The DOI matches its Crossref record; 84 of the 85 references it cites were found in a registry or an index.
Iron Sequestration and Anemia of Inflammation
Open accessAbstract
Anemia of chronic disease, also called anemia of inflammation, is characterized by hypoferremia due to iron sequestration that eventually results in iron-restricted erythropoiesis. During the last decade, the molecular mechanisms of iron sequestration have been found to center on cytokine-stimulated overproduction of the iron-regulatory hormone hepcidin. The inflammatory cytokine interleukin-6 (IL-6) is a particularly prominent inducer of hepcidin, but other cytokines are likely to contribute as well. Hepcidin excess causes the endocytosis and proteolysis of the sole known cellular iron exporter, ferroportin, trapping iron in macrophages and iron-absorbing enterocytes. The supply of iron to hemoglobin synthesis becomes limiting, eventually resulting in anemia. Depending on the details of the underlying disease, other inflammation-related mechanisms may also contribute to anemia.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A dysfunctional or deregulated iron metabolism in cancer patients often results in a decreased red blood cell (RBC) count [14] and anemia is detected in approximately 40–70% of all cancer patients [15,16].”
From Iron as a central player and promising target in cancer progression (2019) · cites this paper as [14]
In the citing paper
“Iron sequestration in macrophages is a described hallmark of the AI and is an efficient mechanism to quickly deplete iron in the serum to limit the growth of extracellular pathogens (5).”
From Iron- and Hepcidin-Independent Downregulation of the Iron Exporter Ferroportin in Macrophages during Salmonella Infection (2017) · cites this paper as [5]
In the citing paper
“Two molecules, namely hepcidin (HAMP) and ferroportin (FPN), have been identified to play key roles in decreasing systemic iron level by promoting macrophage iron sequestration during infection (5).”
From Iron- and Hepcidin-Independent Downregulation of the Iron Exporter Ferroportin in Macrophages during Salmonella Infection (2017) · cites this paper as [5]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803
Self-citationWeiss, G., & Goodnough, L. T. (2005) · New England Journal of Medicine · doi:10.1056/nejmra041809 · Cited by 3,800
Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650
Self-citationHepcidin, a urinary antimicrobial peptide synthesized in the liver
Park, C. H., Valore, E. V., Waring, A. J., & Ganz, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008922200 · Cited by 2,168
Self-citationPositional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S. J., Moynihan, J., Paw, B. H., Drejer, A., Barut, B., Zapata, A., et al. (2000) · Nature · doi:10.1038/35001596 · Cited by 1,667
McKie, A. T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T. J., Farzaneh, F., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80425-6 · Cited by 1,422
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
Nemeth, E., Valore, E. V., Territo, M., Schiller, G., Lichtenstein, A., & Ganz, T. (2003) · Blood · doi:10.1182/blood-2002-10-3235 · Cited by 1,417
Self-citationThe iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
Donovan, A., Lima, C. A., Pinkus, J. L., Pinkus, G. S., Zon, L. I., Robine, S., & Andrews, N. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.01.003 · Cited by 1,275
A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism
Abboud, S., & Haile, D. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000713200 · Cited by 1,267
Nicolas, G., Bennoun, M., Devaux, I., Beaumont, C., Grandchamp, B., Kahn, A., & Vaulont, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151179498 · Cited by 1,233
Research works printed but not linked: 1
- Huang, 2005, Hemojuvelin acts as a bone morphogenetic protein co-receptor to regulate hepcidin expression [abstract], ASH Annual Meeting Abstracts, 106, 511
Cited by
Sorted by citations
Serum ferritin: Past, present and future
Wang, W., Knovich, M. A., Coffman, L. G., Torti, F. M., & Torti, S. V. (2010) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2010.03.011 · Cited by 913
Richardson, D. R., Lane, D. J. R., Becker, E. M., Huang, M. L.-H., Whitnall, M., Rahmanto, Y. S., Sheftel, A. D., & Ponka, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912925107 · Cited by 536
Simcox, J. A., & McClain, D. A. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.02.007 · Cited by 545
What is really dangerous: anaemia or transfusion?
