Cited by 993Obstructive Sleep Apnea ResearchNitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 130 of the 134 references it cites were found in a registry or an index.

Obstructive sleep apnoea syndrome – an oxidative stress disorder

Lavie, Lena·2003·Sleep Medicine Reviews

DOI 10.1053/smrv.2002.0261

Open this paper in CoChat — free account

Abstract

Obstructive sleep apnoea syndrome (OSA) is associated with increased cardiovascular morbidity and mortality. However, the underlying mechanisms are not entirely understood. This review will summarize the evidence that substantiates the notion that the repeated apnoea-related hypoxic events in OSA, similarly to hypoxia/reperfusion injury, initiate oxidative stress. Thus, affecting energy metabolism, redox-sensitive gene expression, and expression of adhesion molecules. A limited number of studies substantiate this hypothesis directly by demonstrating increased free radical production in OSA leukocytes and increased plasma-lipid peroxidation. A great number of studies, however, support this hypothesis indirectly. Increase in circulating levels of adenosine and urinary uric acid in OSA are implicated with increased production of reactive oxygen species (ROS). Activation of redox-sensitive gene expression is suggested by the increase in some protein products of these genes, including VEGF, erythropoietin, endothelin-1, inflammatory cytokines and adhesion molecules. These implicate the participation of redox-sensitive transcription factors as HIF-1 AP-1 and NFkappaB. Finally, adhesion molecule-dependent increased avidity of OSA monocytes to endothelial cells, combined with diminished NO bioavailability, lead to exaggerated endothelial cell damage and dysfunction. Cumulatively, these processes may exacerbate atherogenic sequelae in OSA.

Integrity signals

Registry

Crossref · 10.1053/smrv.2002.0261

Cites

130 of 130 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513
Oxygen-Derived Free Radicals in Postischemic Tissue Injury
Epstein, F. H., & McCord, J. M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501173120305 · Cited by 5,399
[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994
Prospective Study of the Association between Sleep-Disordered Breathing and Hypertension
Peppard, P. E., Young, T., Palta, M., & Skatrud, J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005113421901 · Cited by 4,973
Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
Celermajer, D. S., Sorensen, K. E., Gooch, V. M., Spiegelhalter, D. J., Miller, O. I., Sullivan, I. D., Lloyd, J. K., & Deanfield, J. E. (1992) · The Lancet · doi:10.1016/0140-6736(92)93147-f · Cited by 4,742
A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease
Boushey, C. J. (1995) · JAMA · doi:10.1001/jama.1995.03530130055028 · Cited by 3,708
Association of Sleep-Disordered Breathing, Sleep Apnea, and Hypertension in a Large Community-Based Study
Nieto, F. J. (2000) · JAMA · doi:10.1001/jama.283.14.1829 · Cited by 3,369
Sleep-disordered Breathing and Cardiovascular Disease
SHAHAR, E., WHITNEY, C. W., REDLINE, S., LEE, E. T., NEWMAN, A. B., JAVIER NIETO, F., O'CONNOR, G. T., BOLAND, L. L., SCHWARTZ, J. E., & SAMET, J. M. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.1.2001008 · Cited by 2,901

Show all 134 references

Research works printed but not linked: 4

Yuan, 2001, Activation of HIF-2a by intermittent hypoxia requires CaMKII (Abstract), FASEB J, 15, A154
Lavie, 1998, Production of heat shock protein 70 by peripheral blood monocytes from patients with sleep apnea syndrome, J Sleep Res, 7, 150
Ghandour, 1999, Expression of heat shock proteins in obstructive sleep apnea syndrome, Sleep, 22, S331
Carlson, 1997, Increased plasma concentration of ADMA a naturally occurring nitric oxide synthesis inhibitor in OSA patients, Am J Respir Crit Care Med, 155, A869

