Alterations in composition and diversity of the intestinal microbiota in patients with diarrhea‐predominant irritable bowel syndrome

Carroll, I. M.; Ringel‐Kulka, T.; Siddle, J. P.; Ringel, Y.

doi:10.1111/j.1365-2982.2012.01891.x

Cited by 433Gut microbiota and healthGastrointestinal motility and disordersMicroscopic Colitis

Alterations in composition and diversity of the intestinal microbiota in patients with diarrhea‐predominant irritable bowel syndrome

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Carroll, I. M., Ringel‐Kulka, T., Siddle, J. P., Ringel, Y.·2012·Neurogastroenterology & Motility

DOI 10.1111/j.1365-2982.2012.01891.xPMC PMC3975596

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Abstract

Background The intestinal microbiota has been implicated in the pathophysiology of irritable bowel syndrome (IBS). Due to the variable resolutions of techniques used to characterize the intestinal microbiota, and the heterogeneity of IBS, the defined alterations of the IBS intestinal microbiota are inconsistent. We analyzed the composition of the intestinal microbiota in a defined subgroup of IBS patients (diarrhea‐predominant IBS, D‐IBS) using a technique that provides the deepest characterization available for complex microbial communities. Methods Fecal DNA was isolated from 23 D‐IBS patients and 23 healthy controls (HC). Variable regions V1–V3 and V6 of the 16S rRNA gene were amplified from all samples. PCR products were sequenced using 454 high throughput sequencing. The composition, diversity and richness of microbial communities were determined and compared between D‐IBS and HC using the quantitative insights into microbial ecology pipeline. Key Results The contribution of bacterial groups to the composition of the intestinal microbiota differed between D‐IBS and HC. D‐IBS patients had significantly higher levels of Enterobacteriaceae (P = 0.03), and lower levels of Fecalibacterium genera (P = 0.04) compared to HC. β‐Diversity values demonstrated significantly lower levels of UniFrac distances in HC compared to D‐IBS patients. The richness of 16S rRNA sequences was significantly decreased in D‐IBS patients (P < 0.04). Conclusions & Inferences Our 16S rRNA sequence data demonstrates a community‐level dysbiosis in D‐IBS. The altered composition of the intestinal microbiota in D‐IBS is associated with significant increases in detrimental and decreases in beneficial bacterial groups, and a reduction in microbial richness.

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The colonic microbiome is altered in patients with IBS compared with healthy controls.
“others have shown that the colonic microbiome is altered in patients with IBS, when compared with healthy controls. 15 - 18”
From Efficacy of Probiotics in Irritable Bowel Syndrome: Systematic Review and Meta-analysis (2023) · cites this paper as [16]
The Discussion reports differences in intestinal microbiota between diarrhea-predominant IBS patients and healthy controls. But this study analyzed fecal samples from that IBS subgroup, so it does not directly establish the claim for the colonic microbiome in IBS patients generally (Discussion; page unavailable). (LLM, conf=0.84)
Experimental — accuracy not yet measured
Emerging data support the existence of dysbiosis in a subset of IBS: a decreased complexity in composition, temporary instability, and changes in the mucosa-associated microbiota, with an increase in Bacteroides and Clostridia and a reduction in Bifidobacterium.
“Nonetheless, emerging data support the existence of dysbiosis in a subset of IBS [59] : a decreased complexity in composition [60] , temporary instability [61] , and changes in the mucosa-associated microbiota, with an increase in Bacteroides and Clostridia and a reduction in Bifidobacterium [62] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [60]
Recent studies using advanced molecular biology techniques have demonstrated quantitative alterations of specific bacterial groups in patients with IBS compared with healthy controls.
“Recent studies using these advanced molecular biology techniques have demonstrated quantitative alterations of specific bacterial groups (33, 34, 81, 85, 142, 154) and reduced diversity in gut microbial populations in patients with IBS compared with healthy controls (33, 40).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [34]

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Alterations in composition and diversity of the intestinal microbiota in patients with diarrhea-predominant irritable bowel syndrome: Alterations in composition and diversity of the intestinal microbiota in D-IBS
Ringel‐Kulka, T., Carroll, I. M., Siddle, J. P., & Ringel, Y. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/xdg7-6c29
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Fecal and Mucosa-Associated Intestinal Microbiota in Patients with Diarrhea-Predominant Irritable Bowel Syndrome
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Molecular analysis of the luminal- and mucosal-associated intestinal microbiota in diarrhea-predominant irritable bowel syndrome
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Authors: Carroll, I. M., Ringel‐Kulka, T., Siddle, J. P., & Ringel, Y.
Affiliations: University of North Carolina at Chapel Hill (US)
Corresponding author: Ringel, Y.
ORCID: Carroll, I. M.
Ringel‐Kulka, T.
Venue: Neurogastroenterology & Motility
Publisher: Wiley
Published: 2012-02-20
Volume: 24
Issue: 6
Pages: 521
ISSN: 1350-1925 (ISSN-L)
1365-2982
DOI: 10.1111/j.1365-2982.2012.01891.x
PMC: PMC3975596
OpenAlex: W1487811474
Cited by: 425
References: 63
Citations by year: 2026: 12 · 2025: 18 · 2024: 28 · 2023: 30 · 2022: 39 · 2021: 40 · 2020: 33 · 2019: 35 · 2018: 30 · 2017: 32 · 2016: 31 · 2015: 27 · 2014: 37 · 2013: 25 · 2012: 7
FWCI: 12.33
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Neurogastroenterology & Motility (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (R03DK084294, DK075621, K23DK075621, K01DK092330, DK084294)
National Center for Research Resources (UL1RR025747)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Epidemiology › Microscopic Colitis
Keywords: diarrhea-predominant irritable bowel syndrome, gut microbiota, dysbiosis, microbial diversity, microbial richness, Enterobacteriaceae, 16S rRNA gene sequencing
MeSH terms: Adult, Aged, Diarrhea, DNA, Bacterial, Feces, Female, Humans, Intestines, Male, Middle Aged, Irritable Bowel Syndrome, Metagenome

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Alterations in composition and diversity of the intestinal microbiota in patients with diarrhea‐predominant irritable bowel syndrome

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