The influence of substance use on adolescent brain development
Open accessAbstract
Adolescence is a unique period in neurodevelopment. Alcohol and marijuana use are common. Recent research has indicated that adolescent substance users show abnormalities on measures of brain functioning, which is linked to changes in neurocognition over time. Abnormalities have been seen in brain structure volume, white matter quality, and activation to cognitive tasks, even in youth with as little as 1–2 years of heavy drinking and consumption levels of 20 drinks per month, especially if >4–5 drinks are consumed on a single occasion. Heavy marijuana users show some subtle anomalies too, but generally not the same degree of divergence from demographically similar non-using adolescents. This article reviews the extant literature on neurocognition, brain structure, and brain function in adolescent substance users with an emphasis on the most commonly used substances, and in the context of ongoing neuromaturational processes. Methodological and treatment implications are provided.
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Substance use during adolescence can induce changes in PFC activity and PFC projections to subcortical regions that persist in adulthood.
“Substance use during adolescence can induce changes in PFC activity and PFC projections to subcortical regions that persist in adulthood (Squeglia et al., 2009).”
From Sensitive periods of substance abuse: Early risk for the transition to dependence (2017) · cites this paper as Squeglia et al., 2009
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Research works printed but not linked: 2
- [55]Schweinsburg A McQueeny T Brown S Tapert S Adolescent binge drinkers show altered fMRI response during verbal encoding 2008 Paper presented at: Presented at the second International Conference on Applications of Neuroimaging to Alcoholism New Haven, CT
- [56]McQueeny T Schweinsburg AD Tapert SF Response inhibition in adolescent binge drinkers: An FMRI study 2008 Paper presented at: Presented at the second International Conference on Applications of Neuroimaging to Alcoholism New Haven, CT
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- Authors
- Squeglia, L. M., Jacobus, J., & Tapert, S. F.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Tapert, S.F.
- Venue
- Clinical EEG and Neuroscience
- Publisher
- SAGE Publications
- Published
- 2009-01
- Volume
- 40
- Issue
- 1
- Pages
- 31-38
- ISSN
- 1550-0594 (ISSN-L)
- 2169-5202
- PMC
- PMC2827693
- OpenAlex
- W2033602780
- Cited by
- 542
- References
- 76
- Citations by year
- 2026: 24 · 2025: 34 · 2024: 33 · 2023: 32 · 2022: 32 · 2021: 33 · 2020: 33 · 2019: 37 · 2018: 41 · 2017: 43 · 2016: 46 · 2015: 37 · 2014: 27 · 2013: 35 · 2012: 28
- FWCI
- 12.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical EEG and Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01 AA13419, R01AA013419, F31AA018940)
- National Institute on Drug Abuse (R01 DA02118, R01DA021182)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- adolescent substance use, adolescent brain development, alcohol consumption, cannabis use, neurocognitive function, brain structure, white matter, brain activation, neuromaturation, heavy drinking
- MeSH terms
- Adolescent, Alcoholism, Brain, Marijuana Abuse, Cognition, Cues, Humans, Inhibition, Psychological, Language, Memory, Organ Size, Recurrence, Research Design, Spatial Behavior, Substance-Related Disorders, Adolescent Development
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