐Laguna, I. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2018.36.4_suppl.521 · Cited by 38 · see citing works
Kyrgiou, M., Kalliala, I. E. J., Mitra, A., Ng, K. Y. B., Raglan, O., Fotopoulou, C., Martin‐Hirsch, P. L., Paraskevaidis, E. A., & Arbyn, M. (2016) · International Journal of Cancer · doi:10.1002/ijc.30419 · Cited by 23 · see citing works
Kindler, H. L., Locker, G. Y., Mann, H., & Golan, T. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2015.33.15_suppl.tps4149 · Cited by 12 · see citing works
Self-citationOverall survival of patients with pancreatic adenocarcinoma and BRCA1 or BRCA2 germline mutation.
Aung, K. L., Holter, S., Borgida, A., Connor, A. A., Pintilie, M., Dhani, N. C., Hedley, D. W., Knox, J. J., & Gallinger, S. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.34.15_suppl.4123 · Cited by 10 · see citing works
Flagged first, then by citations
1 of the 60 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Pancreatic cancer: Advances and challenges
Halbrook, C. J., Lyssiotis, C. A., Pasca di Magliano, M., & Maitra, A. (2023) · Cell · doi:10.1016/j.cell.2023.02.014 · Cited by 1,321 · see citing works
Self-citationThe Frequency of Ras Mutations in Cancer
Prior, I. A., Hood, F. E., & Hartley, J. L. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-3682 · Cited by 1,130 · see citing works
Stoop, T. F., Javed, A. A., Oba, A., Koerkamp, B. G., Seufferlein, T. T. W., Wilmink, J. W., & Besselink, M. G. (2025) · The Lancet · doi:10.1016/s0140-6736(25)00261-2 · Cited by 544 · see citing works
Therapeutic developments in pancreatic cancer
Hu, Z., & O'Reilly, E. M. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00840-w · Cited by 425 · see citing works
Mosele, M. F., Westphalen, C. B., Stenzinger, A., Barlési, F., Bayle, A., Bièche, I., Bonastre, J., Castro, E., Dienstmann, R., Krämer, A., et al. (2024) · Annals of Oncology · doi:10.1016/j.annonc.2024.04.005 · Cited by 443 · see citing works
Translational and therapeutic evaluation of RAS-GTP inhibition by RMC-6236 in RAS-driven cancers
Jiang, J., Jiang, L., Maldonato, B. J., Wang, Y., Holderfield, M., Aronchik, I., Winters, I. P., Salman, Z., Blaj, C., Menard, M., et al. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0027 · Cited by 343 · see citing works
Molecular epidemiology and diagnostics of KRAS mutations in human cancer
Timar, J., & Kashofer, K. (2020) · Cancer and Metastasis Reviews · doi:10.1007/s10555-020-09915-5 · Cited by 334 · see citing works
Luchini, C., Brosens, L. A. A., Wood, L. D., Chatterjee, D., Shin, J. I., Sciammarella, C., Fiadone, G., Malleo, G., Salvia, R., Kryklyva, V., et al. (2020) · Gut · doi:10.1136/gutjnl-2020-320726 · Cited by 257 · see citing works
PARP inhibitors in pancreatic cancer: molecular mechanisms and clinical applications
Zhu, H., Wei, M., Xu, J., Hua, J., Chen, L., Meng, Q., Zhang, Y., Liu, J., Zhang, B., Yu, X., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01167-9 · Cited by 258 · see citing works
Translational advances in pancreatic ductal adenocarcinoma therapy
Hosein, A. N., Dougan, S. K., Aguirre, A. J., & Maitra, A. (2022) · Nature Cancer · doi:10.1038/s43018-022-00349-2 · Cited by 249 · see citing works
Self-citationMelisi, D., Oh, D., Hollebecque, A., Calvo, E., Varghese, A. M., Borazanci, E. H., Macarulla, T. M., Merz, V., Zecchetto, C., Zhao, Y., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-002068 · Cited by 214 · see citing works
Paniccia, A., Polanco, P. M., Boone, B. A., Wald, A. I., McGrath, K., Brand, R. E., Khalid, A., Kubiliun, N. M., Lennon, A. M., Park, W. G., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.09.028 · Cited by 211 · see citing works