Sorted by citations

Items 701–800 of 988

Relationship Between Sleep-Disordered Breathing Level and Acute Onset Time of Congestive Heart Failure
Yoneyama, K., Osada, N., Shimozato, T., Ishibashi, Y., Hayashi, A., Takahashi, E., Kida, K., Suzuki, K., Tamura, M., Inoue, K., et al. (2008) · International Heart Journal · doi:10.1536/ihj.49.471 · Cited by 5
Influence of Nasal Continuous Positive Airway Pressure on Response to Exercise in Patients with Obstructive Sleep Apnea Syndrome
Przybyłowski, T., Bielecki, P., Kumor, M., Hildebrand, K., Maskey‐Warzęchowska, M., Wiwała, J., Kościuch, J., Korczyński, P., & Chazan, R. (2006) · Advances in respiratory medicine · doi:10.5603/arm.28067 · Cited by 4
“Obecnie uważa się, że cykliczna hipoksemia oraz powtarzające się wybudzenia to dwa główne elementy zapoczątkowujące szereg nieprawidłowych zjawisk obserwowanych u chorych na OBPS, takich jak aktywacja układu współczulnego, nadmierna produkcja wolnych rodników tlenowych, dysfunkcja śródbłonka naczyń, rozwój zespołu met…”
Sleep and its Disorders Affect Society
Idzikowski, C. (2014) · InTech eBooks · doi:10.5772/56970 · Cited by 6
Additive effects of obstructive sleep apnea syndrome and hypertension on inflammatory reaction
Liu, Z., Xu, Y., Hua, Q., Wang, Y., Liu, R., & Yang, Z. (2011) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb.9000024 · Cited by 5
Early markers of renal damage in obstructive sleep apnea syndrome (OSAS) patients with or without diabetes mellitus
Farghaly, S., Sadek, S. H., Abdel-Aal, A. M., Mahmoud, A., Obiedallah, A. A., & Abdulhamid, S. K. (2017) · Egyptian Journal of Chest Diseases and Tuberculosis · doi:10.1016/j.ejcdt.2017.09.004 · Cited by 5
Developmental and metabolic implications of the hypoxic ventilatory response
Waters, K. A., & Gozal, D. (2004) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2004.04.003 · Cited by 5
Independent Association of Sleep Apnea-Specific Hypoxic Burden and Sleep Breathing Impairment Index with Thyroid Function in Obstructive Sleep Apnea: A Retrospective Study
Zhou, Y., Shi, Y., Zhu, S., Cao, Z., Xie, Y., Lu, C., Niu, X., Ma, L., Wang, Z., Su, Y., et al. (2025) · Nature and Science of Sleep · doi:10.2147/nss.s525750 · Cited by 4
“Some studies suggest a subtle connection, such as hypothyroidism exacerbating OSA through airway narrowing 7 and OSA-induced oxidative stress impairing thyroid hormone synthesis, 12–15 other research, however, indicates no significant associations.”
Mechanisms of upper airway muscle control in sleep reveal therapeutic targets for obstructive sleep apnea
Horner, R. L., Wellman, A., Sands, S. A., Azarbarzin, A., & Taranto‐Montemurro, L. (2026) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1093/ajrcmb/aanag089 · Cited by 4
Reduced serum levels of mitochondria-derived peptide MOTS-c in patients with obstructive sleep apnea
Luo, Z., Ji, R. P., Ye, R., Shi, Y., Pang, Q., & Yin, M. (2025) · Sleep and Biological Rhythms · doi:10.1007/s41105-025-00578-9 · Cited by 4
“A primary characteristic of OSA patients is chronic intermittent hypoxia during the night, which triggers a systemic inflammatory response and an increase in reactive oxygen species (ROS) [26].”
Sleep apnea, oxidative stress, proinflammatory vascular risk factors, and endothelial disease
Berger, S., & Lavie, L. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9781139061056.004 · Cited by 4
Self-citation
The Effect of Septoplasty on Endothelial Function in Patients With Marked Nasal Septal Deviation
Dağıstan, H., & Turan, Y. (2021) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000008027 · Cited by 4
“A decrease in nitric oxide (NO) release or arterial response to NO after a chemical or mechanical effect is the mechanism responsible for ED.13 The increase in the brachial artery diameter is triggered by increased NO levels as a result of increased shear stress in the arterial wall.14 The activity of nitric oxide syn…”
Background
Renalase rs2296545 variant improve hypertension susceptibility by modifying binding affinity to catecholamines in obstructive sleep apnea
Shen, H., Yang, J., Xue, W., Wei, Z., Li, L., Guan, J., Li, X., & Wu, X. (2024) · Hypertension Research · doi:10.1038/s41440-024-01850-0 · Cited by 4
“Additionally, hypoxia-induced oxidative stress promotes ROS formation, causing vasoconstriction by impeding NO synthase, increasing endothelin-1 production, and stimulating angiotensin II activation [39, 42, 43, 61].”
Background
Anatomical, functional, and blood-born predictors of severity of brachycephalic obstructive airway syndrome severity in French Bulldogs
Schmid, C., Steiner, A. R., Spielhofer, L., Galfetti, M., Rentsch, N., Bogdanov, N., Vogel, J., Hofmann‐Lehmann, R., Hartnack, S., Astakhov, G., et al. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1486440 · Cited by 4
Association of Obstructive Sleep Apnea and Uncontrolled Hypertension in the Middle Aged 40–59 in Korean Population
