The DOI matches its Crossref record; 188 of the 188 references it cites were found in a registry or an index.
The Microbiota-Gut-Brain Axis: From Motility to Mood
Open accessAbstract
The gut-brain axis plays an important role in maintaining homeostasis. Many intrinsic and extrinsic factors influence signaling along this axis, modulating the function of both the enteric and central nervous systems. More recently the role of the microbiome as an important factor in modulating gut-brain signaling has emerged and the concept of a microbiota-gut-brain axis has been established. In this review, we highlight the role of this axis in modulating enteric and central nervous system function and how this may impact disorders such as irritable bowel syndrome and disorders of mood and affect. We examine the overlapping biological constructs that underpin these disorders with a special emphasis on the neurotransmitter serotonin, which plays a key role in both the gastrointestinal tract and in the brain. Overall, it is clear that although animal studies have shown much promise, more progress is necessary before these findings can be translated for diagnostic and therapeutic benefit in patient populations.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016) · Cell · doi:10.1016/j.cell.2016.05.041 · Cited by 7,070
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549
Revised Estimates for the Number of Human and Bacteria Cells in the Body
Sender, R., Fuchs, S., & Milo, R. (2016) · PLOS Biology · doi:10.1371/journal.pbio.1002533 · Cited by 5,425
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888
Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis
Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., Nagler, C. R., Ismagilov, R. F., Mazmanian, S. K., & Hsiao, E. Y. (2015) · Cell · doi:10.1016/j.cell.2015.02.047 · Cited by 3,614
Research works printed but not linked: 3
- Diaz Heijtz, 2011, Normal gut microbiota modulates brain development and behavior, Proc Natl Acad Sci U S A, 108, 3047, 10.1073/pnas.1010529108 · DOI · Paper page
- Fulling, 2019, Gut microbe to brain signaling: what happens in vagus, Neuron, 101, 998, 10.1016/j.neuron.2019.02.008 · DOI · Paper page
- Erny, 2015, Host microbiota constantly control maturation and function of microglia in the CNS, Nat Neurosci, 18, 965, 10.1038/nn.4030 · DOI · Paper page
Cited by
Sorted by citations
Items 301–400 of 1,000
Fabà, L., Hulshof, T. G., Venrooij, K. C. M., & van Hees, H. M. J. (2023) · Journal of Animal Science · doi:10.1093/jas/skad419 · Cited by 17
The bidirectional relationship of depression and disturbances in B cell homeostasis: Double trouble
Wu, S., Yin, Y., & Du, L. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.110993 · Cited by 17
Cheng, Y., Zhu, Z., Yang, Z., Liu, X., Qian, X., Zhu, J., Hu, X., Jiang, P., Cui, T., Wang, Y., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-97369-6 · Cited by 21
Social behavior in 16p11.2 and 22q11.2 copy number variations: Insights from mice and humans
Benedetti, A., Molent, C., Barcik, W., & Papaleo, F. (2021) · Genes Brain & Behavior · doi:10.1111/gbb.12787 · Cited by 18
Microbiota-Gut-Brain Axis in Psychiatry: Focus on Depressive Disorders
Wang, I.-C., Buffington, S. A., & Salas, R. (2024) · Current Epidemiology Reports · doi:10.1007/s40471-024-00349-z · Cited by 24
Irritable Bowel Syndrome: A Hallmark of Psychological Distress in Women?