Self-citationAutophagy as a therapeutic target in pancreatic cancer
Piffoux, M., Eriau, E., & Cassier, P. A. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01039-5 · Cited by 182 · see citing works
Singhi, A. D., Nikiforova, M. N., Chennat, J. S., Papachristou, G. I., Khalid, A., Rabinovitz, M., Das, R. K., Sarkaria, S., Ayasso, M. S., Wald, A. I., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-317817 · Cited by 177 · see citing works
Self-citationSinghi, A. D., Wood, L. D., Parks, E., Torbenson, M. S., Felsenstein, M., Hruban, R. H., Nikiforova, M. N., Wald, A. I., Kaya, C., Nikiforov, Y. E., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.10.028 · Cited by 167 · see citing works
Self-citationCasolino, R., Paiella, S., Azzolina, D., Beer, P. A., Corbo, V., Lorenzoni, G., Gregori, D., Golan, T., Braconi, C., Froeling, F. E. M., et al. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.20.03238 · Cited by 144 · see citing works
Self-citationLawlor, R. T., Mattiolo, P., Mafficini, A., Hong, S., Piredda, M. L., Taormina, S. V., Malleo, G., Marchegiani, G., Pea, A., Salvia, R., et al. (2021) · Cancers · doi:10.3390/cancers13133119 · Cited by 134 · see citing works
Pancreatic cancer in 2021: What you need to know to win
Tonini, V., & Zanni, M. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i35.5851 · Cited by 126 · see citing works
Federico, A. D., Mosca, M., Pagani, R., Carloni, R., Frega, G., Giglio, A. D., Rizzo, A., Ricci, D., Tavolari, S., Marco, M. D., et al. (2022) · Cancers · doi:10.3390/cancers14102429 · Cited by 115 · see citing works
BRCA Mutations in Pancreas Cancer: Spectrum, Current Management, Challenges and Future Prospects
Wong, W., Raufi, A. G., Safyan, R. A., Bates, S. E., & Manji, G. A. (2020) · Cancer Management and Research · doi:10.2147/cmar.s211151 · Cited by 109 · see citing works
Arechederra, M., Rullán, M., Amat, I., Oyón, D., Zabalza, L., Elizalde, M., Latasa, M. U., Mercado, M., Ruiz-Clavijo, D., Saldaña, C., et al. (2021) · Gut · doi:10.1136/gutjnl-2021-325178 · Cited by 109 · see citing works
Pishvaian, M. J., Blais, E. M., Brody, J. R., Rahib, L., Lyons, E. E., Arbeloa, P., Hendifar, A. E., Mikhail, S., Chung, V. M., Sohal, D. P. S., et al. (2019) · JCO Precision Oncology · doi:10.1200/po.19.00115 · Cited by 103 · see citing works
Self-citationKRAS wild-type pancreatic ductal adenocarcinoma: molecular pathology and therapeutic opportunities
Luchini, C., Paolino, G., Mattiolo, P., Piredda, M. L., Cavaliere, A., Gaule, M., Melisi, D., Salvia, R., Malleo, G., Shin, J. I., et al. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01732-6 · Cited by 101 · see citing works
Overman, M. J., Javle, M. M., Davis, R. E., Vats, P., Kumar‐Sinha, C., Xiao, L., Mettu, N. B., Parra, E. R., Benson, A. B., Lopez, C. D., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-000587 · Cited by 94 · see citing works
Self-citationOzaka, M., Nakachi, K., Kobayashi, S., Ohba, A., Imaoka, H., Terashima, T., Ishii, H., Mizusawa, J., Katayama, H. G., Kataoka, T., et al. (2022) · European Journal of Cancer · doi:10.1016/j.ejca.2022.12.014 · Cited by 94 · see citing works
Martens, S., Lefesvre, P., Nicolle, R., Biankin, A. V., Puleo, F., Laethem, J. V., & Rooman, I. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz181 · Cited by 78 · see citing works
Masugi, Y. (2022) · Cancers · doi:10.3390/cancers14133293 · Cited by 81 · see citing works
The Role of Imaging in Current Treatment Strategies for Pancreatic Adenocarcinoma
Rhee, H., & Park, M.-S. (2020) · Korean Journal of Radiology · doi:10.3348/kjr.2019.0862 · Cited by 64 · see citing works