Lee, E., & Kim, S. J. (2025) · Journal of Korean Medical Science · doi:10.3346/jkms.2025.40.e129 · Cited by 4
Association between obstructive sleep apnea and hearing loss among a cohort of emergency responders
Appel, D. W., Goldfarb, D. G., Zeig‐Owens, R., Choi, J., Flamme, G. A., Liu, Y., Schwartz, T. M., & Prezant, D. J. (2025) · Sleep And Breathing · doi:10.1007/s11325-025-03338-8 · Cited by 4
Trastornos de sueño en los pacientes en diálisis
Diana, R. B., & Carlos, A. C. C. (2010) · Revista Colombiana de Psiquiatría · doi:10.1016/s0034-7450(14)60227-4 · Cited by 4
Oxidative Stress in the Carotid Body: Implications for the Cardioventilatory Alterations Induced by Obstructive Sleep Apnea
Iturriaga, R., & Del, R. (2012) · InTech eBooks · doi:10.5772/32525 · Cited by 4
“Oxidative stress, inflammation and sympathetic overflow have been proposed as potential pathogenic mechanisms involved in the onset of the hypertension and cardiovascular diseases (Arnardottir et al., 2009, Garvey at al., 2009, Lavie 2003, Somers et al., 2008).”
Background
Trastornos del sueño en pacientes en hemodiálisis
Restrepo, D., Martínez, P. H., Gómez–Restrepo, C., Laverde, F. G., & Cardeño, C. A. (2011) · Revista Colombiana de Psiquiatría · doi:10.1016/s0034-7450(14)60138-4 · Cited by 4
Correlation between Endothelial Dysfunction, Rho-associated Protein Kinase Activity, C-reactive Protein and Obstructive Sleep Apnoea Syndrome in Male Patients
Zhang, L., Zhuang, J.-H., Peng, H., Huang, J., Huang, L.-Q., & Zhao, Z.-X. (2012) · Journal of International Medical Research · doi:10.1177/030006051204000616 · Cited by 4
Effect of intermittent hypoxia on rat INS-1 cells and the protective effect of melatonin.
Lu, W., Liu, L.-Z., Li, H., Li, G., Yu, N. H., Dl, W., Wang, W., & Kang, J. (2014) · PubMed · Cited by 4
Effect of Modified Fujita Technique Uvulopalatoplasty on Oxidative DNA Damage Levels in Patients With Obstructive Sleep Apnea Syndrome
Bakan, E., Fidan, V., Hakan, H., Baygutalp, N. K., & Çokluk, E. (2015) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000001870 · Cited by 4
“It is well established that oxidative stress is correlated with OSAS, since the oxidative damage markers have been found high in this condition.(10,13) Although antioxidant levels were higher in patients with OSA than normal population, there is no report, as far as we are concerned, about the effect of UPPP on antiox…”
Background
Journal of Sleep Medicine & Disorders
Kunal, A., Mohammed, A. J., Luisa, B., & Roehrs, T. (2016) · Cited by 4
Apneic events – A proposed new target for respiratory safety pharmacology
Murphy, D. J. (2016) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2016.07.001 · Cited by 4
“(Lavie, 2003; 166 Lavie, 2015) The presence of ROS and RNS can cause cell and tissue damage through the 167 peroxidation of proteins and lipids, and lead to the activation of inflammatory responses similar 168 to the ischemia and reperfusion injury that has been well studied in the heart.”
Background
Obstructive sleep apnea and retinal microvascular characteristics: a brief review
Lin, K. H., Lin, H. Z., Lin, Y. P., Meng, F. C., Lin, F., Wu, H. T., & Lin, G. M. (2017) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000173 · Cited by 4
“The nature of OSA is cycles of deoxygenation and reoxygenation triggering production of reactive oxygen species and thus increasing oxidative stress leading to endothelial damage [6].”
Background
Sleep Apnea and Cardiovascular Morbidity—a Perspective
Torres, G., Turino, C., Sapiña-Beltrán, E., Sánchez‐de‐la‐Torre, M., & Barbé, F. (2018) · Current Sleep Medicine Reports · doi:10.1007/s40675-018-0108-5 · Cited by 4
Sleep and Cardiovascular Disease
Javaheri, S. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-6645-3.00116-x · Cited by 4
The association between sleep-related breathing disorders and pre-capillary pulmonary hypertension: A chicken and egg question
Esnaud, R., Gagnadoux, F., Beurnier, A., Berréhare, A., Trzépizur, W., Humbert, M. J. C., Montani, D., & Jutant, E. (2021) · Respiratory Medicine and Research · doi:10.1016/j.resmer.2021.100835 · Cited by 4
Koronare Herzkrankheit und schlafbezogene Atmungsstörungen
Steiner, S., & Arzt, M. E. (2014) · Somnologie - Schlafforschung und Schlafmedizin · doi:10.1007/s11818-014-0676-7 · Cited by 4
Sleep-Disordered Breathing and Sleep Duration in Childhood Obesity
Verhulst, S. L. (2010) · Springer eBooks · doi:10.1007/978-1-60327-874-4_17 · Cited by 4
Nutrition, Sleep and Sleep Disorders – Relations of Some Food Constituents and Sleep
Partinen, M., Westermarck, T., & Atroshi, F. (2014) · InTech eBooks · doi:10.5772/58345 · Cited by 4
“Oxidative stress in sleep apnea is thought to be produced by hypoxic events and by hypoxia-reperfusion injury, and in this way it contributes to cardiovascular complications and inflammatory processes [40, 41].”
Background
Intermittent Hypoxia and Obstructive Sleep Apnea: Mechanisms, Interindividual Responses and Clinical Insights