Marano, G., Traversi, G., Pola, R., Gasbarrini, A., Gaetani, E., & Mazza, M. (2025) · Life · doi:10.3390/life15020277 · Cited by 27
The Impact of Diet on the Colonization of Beneficial Microbes from an Ecological Perspective
Chen, Z., Xiao, C., Zhang, J., Jian, S., Li, P., Lin, J., He, C., Chen, Z., Qi, Y., Shi, J., et al. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c02086 · Cited by 19
Microbiota metabolites affect sleep as drivers of brain‑gut communication (Review)
Cheng, H. Y., Yang, W., Xu, H., Zhu, W., Gong, A., Yang, X., Li, S., & Xu, H. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5571 · Cited by 21
A Comprehensive Review of Fortification, Bioavailability, and Health Benefits of Folate
Li, J., Duan, H., Ramaswamy, H. S., & Wang, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26167703 · Cited by 16
Bioinspired in vitro intestinal mucus model for 3D-dynamic culture of bacteria
Sardelli, L., Vangosa, F. B., Merli, M., Ziccarelli, A., Visentin, S., Visai, L., & Petrini, P. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.213022 · Cited by 16
Gastrointestinal and Hepatobiliary Symptoms and Disorders with Long (Chronic) COVID Infection
Rizvi, A., Ziv, Y., Crawford, J. M., & Trindade, A. J. (2023) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2022.09.002 · Cited by 17
The Involvement of Immune Cells Between Ischemic Stroke and Gut Microbiota
Pu, B., Zhu, H., Wei, L., Gu, L., Zhang, S., Jian, Z., & Xiong, X. (2023) · Translational Stroke Research · doi:10.1007/s12975-023-01151-7 · Cited by 16
Wang, Y., Hu, Y., & Shi, P. (2024) · BMC Gastroenterology · doi:10.1186/s12876-024-03311-x · Cited by 19
Wang, M., Sun, P., Chai, X., Liu, Y., Li, L., Zheng, W., Chen, S., Zhu, X., & Zhao, S. (2024) · Theranostics · doi:10.7150/thno.99468 · Cited by 20
Wang, M., Zhu, Z., Wu, X., Cheong, K., Li, X., Yu, W., Yao, Y., Wu, J., & Cao, Z. (2024) · Foods · doi:10.3390/foods13172782 · Cited by 16
Timofticiuc, D. C. P., Bădescu, D., Moța, M., Ștefan, A. G., Mitrea, A., Clenciu, D., Efrem, I. C., Roșu, M. M., Vladu, B. E., Gheonea, T. C., et al. (2024) · Nutrients · doi:10.3390/nu16234057 · Cited by 20
Zhou, W., Zhou, Y., Zhang, S., Li, B., Li, Z., Bai, Z., Sun, D., Huangfu, C., Wang, N., Xia, T., et al. (2024) · Science China Life Sciences · doi:10.1007/s11427-024-2779-9 · Cited by 18
Wang, M., Liu, Y., Zhong, L., Wu, F., & Wang, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1533343 · Cited by 17
Li, X., Su, Q., Xue, J., & Wei, S. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.143320 · Cited by 15
Hajare, S., & Kulkarni, Y. A. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149975 · Cited by 18
Gut–brain communication: types of sensory nerves and mechanisms of activation
Spencer, N. J., Hibberd, T. J., & Hu, H. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01132-1 · Cited by 20
Tongta, S., Sungkaworn, T., & Pathomthongtaweechai, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262210974 · Cited by 19
Traditional Chinese Medicine in Ameliorating Diabetic Kidney Disease Via Modulating Gut Microbiota
Yang, Y., & Wu, C. (2021) · Integrative Medicine in Nephrology and Andrology · doi:10.4103/imna.imna_28_21 · Cited by 15
Yang, C., Xue, J., Qin, Q., Xia, Y., Cheng, S., Jiang, X., Zhang, S., Lu, Z., Qin, X., Zhang, J., et al. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.113402 · Cited by 15
Labrenz, F., Merz, C. J., & Icenhour, A. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1204136 · Cited by 17
Ferrari, S., Galla, R., Mulè, S., Rosso, G., Brovero, A., Macchi, V., Ruga, S., & Uberti, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512281 · Cited by 16