Shander, A., Javidroozi, M., Ozawa, S. J., & Hare, G. M. T. (2011) · British Journal of Anaesthesia · doi:10.1093/bja/aer350 · Cited by 460
Iron Homeostasis and the Inflammatory Response
Wessling-Resnick, M. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104804 · Cited by 480
Means, R. (2020) · Nutrients · doi:10.3390/nu12020447 · Cited by 340
Suppression of iron-regulatory hepcidin by vitamin D
Bacchetta, J., Zaritsky, J. J., Sea, J. L., Chun, R. F., Lisse, T. S., Zavala, K., Nayak, A., Wesseling-Perry, K., Westerman, M., Hollis, B. W., et al. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013040355 · Cited by 350
Obesity as an emerging risk factor for iron deficiency
Aigner, E., Feldman, A., & Datz, C. (2014) · Nutrients · doi:10.3390/nu6093587 · Cited by 328
Developmental neuroinflammation and schizophrenia
Meyer, U. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.11.003 · Cited by 307
Iron as a central player and promising target in cancer progression
Jung, M., Mertens, C., Tomat, E., & Brüne, B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020273 · Cited by 268
“A dysfunctional or deregulated iron metabolism in cancer patients often results in a decreased red blood cell (RBC) count [14] and anemia is detected in approximately 40–70% of all cancer patients [15,16].”
BackgroundKumar, S. B., Arnipalli, S. R., Mehta, P., Carrau, S., & Ziouzenkova, O. (2022) · Nutrients · doi:10.3390/nu14142976 · Cited by 341
Monk, C. E., Georgieff, M., & Osterholm, E. A. (2012) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12000 · Cited by 266
Bachman, E., Feng, R., Travison, T., Li, M., Olbina, G., Ostland, V., Ulloor, J., Zhang, A., Basaria, S., Ganz, T., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0864 · Cited by 247
Self-citationA humanized anti-IL-6 antibody (ALD518) in non-small cell lung cancer
Bayliss, T. J., Smith, J., Schuster, M. K., Dragnev, K. H., & Rigas, J. R. (2011) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2011.627850 · Cited by 250
The role of iron homeostasis in remodeling immune function and regulating inflammatory disease
Mu, Q., Chen, L., Gao, X., Shen, S., Sheng, W., Min, J., & Wang, F. (2021) · 中国科学通报：英文版 · doi:10.1016/j.scib.2021.02.010 · Cited by 232
Hepcidin regulation in prostate and its disruption in prostate cancer
Tesfay, L., Clausen, K. A., Kim, J. W., Hegde, P., Wang, X., Miller, L. D., Deng, Z., Blanchette, N., Arvedson, T., Miranti, C. K., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2465 · Cited by 186
The Role of Iron in the Immune Response to Bacterial Infection
Cherayil, B. J. (2011) · Immunologic Research · doi:10.1007/s12026-010-8199-1 · Cited by 191
Targeting ferroptosis protects against experimental (multi)organ dysfunction and death
Van Coillie, S., Van San, E., Goetschalckx, I., Wiernicki, B., Mukhopadhyay, B., Tonnus, W., Choi, S. M., Roelandt, R., Dumitrascu, C., Lamberts, L., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28718-6 · Cited by 186
Guo, W., Bachman, E., Li, M., Roy, C. N., Blusztajn, J., Wong, S., Chan, S. Y., Serra, C., Jasuja, R., Travison, T. G., et al. (2013) · Aging Cell · doi:10.1111/acel.12052 · Cited by 192
Self-citationHypoxia-inducible factors link iron homeostasis and erythropoiesis
Shah, Y. M., & Xie, L. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.12.031 · Cited by 187
