The DOI matches its Crossref record; 188 of the 188 references it cites were found in a registry or an index.
The Microbiota-Gut-Brain Axis: From Motility to Mood
Open accessAbstract
The gut-brain axis plays an important role in maintaining homeostasis. Many intrinsic and extrinsic factors influence signaling along this axis, modulating the function of both the enteric and central nervous systems. More recently the role of the microbiome as an important factor in modulating gut-brain signaling has emerged and the concept of a microbiota-gut-brain axis has been established. In this review, we highlight the role of this axis in modulating enteric and central nervous system function and how this may impact disorders such as irritable bowel syndrome and disorders of mood and affect. We examine the overlapping biological constructs that underpin these disorders with a special emphasis on the neurotransmitter serotonin, which plays a key role in both the gastrointestinal tract and in the brain. Overall, it is clear that although animal studies have shown much promise, more progress is necessary before these findings can be translated for diagnostic and therapeutic benefit in patient populations.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016) · Cell · doi:10.1016/j.cell.2016.05.041 · Cited by 7,070
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549
Revised Estimates for the Number of Human and Bacteria Cells in the Body
Sender, R., Fuchs, S., & Milo, R. (2016) · PLOS Biology · doi:10.1371/journal.pbio.1002533 · Cited by 5,425
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888
Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis
Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., Nagler, C. R., Ismagilov, R. F., Mazmanian, S. K., & Hsiao, E. Y. (2015) · Cell · doi:10.1016/j.cell.2015.02.047 · Cited by 3,614
Research works printed but not linked: 3
- Diaz Heijtz, 2011, Normal gut microbiota modulates brain development and behavior, Proc Natl Acad Sci U S A, 108, 3047, 10.1073/pnas.1010529108 · DOI · Paper page
- Fulling, 2019, Gut microbe to brain signaling: what happens in vagus, Neuron, 101, 998, 10.1016/j.neuron.2019.02.008 · DOI · Paper page
- Erny, 2015, Host microbiota constantly control maturation and function of microglia in the CNS, Nat Neurosci, 18, 965, 10.1038/nn.4030 · DOI · Paper page
Cited by
Sorted by citations
Items 201–300 of 1,000
Yadav, S. K., Ahmad, R., Moshfegh, C. M., Sankarasubramanian, J., Joshi, V., Elkhatib, S. K., Chhonker, Y. S., Murry, D. J., Talmon, G. A., Guda, C., et al. (2023) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2023.03.005 · Cited by 27
Gut-brain axis: altered microbiome and depression – review
Mohan, A., Godugu, S., Joshi, S., Shah, K. B., Vanka, S. C., Shakil, H., Dhanush, P., Veliginti, S., Sure, P. S., & Goranti, J. (2023) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000000573 · Cited by 28
Buty and the beast: the complex role of butyrate in Parkinson’s disease
Elford, J. D., Becht, N. N., Garssen, J., Kraneveld, A. D., & Perez‐Pardo, P. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1388401 · Cited by 28
Efimov, A. I., Hibberd, T. J., Wang, Y., Wu, M., Zhang, K., Ting, K., Madhvapathy, S. R., Lee, M., Kim, J., Kang, J., et al. (2024) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2024.116298 · Cited by 26
Gastrointestinal Motility Effects of GLP-1 Receptor Agonists
Bellavance, D. R., Chua, S. G., & Mashimo, H. L. (2025) · Current Gastroenterology Reports · doi:10.1007/s11894-025-00995-3 · Cited by 27
Riehl, L., Fürst, J., Kress, M., & Rykalo, N. A. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1302957 · Cited by 30
