Cited by 993Obstructive Sleep Apnea ResearchNitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative Stress

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Obstructive sleep apnoea syndrome – an oxidative stress disorder

Lavie, Lena·2003·Sleep Medicine Reviews

DOI 10.1053/smrv.2002.0261

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Abstract

Obstructive sleep apnoea syndrome (OSA) is associated with increased cardiovascular morbidity and mortality. However, the underlying mechanisms are not entirely understood. This review will summarize the evidence that substantiates the notion that the repeated apnoea-related hypoxic events in OSA, similarly to hypoxia/reperfusion injury, initiate oxidative stress. Thus, affecting energy metabolism, redox-sensitive gene expression, and expression of adhesion molecules. A limited number of studies substantiate this hypothesis directly by demonstrating increased free radical production in OSA leukocytes and increased plasma-lipid peroxidation. A great number of studies, however, support this hypothesis indirectly. Increase in circulating levels of adenosine and urinary uric acid in OSA are implicated with increased production of reactive oxygen species (ROS). Activation of redox-sensitive gene expression is suggested by the increase in some protein products of these genes, including VEGF, erythropoietin, endothelin-1, inflammatory cytokines and adhesion molecules. These implicate the participation of redox-sensitive transcription factors as HIF-1 AP-1 and NFkappaB. Finally, adhesion molecule-dependent increased avidity of OSA monocytes to endothelial cells, combined with diminished NO bioavailability, lead to exaggerated endothelial cell damage and dysfunction. Cumulatively, these processes may exacerbate atherogenic sequelae in OSA.

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Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513
Oxygen-Derived Free Radicals in Postischemic Tissue Injury
Epstein, F. H., & McCord, J. M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501173120305 · Cited by 5,399
[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994
Prospective Study of the Association between Sleep-Disordered Breathing and Hypertension
Peppard, P. E., Young, T., Palta, M., & Skatrud, J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005113421901 · Cited by 4,973
Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
Celermajer, D. S., Sorensen, K. E., Gooch, V. M., Spiegelhalter, D. J., Miller, O. I., Sullivan, I. D., Lloyd, J. K., & Deanfield, J. E. (1992) · The Lancet · doi:10.1016/0140-6736(92)93147-f · Cited by 4,742
A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease
Boushey, C. J. (1995) · JAMA · doi:10.1001/jama.1995.03530130055028 · Cited by 3,708
Association of Sleep-Disordered Breathing, Sleep Apnea, and Hypertension in a Large Community-Based Study
Nieto, F. J. (2000) · JAMA · doi:10.1001/jama.283.14.1829 · Cited by 3,369
Sleep-disordered Breathing and Cardiovascular Disease
SHAHAR, E., WHITNEY, C. W., REDLINE, S., LEE, E. T., NEWMAN, A. B., JAVIER NIETO, F., O'CONNOR, G. T., BOLAND, L. L., SCHWARTZ, J. E., & SAMET, J. M. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.1.2001008 · Cited by 2,901

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Yuan, 2001, Activation of HIF-2a by intermittent hypoxia requires CaMKII (Abstract), FASEB J, 15, A154
Lavie, 1998, Production of heat shock protein 70 by peripheral blood monocytes from patients with sleep apnea syndrome, J Sleep Res, 7, 150
Ghandour, 1999, Expression of heat shock proteins in obstructive sleep apnea syndrome, Sleep, 22, S331
Carlson, 1997, Increased plasma concentration of ADMA a naturally occurring nitric oxide synthesis inhibitor in OSA patients, Am J Respir Crit Care Med, 155, A869