Lavie, L. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.86117 · Cited by 4
“Thus, the multiple cycles of IH in OSA have been shown to resemble mechanisms of ischemia and reperfusion (I/R) injury by eliciting similar fundamental mechanisms, including increased ROS production, activated leukocytes, inflammation, transcriptional reprograming, and vascular dysfunction [5, 6, 8].”
BackgroundSelf-citation
Effects of intermittent hypoxia on the cerebrovascular responses to submaximal exercise in humans
Querido, J. S., Rupert, J. L., McKenzie, D. C., & Sheel, A. W. (2008) · European Journal of Applied Physiology · doi:10.1007/s00421-008-0917-1 · Cited by 4
“IH increases oxidative stress, which decreases the bioavailability of nitric oxide (NO), thereby leading to a blunted dilation of cerebral vessels ( Lavie 2003; Phillips et al. 2004).”
Background
Cardiovascular comorbidity in patients with restless legs syndrome: current perspectives
Vargas-Pérez, N., Bagai, K., & Walters, A. S. (2017) · Journal of Parkinsonism and Restless Legs Syndrome · doi:10.2147/jprls.s99322 · Cited by 4
Association of continuous positive airway pressure with F2-isoprostanes in adults with obstructive sleep apnea: a meta-analysis
Huang, Z.-W., Ouyang, W., Zhang, L., Li, H., Ye, Y.-M., Lin, X., Xu, Q.-Z., Lin, L., & Chen, L. (2019) · Sleep And Breathing · doi:10.1007/s11325-019-01795-6 · Cited by 4
The Role of Adrenomedullin in Obstructive Sleep Apnea
Minoguchi, K., & Adachi, M. (2007) · Hypertension Research · doi:10.1291/hypres.30.1007 · Cited by 4
Association Between the Nutritional Inflammatory Index and Obstructive Sleep Apnea Risk: Insights from the NHANES 2015–2020 and Mendelian Randomization Analyses
Lin, M., Abuduxukuer, K., Ye, L., Zhang, H., Zhang, X., Shi, S., Wang, Y., & Liu, Y. (2025) · Healthcare · doi:10.3390/healthcare13070783 · Cited by 3
“Systemic inflammation is a well-established contributor to OSA pathophysiology and severity [57].”
SCUBE-1 Levels and Their Relationship with Endothelial Dysfunction in Obstructive Sleep Apnea Syndrome Patients
Fazlıoğlu, N., Aydın, C., Demirkıran, A., Gür, D. Ö., Yılmaz, A., & Çelikkol, A. (2025) · Nature and Science of Sleep · doi:10.2147/nss.s509757 · Cited by 3
“15 Other studies have also reported that oxidative stress increases in OSAS patients due to hypoxemia and recurrent apnea episodes, which leads to cell damage and inflammation.”
Relationship between REI and PSA in patients with obstructive sleep apnea: a prospective case-control study
Yang, L., Feng, Y., Xue, J., Tian, J., & Wang, Y. (2025) · Sleep And Breathing · doi:10.1007/s11325-024-03182-2 · Cited by 3
Development and Evaluation of a Hypertension Prediction Model for Community-Based Screening of Sleep-Disordered Breathing
Feng, T., Shan, G., Hu, Y., He, H., Pei, G., Zhou, R., & Ou, Q. (2025) · Nature and Science of Sleep · doi:10.2147/nss.s492796 · Cited by 3
“35 Chronic intermittent hypoxemia may further impair the diurnal blood pressure control by affecting the vascular endothelium (Figure 10).”
Obstructive Sleep Apnea Syndrome: Implications in Cardiovascular Disease
Zamarrón, C., Matias, F., & Egea, C. (2009) · Current Respiratory Medicine Reviews · doi:10.2174/157339809790112492 · Cited by 3
NADPH oxidase, uncoupled endothelial nitric oxide synthase, and NF-KappaB are key mediators of the pathogenic impact of obstructive sleep apnea – Therapeutic implications
McCarty, M. F., DiNicolantonio, J. J., & O’Keefe, J. H. (2016) · Journal of Integrative Cardiology · doi:10.15761/jic.1000177 · Cited by 3
“The markers found to be higher in OSA included TBARs in LDL particles, lag phase of LDL oxidation ex vivo, paraoxonase level, superoxide production by neutrophils stimulated ex vivo, urinary excretion of 8-hydroxydeoxyguanosine and 8-isoprostane, exhalation of 8-isoprostane, plasma levels of C-reactive protein and adh…”
Background
Reactive Oxygen Metabolites (ROMs) as an Index of Oxidative Stress in Obstructive Sleep Apnea Patients
Christou, K., & Gourgoulianis, K. (2007) · Elsevier eBooks · doi:10.1016/b978-044452809-4/50152-6 · Cited by 3
Coronary Artery Disease and Obstructive Sleep Apnea
Peker, Y., Franklin, K. A., & Hedner, J. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-24288-2.00128-8 · Cited by 3
Serum high-mobility group box 1 protein level correlates with the lowest SaO2 in patients with sleep apnea: a preliminary study
Min, H. J., Park, J. S., Kim, K. S., Kang, M., Seo, J. H., Yoon, J., Kim, C., & Cho, H. (2021) · Brazilian Journal of Otorhinolaryngology · doi:10.1016/j.bjorl.2020.11.019 · Cited by 3
Continuous positive airway pressure improved daytime sleepiness and memory function in patients with obstructive sleep apnea
Hong, Y.-L., Shen, Y., Chang, E., & Kung, S.-C. (2022) · Tzu Chi Medical Journal · doi:10.4103/tcmj.tcmj_4_22 · Cited by 3
“It has been shown that intermittent hypoxemia affects hippocampal volume, resulting in impairments in memory consolidation and amnesia [21].”