Role of the gut-microbiota-metabolite-brain axis in the pathogenesis of preterm brain injury
Li, L., Yang, J., Liu, T., & Shi, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115243 · Cited by 28
Farnesoid X receptor: From Structure to Function and Its Pharmacology in Liver Fibrosis
Ding, C., Wang, Z., Dou, X., Yang, Q., Ning, Y., Kao, S., Sang, X., Hao, M., Wang, K., Peng, M., et al. (2023) · Aging and Disease · doi:10.14336/ad.2023.0830 · Cited by 29
Turicibacter and Catenibacterium as potential biomarkers in autism spectrum disorders
Gerges, P., Bangarusamy, D. K., Bitar, T., Alameddine, A., Nemer, G. M., & Hleihel, W. (2024) · Scientific Reports · doi:10.1038/s41598-024-73700-5 · Cited by 28
Mechanistic insight of neurodegeneration due to micro/nano-plastic-induced gut dysbiosis
Ghosh, A., & Gorain, B. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03875-3 · Cited by 27
Microbiota-derived metabolites in the epigenetic regulation of the host
Lei, J., Wang, X., & Liu, X. (2025) · 中国科学通报:英文版 · doi:10.1016/j.scib.2025.09.030 · Cited by 29
Diamanti, T., Prete, R., Battista, N., Corsetti, A., & Jaco, A. D. (2022) · Antibiotics · doi:10.3390/antibiotics11121767 · Cited by 27
Yi, X., Zhou, K., Deng, N., Cai, Y., Peng, X., & Tan, Z. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1090302 · Cited by 25
The effects of hormone replacement therapy on the microbiomes of postmenopausal women
Dothard, M. I., Allard, S. M., & Gilbert, J. A. (2023) · Climacteric · doi:10.1080/13697137.2023.2173568 · Cited by 27
Gut microbiota and type 2 diabetes mellitus: a focus on the gut-brain axis
Pan, Y., Bu, T., Deng, X., Jia, J., & Yuan, G. (2024) · Endocrine · doi:10.1007/s12020-023-03640-z · Cited by 28
Serotonergic Control of Gastrointestinal Development, Motility, and Inflammation
Najjar, S. A., Hung, L. Y., & Margolis, K. G. (2023) · Comprehensive physiology · doi:10.1002/cphy.c220024 · Cited by 53
Thomann, A., Schmitgen, M. M., Stephan, J. C., Ebert, M. P., Thomann, P. A., Szabo, K., Reindl, W., & Wolf, R. C. (2024) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjae078 · Cited by 25
Maternal-infant probiotic transmission mitigates early-life stress-induced autism in mice
Qing, L., Qian, X., Zhu, H., Wang, J., Sun, J., Jin, Z., Tang, X., Zhao, Y., Wang, G., Zhao, J., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2456584 · Cited by 26
Exercise, Diet, and Brain Health: From the Perspective of Gut Microbiota Regulation
Zhang, L., Liu, R., Song, Z., & Zhang, X. (2025) · Nutrients · doi:10.3390/nu17101686 · Cited by 24
Gut-brain relationship in dementia and Alzheimer's disease: Impact on stress and immunity
Mukherjee, U., & Reddy, P. H. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102843 · Cited by 25
Ferrulli, A., Drago, L., Gandini, S., Massarini, S., Bellerba, F., Senesi, P., Terruzzi, I., & Luzi, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094692 · Cited by 24
Emergence of Caenorhabditis elegans as a Model Organism for Dissecting the Gut–Brain Axis
de Ora, L. O., & Bess, E. N. (2021) · mSystems · doi:10.1128/msystems.00755-21 · Cited by 25
Șchiopu, C. G., Ștefănescu, C., Boloș, A., Diaconescu, S., Gîlcă-Blanariu, G.-E., & Ștefănescu, G. (2022) · Microorganisms · doi:10.3390/microorganisms10112199 · Cited by 24
Xiang, Q., Liu, Y., Wu, Z., Wang, R., & Zhang, X. (2023) · Food Frontiers · doi:10.1002/fft2.199 · Cited by 27
Lobo, B., Tramullas, M., Finger, B. C., Lomasney, K. W., Beltrán, C. J., Clarke, G. A., Santos, J., Hyland, N. P., Dinan, T. G., & Cryan, J. F. (2023) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm22009 · Cited by 24
Major depressive disorder and the gut microbiome: what is the link?