Livingston, D. B. H., Sweet, A., Rodrigue, A. F., Kishore, L., Loftus, J., Ghali, F., Mahmoodianfard, S., Celton, C., Hosseinian, F. S., & Power, K. A. (2023) · Nutrients · doi:10.3390/nu15163542 · Cited by 15
Cerdó, T., Nieto-Ruíz, A., García-Santos, J. A., Rodríguez-Pöhnlein, A., García-Ricobaraza, M., Suárez, A., García-Bermúdez, M., & Campoy, C. (2023) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-061021-025355 · Cited by 16
Xie, X., Li, Y., Zhang, Y., Lin, X., Huang, M., Fu, H., Ma, Y., Chen, R., Wang, X., & Tang, J. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.01.101 · Cited by 16
Microglia in Microbiota-Gut-Brain Axis: A Hub in Epilepsy
Liu, Y., Jia, N., Tang, C., Long, H., & Wang, J. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04022-w · Cited by 15
From Gut to Brain: Unraveling the Intricate Link Between Microbiome and Stroke
Raghani, N. R., Postwala, H. I., Shah, Y. B., Chorawala, M. R., & Parekh, P. S. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10295-3 · Cited by 16
Wang, Y., Wang, Y., Ding, K., Liu, Y., Liu, D., Chen, W., Zhang, X., Luo, C., Zhang, H., Xu, T., et al. (2024) · Nutrients · doi:10.3390/nu16131989 · Cited by 20
Yuan, X., Chai, J., Xu, W., & Zhao, Y. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10326-z · Cited by 15
A systematic review of yoga for the treatment of gastrointestinal disorders
Thakur, E. R., Shapiro, J. M., Wellington, J., Sohl, S. J., Danhauer, S. C., Moshiree, B., Ford, A. C., & Koch, K. L. (2024) · Neurogastroenterology & Motility · doi:10.1111/nmo.14915 · Cited by 15
El-Sharkawy, O. S., El-Rashidy, O. F., Elagouza, I. A. A., Nassar, B. A., & Taha, S. (2024) · International Journal of Immunopathology and Pharmacology · doi:10.1177/03946320241291276 · Cited by 15
Barbosa, I. G., de Miranda, A. S., Berk, M., & Teixeira, A. L. (2024) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2024.2438646 · Cited by 16
Ahmad, F., Ahmed, S. H., Choucair, F., Chouliaras, S., Awwad, J. T., & Terranegra, A. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06117-x · Cited by 16
Szklany, K., Engen, P. A., Naqib, A. D., Green, S. J., Keshavarzian, A., Lopez‐Rincon, A., Siebrand, C. J., Diks, M. A. P., van de Kaa, M., Garssen, J., et al. (2021) · Nutrients · doi:10.3390/nu14010173 · Cited by 15
Nutraceuticals in mood disorders: current knowledge and future directions
Travica, N., Teasdale, S. B., & Marx, W. (2022) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000826 · Cited by 16
Wang, W., Wang, M., Peng, H., Huang, J., & Wu, T. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.10.111 · Cited by 15
Ejima, R., Mishima, R., Sen, A., Yamaguchi, K., Mitsuyama, E., Kaneko, H., Kimura, M., Arai, S., Mutoh, N., Hiraku, A., et al. (2024) · Nutrients · doi:10.3390/nu16213580 · Cited by 15
Microbiome and Brain Development: A Tale of Two Systems
Cryan, J. F. (2025) · Annals of Nutrition and Metabolism · doi:10.1159/000544950 · Cited by 15
Barbu, A. C., Stoleru, S., Zugravu, A., Poenaru, E., Dragomir, A.-F., Costescu, M., Aurelian, S. M., Shhab, Y., Stoleru, C. M., Coman, O. A., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010271 · Cited by 20
The Gut Microbiome and Colonic Motility Disorders: A Practical Framework for the Gastroenterologist
Ma, W., Drew, D. A., & Staller, K. D. (2022) · Current Gastroenterology Reports · doi:10.1007/s11894-022-00847-4 · Cited by 16
Reutov, V. P., & Sorokina, E. G. (2022) · BIOPHYSICS · doi:10.1134/s0006350922060197 · Cited by 14
Brouillet, J. Z., Boltri, M., Lengvenytė, A., Lajnef, M., Richard, J., Barrau, C., Strumila, R., Coyac, M., Wu, C., Boukouaci, W., et al. (2023) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2023.100624 · Cited by 15
Zhang, Y., Liu, J., Liu, X., Zhou, Y., Geng, J., Shi, Z., & Ma, L. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03595-2 · Cited by 14
