The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index; 2 of the 23 sources its claims cite were checked for support.
Interleukin 6 Is Important for Survival After Partial Hepatectomy in Mice
Open accessAbstract
The response to partial hepatectomy (PH) is impaired in interleukin 6 (IL–6)–deficient mice. IL–6 is well known for its role in the induction of the acute phase (AP) response, and the impairment of this response after surgery and hepatectomy could explain the defective hepatocyte regeneration. In addition, it was proposed that IL–6 has an important role in stimulating the reentry of quiescent cells into the cell cycle within the first 2 to 4 hours after PH. To further analyze the role for IL–6, we performed two third hepatectomies in wild–type mice, in IL–6 knockout (KO) mice, and in IL–6 KO mice that were treated 30 minutes before surgery with intravenous (IV) (short acting) or subcutaneous (SC) (long acting) injections of recombinant IL–6. The high postoperative mortality of IL–6–deficient mice could be completely prevented by SC, but not by IV IL–6 treatment, showing the requirement of a sustained action of IL–6. However, there is a subset of IL–6 KO mice that survives a PH in good health even without IL–6 treatment. When we analyzed these mice, we found an intact liver regeneration and no indication of a block in cell cycle reentry. We conclude that the major role of IL–6 is the induction of an adaptive response to PH that ensures body homeostasis and survival.
Overview
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Written from the paper’s full text.
TL;DR
In IL-6-deficient mice, partial hepatectomy causes high mortality that can be rescued by subcutaneous but not intravenous IL-6, indicating that sustained IL-6/STAT3-dependent acute-phase signaling is required for survival. Surviving IL-6 knockout mice still regenerate liver mass through hepatocyte proliferation, with delayed cyclin D1/c-myc induction and compensatory cell-cycle mechanisms.
Key findings
- Seven-day survival after partial hepatectomy was 86% in wild-type controls versus 17% in untreated IL-6 knockout mice; subcutaneous IL-6 restored survival to 86%, whereas intravenous IL-6 did not rescue survival.
- Subcutaneous IL-6 produced later peak serum concentrations and prolonged STAT3 activation, and induced the acute-phase protein SAP; intravenous IL-6 did not induce SAP above constitutive levels.
- In IL-6 knockout mice that survived in good health, liver mass restoration was similar to wild-type mice; BrdU incorporation was lower at 40 hours after PH (17% vs. 27% nuclei stained) but not different at 48 or 60 hours.
- Cyclin D1 and c-myc up-regulation were absent early in IL-6 knockout livers, but cyclin E-CDK2 association was unchanged and cyclin D3-CDK6 lacked the inhibitor p27^Kip1 at 36 and 48 hours, suggesting compensatory cell-cycle progression.
Methods
- Eight- to 12-week-old IL-6-deficient mice and C57Bl/6J controls underwent two-thirds partial hepatectomy; IL-6 knockout mice received 500 ng/g body weight recombinant human IL-6 subcutaneously or intravenously 30 minutes before surgery.
- Survival was observed for 7 days; liver regeneration was assessed by liver weight, hepatocyte counts, and in vivo BrdU labeling at time points after PH.
- Molecular analyses included serum IL-6 ELISA, STAT3 electrophoretic mobility shift assay, Northern and Western blots for SAP, and Western blot/immunoprecipitation for cyclins D1/D2/D3, c-myc, CDK2/CDK6, and p27.
Limitations
- The paper states that loss-of-function models such as IL-6-deficient mice cannot distinguish between different functions of a cytokine because all functions are lost simultaneously.
- The paper notes that its BrdU results differ from prior work possibly because it excluded sick mice from regeneration analysis or because of different mouse strains.
- Evident from the text: regeneration and cell-cycle analyses were restricted to the subset of IL-6 knockout mice that survived in good health, while sick mice were euthanized and excluded, so findings may not represent all IL-6-deficient mice after PH.
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Claims the paper makes
2 of 23 cited sources checked · 0 supported · 0 flagged · accuracy not yet measured
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“From experiments with cyclin D1 KO mice, it is known that other D type cyclins can functionally replace cyclin D1 in most tissues.17,18”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Cell Cycle Analysis During Liver Regeneration in IL-6 KO Mice.