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Shah, N. A., Kizer, J. R., & Yaggi, H. K. (2013) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2013.07.015 · Cited by 1
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Sharma, R., Kumar, A. M., & Ramachandran, S. K. (2013) · Current anesthesiology reports · doi:10.1007/s40140-013-0043-4 · Cited by 1
“stress in these patients includes thiobarbituric acid-reactive substances, isoprostanes, nitrotyrosine and oxidized, lowdensity lipoprotein [73–76].”
Background
Effects of Aerobic and Anaerobic Combined Exercise Training on Body Compositions, Cardiovascular Variables, Blood Lipids and Acute Inflammatory Markers in Male Smoker and Non-smokers during 8 Weeks
Byun, J. (2008) · Korean Journal of Sport Science · doi:10.24985/kjss.2008.19.3.51 · Cited by 1
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Cintra, F. D., Poyares, D. R., Guilleminault, C., & Tufik, S. B. (2006) · Cited by 1
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Corgosinho, F. C., Dâmaso, A. R., & de Mello, M. T. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420168-2.00014-4 · Cited by 1
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Handa, T., & Tanizawa, K. (2017) · Vascular Failure · doi:10.30548/vascfail.1.1_22 · Cited by 1
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Billiard, M., & Dauvilliers, Y. A. (2004) · Encyclopédie médico-chirurgicale. Neurologie · doi:10.1016/s0246-0378(04)39470-4 · Cited by 1
Cortical grey matter changes, behavior and cognition in children with sleep disordered breathing
Tan, B., Tamanyan, K., Walter, L. M., Nixon, G. M., Davey, M. J., Ditchfield, M. R., & Horne, R. S. C. (2023) · Journal of Sleep Research · doi:10.1111/jsr.14006 · Cited by 1
“This theory would posit that in paediatric SDB, injury or abnormal development affecting regional brain areas could be a result of intermittent hypoxia causing increased formation of reactive oxygen species and oxidative stress (Chandrakantan & Adler, 2019; Lavie, 2003).”
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“I am convinced that he changed his mind after reading her seminal paper, “Sleep apnea as an oxidative stress disease ” [83] , which is one of the 10 most-cited papers in Sleep Medicine Reviews .”
Background
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Background
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Retracted
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Giulio, C. D. (2013) · Europe PMC (PubMed Central)
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Fitscha, P., & Haoula, D. (2014) · Journal für Kardiologie (Krause & Pachernegg GmbH)
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“Among the possible sources of ROS by hypoxia are the mitochondria, leukocytes (NADPH oxidase pathway) and epithelial tissue enzymes, such as xanthine oxidase, cyclooxygenase, lipooxygenase, NO-synthase and hemeoxygenases (Lavie, 2003).”
Background
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Marín, C. F. (2012) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
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Pandey, A. K., Olafiranye, O., Adedayo, M., Zizi, F., McFarlane, S. I., & Jean‐Louis, G. (2012) · Humana Press eBooks · doi:10.1007/978-1-60327-357-2_5
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Iwama, Y. (2007) · Juntendō Igaku/Juntendo igaku · doi:10.14789/pjmj.53.278
Comorbidity of diabetes and obstructive sleep apnea in hospitalized patients
Sudhakaran, S., & Surani, S. (2015) · Hospital Practice · doi:10.1080/21548331.2015.1004295 · Cited by 1
Markers and mechanisms of metabolic aging.
Ahiawodzi, P. D. (2014) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/17
Cambios hemodinámicos cerebrales en el síndrome de apneas obstructivas del sueño tras tratamiento con presión positiva continua en la vía aérea superior
Caballero, P. E. J. (2009) · doi:10.14201/gredos.76274
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Pinto, P. (2009) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
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Gutierrez, F. P., & Ma, A. (2014) · TDX (Tesis Doctorals en Xarxa)
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Bekçi, T. T., Koçak, N., Özen, F., & Teke, T. (2010) · DergiPark (Istanbul University) · doi:10.7197/cmj.v32i1.1008000344
“The hypoxia attacks that are characteristic for the patients with OSAS cause an increase in reactive oxygen species, which lead to endothelial dysfunction by generating oxidative stress on the vascular endothelium [15, 16].”