Sun, C. C., Vaja, V., Babitt, J. L., & Lin, H. Y.-F. (2011) · American Journal of Hematology · doi:10.1002/ajh.23110 · Cited by 185
Hepcidin and Iron Homeostasis during Pregnancy
Koenig, M. D., Tussing-Humphreys, L. M., Day, J., Cadwell, B., & Nemeth, E. (2014) · Nutrients · doi:10.3390/nu6083062 · Cited by 198
Self-citationBesson-Fournier, C., Latour, C., Kautz, L., Bertrand, J., Ganz, T., Roth, M.-P., & Coppin, H. (2012) · Blood · doi:10.1182/blood-2012-02-411470 · Cited by 179
Self-citationHepcidin is the major predictor of erythrocyte iron incorporation in anemic African children
Prentice, A. M., Doherty, C. P., Abrams, S. A., Cox, S. E., Atkinson, S. H., Verhoef, H., Armitage, A. E., & Drakesmith, H. (2012) · Blood · doi:10.1182/blood-2011-11-391219 · Cited by 167
Iron and Immunity: Immunological Consequences of Iron Deficiency and Overload
Cherayil, B. J. (2010) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-010-0095-9 · Cited by 170
Biofortification for combating ‘hidden hunger’ for iron
Murgia, I., Arosio, P., Tarantino, D., & Soave, C. (2011) · Trends in Plant Science · doi:10.1016/j.tplants.2011.10.003 · Cited by 157
Iron homeostasis and organismal aging
Zeidan, R. S., Han, S. M., Leeuwenburgh, C., & Xiao, R. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101510 · Cited by 155
Anderson, G., & Maes, M. H. J. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.06.014 · Cited by 146
Anderson, G., Berk, M., Dodd, S., Bechter, K., Altamura, A. C., Dell’Osso, B. M., Kanba, S., Monji, A., Fatemi, S. H., Buckley, P. F., et al. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.10.008 · Cited by 140
Lipocalin 2 Deficiency Dysregulates Iron Homeostasis and Exacerbates Endotoxin-Induced Sepsis
Srinivasan, G., Aitken, J. D., Zhang, B., Carvalho, F. A., Chassaing, B., Shashidharamurthy, R., Borregaard, N., Jones, D. P., Gewirtz, A. T., & Vijay–Kumar, M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200892 · Cited by 143
Lee, J., & Hyun, D. (2023) · Antioxidants · doi:10.3390/antiox12040918 · Cited by 142
Retinal iron homeostasis in health and disease
Song, D., & Dunaief, J. L. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00024 · Cited by 122
Anemia in Hodgkin's Lymphoma: The Role of Interleukin-6 and Hepcidin
Hohaus, S., Massini, G., Giachelia, M., Vannata, B., Bozzoli, V., Cuccaro, A., D'Alo', F., Larocca, L. M., Raymakers, R. A. P., Swinkels, D. W., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.27.6873 · Cited by 110
Expression of the iron hormone hepcidin distinguishes different types of anemia in African children
Pasricha, S.-R., Atkinson, S. H., Armitage, A. E., Khandwala, S., Veenemans, J., Cox, S. E., Eddowes, L. A., Hayes, T., Doherty, C. P., Demir, A. Y., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008249 · Cited by 108
Gardenghi, S., Renaud, T. M., Meloni, A., Casu, C., Crielaard, B. J., Bystrom, L. M., Greenberg-Kushnir, N., Sasu, B. J., Cooke, K. S., & Rivella, S. (2014) · Blood · doi:10.1182/blood-2013-08-521625 · Cited by 107
Isaacs, J. D., Harari, O., Kobold, U., Lee, J. S., & Bernasconi, C. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4397 · Cited by 105
Kumar, V., & Choudhry, V. P. (2010) · The Indian Journal of Pediatrics · doi:10.1007/s12098-010-0120-3 · Cited by 100
The many faces of the octahedral ferritin protein
Watt, R. K. (2011) · BioMetals · doi:10.1007/s10534-011-9415-8 · Cited by 98
Iron-Sensing Proteins that Regulate Hepcidin and Enteric Iron Absorption