What the sources say
- Not checked — no full text of the sourcecites [17] Sicinski, 1995, Cell source
- Partly supportedcites [18] Fantl, 1995, Genes Dev sourceExperimental — accuracy not yet measured
The Discussion (page not provided) proposes that D-type cyclins might substitute for one another, but also offers alternative signaling pathways as an explanation and says further experiments are needed to distinguish them. It therefore does not establish that other D-type cyclins functionally replace cyclin D1 in most tissues. (LLM, conf=0.87)
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesThe cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Simi-lar results have been reported with a different strain of IL-6 -deficient mice.16”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Discussion
What the sources say
- Partly supportedcites [16] Sakamoto, 1999, Hepatology sourceExperimental — accuracy not yet measured
The “Sequential Liver Weight Before and After PH” section reports that liver-weight recovery was significantly impaired in IL-6-deficient mice at 48, 60, and 72 hours. The groups reached the same percentage of normal liver weight by 96 hours, so the claim holds for that endpoint but not for remnant liver growth throughout recovery. (LLM, conf=0.88)
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes- Partly supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“When we analyzed these mice, we found an intact liver regeneration and no indication of a block in cell cycle reentry.”
- Also stated in: § Abstract · plain
“Contrary to previously published results, we do not find a significant inhibition of hepatocyte proliferation in those IL-6deficient mice that survive PH.”
- Also stated in: § Liver Regeneration in IL-6 -Deficient Mice That Survive After PH. · plain
“Interestingly, IL-6 KO mice that survived in good health after PH showed a very similar regain of liver weight as controls (Fig. 3A).”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Abstract
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Rests on an assumption: The IL-6 knockout mice that survive partial hepatectomy in good health are representative of all IL-6 knockout mice that survive partial hepatectomy.
- Also stated in: § Abstract · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“When we analyzed these mice, we found an intact liver regeneration and no indication of a block in cell cycle reentry.”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Abstract
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Rests on an assumption: The IL-6 knockout mice that survive partial hepatectomy in good health are representative of all IL-6 knockout mice that survive partial hepatectomy.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“However, there is a subset of IL-6 KO mice that survives a PH in good health even without IL-6 treatment.”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Abstract
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“It is noteworthy that the induction of the AP protein SAP is observed only after SC, and not after IV IL-6 treatment.”
- Also stated in: § Discussion · plain
“Concentration of the AP protein SAP in the serum of mice after IV or SC injection of 500 ng/g bodyweight rhIL-6.”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Discussion
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Also stated in: § Discussion · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In agreement with this, the serum concentration of SAP was much more strongly up-regulated in mice after SC than after IV injection of IL-6 (Fig. 2D).”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > SC Injection of IL-6 Results in Prolonged STAT3 Activation and Induction of AP Proteins.
Strength:boosted· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Survival during the 7 days after surgery was 86% for controls and 17% for KO mice not treated with IL-6 (Fig. 1).”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Mortality After PH.
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Rests on an assumption: IL-6 knockout mice and wild-type controls are comparable except for the IL-6 deficiency, including their genetic background.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“We found a strong induction of SAP 8 and 24 hours after SC injection of 500 ng/g bodyweight rhIL-6 in IL-6 KO mice.”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > SC Injection of IL-6 Results in Prolonged STAT3 Activation and Induction of AP Proteins.
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“We show here, that in the subset of IL-6 KO mice that survive in good health after PH, liver regeneration takes place without the induction of cyclin D1.”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Discussion
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes
- It may state two separate claims as one. 19
- Probably not a substantial claim. 9
- The quote only partly states this claim. 1
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The high postoperative mortality of IL-6 -deficient mice could be completely prevented by SC, but not by IV IL-6 treatment, showing the requirement of a sustained action of IL-6.”
- Also stated in: § Abstract · plain
“SC, but not IV, IL-6 injections can protect IL-6deficient mice from excess mortality.”
- Also stated in: § Mortality After PH. · plain
“SC IL-6 treatment allowed 86% survival, whereas an IV injection could not rescue the IL-6 KO mice.”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Abstract
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: IL-6 knockout mice and wild-type controls are comparable except for the IL-6 deficiency, including their genetic background.
- Also stated in: § Abstract · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“We found that the high mortality observed in IL-6 KO mice could be corrected by SC, but not by IV IL-6 substitution.”
- Also stated in: § Discussion · plain
“SC injection of IL-6 resulted in survival of 86% (}), not different from the wild-type mice.The injection of the same amount of IL-6 into the tail vein could not improve survival of IL-6 KO mice (F).”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Discussion
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Also stated in: § Discussion · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“As shown in Fig. 5C and 5D, both cyclins are present in liver extracts, but neither of them is up-regulated during the G1 phase of the cell cycle.”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Cell Cycle Analysis During Liver Regeneration in IL-6 KO Mice.
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: The IL-6 knockout mice that survive partial hepatectomy in good health are representative of all IL-6 knockout mice that survive partial hepatectomy.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“a complex we found free of the inhibitor p27 Kip1 during liver regeneration in IL-6 KO mice, but not in controls.”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Discussion
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In IL-6 KO mice, cyclin D1 up-regulation remains undetectable in the first 48 hours and is up-regulated only later, at 72 hours and 96 hours (Fig. 5A).”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Cell Cycle Analysis During Liver Regeneration in IL-6 KO Mice.
