Adolescent Substance Use Disorders
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Adolescent Substance Use DisordersSubstance use disorders contribute to the leading causes of death among adolescents, including homicide and suicide. Here, Simon et al. review the most recent published data on adolescent substance use disorders and the implications for clinical practice.
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One randomized controlled trial from that meta-analysis showed that cocaine craving decreased more rapidly in the treatment group compared with placebo.
“one RCT from that meta-analysis showed that cocaine craving decreased more rapidly in the treatment group compared to placebo.137”
From The ASAM/AAAP Clinical Practice Guideline on the Management of Stimulant Use Disorder (2024) · cites this paper as [137]
The Evidence for Pharmacotherapy section discusses treatments for adolescent opioid, tobacco, cannabis, and alcohol use disorders, but does not report a cocaine-craving result. Searches for the claimed randomized trial, meta-analysis, and faster reduction in cocaine craving versus placebo found no passage addressing that comparison in our copy. (LLM, conf=0.76)
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- Authors
- Simon, K. M., Levy, S. J., & Bukstein, O. G.
- Affiliations
- Boston Children's Hospital (US)
- Venue
- NEJM Evidence
- Publisher
- Massachusetts Medical Society
- Published
- 2022-05-24
- Volume
- 1
- Issue
- 6
- Pages
- EVIDra2200051-EVIDra2200051
- ISSN
- 2766-5526 (ISSN-L)
- PMC
- PMC11003516
- OpenAlex
- W4294977169
- Cited by
- 43
- References
- 61
- Citations by year
- 2026: 27 · 2025: 10 · 2024: 6
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NEJM Evidence (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (K12DA000357)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Keywords
- adolescent substance use disorders, adolescent mortality, suicide, homicide, clinical practice implications
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