Knutson, M. D. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104801 · Cited by 96
Iron deficiency and iron deficiency anemia in women
Coad, J. E., & Pedley, K. C. (2014) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2014.936694 · Cited by 115
Okada, Y., Takahashi, A., Ohmiya, H., Kumasaka, N., Kamatani, Y., Hosono, N., Tsunoda, T., Matsuda, K., Tanaka, T., Kubo, M., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq551 · Cited by 93
Grayfer, L., Hodgkinson, J. W., & Belosevic, M. (2013) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2013.08.003 · Cited by 98
Kobayashi, H. H., Abe, M., Okada, K., Tei, R., Maruyama, N., Kikuchi, F., Higuchi, T., & Soma, M. (2015) · Nutrients · doi:10.3390/nu7053783 · Cited by 90
Fletcher, A. A., Forbes, A., Svenson, N., Thomas, W., & and A British Society for Haematology Good Practice Paper (2021) · British Journal of Haematology · doi:10.1111/bjh.17900 · Cited by 90
Pérgola, P. E., Devalaraja, M., Fishbane, S., Chonchol, M., Mathur, V. S., Smith, M. T., Lo, L., Herzog, K., Kakkar, R. K., & Davidson, M. (2020) · Journal of the American Society of Nephrology · doi:10.1681/asn.2020050595 · Cited by 85
Iron: An emerging factor in colorectal carcinogenesis
Chua, A. C. G. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i6.663 · Cited by 77
Not so benign haematology: anaemia of the elderly
Merchant, A. A., & Roy, C. N. (2011) · British Journal of Haematology · doi:10.1111/j.1365-2141.2011.08920.x · Cited by 78
Iron, hepcidin, and the metal connection
Loréal, O., Cavey, T., Bardou‐Jacquet, E., Guggenbuhl, P., Ropert, M., & Brissot, P. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00128 · Cited by 78
Merrill, R. D., Shamim, A. A., Ali, H., Labrique, A. B., Schulze, K. J., Christian, P. S., & West, K. P. (2012) · PubMed · Cited by 75
Plant-Based Dietary Practices and Socioeconomic Factors That Influence Anemia in India
Bhatnagar, R. S., & Padilla‐Zakour, O. I. (2021) · Nutrients · doi:10.3390/nu13103538 · Cited by 85
Emerging Roles of the Iron Chelators in Inflammation
Paola, A. D., Tortora, C., Argenziano, M., Marrapodi, M. M., & Rossi, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147977 · Cited by 80
Kolarš, B., Mijatović Jovin, V., Živanović, N., Minaković, I., Gvozdenović, N., Dickov Kokeza, I., & Lesjak, M. (2025) · Pharmaceuticals · doi:10.3390/ph18081104 · Cited by 71
The reproductive ecology of iron in women
Miller, E. M. (2016) · American Journal of Physical Anthropology · doi:10.1002/ajpa.22907 · Cited by 73
Hepcidin induces HIV-1 transcription inhibited by ferroportin
Xu, M., Kashanchi, F., Foster, A., Rotimi, J., Turner, W., Gordeuk, V. R., & Nekhai, S. A. (2010) · Retrovirology · doi:10.1186/1742-4690-7-104 · Cited by 70
Shah, H. E., Bhawnani, N., Ethirajulu, A., Alkasabera, A., Onyali, C. B., Anim-Koranteng, C., & Mostafa, J. A. (2021) · Cureus · doi:10.7759/cureus.18138 · Cited by 77
Renders, L., Budde, K., Rosenberger, C., van Swelm, R. P. L., Swinkels, D. W., Dellanna, F., Feuerer, W., Wen, M., Erley, C. M. M., Bader, B. D., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212023 · Cited by 67
The bone morphogenetic protein–hepcidin axis as a therapeutic target in inflammatory bowel disease
Wang, L., Trebicka, E., Fu, Y., Ellenbogen, S., Hong, C. C., Babitt, J. L., Lin, H. Y.-F., & Cherayil, B. J. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21675 · Cited by 66