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: The IL-6 knockout mice that survive partial hepatectomy in good health are representative of all IL-6 knockout mice that survive partial hepatectomy.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“SC IL-6 treatment allowed 86% survival, whereas an IV injection could not rescue the IL-6 KO mice.”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Mortality After PH.
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: IL-6 knockout mice and wild-type controls are comparable except for the IL-6 deficiency, including their genetic background.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The IV route resulted in a rapid but transient STAT3 activation that lasted 2 hours and was very weak after 4 hours.”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > SC Injection of IL-6 Results in Prolonged STAT3 Activation and Induction of AP Proteins.
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Indeed, peak concentrations were measured later (after 30 minutes vs. 10 minutes in IV-injected animals), and elevated IL-6 concentrations were found up to 4 hours after SC injections of 500 ng/g body weight rhIL-6 (Fig. 2A).”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > SC Injection of IL-6 Results in Prolonged STAT3 Activation and Induction of AP Proteins.
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The cells look slightly larger in IL-6 KO mice, but are otherwise normal, without increased glycogen or fat content.”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Liver Regeneration in IL-6 -Deficient Mice That Survive After PH.
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: The IL-6 knockout mice that survive partial hepatectomy in good health are representative of all IL-6 knockout mice that survive partial hepatectomy.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“We found that 4.8% of the hepatocytes were binucleated in wild-type, and 5.8% in IL-6 KO mice, a difference that is not significant in our context.”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Liver Regeneration in IL-6 -Deficient Mice That Survive After PH.
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: The IL-6 knockout mice that survive partial hepatectomy in good health are representative of all IL-6 knockout mice that survive partial hepatectomy.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“After SC application, STAT3 remained strongly activated in the first 4 hours and was detectable in electrophoretic mobility shift assays for up to 8 hours (Fig. 2B).”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > SC Injection of IL-6 Results in Prolonged STAT3 Activation and Induction of AP Proteins.
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Interleukin 6 (IL-6) was identified as the principal activator of STAT3, whereas tumor necrosis factor ␣ (TNF-␣) induces NFB.7,8”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Abstract
What the sources say
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Several of these induced genes are target genes of signal transducer and activator of transcription (STAT)3 and nuclear factor kappa B (NFB), two transcription factors that are activated early during liver regeneration.5,6”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Abstract
What the sources say
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Convincing evidence has been found that mitogenic signals for hepatocytes are transported in the blood 2,3 and that they induce a number of immediate early genes within 30 minutes after PH. 4”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Abstract
What the sources say
Strength:boosted· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“It was reported previously that IL-6 KO mice suffer from significant morbidity and mortality after PH and that the mice could be protected by SC injection of IL-6 30 minutes before surgery.7”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Mortality After PH.
What the sources say
- Not checked — no full text of the sourcecites [7] Cressman, 1996, Science source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The size of females was between 19 and 22 g, the size of males between 26 and 30 g, with no differences between KO animals and controls.”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Animals.
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“In all experiments, controls were age-and sex-matched.”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Animals.
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“IL-6 KO mice do have fewer cells per area, but the difference is small and not compatible with a cell growth without division mechanism for restoration of liver mass in IL-6 KO mice.”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Liver Regeneration in IL-6 -Deficient Mice That Survive After PH.
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: The IL-6 knockout mice that survive partial hepatectomy in good health are representative of all IL-6 knockout mice that survive partial hepatectomy.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“For this experiment, only mice in a good state of health after PH were analyzed.”
- Also stated in: § Liver Regeneration in IL-6 -Deficient Mice That Survive After PH. · plain
“The sick mice were spared from further experiments and euthanized and not used for further analysis.”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Liver Regeneration in IL-6 -Deficient Mice That Survive After PH.
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. The quote only partly states this claim.
- Also stated in: § Liver Regeneration in IL-6 -Deficient Mice That Survive After PH. · plain
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Cell cycle progression in the KO mice is somewhat slower, but finally takes place with the help of compensatory cyclin D3-CDK6 activation.”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Cell Cycle Analysis During Liver Regeneration in IL-6 KO Mice.