Modesto‐Lowe, V., Chaplin, M., & Sgambato, D. (2023) · General Psychiatry · doi:10.1136/gpsych-2022-100973 · Cited by 25
Zhang, X., Jia, X., Wang, S., Xin, J., Sun, N., Wang, Y., Zhang, X., Wan, Z., Fan, J., Li, H., et al. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115035 · Cited by 27
Ma, J., Chen, Y., Wang, Z., Wang, R., & Dong, Y. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105710 · Cited by 25
Perturbations in gut microbiota in autism spectrum disorder: a systematic review
Tao, X., Li, Z., Wang, D., Pu, J., Liu, Y., Gui, S., Zhong, X., Yang, D., Zhou, H., Tao, W., et al. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1448478 · Cited by 23
Guo, H., Tang, X., He, X., Weng, Y., Zhang, Q., Fang, Q., & Zhang, L. (2025) · Biomolecules · doi:10.3390/biom15070920 · Cited by 29
Shi, H., Nelson, J. W., Phillips, S. C., Petrosino, J. F., Bryan, R. M., & Durgan, D. J. (2022) · Scientific Reports · doi:10.1038/s41598-022-12578-7 · Cited by 25
Patil, R. S., & Tupe, R. S. (2023) · Medicinal Research Reviews · doi:10.1002/med.21987 · Cited by 23
Overview of the Gut–Brain Axis: From Gut to Brain and Back Again
Post, Z., Manfready, R. A., & Keshavarzian, A. (2023) · Seminars in Neurology · doi:10.1055/s-0043-1771464 · Cited by 25
Zhou, X., Zhou, J., Ban, Q., Zhang, M., & Ban, B. (2024) · Endocrine · doi:10.1007/s12020-024-03843-y · Cited by 27
Wang, Y., Fan, D., Zhang, Y., Wang, J., Dong, L., Hu, Y., & Wang, S. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.140864 · Cited by 22
Beyond digestion: Exploring how the gut microbiota modulates human social behaviors
Abavisani, M., Faraji, N., Ebadpour, N., Kesharwani, P., & Sahebkar, A. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.11.068 · Cited by 26
Gut‐on‐a‐chip platforms: Bridging in vitro and in vivo models for advanced gastrointestinal research
Ofori‐Kwafo, A., Sigdel, I., Mamun, E. A., Zubcevic, J. A., & Tang, Y. (2025) · Physiological Reports · doi:10.14814/phy2.70356 · Cited by 23
Cross-talk between microbiota–gut–brain axis and blood pressure regulation
Welathanthree, M., Keating, D. J., Macefield, V. G., Carnevale, D., Marques, F. Z., & Muralitharan, R. R. (2025) · Clinical Science · doi:10.1042/cs20240787 · Cited by 24
Li, Q., He, X., Gao, F., Fan, Y., Zhao, B., Ma, Q., Yan, B., Wang, W., Ma, X., & Yang, J. (2022) · Schizophrenia · doi:10.1038/s41537-022-00244-w · Cited by 22
Cluny, N. L., Nyuyki, K. D., Almishri, W., Griffin, L., Lee, B. H., Hirota, S. A., Pittman, Q. J., Swain, M. G., & Sharkey, K. A. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02431-z · Cited by 25
Contribution of gut microbiota toward renal function in sepsis
Xu, Y., Kong, X., Zhu, Y., Xu, J., Mao, H., Li, J., Zhang, J., & Zhu, X. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.985283 · Cited by 22
Ou, Y., Belzer, C., Smidt, H., & de Weerth, C. (2023) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-023-02205-9 · Cited by 25
Hamasaki, H. (2023) · Medicines · doi:10.3390/medicines10090053 · Cited by 26
Zhang, Y., Wang, Y., Zhou, Z., Yang, Y., Zhao, J., Kang, X., Li, Z., Shen, X. P., He, F., & Cheng, R. (2024) · Nutrients · doi:10.3390/nu16060844 · Cited by 23
DeSana, A. J., Estus, S., Barrett, T. A., & Saatman, K. E. (2024) · Scientific Reports · doi:10.1038/s41598-024-53430-4 · Cited by 21
The role of the gut microbiome in disorders of gut–brain interaction
Gawey, B. J., Mars, R. A. T., & Kashyap, P. (2024) · FEBS Journal · doi:10.1111/febs.17200 · Cited by 30
Indole induces anxiety-like behaviour in mice mediated by brainstem locus coeruleus activation
Mir, H.-D., Yang, Q., Maximin, E., Montardy, Q., Ji, S., Cheng, Q., Shan, X., Wang, L., Naudon, L., Rabot, S., et al. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106606 · Cited by 21