Mécanismes et conséquences de l’hypoxie intermittente au cours du syndrome des apnées du sommeil
Meurice, J.-C. (2010) · Revue des Maladies Respiratoires Actualités · doi:10.1016/s1877-1203(10)70130-0
Pathologie respiratoire du sommeil
Lamia, B., & Meurice, J.-C. (2011) · Revue des Maladies Respiratoires Actualités · doi:10.1016/s1877-1203(11)70004-0
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Foucher, A., Pillière, R., de Roquefeuil, F., Leroy, M., Dubourg, O., & Raffestin, B. (2006) · Médecine du Sommeil · doi:10.1016/s1769-4493(06)70065-6
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Effect of continuous positive airway pressure on myocardial structure and plasma NO and ET in mini pigs with obstructive sleep apnea syndrome
Zhao, L., Li, B., Xiu, Q., Shen, J., Zhang, H., & Qiu-hong, L. I. U. (2010) · Academic Journal of Second Military Medical University · doi:10.3724/sp.j.1008.2009.00680
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Minoguchi, K. (2008) · Springer eBooks · doi:10.1007/978-4-431-76428-1_12
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Ordaz, O. P. (2011) · Archivos de Bronconeumología · doi:10.1016/j.arbr.2011.05.009
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Charles, L. E., Burchfiel, C. M., Fekedulegn, D. B., Violanti, J. M., Browne, R. W., McCanlies, E. C., & Andrew, M. E. (2008) · The Open Sleep Journal · doi:10.2174/1874620900801010015
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Background
BPCO, sindrome delle apnee ostruttive del sonno e disturbi del sonno
Vagheggini, G., Digiorgio, M., & Reitano, S. (2011) · Italian Journal of Medicine · doi:10.1016/j.itjm.2011.01.021
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Background
Management of sleep apnea syndrome as an important strategy for cardiovascular diseases
Iwama, Y., & Daida, H. (2005) · Juntendō Igaku/Juntendo igaku · doi:10.14789/pjmj.51.322
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El-Shamy, E., Eskaros, S., Dief, A. E., Nassar, S. Z., Algenady, A., & Eldin, N. H. (2012) · Egyptian Journal of Chest Diseases and Tuberculosis · doi:10.1016/j.ejcdt.2012.09.013
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Espuig, M. N. (2008) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
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Bilen, Ş., Arlı, B., Titiz, A. P., Ulusoy, E. K., Sezer, S., Öztekin, N., Özcan, M., & Ak, F. (2013) · Sleep and Biological Rhythms · doi:10.1111/sbr.12037
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BackgroundSelf-citation
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Nelson, M. (2014) · UWM Digital Commons (University of Wisconsin–Milwaukee)
Apnea ostruttiva durante il sonno: review clinica per l'internista Obstructive sleep apnea: a clinical review
Marvisi, M., Bassi, E., Zanlari, L., & Civardi, G. (2007)
UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL INSTITUTO DE BIOCIÊNCIAS CENTRO DE BIOTECNOLOGIA DO ESTADO DO RIO GRANDE DO SUL PROGRAMA DE PÓS-GRADUAÇÃO EM BIOLOGIA CELULAR E MOLECULAR ESTRESSE OXIDATIVO E HORMÔNIOS ESTEROIDES NA ASSOCIAÇÃO ENTRE DISTÚRBIOS RESPIRATÓRIOS DO SONO E DOENÇA ATEROSCLERÓTICA CORONARIANA
Hackenhaar, F. S. (2011)
nitric oxide synthase hypoxia: modulation by neuronal and endothelial Cerebrovascular inflammation after brief episodic
Altay, T., Gonzales, E. R., Park, T., Gidday, J. M., Mueller, B. R., Bale, T. L., Douglas, R. M., Haddad, G. G., & Aging, D. I. P. (2015)
Evidence for Mechanisms Linking Obstructive Sleep Apnea to Cardiovascular Disease
Shah, N. A., Redline, S. S., & Quan, S. F. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1185-1_14
INTERMITTENT VERSUS CONTINUOUS HYPOXIA: IMPACT ON HEMODYNAMIC VARIABLES AND GENE EXPRESSION
Rodway, G. W. (2005) · D-Scholarship@Pitt (University of Pittsburgh)
Estresse oxidativo e hormônios esteroides na associação entre distúrbios respiratórios do sono e doença aterosclerótica coronariana
Hackenhaar, F. S. (2011) · Americanae (AECID Library)
Étude des anomalies structurales et fonctionnelles cardiovasculaires chez 130 patients porteurs d'un syndrome d'apnées obstructives du sommeil
Nadra, M. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)
Caractère biphasique de l'hypoxie intermittente : mécanismes cardioprotecteurs induits par une exposition aiguë et conséquences inflammatoires d'une exposition chronique.