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: The IL-6 knockout mice that survive partial hepatectomy in good health are representative of all IL-6 knockout mice that survive partial hepatectomy.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Cyclin D1 is up-regulated during liver regeneration after PH, 7,28,29”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Discussion
What the sources say
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“overexpression of cyclin D1 in hepatocytes promotes hepatocyte proliferation in vitro and in vivo.30,31”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Discussion
What the sources say
- Not checked — no full text of the sourcecites [30] Albrecht, 1999, Cell Growth Differ
- Not matchedcites [31] Nelsen, 2001, Cancer Res
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“Furthermore, not only other D type cyclins, but also cyclin E can compensate for loss of D1. 19”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Cell Cycle Analysis During Liver Regeneration in IL-6 KO Mice.
What the sources say
- Not checked — no full text of the sourcecites [19] Bowe, 2002, Oncogene source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“We conclude that IL-6 is not required for liver cell proliferation, but has an essential role in recovery and survival after PH.”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Discussion
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“it is obvious that compensatory mechanisms correct for the absence of c-myc and cyclin D1 induction, because liver cell proliferation clearly takes place in IL-6 KO mice.”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Discussion
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The induction of the cell cycle proteins c-myc and cyclin D1 helps to promote liver cell proliferation, but is not a requirement for liver regeneration.”
§ Interleukin 6 is Important for Survival After Partial Hepatectomy in Mice > Discussion
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
The paper relies on this without support.
IL-6 knockout mice and wild-type controls are comparable except for the IL-6 deficiency, including their genetic background.
“Eight-to 12-week old IL-6 -deficient mice (Jackson Laboratories, Bar Harbor, Maine; strain name B6; 129S2-Il6tm1Kopf; original reference 11) and C57Bl/6J mice (Biological Research Laboratories, Fu ¨llinsdorf, Switzerland) were used for the PH experiments.”
“In all experiments, controls were age-and sex-matched.”
The paper relies on this without support.
The IL-6 knockout mice that survive partial hepatectomy in good health are representative of all IL-6 knockout mice that survive partial hepatectomy.
“For this experiment, only mice in a good state of health after PH were analyzed.”
“The sick mice were spared from further experiments and euthanized and not used for further analysis.”
The paper relies on this without support.
The subset of IL-6 KO mice that survived in good health after partial hepatectomy is representative for assessing whether IL-6 is required for liver cell proliferation.
“We then focused on the analysis of liver regeneration in the subset of IL-6 KO mice that survived well and in apparently good health after PH.”
“The different results of the BrdU labeling experiments in our work compared with the previous report 7 could result from our exclusion of all sick mice for the analysis of liver regeneration after PH, or from the use of different mouse strains.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“The IL-6-promoted liver regeneration was determined in IL-6 knockout mice, as the deletion of il6 impaired the compensatory proliferation of hepatocytes by reducing the downstream STAT3 activation [3, 4], thus promoting liver failure, which could be corrected by the treatment of IL-6.”
From The double-edged effects of IL-6 in liver regeneration, aging, inflammation, and diseases (2024) · cites this paper as [3]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“However, the deletion of il6 gene also impairs the hepatocyte homeostasis and liver regeneration [3–5].”
From The double-edged effects of IL-6 in liver regeneration, aging, inflammation, and diseases (2024) · cites this paper as [3]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Both PAMPs and LPS activate Kupffer cells, which subsequently synthesize two key cytokines—IL-6[45] and tumour necrosis factor-alpha (TNF-α)[46].”
From Liver regeneration after partial hepatectomy: Triggers and mechanisms (2025) · cites this paper as [45]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Hepatocyte counting uses a different number of fields
MinorThe methods say three fields were counted per mouse, but the results say two to three fields were counted per mouse.
“Three high-power microscope fields of 0.31 mm 2 each were counted per mouse and time point.”
“in 8 control mice and 5 IL-6 KO mice (2 to 3 fields for each mouse) 96 hours after PH.”
Figure 5D identifies different CDK partners
MinorThe Figure 5D heading names CDK4, whereas its description says the extracts were immunoprecipitated with CDK6 antibodies.
“(D) Association of cyclin D3 with CDK4 and p27 Kip1 .”
“Extracts were immunoprecipitated with either CDK6 antibodies or with p27 antibodies, followed by Western blots with cyclin D3 specific antibodies.”
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The involvement of heat shock proteins in murine liver regeneration.
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“As Kupffer cell is considered to be the primary source of hepatic IL-6, it is speculated that Con A-induced IL-6 production by Kupffer cells also plays key role in enhanced liver regeneration.”
BackgroundLiver regeneration after partial hepatectomy: Triggers and mechanisms
Korchilava, B., Khachidze, T., Megrelishvili, N., Svanadze, L., Kakabadze, M., Tsomaia, K., Jintcharadze, M., & Kordzaia, D. (2025) · World Journal of Hepatology · doi:10.4254/wjh.v17.i7.107378 · Cited by 21
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“For instance, lethality of Il-6 null animals was initially found to be very high [27,49] but was absent when the lobes were resected separately and the gallbladder was left undisrupted [37].”