Background
Correlation between cognitive impairment and serum markers in patients with obstructive sleep apnea–hypopnea syndrome
Pan, Q., Li, H., Gan, X., Chen, X., Liu, X., & Li, J. (2023) · Sleep And Breathing · doi:10.1007/s11325-023-02942-w · Cited by 3
“This inflammation can alter the transport of molecules across the barrier, contributing to cognitive dysfunction [27, 28].”
Screening of obstructive sleep apnea and diabetes mellitus -related biomarkers based on integrated bioinformatics analysis and machine learning
Yang, J., Han, Y., Diao, X., Yuan, B., & Gu, J. (2025) · Sleep And Breathing · doi:10.1007/s11325-024-03240-9 · Cited by 3
“The intermittent hypoxemia and repetitive awakenings of OSA trigger a series of pathophysiological events, including activation of the sympathetic nervous system, increase in oxidative stress, alterations of pro-adrenocorticotropic function, and inflammatory reason of adipocytokines [11].”
Upper airway microcirculation remodeling in obstructive sleep apnea is not driven by endothelial activation
Fahl, K., Mauad, T., de Brito, J. M., Costa, N. D. S. X., Dantas, D. A. S., de Souza, H. P., Sampaio, R. O., Sennes, L. U., & Cahali, M. B. (2025) · Scientific Reports · doi:10.1038/s41598-025-98190-x · Cited by 3
Melatonin as a Therapeutic Adjunct in Obstructive Sleep Apnea: A Review of Potential Benefits
Lasala, J. J., & Lucero‐Prisno, D. E. (2025) · Sleep Medicine Research · doi:10.17241/smr.2025.02628 · Cited by 3
Effects of positive airway pressure therapy on cardiovascular and metabolic markers in males with obstructive sleep apnea
Feliciano, A., Oliveira, M. J., Cysneiros, A. S. D., Martinho, C., dos Reis, R. P., Penque, D., Pinto, P., & Bárbara, C. (2017) · Revista Portuguesa de Pneumologia · doi:10.1016/j.rppnen.2017.02.010 · Cited by 3
CARDIOVASCULAR AND METABOLIC IMPAIRMENT IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA
Gorbunova, M. V., Babak, S. L., & Малявин, А. Г. (2018) · The Russian Archives of Internal Medicine · doi:10.20514/2226-6704-2018-8-1-12-21 · Cited by 3
CPAP-therapy in pharmacologically-treated hypertensive patients with sleep apnea
Sviryaev, Y. V., Звартау, Н. Э., Rotar, О. P., Korostovtceva, L. S., Конради, А. О., & Kalinkin, A. L. (2008) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2008-14-3-264-269 · Cited by 3
Atherosclerosis, Arteriosclerosis and Arteriolosclerosis
Gianturco, L. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.83058 · Cited by 4
Obstructive sleep apnoea: What is the evidence for vascular pathogenesis?
IP, M. S. M. (2007) · Respirology · doi:10.1111/j.1440-1843.2007.01066.x · Cited by 3
Obstructive sleep apnoea: time for a radical change?
Phillips, C. L., & Grunstein, R. R. (2006) · European Respiratory Journal · doi:10.1183/09031936.06.00017206 · Cited by 3
Le syndrome d’apnées-hypopnées obstructif du sommeil : évolution d’un concept ancien
Vecchierini, M.-F. (2006) · Neurochirurgie · doi:10.1016/s0028-3770(06)71242-5 · Cited by 3
Cardiovascular complications of obstructive sleep apnea
Ramar, K., & Guilleminault, C. (2008) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2.1.63 · Cited by 4
Effects of Aerobic Exercise on Middle-aged Male Smokers' Blood Vessel Health
Kim, J., Jeong, H.-C., Won, J., Ka, S.-S., & Oh, B.-S. (2014) · Journal of Digital Convergence · doi:10.14400/jdc.2014.12.4.349 · Cited by 3
Respiratory and Cardiac Manifestations of Obstructive Sleep Apnea
Lee, D. S. (2008) · Nursing Clinics of North America · doi:10.1016/j.cnur.2007.11.002 · Cited by 3
Sleep apnoea, hypertension and vascular disease: where are we now?
Buyse, B., & Hedner, J. (2007) · European Respiratory Review · doi:10.1183/09059180.00010606 · Cited by 3
Sex Differences in Murine Sternohyoid Muscle Tolerance of Acute Severe Hypoxic Stress
Lewis, P., & O’Halloran, K. D. (2016) · Physiological Research · doi:10.33549/physiolres.933169 · Cited by 3
“Given the association of hypoxia with oxidative/nitrosative stress and muscle functional adaptation in patients and animal models (Lavie 2003, Zhu et al. 2003, 2005, Koechlin et al. 2005, Ottenheijm et al. 2006, Marin-Corral et al. 2009, Sadasivam et al. 2011, Skelly et al. 2012a, 2013, Shortt et…”
Background
Orofacial Pain and Temporomandibular Disorders in Relation to Sleep-Disordered Breathing and Sleep Bruxism
Essick, G., Raphael, K. G., Sanders, A. E., & Lavigne, G. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-24288-2.00146-x · Cited by 3
Coronary Artery Disease and Obstructive Sleep Apnea
Hedner, J. A., Franklin, K. A., & Peker, Y. (2005) · Elsevier eBooks · doi:10.1016/b0-72-160797-7/50108-7 · Cited by 3
The paradigm of obstructive sleep apnea in aging: interactions with telomere length
Tempaku, P. F., & Tufik, S. (2018) · Sleep Medicine · doi:10.1016/j.sleep.2018.05.009 · Cited by 3
Neuropsychological Test Pattern Associated With a High Percentage of Sleep Apnea Diagnosis