The tumor therapy landscape of synthetic lethality
Zhang, B., Tang, C., Yao, Y., Chen, X., Zhou, C., Wei, Z., Xing, F., Chen, L., Cai, X., Zhang, Z., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21544-2 · Cited by 72 · see citing works
Clinical and genomic characterisation of mismatch repair deficient pancreatic adenocarcinoma
Grant, R. C., Denroche, R. E., Jang, G. H., Nowak, K. M., Zhang, A. X. W., Borgida, A., Holter, S., Topham, J. T., Wilson, J. M., Dodd, A., et al. (2020) · Gut · doi:10.1136/gutjnl-2020-320730 · Cited by 71 · see citing works
The Role of Inherited Pathogenic CDKN2A Variants in Susceptibility to Pancreatic Cancer
Kimura, H., Klein, A. P., Hruban, R. H., & Roberts, N. J. (2021) · Pancreas · doi:10.1097/mpa.0000000000001888 · Cited by 65 · see citing works
Immunotherapy in Pancreatic Adenocarcinoma: Beyond “Copy/Paste”
Hester, R., Mazur, P. K., & McAllister, F. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-0900 · Cited by 65 · see citing works
Nikiforova, M. N., Wald, A. I., Spagnolo, D. M., Melan, M. A., Grupillo, M., Lai, Y.-T., Brand, R. E., Lennon, A. M., McGrath, K., Park, W. G., et al. (2023) · Annals of Surgery · doi:10.1097/sla.0000000000005904 · Cited by 66 · see citing works
Self-citationImproving outcomes of patients with pancreatic cancer
Dreyer, S. B., Beer, P. A., Hingorani, S. R., & Biankin, A. V. (2025) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-025-01019-9 · Cited by 66 · see citing works
Characterization of the genomic landscape in large-scale Chinese patients with pancreatic cancer
Zhang, X., Mao, T., Zhang, B., Xu, H., Cui, J., Jiao, F., Chen, D., Wang, Y., Hu, J., Xia, Q., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.103897 · Cited by 62 · see citing works
Shen, H., Lundy, J., Strickland, A. H., Harris, M., Swan, M. P., Desmond, C., Jenkins, B. J., & Croagh, D. G. (2022) · Cells · doi:10.3390/cells11193175 · Cited by 57 · see citing works
Gupta, M., Sherrow, C., Krone, M. E., Blais, E. M., Pishvaian, M. J., Petricoin, E. F., Matrisian, L. M., DeArbeloa, P., Gregory, G., Brown, A., et al. (2021) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2020.7641 · Cited by 53 · see citing works
Molecular Subtyping and Precision Medicine for Pancreatic Cancer
Froeling, F. E. M., Casolino, R., Pea, A., Biankin, A. V., Chang, D. K.-F., & Precision-Panc, O. B. O. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10010149 · Cited by 50 · see citing works
Pancreatic Ductal Adenocarcinoma: Molecular Pathology and Predictive Biomarkers
Taherian, M., Wang, H., & Wang, H. (2022) · Cells · doi:10.3390/cells11193068 · Cited by 49 · see citing works
Oncogenic Drivers and Therapeutic Vulnerabilities in KRAS Wild-Type Pancreatic Cancer
Singh, H., Keller, R. B., Kapner, K. S., Dilly, J., Raghavan, S., Yuan, C., Cohen, E. F., Tolstorukov, M. Y., Andrews, E., Brais, L. K., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-3930 · Cited by 46 · see citing works
Next-generation therapies for pancreatic cancer
Buckley, C. W., & O'Reilly, E. M. (2024) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2024.2322648 · Cited by 47 · see citing works
Liu, X., Wang, W., Liu, X., Zhang, Z., Yu, L., Li, R., Guo, D., Cai, W., Quan, X., Wu, H., et al. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.670 · Cited by 43 · see citing works
Pancreatic cancer: molecular pathogenesis and emerging therapeutic strategies
Rozengurt, E., & Eibl, G. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02499-y · Cited by 45 · see citing works
Targeting DNA damage repair pathways in pancreas cancer