MethodRegulation of Signal Transduction and Role of Platelets in Liver Regeneration
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“For IL-6, due to its ability to reduce oxidative stress and avoid mitochondrial dysfunction, it was initially thought to be a hepatoprotective factor in hepatic steatosis (19,20), which was confirmed by further studies in other liver disease models (21-23).”
The Effect of Geraniol on Liver Regeneration Αfter Hepatectomy in Rats
Canbek, M., Uyanoğlu, M., Canbek, S., Ceyhan, E., OZEN, A., Durmus, B., & Turgak, O. (2017) · In Vivo · doi:10.21873/invivo.11047 · Cited by 21
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“…both cytokines function as pivotal acute phase mediators in response to inflammation, tissue injury and/or stress (Ramadori and Armbrust 2001), and the lack of such a response contributes to excess mortality and impairment in liver regeneration as recently shown by Blindenbacher et al. (2003).”
BackgroundA20-An Omnipotent Protein in the Liver: Prometheus Myth Resolved?
da Silva, C. G., Revuelta‐Cervantes, J., Studer, P., & Ferran, C. J. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0398-6_8 · Cited by 20
Interleukin-17A plays a pivotal role after partial hepatectomy in mice
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Markers in Nonalcoholic Steatohepatitis
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Otsuka, N., Yoshioka, M., Abe, Y., Nakagawa, Y., Uchinami, H., & Yamamoto, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114077 · Cited by 18
“STAT3 plays an important role in liver regeneration after partial hepatectomy [18], and IL-6 deficient mice do not realize normal regeneration [19,20].”
BackgroundQuantification of Hepatic Vascular and Parenchymal Regeneration in Mice
Xie, C., Schwen, L. O., Wei, W., Schenk, A., Zafarnia, S., Gremse, F., & Dahmen, U. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160581 · Cited by 17
“Similar results in terms of fold increase were reported when studying liver weight recovery in mice [31].”
ResultCastoldi, M., Kordes, C., Sawitza, I., & Häussinger, D. (2016) · Scientific Reports · doi:10.1038/srep31869 · Cited by 17
Tmub1 negatively regulates liver regeneration via inhibiting STAT3 phosphorylation
Fu, H., Dong, R., Zhang, Y., Xu, J., Liu, M., & Chen, P. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2018.12.013 · Cited by 17
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Advances in alcoholic liver disease
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Liu, Z. C., & Chang, T. M. S. (2012) · Stem Cells International · doi:10.1155/2012/697094 · Cited by 16
“Furthermore, IL-6 stimulates the reentry of quiescent cells into the cell cycle within the first 2 to 4 hours after PH [18].”
BackgroundLiver Regeneration in the Acute Liver Failure Patient
Wirth, K. M., Kizy, S., & Steer, C. J. (2018) · Clinics in Liver Disease · doi:10.1016/j.cld.2018.01.004 · Cited by 16
Caspase-mediated cleavage of the signal-transducing IL-6 receptor subunit gp130
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“It has also been shown that IL-6 is essential for liver regeneration after partial hepatectomy [37, 38].”
BackgroundOxidative Stress in Nonalcoholic Fatty Liver Disease
Marí, M., Morales, A., Colell, A., García‐Ruiz, C., & Fernández-Checa, J. C. (2015) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-3-319-15539-5_12 · Cited by 14
Gut and liver handling of interleukin-6 during liver resection in man
Dello, S. A. W. G., Bloemen, J. G., van de Poll, M. C. G., van Dam, R. M., Stoot, J. H. M. B., van den Broek, M. A. J., Buurman, W. A., Bemelmans, M. H. A., Damink, S. W. M. O., & Dejong, C. H. C. (2011) · HPB · doi:10.1111/j.1477-2574.2010.00289.x · Cited by 14
“Although the nature of this process requires further clarification, an explanation for this process may be that IL-6 is necessary for liver regeneration.(14,25) Cressman et al.”
BackgroundTranscriptomic fingerprinting of bone marrow-derived hepatic β2m−/Thy-1+ stem cells
Wang, C., Chelly, M. R., Chai, N., Tan, Y., Hui, T., Li, H., Farkas, D. L., & Demetriou, A. A. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.11.159 · Cited by 14
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“Another important feature of liver regeneration is the increased production of IL-6 as in other acute liver damages [18] and some studies have also shown that this cytokine plays an important role in protection against liver injury during liver regeneration [19, 20].”