Przybelski, R. J., Przybelski, A. G., Rumble, M. E., Plante, D. T., Irwin, A. M., & Jones, J. E. (2025) · Brain and Behavior · doi:10.1002/brb3.71097 · Cited by 2
“(Lavie 2003) The hippocampus, playing a pivotal role in memory, has been reported to be especially vulnerable to these phenomena.”
Relationships between oxidative stress and sleep parameters in patients with obstructive sleep apnea syndrome
Abakay, A., Abakay, Ö., Şen, H. S., Yüksel, H., Yılmaz, S., Palanci, Y., & Tanrıkulu, A. Ç. (2014) · Journal of Clinical and Experimental Investigations · doi:10.5799/ahinjs.01.2014.02.0401 · Cited by 2
Is Hepcidin a Good Marker for Inflammation in Obstructive Sleep Apnea Syndrome (OSAS) Patients?
Fırat, H., Özdemir, C., Bilgin, E., Luyster, F. S., Yüceege, M., Kızılgün, M., Demır, A. U., Strollo, P. J., & Ardıç, S. (2015) · Journal of Turkish Sleep Medicine · doi:10.4274/jtsm.02.009 · Cited by 2
“Obstructive Apnea syndrome (OSAS) is characterized by repetitive periods of upper airway collapse resulting in cyclic periods of hypoxia/reoxygeneration and causing increased generation of oxygen species by oxidative stress (1).”
Background
GCH1 (rs841) polymorphism in the nitric oxide-forming pathway has protective effects on obstructive sleep apnea
Kouhsar, S. S., Bigdeli, M., Shakiba, Y., & Sadeghniiat‐Haghighi, K. (2019) · Scientific Reports · doi:10.1038/s41598-019-55244-1 · Cited by 2
Clinical Characteristics and Surgical Outcomes of Obstructive Sleep Apnea Patients With Mixed Apnea Components
Rha, M., Jeong, Y., Kim, C., Yoon, J., & Cho, H. (2022) · Otolaryngology · doi:10.1177/01945998221103800 · Cited by 2
Combining Heart Rate Variability and Oximetry to Improve Apneic Event Screening in Non-Desaturating Patients
González, M., Ravelo-García, A. G., Navarro-Mesa, J. L., & Hernández-Pérez, E. (2023) · Sensors · doi:10.3390/s23094267 · Cited by 2
“It is considered a public health problem because of its high prevalence, which is 4% among men and 2% among women [1], as well as its serious health implications, such as cardiovascular disorders, strokes, glucose metabolism abnormalities, sudden death, or depression, that lead to increased mortality rates [2].”
Background
Outcomes and Predictors of Success Following Multilevel Surgery in Positional and Nonpositional Obstructive Sleep Apnea
Noh, H. E., Rha, M., Jeong, Y., Kim, C., & Cho, H. (2024) · Otolaryngology · doi:10.1002/ohn.912 · Cited by 2
Genetic Evidence Supporting a Causal Role of Snoring in Keratoconus: A Bidirectional Mendelian Randomization Study
Chen, X., Liu, S., Liu, C. X., Huang, Y., Hou, X., Zhuang, J., Luo, Y., Yu, N., Zhuang, J., & Yu, K. (2024) · Cornea · doi:10.1097/ico.0000000000003741 · Cited by 2
“25 Several studies have demonstrated that patients with OSA have elevated levels of oxidative stress in various tissues, 26,27 and considerable researchers have pointed to a close association of oxidative stress with KCN.”
Pathophysiological Mechanisms in Obstructive Sleep Apnea Syndrome
Aygün, D. (2025) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815322132125010022 · Cited by 2
Deep Proteomics Analysis Unravels the Molecular Signatures of Tonsillar B Cells in PFAPA and OSAS in the Pediatric Population
Kharrat, F., Balasan, N., Ura, B., Golino, V., Campiglia, P., Peri, G., Valencic, E., Qaisiya, M., de Moura, R. R., Stazio, M. D., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146621 · Cited by 2
“It likely promotes a dynamic repression response [41], including KRAB zinc finger proteins and their core-pressors, such as GATAD2A , which maintain genome stability under fluctuating oxygen levels [42].”
Obstructive Sleep Apnea and Postoperative Hyperalgesia in Bariatric Surgery: A Prospective Observational Cohort Study
Zhong, Z., Lu, X. L., Zhang, Q., & Zhang, Y. (2025) · Journal of Pain Research · doi:10.2147/jpr.s508324 · Cited by 3
Non-invasive Monitoring of Pulse Rate and Desaturation Events with Oximeter in Copd Patients with Cardiovascular Comorbidities
Popa, A., Caproş, N., Dumitraș, T., Corlateanu, O., Dogot, M., Smolenschi, I., Sîrbu, I., & Dumitras, M. (2022) · World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany · doi:10.1007/978-3-030-92328-0_94 · Cited by 2
Efficacy of Continuous Positive Airway Pressure in Cardiovascular Complications of Obstructive Sleep Apnea
BaHammam, A. S., & Chaudhry, M. K. A. (2010) · Springer eBooks · doi:10.1007/978-3-642-11365-9_18 · Cited by 2
“intermittent swings in blood gas chemistry that range from hypoxia–reoxygenation to hypercapnia–hypocapnia, (2) arousals, and (3) intrathoracic pressure changes [4].”
Background
Contribution of Autonomic Nervous System to the Hypertension Induced by Obstructive Sleep Apnea
Iturriaga, R., & Idiáquez, J. (2014) · InTech eBooks · doi:10.5772/57565 · Cited by 2
“It is relevant to note that the OSA-hypertension link is independent from other comorbidities like obesity [33, 45, 51, 79, 100].”
Background