Crowley, F., Park, W., & O’Reilly, E. M. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-09983-1 · Cited by 43 · see citing works
Adamopoulos, C., Cave, D. D., & Papavassiliou, A. G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031631 · Cited by 41 · see citing works
RET gene rearrangements occur in a subset of pancreatic acinar cell carcinomas
Chou, A. S. Y., Brown, I., Kumarasinghe, P. M., Perren, A. A., Riley, D., Kim, Y., Pajic, M., Steinmann, A. M., Rathi, V., Jamieson, N. B., et al. (2019) · Modern Pathology · doi:10.1038/s41379-019-0373-y · Cited by 40 · see citing works
Therapeutic advances in metastatic pancreatic cancer: a focus on targeted therapies
Turpin, A., Neuzillet, C., Colle, E., Dusetti, N., Nicolle, R., Cros, J. F., de Mestier, L., Bachet, J., & Hammel, P. R. (2022) · Therapeutic Advances in Medical Oncology · doi:10.1177/17588359221118019 · Cited by 39 · see citing works
Thompson, E. D., Roberts, N. J., Wood, L. D., Eshleman, J. R., Goggins, M., Kern, S. E., Klein, A. P., & Hruban, R. H. (2020) · Modern Pathology · doi:10.1038/s41379-020-0629-6 · Cited by 39 · see citing works
Evolving pancreatic cancer treatment: From diagnosis to healthcare management
Milella, M., Bassi, C., Boggi, U., Brunetti, O., Cavaliere, A., Crippa, S., Vita, F. D., Falconi, M., Frassineti, G. L., Giommoni, E., et al. (2021) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2021.103571 · Cited by 37 · see citing works
Giannis, D., Moris, D., & Barbas, A. S. (2021) · Cancers · doi:10.3390/cancers13051071 · Cited by 37 · see citing works
Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity
Fu, Z., Chen, S., Zhu, Y., Zhang, D., Xie, P., Jiao, Q., Chi, J. J., Xu, S., Xue, Y., Lu, X., et al. (2023) · Science Advances · doi:10.1126/sciadv.add6626 · Cited by 37 · see citing works
Chakrabarti, S., Kamgar, M., & Mahipal, A. (2022) · Cancers · doi:10.3390/cancers14112588 · Cited by 36 · see citing works
Cortese, N., Capretti, G. L., Barbagallo, M., Rigamonti, A., Takis, P. G., Castino, G. F., Vignali, D., Maggi, G., Gavazzi, F., Ridolfi, C., et al. (2020) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-19-0403 · Cited by 35 · see citing works
George, B., Kudryashova, O. M., Kravets, A. D., Thalji, S. Z., Malarkannan, S., Kurzrock, R., Chernyavskaya, E. F., Gusakova, M., Kravchenko, D., Tychinin, D. I., et al. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.01.028 · Cited by 35 · see citing works
Self-citationFusion genes in pancreatic tumors
Γκουντάκος, Α., Singhi, A. D., Westphalen, C. B., Scarpa, A., & Luchini, C. (2024) · Trends in cancer · doi:10.1016/j.trecan.2024.01.009 · Cited by 34 · see citing works
Self-citationMoving the Needle on Precision Medicine in Pancreatic Cancer
O'Kane, G. M., & Lowery, M. A. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.21.02514 · Cited by 34 · see citing works
Cheng, K., Li, X., Lv, W., Zhao, G., Zhou, R., Chen, C., Yang, H., Li, R., Li, Z., Chen, Y., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02031-8 · Cited by 33 · see citing works
From Genetic Alterations to Tumor Microenvironment: The Ariadne’s String in Pancreatic Cancer
Bazzichetto, C., Conciatori, F., Luchini, C., Simionato, F., Santoro, R., Vaccaro, V., Corbo, V., Falcone, I., Ferretti, G., Cognetti, F., et al. (2020) · Cells · doi:10.3390/cells9020309 · Cited by 33 · see citing works
Fusco, M. J., Saeed‐Vafa, D., Carballido, E. M., Boyle, T. A., Malafa, M. P., Blue, K., Teer, J. K., Walko, C. M., McLeod, H. L., Hicks, J. K., et al. (2021) · JCO Precision Oncology · doi:10.1200/po.20.00265 · Cited by 34 · see citing works