Serum hepcidin levels are associated with obesity but not liver disease
Vuppalanchi, R., Troutt, J. S., Konrad, R. J., Ghabril, M., Saxena, R., Bell, L. N., Kowdley, K. V., & Chalasani, N. (2013) · Obesity · doi:10.1002/oby.20403 · Cited by 61
Biomarkers of Hypochromia: The Contemporary Assessment of Iron Status and Erythropoiesis
Urrechaga, E., Borque, L., & Escanero, J. F. (2013) · BioMed Research International · doi:10.1155/2013/603786 · Cited by 63
Antimicrobial Peptides in Innate Immunity against Mycobacteria
Shin, D., & Jo, E. (2011) · Immune Network · doi:10.4110/in.2011.11.5.245 · Cited by 62
Huang, Y., & Hu, Z.-D. (2016) · Annals of Translational Medicine · doi:10.21037/atm.2016.03.42 · Cited by 57
Hepcidin as a Major Component of Renal Antibacterial Defenses against Uropathogenic Escherichia coli
Houamel, D., Ducrot, N., Lefèbvre, T., Daher, R., Moulouel, B., Sari, M., Lettéron, P., Lyoumi, S., Millot, S., Tourret, J., et al. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014101035 · Cited by 57
The utility of iron chelators in the management of inflammatory disorders
Lehmann, C., Islam, S., Jarosch, S., Zhou, J., Hoskin, D., Greenshields, A., Al-Banna, N., Sharawy, N., Sczcesniak, A., Kelly, M., et al. (2015) · Mediators of Inflammation · doi:10.1155/2015/516740 · Cited by 54
“Colitis is another example for chronic inflammation, leading to anemia of inflammation as a consequence of low serum iron and low iron-binding capacity [92].”
BackgroundThompson, K. N., Bonham, K. S., Ilott, N. E., Britton, G. J., Colmenero, P., Bullers, S. J., McIver, L. J., Ma, S., Nguyen, L. H., Filer, A. D., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.abn4722 · Cited by 57
Diet-induced obesity leads to decreased hepatic iron storage in mice
Chung, J., Kim, M. S., & Han, S. N. (2011) · Nutrition Research · doi:10.1016/j.nutres.2011.09.014 · Cited by 54
Iron status in athletic females, a shift in perspective on an old paradigm
Badenhorst, C. E., Goto, K., O’Brien, W. J., & Sims, S. T. (2021) · Journal of Sports Sciences · doi:10.1080/02640414.2021.1885782 · Cited by 54
The effects of some essential and toxic metals/metalloids in COVID-19: A review
Domingo, J. L., & Marquès, M. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112161 · Cited by 52
Chinjarernpan, P., Itthipanichpong, C., & Limpanasithikul, W. (2014) · Journal of Advanced Pharmaceutical Technology amp Research · doi:10.4103/2231-4040.143034 · Cited by 55
Grimes, C. N., & Fry, M. M. (2014) · Veterinary Pathology · doi:10.1177/0300985814529315 · Cited by 62
Zhong, Y., Pouliot, M., Downey, A.-M., Mockbee, C., Roychowdhury, D., Wierzbicki, W., & Authier, S. (2021) · International Journal of Radiation Biology · doi:10.1080/09553002.2019.1673499 · Cited by 52
Lefèbvre, T., Dessendier, N., Houamel, D., Ialy-Radio, N., Kannengiesser, C., Manceau, H., Beaumont, C., Nicolas, G., Gouya, L., Puy, H., et al. (2015) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2014-1093 · Cited by 50
Infection perturbs Bach2- and Bach1-dependent erythroid lineage ‘choice’ to cause anemia
Kato, H., Itoh-Nakadai, A., Matsumoto, M., Ishii, Y., Watanabe-Matsui, M., Ikeda, M., Ebina-Shibuya, R., Sato, Y., Kobayashi, M., Nishizawa, H., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0202-3 · Cited by 44
Understanding Metal Dynamics Between Cancer Cells and Macrophages: Competition or Synergism?