Más allá del molesto ronquido: síndrome de apnea obstructiva del sueño y su peligrosa asociación con el síndrome metabólico
Yurgaky, J. M., Bastidas, A., Jhon, A., Montaña, J. A., & Ana María Arredondo, G. (2011) · Revista Med · doi:10.18359/rmed.1275 · Cited by 2
Obstructive sleep apnea syndrome and blood flow to the eyes
Aşker, S., Timuçin, Ö. B., Ursavaş, A., Aslancı, M. E., Baykara, M., Ertürk, H., Asker, M., Yılmaz, S., & Kaya, D. (2013) · DergiPark (Istanbul University) · Cited by 2
Sleep Apnea and Stroke: A Risk Factor or an Association?
Yaggi, H. K., & Mohsenin, V. (2007) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2007.07.004 · Cited by 2
Proceedings From the 2011 American Association of Oral and Maxillofacial Surgeons Research Summit
Peacock, Z. S., Kademani, D., Le, A. D., Lee, J. S., Hale, R. G., & Cunningham, L. L. (2012) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2012.01.029 · Cited by 2
Embedded realization of a real time Heart Rate Variability logger for at-home sleep studies
Rekha, B. B., Kandaswamy, A., & Mitha, V. M. (2015) · IEEE Workshop on Computational Intelligence: Theories, Applications and Future Directions (WCI) · doi:10.1109/wci.2015.7495532 · Cited by 2
“During polysomnography procedure, there is a possibility to miss diagnosis of OSA in patients who are at the risk for the disease [10].”
Method
The relation and mechanism of kidney injury in obstructive sleep apnea: a literature review
Poonit, N. D., & Cai, X. H. (2018) · Sleep and Biological Rhythms · doi:10.1007/s41105-018-0146-x · Cited by 2
Systemic Comorbidities in Patients with Obstructive Sleep Apnea Syndrome
Mutlu, P., & Mirici, N. A. (2018) · Sleep and Vigilance · doi:10.1007/s41782-018-0047-8 · Cited by 2
Obstructive Sleep Apnea and Perioperative Complications
Ramachandran, S. K. (2012) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2012.12.004 · Cited by 2
Feature Selection for Obstructive Sleep Apnea Recognition
Sert, M. (2019) · Bilişim Teknolojileri Dergisi · doi:10.17671/gazibtd.615014 · Cited by 2
Circulating sTweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome
Çilekar, Ş., Beysel, S., Karataş, S., Balcı, A., Akaslan, K., & Uncu, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-01553-3 · Cited by 2
Factors Affecting Device Adherence of Patients with Obstructive Sleep Apnea Syndrome in the COVID-19 Pandemic and Normalization Process
Sünbül, E. A., Karacı, R., Güleç, H., & Domaç, F. M. (2022) · Journal of Turkish Sleep Medicine · doi:10.4274/jtsm.galenos.2021.89421 · Cited by 2
“Obstructive apneic events; oxidative stress triggers sympathetic activation and inflammation, leading to the onset and progression of cardiac, vascular, metabolic, and cerebrovascular diseases (5,6).”
Background
Hypersomnies
Billiard, M. M., & Dauvilliers, Y. A. (2004) · Encyclopédie médico-chirurgicale. Neurologie · doi:10.1016/j.emcn.2004.04.001 · Cited by 2
Cardiopathie ischémique et syndrome d’apnées obstructives du sommeil : mécanismes impliqués dans la réponse à l’hypoxie intermittente
Détrait, M., Billoir, E., Belaïdi, E., & Arnaud, C. (2023) · Médecine du Sommeil · doi:10.1016/j.msom.2023.01.217 · Cited by 2
Ocular disorders associated with obstructive sleep apnea: A review
Maurya, R. P., Manisha, M., Singh, V., Gupta, A. O., Agarwal, S. K., Singh, V. P., Singh, M. K., Srivastav, G. N., & Kadir, S. M. U. (2021) · Indian Journal of Clinical and Experimental Ophthalmology · doi:10.18231/j.ijceo.2021.057 · Cited by 2
Sleep-Disordered Breathing and Sleep Duration in Childhood Obesity
Eyck, A. V., & Verhulst, S. L. (2017) · Contemporary Endocrinology · doi:10.1007/978-3-319-68192-4_28 · Cited by 2
The Liver in Lung Diseases
Blei, A. T., & Sznajder, J. I. (2007) · doi:10.1002/9780470691861.ch20b · Cited by 2
Cost-effectiveness of CPAP treatment related to cardiovascular disease in patients with severe OSAS: the Greek experience
Mermigkis, C. M., Bouloukaki, I., & Schiza, S. E. (2014) · Sleep And Breathing · doi:10.1007/s11325-014-1063-0 · Cited by 2
Inflammation and Obstructive Sleep Apnea: Thinking Outside of the Fat
Patel, A. D., & Cohen, Z. I. (2008) · Respiration · doi:10.1159/000158547 · Cited by 2
A systems engineering approach to coronary heart disease
Mathews, M. J. (2015) · Cited by 2
Obstructive Sleep Apnea and Hypertension
Gami, A. S., & Somers, V. K. (2005) · Elsevier eBooks · doi:10.1016/b978-0-7216-0258-5.50163-0 · Cited by 2
Increased carotid intima-media thickness is independently associated with the occurrence of depressive disorders in patients with obstructive sleep apnea without cardiocerebrovascular disease
Li, X., Wang, X., Li, W., & Wang, W. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.03.043 · Cited by 1
Erectile dysfunction and sleep related bruxism: An exploratory review of an improbable association
Andersen, M. L., Lavigne, G. J., Fabbro, C. D., & Tufik, S. B. (2024) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2024.101970 · Cited by 1