Wang, Z., Li, J., Xu, Y., Liu, Y., Zhang, Z., Xu, Q., Lin, J., Jiang, Y., Wang, Y., Jing, J., et al. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1388748 · Cited by 14
Bai, M., Wang, X., Liu, D., Xu, A., Cheng, H., Li, L., & Zhang, C. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300759 · Cited by 14
The gut microbiome and the brain
Rykalo, N. A., Riehl, L., & Kress, M. (2024) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000717 · Cited by 16
Just a SNP away: The future of in vivo massively parallel reporter assay
Degner, K. N., Bell, J., Jones, S. D., & Won, H. (2024) · Cell Insight · doi:10.1016/j.cellin.2024.100214 · Cited by 14
Winnie Mice: A Chronic and Progressive Model of Ulcerative Colitis
Chieppa, M., Santis, S. D., & Verna, G. (2025) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaf006 · Cited by 15
Tzikos, G., Chamalidou, E., Christopoulou, D., Apostolopoulou, A., Gkarmiri, S., Pertsikapa, M., Menni, A.-E., Theodorou, I. M., Stavrou, G., Doutsini, N.-D., et al. (2025) · Nutrients · doi:10.3390/nu17050857 · Cited by 17
Eastwood, J., van Hemert, S., Stolaki, M., Williams, C. M., Walton, G., & Lamport, D. J. (2025) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2025.04.002 · Cited by 19
Neural influences in colorectal cancer progression and therapeutic strategies
Zeng, Z., Cai, S., Ye, C., Li, T., Tian, Y., Liu, E., Cai, J., Yuan, X., Yang, H., Liang, Q., et al. (2025) · International Journal of Colorectal Disease · doi:10.1007/s00384-025-04887-w · Cited by 16
Metformin as a potential antidepressant: Mechanisms and therapeutic insights in depression
Cheng, Y., Yao, Q. Z., Miao, Y., & Guan, W. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116773 · Cited by 16
The Role of Livestock Antibiotic Use in Microbiota Dysbiosis and Neuroinflammation
Silvestro, S., Biondo, C., Midiri, A., Lucia, B. P. A., & Mancuso, G. (2025) · Antibiotics · doi:10.3390/antibiotics14060608 · Cited by 17
Liu, Q., He, Y., Fan, Q., Wu, Y., Li, J., Deng, S., Xie, Q., Zhao, Y., Guo, J., & Du, X. (2025) · Theranostics · doi:10.7150/thno.113573 · Cited by 15
Chronic stress, gut microbiota, and immunity: interconnections and implications for health
Jia, H., Guo, X., Wei, Y., Can, C., He, N., Zhang, H., Yang, X., Wu, H., Liu, W., & Ma, D. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05376-y · Cited by 14
Hu, R., Geng, Y., Huang, Y., Liu, Z., Li, F., Dong, H., Ma, W., Song, K., Zhang, M., Zhang, Z., et al. (2023) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.14988 · Cited by 15
Chen, F., Zhang, L., Liu, Y., Zhang, A., & Wang, W. (2023) · Environmental Toxicology · doi:10.1002/tox.23973 · Cited by 13
Staller, K. D., Olén, O., Söderling, J. K., Roelstraete, B., Törnblom, H., Kuo, B., Nguyen, L. H., & Ludvigsson, J. F. (2023) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.17736 · Cited by 15
Chen, M., Li, Y., Li, L., Ma, Q., Zhou, X., Ding, F., Mo, X., Zhu, W., Bian, Q., Zou, X., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117304 · Cited by 13
Unveiling the Connection between Microbiota and Depressive Disorder through Machine Learning
Angelova, I. Y., Kovtun, A. S., Averina, O. V., Koshenko, T. A., & Даниленко, В. Н. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216459 · Cited by 14
Gut-brain axis interacts with immunomodulation in inflammatory bowel disease
Ye, X., Zhang, M., Zhang, N., Wei, H., & Wang, B. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115949 · Cited by 15
Dai, R., Huang, J., Cui, L., Sun, R., Qiu, X., Wang, Y., & Sun, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1282694 · Cited by 14
Effects of X-ray cranial irradiation on metabolomics and intestinal flora in mice