Béguin, P. C. (2006) · OpenGrey (Institut de l'Information Scientifique et Technique)
Extracellular adenosine as a novel neuroimmune modulator
Chiu, G. S. (2014) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Dietary intake, physical activity, and eating behaviour in obese patients with high cardiovascular risk : Assessments and implications for treatment
Svendsen, M. N. (2009) · NORA - Norwegian Open Research Archives
Prevalence of Metabolic Syndrome in Obstructive Sleep Apnea Syndrome
Shah, M., & Karkhanis, V. S. (2014) · Indian Journal of Sleep Medicine · doi:10.5958/0974-0155.2014.01106.1
“This pathogenesis eventually leads to the development of characteristic features of MS.(11,15,16) We found 79% prevalence of MS in patients with OSAS, which is in concordance with that reported in a similar recently conducted hospitalbased study among the Indian population by Agrawal et al.”
BackgroundResult
UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL INSTITUTO DE BIOCIÊNCIAS CENTRO DE BIOTECNOLOGIA DO ESTADO DO RIO GRANDE DO SUL PROGRAMA DE PÓS-GRADUAÇÃO EM BIOLOGIA CELULAR E MOLECULAR ASSOCIAÇÃO ENTRE DISTÚRBIOS RESPIRATÓRIOS DO SONO, ESTRESSE OXIDATIVO E DOENÇA ARTERIAL CORONARIANA.
Klein, C. (2010)
Influence of Obstructive Sleep Apnea on Soluble Intercellular Adhesion Molecule-1 and Vascular Endothelial Growth Factor
Kim, J. P., Lee, S. H., Kwon, S. S., Kim, Y. K., Kim, K. H., Song, J. S., Park, S. H., & Moon, H. S. (2004) · Tuberculosis & respiratory diseases · doi:10.4046/trd.2004.56.4.364
Cœur et obésité
Galinier, M., Pathak, A., Roncalli, J. G., & MASSABUAU, P. (2006) · EMC - Cardiologie · doi:10.1016/s1166-4568(06)41724-1
The assessment and characterisation of obstructive sleep apnoea in severe obesity
Seetho, I. W. (2015) · University of Liverpool · doi:10.17638/02017419
The state of the great arteries in type 2 diabetes mellitus patients with obstructive sleep apnea syndrome
Oleynikov, V. E., Сергацкая, Н. В., Gusakovskaya, L. I., & Анатольевна, Х. А. (2015) · Terapevticheskii arkhiv · doi:10.17116/terarkh2015871026-30
“Установлено, что СОАС ассоциирован с этиологическими механизмами развития ДЭ и атеросклероза [6, 7].”
Free Radicals and Sleep Apnea
Kanlı́kama, M., & Baysal, E. (2015) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-3-319-13473-4_23
Novel Insights into the Pathophysiology and Treatment of Obstructive Sleep Apnea
Levy, P. A. (2014) · doi:10.2217/9781780842103
Intermittent hypoxia and neurocognitive function
Gozal, D., Gozal, D., Wang, Y., & Zhang, S. X. L. (2011) · Informa Healthcare eBooks · doi:10.3109/9781420020885.015
использования CPAP-терапии на фоне медикаментозного лечения артериальной гипертензии у больных с синдромом апноэ во сне
Sviryaev, Y. V., Звартау, Н. Э., Rotar, О. P., Конради, А. О., & Kalinkin, A. L. (2008) · CyberLeninK (CyberLeninka)
Role of HIF-1α in the regulation ACE and ACE2 expression in hypoxic human
Zhang, R., Wu, Y., Zhao, M. L., Liu, C., Zhou, L., Shen, S.-M., Liao, S., Yang, K., Li, Q. Y., & Wan, H. (2009)
INSULINE RESISTANCE AND INSULINE SENSIBILITY IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA
Campisi, R. (2013)
Dieta hipercalórica e hipoxia intermitente crónica como modelos de obesidad y apnea obstructiva del sueño. Significado de la leptina en el control respiratorio
Fraile, E. O. (2016) · UVaDOC UVaDOC University of Valladolid Documentary Repository (University of Valladolid) · doi:10.35376/10324/20828
Genetics of Cardiovascular of Obstructive Sleep Apnea Syndrome
Ryan, S. J., Kent, B. D., & McNicholas, W. T. (2011)
IAH como factor de riesgo independiente de la somnolencia
Ordaz, O. P. (2011) · Archivos de Bronconeumología · doi:10.1016/j.arbres.2011.05.007
“…relación entre SAHS y patología cardiovascular, a través de la liberación de factores inﬂamatorios, procoagulantes y generación de estrés oxidativo 8–10 , y en último término rematar con la implicación del SAHS en la génesis de la arteriosclerosis como causa fundamental de la patología…”
MRI Based Quantification Of Cerebrovascular Health In Pediatric Subjects With Sickle Cell Disease
Kim, J. (2015) · TSpace (University of Toronto)
Associação entre distúrbios respiratórios do sono, estresse oxidativo e doença arterial coronariana
Klein, C. (2010) · Americanae (AECID Library)
"A importância do diagnóstico do síndrome de apneia obstrutiva do sono na prevenção das doenças cardiovasculares"
Pipa, J. (2011) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/gqcy-fq73