Xu, M., Li, W., Hu, X., & Zhang, J. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c11643 · Cited by 22
Material Engineering in Gut Microbiome and Human Health
Yang, L., Hung, L. Y., Zhu, Y., Ding, S., Margolis, K. G., & Leong, K. W. (2022) · Research · doi:10.34133/2022/9804014 · Cited by 24
Disengaging spinal afferent nerve communication with the brain in live mice
Kyloh, M. A., Hibberd, T. J., Castro, J., Harrington, A. M., Travis, L., Dodds, K. N., Wiklendt, L., Brierley, S. M., Zagorodnyuk, V. P., & Spencer, N. J. (2022) · Communications Biology · doi:10.1038/s42003-022-03876-x · Cited by 21
Lee, A., Lee, J. Y., Jung, S.-W., Shin, S. Y., Ryu, H. S., Jang, S.-H., Kwon, J. G., & Kim, Y. S. (2023) · Korean Journal of Gastroenterology · doi:10.4166/kjg.2023.028 · Cited by 26
Wang, T., Pan, C.-L., Xie, C., Chen, L., Song, Z., Liao, H.-L., & Xin, C. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03473-x · Cited by 22
Clinical and Preclinical Evidence for Gut Microbiome Mechanisms in Substance Use Disorders
Hofford, R. S., & Kiraly, D. D. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.08.004 · Cited by 20
Wang, Y., Yu, S., & Li, M. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1226580 · Cited by 20
Roussin, L., Gry, E., Macaron, M., Ribes, S., Monnoye, M., Douard, V., Naudon, L., & Rabot, S. (2024) · The FASEB Journal · doi:10.1096/fj.202400334r · Cited by 20
Spencer, N. J., Kyloh, M. A., Travis, L., & Hibberd, T. J. (2024) · The Journal of Comparative Neurology · doi:10.1002/cne.25613 · Cited by 24
Role of microbes in the pathogenesis of neuropsychiatric disorders
Goswami, A., Wendt, F. R., Pathak, G. A., Tylee, D. S., Angelis, F. D., Lillo, A. D., & Polimanti, R. A. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100917 · Cited by 21
The Role of the Gut Microbiota in Anorexia Nervosa in Children and Adults—Systematic Review
Anton-Păduraru, D.-T., Trofin, F., Năstase, E. V., Miftode, R.-Ş., Miftode, I.-L., Trandafirescu, M. F., Cojocaru, E., Țarcă, E., Mîndru, D. E., & Dorneanu, O. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010041 · Cited by 21
Cai, C., Song, Z., Xu, X., Yang, X., Wei, S., Chen, F., Dong, X., Zhang, X., & Zhu, Y. (2024) · Food & Function · doi:10.1039/d4fo03002h · Cited by 20
Ma, Z., Zhao, H., Zhao, M., Zhang, J., & Qu, N. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.11.049 · Cited by 23
Stomach–brain coupling indexes a dimensional signature of mental health
Banellis, L., Rebollo, I., Nikolova, N. E., & Allen, M. (2025) · Nature Mental Health · doi:10.1038/s44220-025-00468-6 · Cited by 34
Parment, R., Dubois, M., Desrues, L., Mutel, A., Dembélé, K.-P., Belin, N., Tron, L., Guérin, C., Coëffier, M., Compère, V., et al. (2022) · Cancers · doi:10.3390/cancers14184403 · Cited by 20
Yuan, F., Zhou, Z., Wu, S., Jiao, F., Chen, L., Fang, L., Yin, H., Hu, X., Jiang, X., Liu, K., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2215590120 · Cited by 19
Keubler, L. M., Talbot, S. R., Bleich, A., & Boyle, E. C. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105316 · Cited by 20
Dichotomous colorectal cancer behaviour
Aljama, S., Lago, E. P., Zafra, O., Sierra, J., Simón, D., Santos, C., Rodríguez-Pascual, J., & Garcia‐Romero, N. (2023) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2023.104067 · Cited by 21
Katagiri, S., Ohsugi, Y., Shiba, T., Yoshimi, K., Nakagawa, K., Nagasawa, Y., Uchida, A., Liu, A., Lin, P., Tsukahara, Y., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1215236 · Cited by 25
Sikaroudi, M. K., Soltani, S., Ghoreishy, S. M., Ebrahimi, Z., Shidfar, F., & Dehnad, A. (2024) · Food & Function · doi:10.1039/d3fo03717g · Cited by 27