Wang, X., Guo, L. T., Qin, T., Lai, P., Jing, Y., Zhang, Z.-W., Zhou, G., Gao, P., & Ding, G. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115898 · Cited by 13
The coming future: The role of the oral–microbiota–brain axis in aroma release and perception
Xi, Y., Yu, M., Li, X., Zeng, X., & Li, J. (2024) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13303 · Cited by 15
Common Pathophysiological Mechanisms and Treatment of Diabetic Gastroparesis
Zhang, Y., Zhang, Y., Li, M., Tian, J., & Tong, X. (2024) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm23100 · Cited by 17
Liu, T., Wang, H., Liu, J., Tan, R., Chen, L., Liang, X., Li, A., Qi, C., & Wang, Z. (2024) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/0113862073306526240403063736 · Cited by 13
Ferroptosis: An important mechanism of disease mediated by the gut-liver-brain axis
Yu, X., Wang, S., Ji, Z., Meng, J., Mou, Y., Wu, X., Yang, X., Xiong, P., Li, M., & Guo, Y. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122650 · Cited by 14
Fecal microbial transplants as investigative tools in cancer
Bohm, M. S., Ramesh, A. V., Pierre, J. F., Cook, K. L., Murphy, E. A., & Makowski, L. (2024) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00171.2024 · Cited by 15
Protective Effects of Bifidobacterium Breve MCC1274 as a Novel Therapy for Alzheimer’s Disease
Abdelhamid, M., Counts, S., Zhou, C., Hida, H., Kim, J., Michikawa, M., & Jung, C. (2025) · Nutrients · doi:10.3390/nu17030558 · Cited by 16
Han, H., & Jang, J. (2022) · Frontiers in Medical Technology · doi:10.3389/fmedt.2022.931411 · Cited by 14
Grozić, A., Coker, K., Dussik, C. M., Sabir, M. S., Sabir, Z. L., Bradley, A., Zhang, L., Park, J. G., Yale, S. H., Kaneko, I., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0275683 · Cited by 13
Lee, K. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00920-5 · Cited by 14
Zheng, W., Su, M., Hong, N., & Ye, P. (2025) · Advances in Ophthalmology Practice and Research · doi:10.1016/j.aopr.2025.01.003 · Cited by 13
Lyu, J., Yeh, C.-H., Shi, W., & Penzel, T. (2025) · Communications Biology · doi:10.1038/s42003-025-08685-6 · Cited by 17
Marano, G., Sfratta, G., Marzo, E. M., Cozzo, G., Abate, F., Traversi, G., Mazza, O., Capristo, E., Gaetani, E., & Mazza, M. (2025) · Children · doi:10.3390/children12111561 · Cited by 18
Yang, J., Song, X., Yan, S., Li, Q., & Yang, W. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1739329 · Cited by 13
Mir, P. A., Kumar, N. G., Bhutia, G. T., Chaudhary, P., Kaur, G., & Gupta, S. K. (2026) · GeroScience · doi:10.1007/s11357-025-02062-1 · Cited by 13
Gut–brain axis in health and brain disease
Olasunkanmi, O. I., Zheng, L., & Zheng, P. (2026) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003920 · Cited by 12
The Serotonergic System and Amyotrophic Lateral Sclerosis: A Review of Current Evidence
Lu, Y., Cheng, Y., Zhu, Y., Cui, L., & Li, X. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01320-0 · Cited by 12
Zhang, M., Zhai, Z., Yang, B., He, L., Wang, J., Dai, W., Xue, L., Yang, X., Feng, Y., & Wang, H. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1148546 · Cited by 12
Methodological recommendations for human microbiota-gut-brain axis research
Ou, Y., Belzer, C., Smidt, H., & de Weerth, C. (2023) · Microbiome Research Reports · doi:10.20517/mrr.2023.33 · Cited by 14
Ketel, J., Bruguera, M. B., Auchter, G., Cuntz, U., Zipfel, S., Enck, P., & Mack, I. (2024) · Nutrients · doi:10.3390/nu16060891 · Cited by 12
Intestinal Akkermansia muciniphila is Beneficial to Functional Recovery Following Ischemic Stroke
Li, K., Ding, W., Li, X., Gao, H., Wang, S., Li, T., Zhao, H., & Zhang, S. (2024) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-024-10146-6 · Cited by 14