Serra, M., Columbano, A., Ammarah, U., Mazzone, M., & Menga, A. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00646 · Cited by 49
Anemia and Blood Transfusions in Critically Ill Patients
Athar, M. K., Puri, N., & Gerber, D. R. (2012) · Journal of Blood Transfusion · doi:10.1155/2012/629204 · Cited by 48
Interplay of Heme with Macrophages in Homeostasis and Inflammation
Pradhan, P., Vijayan, V., Gueler, F., & Immenschuh, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030740 · Cited by 51
The role of iron homeostasis in adipocyte metabolism
Wan, M., Jia, L., Xiong, Q., Feng, Y., & Du, H. (2021) · Food & Function · doi:10.1039/d0fo03442h · Cited by 46
Willemetz, A., Beatty, S., Richer, E., Rubio, A., Auriac, A., Milkereit, R. J., Thibaudeau, O., Vaulont, S., Malo, D., & Canonne-Hergaux, F. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00498 · Cited by 45
Bacterial cell wall constituents induce hepcidin expression in macrophages through MyD88 signaling
Layoun, A., & Santos, M. M. (2012) · Inflammation · doi:10.1007/s10753-012-9463-4 · Cited by 44
The Potential Role of Iron and Copper in Pediatric Obesity and Nonalcoholic Fatty Liver Disease
Feldman, A., Aigner, E. S., Weghuber, D., & Paulmichl, K. (2015) · BioMed Research International · doi:10.1155/2015/287401 · Cited by 45
Theurl, M., Nairz, M., Schroll, A., Sonnweber, T., Asshoff, M., Haschka, D., Seifert, M., Willenbacher, W., Wilflingseder, D., Posch, W., et al. (2014) · Haematologica · doi:10.3324/haematol.2013.099481 · Cited by 42
Paesano, R., Natalizi, T., Berlutti, F., & Valenti, P. (2012) · Pathogens and Global Health · doi:10.1179/2047773212y.0000000043 · Cited by 44
Hohlbaum, A. M., Gille, H., Trentmann, S. M., Kolodziejczyk, M., Rattenstetter, B., Laarakkers, C. M., Katzmann, G., Christian, H., Andersen, N., Allersdorfer, A., et al. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14143 · Cited by 42
Güleç, Ş., & Collins, J. F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066010 · Cited by 40
Lee, H.-M., Sugino, H., Aoki, C., Shimaoka, Y., Suzuki, R., Ochi, K., Ochi, T., & Nishimoto, N. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3364 · Cited by 41
Layoun, A., Huang, H., Calvé, A., & Santos, M. M. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.01.046 · Cited by 43
Role of Cellular Iron and Oxygen in the Regulation of HIV-1 Infection
Nekhai, S. A., Kumari, N., & Dhawan, S. (2013) · Future Virology · doi:10.2217/fvl.13.6 · Cited by 40
Kim, S. E., Kim, U. J., Jang, M. O., Kang, S., Jang, H., Jung, S., Lee, S. S., & Park, K. H. (2013) · Disease Markers · doi:10.1155/2013/915389 · Cited by 39
Iron metabolism in critically ill patients developing anemia of inflammation: a case control study
Boshuizen, M., Binnekade, J. M., Nota, B., van de Groep, K., Cremer, O. L., Tuinman, P. R., Horn, J., Schultz, M. J., van Bruggen, R., Juffermans, N. P., et al. (2018) · Annals of Intensive Care · doi:10.1186/s13613-018-0407-5 · Cited by 39
Hyperferritinemia and iron metabolism in Gaucher disease: Potential pathophysiological implications
Regenboog, M., Kuilenburg, A. B. P., Verheij, J., Swinkels, D. W., & Hollak, C. E. M. (2016) · Blood Reviews · doi:10.1016/j.blre.2016.05.003 · Cited by 41
Ishibashi, A., Maeda, N., Sumi, D., & Goto, K. (2017) · Nutrients · doi:10.3390/nu9030277 · Cited by 41
Iron administration prevents BDNF decrease and depressive-like behavior following chronic stress
Mehrpouya, S., Nahavandi, A., Khojasteh, F., Soleimani, M., Ahmadi, M., & Barati, M. (2014) · Brain Research · doi:10.1016/j.brainres.2014.10.057 · Cited by 38
HEPCIDIN, ANAEMIA, AND PROSTATE CANCER
Tanno, T., Rabel, A., Alleyne, M., Lee, Y. T., Dahut, W. L., Gulley, J. L., & Miller, J. L. (2011) · British Journal of Urology · doi:10.1111/j.1464-410x.2011.10108.x · Cited by 37
Development and Maintenance of Cancer Stem Cells under Chronic Inflammation
Tanno, T., & Matsui, W. H. (2011) · Journal of Nippon Medical School · doi:10.1272/jnms.78.138 · Cited by 39
Hepcidin in anemia of chronic kidney disease: review for the pediatric nephrologist
Atkinson, M. A., & White, C. T. (2011) · Pediatric Nephrology · doi:10.1007/s00467-011-1832-y · Cited by 37
Urinary hepcidin: an inverse biomarker of acute kidney injury after cardiopulmonary bypass?
