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The Microbiota-Gut-Brain Axis: From Motility to Mood
Open accessAbstract
The gut-brain axis plays an important role in maintaining homeostasis. Many intrinsic and extrinsic factors influence signaling along this axis, modulating the function of both the enteric and central nervous systems. More recently the role of the microbiome as an important factor in modulating gut-brain signaling has emerged and the concept of a microbiota-gut-brain axis has been established. In this review, we highlight the role of this axis in modulating enteric and central nervous system function and how this may impact disorders such as irritable bowel syndrome and disorders of mood and affect. We examine the overlapping biological constructs that underpin these disorders with a special emphasis on the neurotransmitter serotonin, which plays a key role in both the gastrointestinal tract and in the brain. Overall, it is clear that although animal studies have shown much promise, more progress is necessary before these findings can be translated for diagnostic and therapeutic benefit in patient populations.
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Metadata
- Authors
- Margolis, K. G., Cryan, J. F., & Mayer, E. A.
- Affiliations
- Morgan Stanley Children's Hospital (US)
- University College Cork (IE)
- University of California, Los Angeles (US)
- Corresponding author
- Margolis, Kara G.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 160
- Issue
- 5
- Pages
- 1486-1501
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC8634751
- OpenAlex
- W3122128474
- Cited by
- 999
- References
- 188
- Citations by year
- 2026: 171 · 2025: 240 · 2024: 208 · 2023: 226 · 2022: 113 · 2021: 40
- FWCI
- 15.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Gastroenterology (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (RO1 NS015547, R01 DK048351)
- U.S. Department of Defense (PR160365)
- Science Foundation Ireland (SFI/12/RC/ 2273_P2)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- microbiota-gut-brain axis, gut microbiota, intestinal motility, mood disorders, irritable bowel syndrome, serotonin, enteric nervous system, central nervous system, gut-brain signaling, translational research
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Affect, Animals, Bacteria, Brain, Central Nervous System Diseases, Gastrointestinal Diseases, Gastrointestinal Motility, Humans, Intestines, Dysbiosis
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