Ontiveros‐Ángel, P., Vega-Torres, J. D., Simon, T. B., Williams, V., Inostroza‐Nieves, Y., Alvarado-Crespo, N., Gonzalez, Y. V., Pompolius, M., Katzka, W. R., Lou, J., et al. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100879 · Cited by 12
Wang, J., Xiang, J.-H., Peng, X.-Y., Liu, M., Sun, L., Zhang, M., Zhang, L.-Y., Chen, Z., Tang, Z., & Cheng, L. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.01878-24 · Cited by 13
Li, W., Wang, Y., Shi, Y., He, F., Zhao, Z., Liu, J., Gao, Z., Zhang, J., & Shen, X. (2024) · FEBS Journal · doi:10.1111/febs.17365 · Cited by 12
Mamun, A. A., Geng, P., Wang, S., Shao, C., & Xiao, J. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107559 · Cited by 15
Pich, E. M., Tarnanas, I., Brigidi, P., & Collo, G. (2025) · Neurobiology of Stress · doi:10.1016/j.ynstr.2025.100713 · Cited by 16
Saadh, M. J., Ahmed, H. H., Kareem, R. A., Sanghvi, G. V., Ganesan, S., Agarwal, M., Kaur, P., Taher, W. M., Alwan, M., Jawad, M. J., et al. (2025) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2025.173972 · Cited by 12
The gut-brain axis mechanism of normal appetite induced by kynurenic acid
Pan, L., Li, R., Li, Q., Zhu, Q., Zhou, Q., Su, A., Qi, R., Liu, Z., Wu, R., Wang, S., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115659 · Cited by 12
The complex relationship between gut microbiota dysregulation and mood disorders: A narrative review
Minuti, A., Brufani, F., Menculini, G., Moretti, P., & Tortorella, A. A. V. (2022) · Current Research in Neurobiology · doi:10.1016/j.crneur.2022.100044 · Cited by 13
Dong, J., Xie, T., Shi, C., Feng, G., Zhang, H., Xu, Z., & Dong, L. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s543912 · Cited by 12
Targeting gut microbiota and metabolites in cancer radiotherapy
Ma, S., Li, X., Shang, S., Zhai, Z., Wu, M., Song, Q., & Chen, D. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70481 · Cited by 12
Gut Microbiota Alternation in Disease Progression of Neurosyphilis
Wang, G., Zou, D., Lu, X., Gu, X., Cheng, Y., Qi, T., Cheng, Y., Yu, J., Ye, M., & Zhou, P. (2022) · Infection and Drug Resistance · doi:10.2147/idr.s389155 · Cited by 12
Birmann, P. T., Casaril, A. M., Pesarico, A. P., Rodrigues, R. R., Conceição, F. R., Sousa, F. S. S., Collares, T. V., Seixas, F. K., & Savegnago, L. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03326-7 · Cited by 13
Moreno, L. O., Bagüés, A., Martínez, V., & Abalo, R. (2023) · Nutrients · doi:10.3390/nu15122775 · Cited by 11
Metadata
- Authors
- Margolis, K. G., Cryan, J. F., & Mayer, E. A.
- Affiliations
- Morgan Stanley Children's Hospital (US)
- University College Cork (IE)
- University of California, Los Angeles (US)
- Corresponding author
- Margolis, Kara G.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 160
- Issue
- 5
- Pages
- 1486-1501
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC8634751
- OpenAlex
- W3122128474
- Cited by
- 999
- References
- 188
- Citations by year
- 2026: 171 · 2025: 240 · 2024: 208 · 2023: 226 · 2022: 113 · 2021: 40
- FWCI
- 15.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Gastroenterology (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (RO1 NS015547, R01 DK048351)
- U.S. Department of Defense (PR160365)
- Science Foundation Ireland (SFI/12/RC/ 2273_P2)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- microbiota-gut-brain axis, gut microbiota, intestinal motility, mood disorders, irritable bowel syndrome, serotonin, enteric nervous system, central nervous system, gut-brain signaling, translational research
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Affect, Animals, Bacteria, Brain, Central Nervous System Diseases, Gastrointestinal Diseases, Gastrointestinal Motility, Humans, Intestines, Dysbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