Authors: Lavie, L.
Affiliations: Technion – Israel Institute of Technology (IL)
Corresponding author: Lavie, Lena
Venue: Sleep Medicine Reviews
Publisher: Elsevier BV
Published: 2003-02
Volume: 7
Issue: 1
Pages: 35-51
ISSN: 1087-0792 (ISSN-L)
DOI: 10.1053/smrv.2002.0261
OpenAlex: W1988114644
Cited by: 993
References: 134
Citations by year: 2026: 17 · 2025: 44 · 2024: 28 · 2023: 30 · 2022: 33 · 2021: 43 · 2020: 42 · 2019: 31 · 2018: 38 · 2017: 37 · 2016: 44 · 2015: 51 · 2014: 58 · 2013: 48 · 2012: 51
FWCI: 4.50
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Sleep Medicine Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Health, State of Israel
Topics: Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: obstructive sleep apnea, oxidative stress, hypoxia/reoxygenation injury, reactive oxygen species, lipoprotein oxidation, adhesion molecules, adenosine, uric acid, HIF-1, NF-κB, AP-1, endothelial dysfunction, monocyte adhesion, nitric oxide bioavailability, atherosclerosis, cardiovascular risk
MeSH terms: Cardiovascular Diseases, Free Radicals, Humans, Leukocytes, Lymphokines, Nitric Oxide, Lipid Peroxidation, Endothelial Growth Factors, Oxidative Stress, Hyperhomocysteinemia, Sleep Apnea, Obstructive, Intercellular Signaling Peptides and Proteins, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Obstructive sleep apnoea syndrome – an oxidative stress disorder

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks