Cited by 1,000Gut microbiota and healthGastrointestinal motility and disordersTryptophan and brain disorders

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The Microbiota-Gut-Brain Axis: From Motility to Mood

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Margolis, Kara G., Cryan, John F., Mayer, Emeran A.·2021·Gastroenterology

DOI 10.1053/j.gastro.2020.10.066PMC PMC8634751

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Abstract

The gut-brain axis plays an important role in maintaining homeostasis. Many intrinsic and extrinsic factors influence signaling along this axis, modulating the function of both the enteric and central nervous systems. More recently the role of the microbiome as an important factor in modulating gut-brain signaling has emerged and the concept of a microbiota-gut-brain axis has been established. In this review, we highlight the role of this axis in modulating enteric and central nervous system function and how this may impact disorders such as irritable bowel syndrome and disorders of mood and affect. We examine the overlapping biological constructs that underpin these disorders with a special emphasis on the neurotransmitter serotonin, which plays a key role in both the gastrointestinal tract and in the brain. Overall, it is clear that although animal studies have shown much promise, more progress is necessary before these findings can be translated for diagnostic and therapeutic benefit in patient populations.

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Authors: Margolis, K. G., Cryan, J. F., & Mayer, E. A.
Affiliations: Morgan Stanley Children's Hospital (US)
University College Cork (IE)
University of California, Los Angeles (US)
Corresponding author: Margolis, Kara G.
ORCID: Margolis, Kara G.
Cryan, John F.
Mayer, Emeran A.
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2021-04
Volume: 160
Issue: 5
Pages: 1486-1501
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2020.10.066
PMC: PMC8634751
OpenAlex: W3122128474
Cited by: 999
References: 188
Citations by year: 2026: 171 · 2025: 240 · 2024: 208 · 2023: 226 · 2022: 113 · 2021: 40
FWCI: 15.59
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 370 d)
Locations: Gastroenterology (acceptedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (RO1 NS015547, R01 DK048351)
U.S. Department of Defense (PR160365)
Science Foundation Ireland (SFI/12/RC/ 2273_P2)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: microbiota-gut-brain axis, gut microbiota, intestinal motility, mood disorders, irritable bowel syndrome, serotonin, enteric nervous system, central nervous system, gut-brain signaling, translational research
MeSH terms: Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Affect, Animals, Bacteria, Brain, Central Nervous System Diseases, Gastrointestinal Diseases, Gastrointestinal Motility, Humans, Intestines, Dysbiosis

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