BackgroundTsuchiya, A., Heike, T., Baba, S., Fujino, H., Umeda, K., Matsuda, Y., Nomoto, M., Ichida, T., Aoyagi, Y., & Nakahata, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.10.150 · Cited by 15
Contribution of organokines in the development of NAFLD/NASH associated hepatocellular carcinoma
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Inhaled Argon Impedes Hepatic Regeneration after Ischemia/Reperfusion Injury in Rats
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“EGFR and TNFα after 2/3 PH. HGF, EGFR, and TNF α are important growth factors that stimulate hepatocyte mitogenesis in liver regeneration [44, 45].”
Histological and Morphometrical Studies in Liver Regeneration in Mice
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The Cholangiocyte Adenosine‐IL-6 Axis Regulates Survival During Biliary Cirrhosis
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Alghamdi, T. H., Atta, I. S., & El‐Refaei, M. F. (2020) · Clinical and Experimental Hepatology · doi:10.5114/ceh.2020.93055 · Cited by 10
“The weight of rats is decreased in the treated group at sacrification owing to generalized weight loss due to the increased metabolic process with energy loss induced by growth factors and cytokines that have been elevated by the effect of treatment with IL-6 [11-15].”
BackgroundZhang, W., Yu, J., Dong, Q., et al. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.04.003 · Cited by 9
Mechanisms determining phenotypic heterogeneity of hepatocytes
Федорович, У. И., & Panin, L. E. (2008) · Biochemistry (Moscow) · doi:10.1134/s0006297908040019 · Cited by 9
A mesoscale model of G1/S phase transition in liver regeneration
Chauhan, A., Legewie, S., Westermark, P. O., Lorenzen, S., & Herzel, H. (2008) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2008.01.020 · Cited by 9
“PH, with mass restoration being essentially complete after 96 h (Blindenbacher et al., 2003; Taub, 2004).”
BackgroundRole of mitogens in normal and pathological liver regeneration
Vosough, M., Shokouhian, B., Sharbaf, M. A., Solhi, R., Heidari, Z., Seydi, H., Hassan, M., Ezhilarasan, D., & Najimi, M. (2025) · Hepatology Communications · doi:10.1097/hc9.0000000000000692 · Cited by 8
“[130] It was reported that IL-6 knockout mice have impaired liver regeneration, [131] while elevated expression of IL-6 or its receptor promotes liver regeneration and hepatocyte proliferation.”
Bone marrow-derived c-jun N-terminal kinase-1 (JNK1) mediates liver regeneration
Schaefer, F. M., Peng, J., Hu, W., Drvarov, O., Nevzorova, Y. A., Zhao, G., Masaoudi, M. A., Davis, R. J., Trautwein, C., & Cubero, F. J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.10.011 · Cited by 8
Heme oxygenase-1 inhibitor tin-protoporphyrin improves liver regeneration after partial hepatectomy
Pibiri, M., Leoni, V. P., & Atzori, L. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.05.011 · Cited by 8
Liver Regeneration in Acute on Chronic Liver Failure
Blake, M. J., & Steer, C. J. (2023) · Clinics in Liver Disease · doi:10.1016/j.cld.2023.03.005 · Cited by 7
Pufal, K. R., Lawson, A. W., Hodson, J. A., Bangash, M. N., Patel, J., Weston, C. J., van Gulik, T. M., & Dasari, B. V. M. (2021) · Annals of Hepato-Biliary-Pancreatic Surgery · doi:10.14701/ahbps.2021.25.2.171 · Cited by 7
“In contrast, cytokines are demonstrated to have a role in hepatic injury during sepsis and ischemia-reperfusion injury,(30) and chronically elevated IL-6 levels are associated with inhibition of liver regeneration after injury.(34) Overall, the role of growth factors and cytokines in the regulation of liver regenerati…”
BackgroundYang, S. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i7.1070 · Cited by 7
“. In IL-6 deficient mice, liver failure and defective hepatocyte regeneration is observed following PH. Subcutaneous injection of IL-6 which results in sustained action of IL-6 was able to completely reverse the high post-operative mortality of IL-6 deficient mice [ 47 ]”
BackgroundEffect of erythropoietin production induced by hypoxia on autophagy in HepG2 cells
Nishimura, K., Goto, K., & Nakagawa, H. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.11.167 · Cited by 6
Argon Delays Initiation of Liver Regeneration after Partial Hepatectomy in Rats
Ulmer, T. F., Fragoulis, A., Dohmeier, H., Kroh, A., Andert, A., Stoppe, C., Alizai, H. P., Klink, C., Coburn, M., & Neumann, U. P. (2017) · European Surgical Research · doi:10.1159/000466690 · Cited by 6
Impact of laparoscopic liver resection on liver regeneration
Matsuo, Y., Hokuto, D., Yasuda, S., Yoshikawa, T., Kamitani, N., Doi, S., Nakagawa, K., Nishiwada, S., Nagai, M., Terai, T., et al. (2022) · Surgical Endoscopy · doi:10.1007/s00464-022-09155-4 · Cited by 6
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Giri, S., Açıkgöz, A., & Bader, A. (2015) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2015.03.003 · Cited by 5
Schattenberg, J. M., & Czaja, M. J. (2009) · Springer eBooks · doi:10.1007/978-3-642-00150-5_10 · Cited by 5
Remih, K., Hufnagel, F.-M., Karl, A. S., Durkalski‐Mauldin, V. L., Lee, W. M., Karvellas, C. J., Su, Z., Rule, J. A., Tomanová, P., Krieg, L., et al. (2025) · JHEP Reports · doi:10.1016/j.jhepr.2025.101338 · Cited by 5
“42,43 It is also consistent with a previous report that uncovered hepcidin, that is another well-established APP, as a good predictor of ALF outcome.”