Ambrosini, M., Re, M. D., Manca, P., Hendifar, A. E., Drilon, A. E. D. C., Harada, G., Ree, A. H., Klempner, S. J., Mælandsmo, G. M., Flatmark, K., et al. (2022) · JCO Precision Oncology · doi:10.1200/po.22.00015 · Cited by 33 · see citing works
Self-citationClinical significance of circulating-tumour DNA analysis by metastatic sites in pancreatic cancer
Umemoto, K., Sunakawa, Y., Ueno, M., Furukawa, M., Mizuno, N., Sudo, K., Kawamoto, Y., Kajiwara, T., Ohtsubo, K., Okano, N., et al. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02189-y · Cited by 34 · see citing works
Malignant epithelial/exocrine tumors of the pancreas
Luchini, C., Grillo, F., Fassan, M., Vanoli, A., Capelli, P., Paolino, G., Ingravallo, G., Renzulli, G., Doglioni, C., D’Amuri, A., et al. (2020) · Pathologica · doi:10.32074/1591-951x-167 · Cited by 32 · see citing works
Precision medicine for KRAS wild-type pancreatic adenocarcinomas
Ben-Ammar, I., Rousseau, A., Nicolle, R., Tarabay, A., Boige, V., Valéry, M., Pudlarz, T., Malka, D., Gelli, M., Fernandez-De-Sevilla, E., et al. (2023) · European Journal of Cancer · doi:10.1016/j.ejca.2023.113497 · Cited by 31 · see citing works
Rozengurt, E., & Eibl, G. (2021) · Cancers · doi:10.3390/cancers13205126 · Cited by 30 · see citing works
ATM Serine/Threonine Kinase and its Role in Pancreatic Risk
Nanda, N., & Roberts, N. J. (2020) · Genes · doi:10.3390/genes11010108 · Cited by 29 · see citing works
Sugimoto, M., Irie, H., Takagi, T. J., Suzuki, R., Konno, N., Asama, H., Sato, Y., Nakamura, J., Takasumi, M., Hashimoto, M., et al. (2020) · BMC Cancer · doi:10.1186/s12885-020-07588-5 · Cited by 29 · see citing works
Tarasiuk, A., Mackiewicz, T., Malecka-Panas, E. I., & Fichna, J. (2021) · Cancer Biology & Therapy · doi:10.1080/15384047.2021.1941584 · Cited by 29 · see citing works
Hendifar, A. E., Blais, E. M., Wolpin, B. M., Subbiah, V., Collisson, E. A., Singh, I., Cannon, T. L., Shaw, K. R. M., Petricoin, E. F., Klempner, S. J., et al. (2021) · JCO Precision Oncology · doi:10.1200/po.20.00494 · Cited by 31 · see citing works
Self-citationUmemoto, K., Yamamoto, H., Oikawa, R., Takeda, H., Doi, A., Horie, Y., Arai, H., Ogura, T., Mizukami, T., Izawa, N., et al. (2022) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djac106 · Cited by 29 · see citing works
Emerging Role of Targeted Therapy in Metastatic Pancreatic Adenocarcinoma
Huffman, B. M., Ellis, H., Jordan, A. C., Freed-Pastor, W. A., Perez, K. J., Rubinson, D. A., Sethi, N. S., Singh, H., Surana, R., Wolpin, B. M., et al. (2022) · Cancers · doi:10.3390/cancers14246223 · Cited by 30 · see citing works
Clinical and genomic characterisation of early-onset pancreatic cancer
Castet, F., Fabregat-Franco, C., Castillo, G., Navarro, V., Sierra, A., Acosta, D. A., López-Valbuena, D., Dienstmann, R., Tabernero, J. M., Vivancos, A. P., et al. (2023) · European Journal of Cancer · doi:10.1016/j.ejca.2023.113338 · Cited by 29 · see citing works
The Roles of Frequently Mutated Genes of Pancreatic Cancer in Regulation of Tumor Microenvironment
Sun, H., Zhang, B., & Li, H. (2020) · Technology in Cancer Research & Treatment · doi:10.1177/1533033820920969 · Cited by 28 · see citing works
Lee, M. S., & Pant, S. (2021) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_321255 · Cited by 29 · see citing works
Targeting KRAS in Pancreatic Cancer
Cowzer, D., Zameer, M., Conroy, M. R., Kölch, W., & Duffy, A. G. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12111870 · Cited by 29 · see citing works
Bansod, S., Dodhiawala, P. B., & Lim, K. (2021) · Cancers · doi:10.3390/cancers13215481 · Cited by 26 · see citing works
Are targeted therapies or immunotherapies effective in metastatic pancreatic adenocarcinoma?