Authors: Lavie, L.
Affiliations: Technion – Israel Institute of Technology (IL)
Corresponding author: Lavie, Lena
Venue: Sleep Medicine Reviews
Publisher: Elsevier BV
Published: 2003-02
Volume: 7
Issue: 1
Pages: 35-51
ISSN: 1087-0792 (ISSN-L)
DOI: 10.1053/smrv.2002.0261
OpenAlex: W1988114644
Cited by: 993
References: 134
Citations by year: 2026: 17 · 2025: 44 · 2024: 28 · 2023: 30 · 2022: 33 · 2021: 43 · 2020: 42 · 2019: 31 · 2018: 38 · 2017: 37 · 2016: 44 · 2015: 51 · 2014: 58 · 2013: 48 · 2012: 51
FWCI: 4.50
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Sleep Medicine Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Health, State of Israel
Topics: Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: obstructive sleep apnea, oxidative stress, hypoxia/reoxygenation injury, reactive oxygen species, lipoprotein oxidation, adhesion molecules, adenosine, uric acid, HIF-1, NF-κB, AP-1, endothelial dysfunction, monocyte adhesion, nitric oxide bioavailability, atherosclerosis, cardiovascular risk
MeSH terms: Cardiovascular Diseases, Free Radicals, Humans, Leukocytes, Lymphokines, Nitric Oxide, Lipid Peroxidation, Endothelial Growth Factors, Oxidative Stress, Hyperhomocysteinemia, Sleep Apnea, Obstructive, Intercellular Signaling Peptides and Proteins, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A

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Obstructive sleep apnoea syndrome – an oxidative stress disorder

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