Frick, J., Frobert, A., Pousa, A. M. Q., Balaphas, A., Meyer, J., Schäfer, K., Giraud, M., Egger, B., Bühler, L., & Gonelle‐Gispert, C. (2024) · The FASEB Journal · doi:10.1096/fj.202400345r · Cited by 5
Rudnick, D. A. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-398523-1.00025-2 · Cited by 4
Redox experimental medicine and liver regeneration
Bellanti, F., Vendemiale, G., & Serviddio, G. (2022) · Redox Experimental Medicine · doi:10.1530/rem-22-0008 · Cited by 4
Yang, S., Leow, C. K., & Tan, T. M. C. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i7.1063 · Cited by 4
STAT3 Mediates Protection From Liver Inflammation After Partial Hepatectomy
Xu, Y., Feng, D., Wang, Y., Luo, Q., & Xu, L. (2009) · Cellular Physiology and Biochemistry · doi:10.1159/000218184 · Cited by 4
Fausto, N., & Campbell, J. S. (2009) · Wiley eBooks · doi:10.1002/9780470747919.ch36 · Cited by 4
Purinergic signaling and cholangiocyte regeneration: a new frontier in ischemic liver injury
Nwaduru, C. E., Anyagwa, O. E., Fenlon, M., Buff, M., Selim, M., Botha, J. F., Kastenberg, Z. J., & Zimmerman, M. A. (2026) · Frontiers in Transplantation · doi:10.3389/frtra.2025.1731982 · Cited by 3
“IL-6 is a trophic factor for cholangiocytes known to promote their survival and proliferation during injury and cirrhosis (84).”
Alghamdi, T. H., Atta, I. S., & El‐Refaei, M. F. (2020) · Clinical and Experimental Hepatology · doi:10.5114/ceh.2020.95679 · Cited by 3
“The color development was stopped and the intensity of the color was measured [27].”
BackgroundModulation of liver regeneration by the nuclear factor erythroid 2-related factor 2
Bellanti, F., Serviddio, G., & Vendemiale, G. (2023) · Advances in Redox Research · doi:10.1016/j.arres.2023.100066 · Cited by 3
Structure, Function and Responses to Injury
Crawford, J. M., Bioulac‐Sage, P., & Hytiroglou, P. (2023) · Elsevier eBooks · doi:10.1016/b978-0-7020-8228-3.00001-6 · Cited by 3
Zhang, L., Wang, W., Liu, L., Zhang, Y., & Zhang, X. (2021) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13697 · Cited by 2
“Additionally, the G0-to-G1 transition in hepatocytes after a PH is induced by TNF-α and IL6.(22,33,34) Our results show that the expression of these cytokines was significantly increased in both the fibrotic and control livers after PH.”
BackgroundJung, J., Na, K.-H., Lee, M.-J., Moon, J., Kim, G. I., Jang, J.-J., Hwang, S., & Kim, G. J. (2013) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-013-0364-x · Cited by 3
Cytokines in Liver Health and Disease
Invernizzi, P., Bianchi, I., Locati, M., et al. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-518-3_8 · Cited by 3
“Probably it has an important antiapoptotic and hepatocyte survival activity ( 80 ).”
BackgroundNature and Function of Hepatic Tumor Necrosis Factor-α Signaling
Schattenberg, J. M., & Czaja, M. J. (2005) · Springer eBooks · doi:10.1007/3-540-27194-5_10 · Cited by 3
“In another study, similar effects were seen, although some mice survived and had a normal regenerative response [16].”
