Cited by 59Circadian rhythm and melatoninPancreatic function and diabetesRegulation of Appetite and Obesity

Electrical stimulation of the suprachiasmatic nucleus of the hypothalamus causes hyperglycemia

Nagai, K., Fujii, T., Inoue, S., Takamura, Y., Nakagawa, H.·1988·Hormone and Metabolic Research

Abstract

We have presented evidence suggesting that the suprachiasmatic nucleus (SCN) is involved in central regulation of glucose homeostasis. To elucidate this role of the SCN, we examined the effects of its electrical stimulation on glucose metabolism in male Wistar rats. During and shortly after this stimulation, we observed hyperglycemia associated with enhanced hyperglucagonemia but no immediate hyperinsulinemia. In addition, we detected significant increase in liver glycogen phosphorylase alpha activity and significant decrease in the liver glycogen content. These findings suggest that the SCN is important in control of glucose homeostasis through effects on glucagon and insulin secretions and liver glycogen metabolism.

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Crossref · 10.1055/s-2007-1010743

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  • Electrical stimulation of the SCN results in hyperglycaemia, an effect that can be prevented by blocking ANS activity with α and β-adrenergic blockers.

    “They showed that electrical stimulation of the SCN resulted in hyperglycaemia, an effect that could be prevented by blocking ANS activity by means of (i.p.) administration of α and β-adrenergic blockers [64,65].”

    From Circadian control of glucose metabolism (2014) · cites this paper as [65]

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Authors
Nagai, K., Fujii, T., Inoue, S., Takamura, Y., & Nakagawa, H.
Affiliations
  • Institute for Protein Research, The University of Osaka (JP)
  • Yokohama City University (JP)
Venue
Hormone and Metabolic Research
Published
1988-01
Volume
20
Issue
01
Pages
37-39
ISSN
  • 0018-5043 (ISSN-L)
  • 1439-4286
OpenAlex
W2094080002
Cited by
59
References
0
Citations by year
2021: 1 · 2019: 1 · 2018: 1 · 2016: 2 · 2015: 1 · 2014: 3 · 2012: 1
FWCI
2.26
Type
journal article
Language
en
Open access
closed
Locations
  • Hormone and Metabolic Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
suprachiasmatic nucleus, electrical stimulation, hyperglycemia, glucose homeostasis, glucagon secretion, insulin secretion, liver glycogen
MeSH terms
Animals, Electric Stimulation, Electrodes, Glucose, Glycogen, Phosphorylases, Homeostasis, Hyperglycemia, Insulin, Liver, Male, Rats, Inbred Strains, Suprachiasmatic Nucleus, Rats

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