Prowle, J. R., Westerman, M. E., & Bellomo, R. (2010) · Current Opinion in Critical Care · doi:10.1097/mcc.0b013e32833ecdcc · Cited by 37
Shanmugam, N. K. N., Ellenbogen, S., Trebicka, E., Wang, L., Mukhopadhyay, S., Lacy‐Hulbert, A., Gallini, C. A., Garrett, W. S., & Cherayil, B. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038136 · Cited by 37
Teng, I., Tseng, S., Aulia, B., Shih, C., Bai, C., & Chang, J. (2020) · Obesity Reviews · doi:10.1111/obr.13080 · Cited by 35
Stijlemans, B., Vankrunkelsven, A., Caljon, G., Bockstal, V., Guilliams, M., Bosschaerts, T., Beschin, A., Raes, G., Magez, S., & Baetselier, P. (2010) · Endocrine, Metabolic & Immune Disorders - Drug Targets · doi:10.2174/187153010790827966 · Cited by 35
Neglected Comorbidity of Chronic Heart Failure: Iron Deficiency
Manceau, H., Ausseil, J., Masson, D., Feugeas, J., Sablonnière, B., Guieu, R., Puy, H., & Peoc’h, K. (2022) · Nutrients · doi:10.3390/nu14153214 · Cited by 36
Mean Platelet Volume and Platelet Distribution Width Level in Patients with Panic Disorder
Ransing, R. S., Patil, B., & Grigo, O. (2017) · Journal of Neurosciences in Rural Practice · doi:10.4103/jnrp.jnrp_445_16 · Cited by 34
Metadata
- Authors
- Ganz, T., & Nemeth, E.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Ganz, Tomas
- Venue
- Seminars in Hematology
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 46
- Issue
- 4
- Pages
- 387-393
- ISSN
- 0037-1963 (ISSN-L)
- PMC
- PMC2755591
- OpenAlex
- W1973938903
- Cited by
- 361
- References
- 85
- Citations by year
- 2026: 15 · 2025: 16 · 2024: 28 · 2023: 21 · 2022: 30 · 2021: 23 · 2020: 32 · 2019: 18 · 2018: 11 · 2017: 18 · 2016: 13 · 2015: 22 · 2014: 22 · 2013: 18 · 2012: 33
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Seminars in Hematology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL091531)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK065029)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Keywords
- anemia of chronic disease, iron sequestration, hypoferremia, hepcidin, interleukin-6, ferroportin, iron regulatory hormone, iron-restricted erythropoiesis, hemoglobin synthesis
- MeSH terms
- Ferroportin, Anemia, Biological Transport, Erythropoiesis, Hematinics, Hemoglobins, Humans, Inflammation, Iron, Macrophages, Interleukin-6, Enterocytes, Antimicrobial Cationic Peptides, Cation Transport Proteins, Hepcidins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