Rémond, M., Pellat, A., Brézault, C., Dhooge, M., & Coriat, R. (2022) · ESMO Open · doi:10.1016/j.esmoop.2022.100638 · Cited by 27 · see citing works
Immunosuppressive tumor microenvironment in pancreatic cancer: mechanisms and therapeutic targets
Pan, D., Li, X., Qiao, X., & Wang, Q. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1582305 · Cited by 26 · see citing works
Targeting DNA Damage Repair Mechanisms in Pancreas Cancer
Perkhofer, L., Golan, T., Cuyle, P.-J. A., Matysiak‐Budnik, T., Laethem, J. V., Macarulla, T. M., Cauchin, E., Kleger, A., Beutel, A. K., Gout, J., et al. (2021) · Cancers · doi:10.3390/cancers13174259 · Cited by 25 · see citing works
Self-citationZhan, Q., Wen, C., Zhao, Y., Fang, L., Jin, Y., Zhang, Z., Zou, S., Li, F., Yang, Y., Wu, L., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103716 · Cited by 25 · see citing works
BRAF-Driven Pancreatic Cancer: Prevalence, Molecular Features, and Therapeutic Opportunities
Ciner, A., Jiang, Y., & Hausner, P. F. (2022) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-22-0626 · Cited by 25 · see citing works
Semaan, A., Bernard, V., Lee, J. J., Wong, J., Huang, J. H., Swartzlander, D. B., Stephens, B. M., Monberg, M. E., Weston, B. R., Bhutani, M. S., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-2667 · Cited by 24 · see citing works
Self-citationAnimal Models of Cancer-Related Pain: Current Perspectives in Translation
Pineda-Farías, J. B., Saloman, J. L., & Scheff, N. N. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.610894 · Cited by 24 · see citing works
Roles of the nervous system in pancreatic cancer
Wakiya, T., Ishido, K., Yoshizawa, T., Kanda, T., & Hakamada, K. (2021) · Annals of Gastroenterological Surgery · doi:10.1002/ags3.12459 · Cited by 22 · see citing works
Age and prognosis in patients with pancreatic cancer: a population-based study
van Dongen, J. C., van der Geest, L. G., de Meijer, V. E., van Santvoort, H. C., de Vos‐Geelen, J., Besselink, M. G., Koerkamp, B. G., Wilmink, J. W., van Eijck, C. H. J., & on behalf of the Dutch Pancreatic Cancer Group (2021) · Acta Oncologica · doi:10.1080/0284186x.2021.2016949 · Cited by 24 · see citing works
KRAS as a Key Oncogene in the Clinical Precision Diagnosis and Treatment of Pancreatic Cancer
Dai, M., Chen, S., Teng, X., Chen, K., & Cheng, W. (2022) · Journal of Cancer · doi:10.7150/jca.76695 · Cited by 24 · see citing works
Ca2+ Signaling and Its Potential Targeting in Pancreatic Ductal Carcinoma
Bettaieb, L., Brulé, M., Chomy, A., Diedro, M., Fruit, M., Happernegg, E., Heni, L., Horochowska, A., Housseini, M., Klouyovo, K., et al. (2021) · Cancers · doi:10.3390/cancers13123085 · Cited by 24 · see citing works
Kimura, H., Paranal, R. M., Nanda, N., Wood, L. D., Eshleman, J. R., Hruban, R. H., Goggins, M. G., Klein, A. P., The Familial Pancreatic Cancer Genome Sequencing Project, & Roberts, N. J. (2022) · eLife · doi:10.7554/elife.71137 · Cited by 23 · see citing works
Exceptional Response to Erdafitinib in FGFR2-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
Ng, C., Glaspy, J. A., Placencio-Hickok, V., Thomassian, S., Gong, J., Osipov, A., Hendifar, A. E., & Moshayedi, N. (2022) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2022.7039 · Cited by 23 · see citing works
Self-citationAdherence to NCCN Genetic Testing Guidelines in Pancreatic Cancer and Impact on Treatment
Crowley, F., Gandhi, S., Rudshteyn, M., Sehmbhi, M., & Cohen, D. J. (2023) · The Oncologist · doi:10.1093/oncolo/oyad044 · Cited by 23 · see citing works
Sakakida, T., Ishikawa, T., Doi, T., Morita, R., Kataoka, S., Miyake, H., Yamaguchi, K., Moriguchi, M., Sogame, Y., Yasuda, H., et al. (2023) · Journal of Gastroenterology · doi:10.1007/s00535-023-02058-8 · Cited by 23 · see citing works
Resection of Recurrent Pancreatic Cancer: Who Can Benefit?