ResultAcetylsalicylic acid (Aspirin®) and liver regeneration: experimental study in rats
Biondo-Simões, M. D. L. P., Pessini, V. C. D. A., ICHI, C. A., Robes, R. R., & Ioshii, S. O. (2021) · Revista do Colégio Brasileiro de Cirurgiões · doi:10.1590/0100-6991e-20213164 · Cited by 2
“…demonstrate that inflammatory cytokines and growth factors released by platelets may be crucial for the initiation of hepatocyte proliferation 35,36,40 , and direct contact between platelets and endothelial cells of the hepatic sinusoids seem to play an important role in stimulating to the release…”
BackgroundLiu, L., Zhang, C., Lu, T., et al. (2022) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2023.2162878 · Cited by 2
“Postoperative stress response can increase the secretion of tumor necrosis factor α (TNF -α) and Interleukin-6 (IL-6) [9], which can maintain the acute response of hepatectomy patients and promote the proliferation of hepatocytes [10].”
BackgroundDevelopmental Pathways in Liver Regeneration-I
Nejak‐Bowen, K. N., & Monga, S. P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420128-6.00006-3 · Cited by 3
Gal`perin, E. I., Ataullakhanov, R. I., Dyuzheva, Т. G., Platonova, L. V., Mel’nikova, T. M., Monakov, M. Y., Dudchenko, A. M., Lyundup, A. V., & Klabukov, I. (2017) · Biomeditsinskaya Khimiya · doi:10.18097/pbmc20176305440 · Cited by 2
Πασπάλα, Ά., Papaconstantinou, D., Prodromidou, A., Danias, N., Machairas, A., Agrogiannis, G., Machairas, N., Zavras, N. J., Patapis, P., & Pikoulis, E. A. (2020) · Cureus · doi:10.7759/cureus.12120 · Cited by 2
“On one hand, TNF-a and Il-6 are regarded as key players in the initiation of the regenerative process after hepatectomy, based on the results of studies on knock-out animals [9,19,20], and on the other hand, UDCA seems to decrease circulating levels of both cytokines in hepatic regeneration after chemically induced in…”
BackgroundTrautwein, C. (2006) · Elsevier eBooks · doi:10.1016/b978-1-4160-3258-8.50007-3 · Cited by 2
Zhu, M., Li, Y., Liu, D., & Gong, Z. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150937 · Cited by 1
Enhanced liver regeneration via targeted mRNA delivery for partial in vivo reprogramming
Jo, B., Song, Y. S., Song, W., Eom, H.-J., Lee, Y. J., Kim, J., 홍승희, Cho, S., & Cha, H. (2026) · Cell Reports Medicine · doi:10.1016/j.xcrm.2026.103084 · Cited by 2
Viral Disease, Tissue Injury, Repair and Regeneration
Ten, N. S. (2014) · Journal of Molecular and Genetic Medicine · doi:10.4172/1747-0862.1000148 · Cited by 1
“In these acute phases of injury, the hepatocytes are able to enter the cell cycle through a combinedparacrine cascade of induced cytokines and growth factors such as HGF, EGF, TGF-α, TNF-α, u-PA (plasminogen activator, urokinase) and IL-6, which are mainly generated by the surrounding nonparenchymal cells that constit…”
BackgroundThe Priming and Progression Theory of Liver Regeneration
Riehle, K. J., Riggle, K. M., & Campbell, J. S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420128-6.00004-x · Cited by 1
Nevzorova, Y. A., & Trautwein, C. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0881-3.00002-4 · Cited by 1
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“It has been shown that many inflammatory cytokines including TNF-alpha and IL-6 are up-regulated during hepatic regeneration (31,32).”
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Metadata
- Authors
- Blindenbacher, A., Wang, X., Langer, I., Savino, R., Terracciano, L., & Heim, M. H.
- Affiliations
- University Hospital of Basel (CH)
- Magna Graecia University (IT)
- Corresponding author
- Heim, Markus H.
- Venue
- Hepatology
- Published
- 2003-09
- Volume
- 38
- Issue
- 3
- Pages
- 674-682
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2048242463
- Semantic Scholar
- 78c7f4e4325ae9116023347a3571832ba7e4a329
- Cited by
- 202
- References
- 33
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 11 · 2019: 6 · 2018: 6 · 2017: 13 · 2016: 5 · 2015: 7 · 2014: 11 · 2013: 5 · 2012: 12
- FWCI
- 6.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- interleukin-6, partial hepatectomy, postoperative survival, acute phase response, liver regeneration, IL-6 knockout mice, homeostasis
- MeSH terms
- Acute-Phase Proteins, Animals, Cell Cycle, DNA-Binding Proteins, Hepatectomy, Injections, Subcutaneous, Liver, Liver Regeneration, Time Factors, Trans-Activators, Interleukin-6, Survival Rate, Mice, Knockout, STAT3 Transcription Factor, Mice
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