The potential influence of microplastics on the microbiome and disease susceptibility in sea turtles
Iurk, V. B., Ingles, M., Correa, G. S., Silva, C. R., Staichak, G., Pileggi, S. A. V., Christo, S. W., Domit, C., & Pileggi, M. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.174298 · Cited by 21
Liu, R., Luo, Y., Ma, J., Zhang, Q., Sheng, Y., Li, J., Li, H., & Zhao, T. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1444922 · Cited by 23
Feng, Y., & Hao, F. (2024) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2024.104678 · Cited by 19
Bidirectional regulation of the brain–gut–microbiota axis following traumatic brain injury
You, X., Niu, L., Fu, J., Ge, S., Shi, J., Zhang, Y., & Zhuang, P. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00088 · Cited by 23
Microbes Saving Lives and Reducing Suffering
Timmis, K. N., Karahan, Z. C., Ramos, J. L., Koren, O., Pérez‐Cobas, A. E., Steward, K. F., de Lorenzo, V., Caselli, E., Douglas, M., Schwab, C., et al. (2025) · Microbial Biotechnology · doi:10.1111/1751-7915.70068 · Cited by 23
Mucus and mucin: changes in the mucus barrier in disease states
Fan, F., Guo, R., Pan, K., Xu, H., & Chu, X. (2025) · Tissue Barriers · doi:10.1080/21688370.2025.2499752 · Cited by 20
Zhou, J., He, L., Liu, M., Guo, X., Du, G., Yan, L., Zhang, Z., Zhong, Z.-D., & Chen, H. (2023) · Cell Proliferation · doi:10.1111/cpr.13437 · Cited by 19
Yu, K., Qiu, Y., Shi, Y., Yu, X., Zhou, B., Sun, T. S., Wu, Y., Xu, S., Chen, L., Shu, Q., et al. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.163482 · Cited by 19
Progress in Fermented Unconventional Feed Application in Monogastric Animal Production in China
Sun, H., Kang, X., Tan, H., Cai, H., & Chen, D. W. (2023) · Fermentation · doi:10.3390/fermentation9110947 · Cited by 19
Santi, D., Debbi, V., Costantino, F., Spaggiari, G., Simoni, M., Greco, C., & Casarini, L. (2023) · Clocks & Sleep · doi:10.3390/clockssleep5040050 · Cited by 20
Xue, D., Guo, X., Liu, J., Li, Y., Liu, L., Liao, G., Zhang, M., Cao, J., Liu, Y., Lou, J., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03239-9 · Cited by 21
Associations of Microbiota and Nutrition with Cognitive Impairment in Diseases
Młynarska, E., Jakubowska, P., Frąk, W., Gajewska, A., Sornowska, J., Skwira, S., Wasiak, J., Rysz, J., & Franczyk, B. (2024) · Nutrients · doi:10.3390/nu16203570 · Cited by 19
Microbiota-Gut-Brain Axis in Age-Related Neurodegenerative Diseases
Nie, T., Li, Y., Tang, F., Duan, Y., Nepovimová, E., Kuča, K., Wu, Q., & Wei, W. (2024) · Current Neuropharmacology · doi:10.2174/1570159x23666241101093436 · Cited by 20
Li, L., Meng, Z., Huang, Y., Xu, L., Chen, Q., Qiao, D., & Yue, X. (2024) · Biomedicines · doi:10.3390/biomedicines12122654 · Cited by 21
Nemati, M. H., Yazdanpanah, E., Kazemi, R., Orooji, N., Dadfar, S., Oksenych, V., & Haghmorad, D. (2025) · Biology · doi:10.3390/biology14040435 · Cited by 21
CRISPR-based genetic tools for the study of host-microbe interactions
Galindo, M. E., & Lai, Y. (2025) · Infection and Immunity · doi:10.1128/iai.00510-24 · Cited by 20
Animal models of visceral pain and the role of the microbiome
West, C. L., & Neufeld, K. M. (2021) · Neurobiology of Pain · doi:10.1016/j.ynpai.2021.100064 · Cited by 17
Wang, Y., Wang, M., Xie, B., Wen, D., Li, W., Zhou, M., Wang, X., Lu, Y., Cong, B., Ni, Z., et al. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.12.003 · Cited by 18
Zhou, C., Chen, Y., Xue, S., Shi, Q., Guo, L., Yu, H., Xue, F., Cai, M., Wang, H., & Peng, Z. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14287 · Cited by 17
A review of the auditory-gut-brain axis
Graham, A. S., Ben‐Azu, B., Tremblay, M., Torre, P., Senekal, M., Laughton, B., van der Kouwe, A. J. W., Jankiewicz, M., Kaba, M., & Holmes, M. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1183694 · Cited by 22
