Epigenetic control and the circadian clock: Linking metabolism to neuronal responses
Open accessAbstract
Experimental and epidemiological evidence reveal the profound influence that industrialized modern society has imposed on human social habits and physiology during the past 50 years. This drastic change in life-style is thought to be one of the main causes of modern diseases including obesity, type 2 diabetes, mental illness such as depression, sleep disorders, and certain types of cancer. These disorders have been associated to disruption of the circadian clock, an intrinsic time-keeper molecular system present in virtually all cells and tissues. The circadian clock is a key element in homeostatic regulation by controlling a large array of genes implicated in cellular metabolism. Importantly, intimate links between epigenetic regulation and the circadian clock exist and are likely to prominently contribute to the plasticity of the response to the environment. In this review, we summarize some experimental and epidemiological evidence showing how environmental factors such as stress, drugs of abuse and changes in circadian habits, interact through different brain areas to modulate the endogenous clock. Furthermore we point out the pivotal role of the deacetylase silent mating-type information regulation 2 homolog 1 (SIRT1) as a molecular effector of the environment in shaping the circadian epigenetic landscape.
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The circadian system is the major regulator of almost every aspect of human health and metabolism.
“The circadian system is the major regulator of almost every aspect of human health and metabolism.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [4]
Light is the main cue influencing the SCN master circadian clock, turning on or off genes that control the individual's internal clock function.
“Light is the main cue influencing the SCN master circadian clock, turning on or off genes that control the individual's internal clock function.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [4]
The master clock regulates the body's metabolism through controlling body functions and synchronizing peripheral clocks in almost all cells, including heart, liver, muscle and adipose tissue.
“This master clock regulates the body's metabolism through controlling body functions, and synchronizing peripheral clocks in almost all cells in the body, including the body's key tissues such as the heart, liver, muscle and adipose tissue 3, 4, 5, 6.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [4]
Temperature change and nutritional intake mainly affect peripheral clocks.
“Other environmental factors include temperature change and nutritional intake, which mainly affect peripheral clocks 4, 7.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [4]
Recent developments in epigenetics may provide the basis for a better understanding of the pathophysiological mechanisms underlying the Metabolic Syndrome.
“Recent developments in epigenetics may also provide the basis for a better understanding of the pathophysiological mechanisms underlying what to date we have called the Metabolic Syndrome 4, 47.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [4]
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- Authors
- Orozco-Solis, R., & Sassone-Corsi, P.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 264
- Pages
- 76-87
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC6501790
- OpenAlex
- W2041979789
- Cited by
- 94
- References
- 134
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 11 · 2023: 9 · 2022: 5 · 2021: 4 · 2020: 8 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 12 · 2015: 12 · 2014: 9
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Drug Abuse (R21DA035600)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- circadian clock, epigenetic regulation, SIRT1, circadian metabolism, environmental stress, drugs of abuse, obesity, type 2 diabetes, depression, sleep disorders, cancer, neuroplasticity, homeostatic regulation
- MeSH terms
- Animals, Brain, Humans, Male, Stress, Psychological, Epigenesis, Genetic, Sirtuin 1, Circadian Clocks
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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