Nienhüser, H., Büchler, M. W., & Schneider, M. A. (2021) · Visceral Medicine · doi:10.1159/000519754 · Cited by 22 · see citing works
Ashida, R., & Kitano, M. (2022) · Digestive Endoscopy · doi:10.1111/den.14344 · Cited by 22 · see citing works
Gleeson, F. C., Levy, M. J., Jackson, R. A., Murphy, S. J., Halling, K. C., Kipp, B. R., Graham, R. P., & Zhang, L. (2019) · Pancreatology · doi:10.1016/j.pan.2019.12.002 · Cited by 21 · see citing works
Intraductal Pancreatic Mucinous Neoplasms: A Tumor-Biology Based Approach for Risk Stratification
Nasca, V., Chiaravalli, M., Piro, G., Esposito, A., Salvatore, L., Tortora, G., Corbo, V., & Carbone, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176386 · Cited by 21 · see citing works
Poly( ADP ‐ribose) polymerase inhibition in pancreatic cancer
Singh, H. M., Bailey, P. J., Hübschmann, D., Berger, A. K., Neoptolemos, J. P., Jäger, D., Siveke, J. T., & Springfeld, C. (2020) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22932 · Cited by 21 · see citing works
First international workshop of the ATM and cancer risk group (4-5 December 2019)
Lesueur, F., Easton, D. F., Renault, A., Tavtigian, S. V., Bernstein, J. L., Kote‐Jarai, Z., Eeles, R. A., Plaseska-Karanfia, D., Feliubadaló, L., Spanish ATM working group, et al. (2021) · Familial Cancer · doi:10.1007/s10689-021-00248-y · Cited by 21 · see citing works
Immunotherapy and Pancreatic Cancer: A Lost Challenge?
Laface, C., Memeo, R., Maselli, F. M., Santoro, A. N., Iaia, M. L., Ambrogio, F., Laterza, M., Cazzato, G., Guarini, C., Santis, P. D., et al. (2023) · Life · doi:10.3390/life13071482 · Cited by 21 · see citing works
Gower, A., Golestany, B., Gong, J., Singhi, A. D., & Hendifar, A. E. (2020) · JCO Precision Oncology · doi:10.1200/po.19.00365 · Cited by 23 · see citing works
Self-citationBiological Hallmarks and New Therapeutic Approaches for the Treatment of PDAC
Digiacomo, G., Volta, F., Garajová, I., Balsano, R., & Cavazzoni, A. (2021) · Life · doi:10.3390/life11080843 · Cited by 20 · see citing works
Advancements in Systemic Therapy for Pancreatic Cancer
Brown, T. J., Reiss, K. A., & O’Hara, M. H. (2023) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_397082 · Cited by 20 · see citing works
- Authors
- Singhi, A. D., George, B., Greenbowe, J. R., Chung, J., Suh, J., Maitra, A., Klempner, S. J., Hendifar, A., Milind, J. M., Golan, T., Brand, R. E., Zureikat, A. H., Roy, S., Schrock, A. B., Miller, V. A., Ross, J. S., Ali, S. M., & Bahary, N.
- Affiliations
- University of Pittsburgh Medical Center (US)
- Medical College of Wisconsin (US)
- Foundation Medicine (United States) (US)
- The University of Texas MD Anderson Cancer Center (US)
- Cedars-Sinai Medical Center (US)
- Tel Aviv University (IL)
- Corresponding author
- Singhi, Aatur D.
- ORCID
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 156
- Issue
- 8
- Pages
- 2242-2253.e4
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2919944461
- Cited by
- 348
- References
- 60
- Citations by year
- 2026: 27 · 2025: 43 · 2024: 51 · 2023: 55 · 2022: 56 · 2021: 63 · 2020: 43 · 2019: 9
- FWCI
- 17.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Gastroenterology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Pancreatic Cancer Action Network
- Association for Molecular Pathology
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- pancreatic ductal adenocarcinoma, actionable genomic alterations, KRAS mutation, TP53, CDKN2A, SMAD4, MAPK signaling, gene fusion, gene amplification, microsatellite instability, tumor mutational burden, DNA repair, intraductal papillary mucinous neoplasm, biomarkers, therapeutic target
- MeSH terms
- Fibroblast Growth Factor-23, Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Adenocarcinoma, Mucinous, Chromosome Mapping, Female, Humans, Male, Middle Aged, Neoplasm Invasiveness, Neoplasm Staging, Pancreatic Neoplasms, Retrospective Studies, Biomarkers, Tumor, Genetic Variation, Cohort Studies, Gene Expression Regulation, Neoplastic, Carcinoma, Pancreatic Ductal, Young Adult, Genomic Structural Variation, Molecular Targeted Therapy, Real-Time Polymerase Chain Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review