Kiran, N. S., Yashaswini, C., & Chatterjee, A. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122311 · Cited by 19
Campanale, A., Inserra, A., & Comai, S. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111058 · Cited by 19
Feng, J., Wu, Y., Meng, M., Zeng, R., Ma, Y., Luo, D., Zhang, L., Zhang, Y., Li, Y., Huang, W., et al. (2024) · International Journal of Surgery · doi:10.1097/js9.0000000000001831 · Cited by 19
Impact of Enteric Nervous Cells on Irritable Bowel Syndrome: Potential Treatment Options
Pastras, P., Aggeletopoulou, I., & Triantos, C. K. (2024) · Microorganisms · doi:10.3390/microorganisms12102036 · Cited by 18
Chen, L., Xu, S., Wang, S., Chen, H., & Han, Y. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156346 · Cited by 17
Impact of Microbiota on Irritable Bowel Syndrome Pathogenesis and Management: A Narrative Review
Almonajjed, M. B., Wardeh, M., Atlagh, A., Ismaiel, A., Popa, S., Rusu, F., & Dumitrascu, D. L. (2025) · Medicina · doi:10.3390/medicina61010109 · Cited by 23
Unraveling the role of the gut microbiome in pregnancy disorders: insights and implications
Xie, Y., Chen, Q., Shan, D., Pan, X., & Hu, Y. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1521754 · Cited by 18
The Gut Microbiome in Anxiety Disorders
Butler, M., Kittel‐Schneider, S., Wagner‐Skacel, J., Mörkl, S., & Clarke, G. A. (2025) · Current Psychiatry Reports · doi:10.1007/s11920-025-01604-w · Cited by 21
Nabil, Y., Helal, M. M., Qutob, I. A., Dawoud, A. L. A., Allam, S., Haddad, R., Manasrah, G. M., AlEdani, E. M., Sleibi, W., faris, A., et al. (2025) · BMC Neurology · doi:10.1186/s12883-025-04105-8 · Cited by 21
The Role of Gut Microbiota in Modulating Immune Signaling Pathways in Autoimmune Diseases
Younis, N. K., Alfarttoosi, K. H., Sanghvi, G. V., Roopashree, R., Kashyap, A., Krithiga, T., Taher, W. M., Alwan, M., Jawad, M. J., & Al-Nuaimi, A. M. A. (2025) · NeuroMolecular Medicine · doi:10.1007/s12017-025-08883-9 · Cited by 19
Ma, M., Zhang, Y., Tao, K., & Lu, Z. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1675814 · Cited by 19
Shao, M., Yuan, F., Liu, J., & Luo, H. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s383812 · Cited by 17
Jessup, D., Woods, K., Thakker, S., Damaj, M. I., & Akbarali, H. I. (2023) · Scientific Reports · doi:10.1038/s41598-023-44857-2 · Cited by 17
Metadata
- Authors
- Margolis, K. G., Cryan, J. F., & Mayer, E. A.
- Affiliations
- Morgan Stanley Children's Hospital (US)
- University College Cork (IE)
- University of California, Los Angeles (US)
- Corresponding author
- Margolis, Kara G.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 160
- Issue
- 5
- Pages
- 1486-1501
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC8634751
- OpenAlex
- W3122128474
- Cited by
- 999
- References
- 188
- Citations by year
- 2026: 171 · 2025: 240 · 2024: 208 · 2023: 226 · 2022: 113 · 2021: 40
- FWCI
- 15.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Gastroenterology (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (RO1 NS015547, R01 DK048351)
- U.S. Department of Defense (PR160365)
- Science Foundation Ireland (SFI/12/RC/ 2273_P2)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- microbiota-gut-brain axis, gut microbiota, intestinal motility, mood disorders, irritable bowel syndrome, serotonin, enteric nervous system, central nervous system, gut-brain signaling, translational research
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Affect, Animals, Bacteria, Brain, Central Nervous System Diseases, Gastrointestinal Diseases, Gastrointestinal Motility, Humans, Intestines, Dysbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review