Electrical stimulation of the suprachiasmatic nucleus of the hypothalamus causes hyperglycemia
Abstract
We have presented evidence suggesting that the suprachiasmatic nucleus (SCN) is involved in central regulation of glucose homeostasis. To elucidate this role of the SCN, we examined the effects of its electrical stimulation on glucose metabolism in male Wistar rats. During and shortly after this stimulation, we observed hyperglycemia associated with enhanced hyperglucagonemia but no immediate hyperinsulinemia. In addition, we detected significant increase in liver glycogen phosphorylase alpha activity and significant decrease in the liver glycogen content. These findings suggest that the SCN is important in control of glucose homeostasis through effects on glucagon and insulin secretions and liver glycogen metabolism.
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Electrical stimulation of the SCN results in hyperglycaemia, an effect that can be prevented by blocking ANS activity with α and β-adrenergic blockers.
“They showed that electrical stimulation of the SCN resulted in hyperglycaemia, an effect that could be prevented by blocking ANS activity by means of (i.p.) administration of α and β-adrenergic blockers [64,65].”
From Circadian control of glucose metabolism (2014) · cites this paper as [65]
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- Authors
- Nagai, K., Fujii, T., Inoue, S., Takamura, Y., & Nakagawa, H.
- Affiliations
- Institute for Protein Research, The University of Osaka (JP)
- Yokohama City University (JP)
- ORCID
- Nagai, K.
- Venue
- Hormone and Metabolic Research
- Publisher
- Georg Thieme Verlag KG
- Published
- 1988-01
- Volume
- 20
- Issue
- 01
- Pages
- 37-39
- ISSN
- 0018-5043 (ISSN-L)
- 1439-4286
- OpenAlex
- W2094080002
- Cited by
- 59
- References
- 0
- Citations by year
- 2021: 1 · 2019: 1 · 2018: 1 · 2016: 2 · 2015: 1 · 2014: 3 · 2012: 1
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormone and Metabolic Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- suprachiasmatic nucleus, electrical stimulation, hyperglycemia, glucose homeostasis, glucagon secretion, insulin secretion, liver glycogen
- MeSH terms
- Animals, Electric Stimulation, Electrodes, Glucose, Glycogen, Phosphorylases, Homeostasis, Hyperglycemia, Insulin, Liver, Male, Rats, Inbred Strains, Suprachiasmatic Nucleus, Rats
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