Cited by 1,101Smoking Behavior and CessationBlood Pressure and Hypertension StudiesReceptor Mechanisms and Signaling

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Norepinephrine and Epinephrine Release and Adrenergic Mediation of Smoking-Associated Hemodynamic and Metabolic Events

Cryer, Philip E., Haymond, Morey W., Santiago, Julio V., Shah, Suresh D.·1976·New England Journal of Medicine

DOI 10.1056/nejm197609092951101

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Abstract

We studied the effects of cigarette smoking, sham smoking and smoking during adrenergic blockade in 10 subjects to determine whether smoking released the sympathetic neurotransmitter norepinephrine, as well as the adrenomedullary hormone epinephrine, and whether smoking-associated hemodynamic and metabolic changes were mediated through adrenergic mechanisms. Smoking-associated increments in mean (+/- S.E.M.) plasma norepinephrine (227 +/- 23 to 324 +/- 39 pg per milliliter, P less than 0.01) and epinephrine (44 +/- to 113 +/- 27 pg per milliliter, P less than 0.05) were demonstrated. Smoking-associated increments in pulse rate, blood pressure, blood glycerol and blood lactate/pyruvate ratio were prevented by adrenergic blockade; increments in plasma growth hormone and cortisol were not. Since significant smoking-associated increments, in pulse rate, blood pressure and blood lactate/pyruvate ratio, preceded measurable increments in plasma catecholamine concentrations, but were adrenergically mediated, these changes should be attributed to norepinephrine released locally from adrenergic axon terminals within the tissues rather than to increments in circulating catecholamines.

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Effect of Ischemia on Known Substrates and Cofactors of the Glycolytic Pathway in Brain
Lowry, O. H., Passonneau, J. V., Hasselberger, F. X., & Schulz, D. W. (1964) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51740-3 · Cited by 2,222
Immunoassay of Insulin: Two Antibody System: Plasma Insulin Levels of Normal, Subdiabetic and Diabetic Rats
Morgan, C. R., & Lazarow, A. (1963) · Diabetes · doi:10.2337/diab.12.2.115 · Cited by 2,197
Hormone-fuel interrelationships during fasting.
Cahill, G. F., Herrera, M. G., Morgan, A. P., Soeldner, J. S., Steinke, J., Levy, P. L., Reichard, G. A., & Kipnis, D. M. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105481 · Cited by 1,036
A simplified radiometric assay for plasma norepinephrine and epinephrine
Passon, P. G., & Peuler, J. D. (1973) · Analytical Biochemistry · doi:10.1016/0003-2697(73)90517-4 · Cited by 637
A Sensitive Double Antibody Immunoassay for Human Growth Hormone in Plasma
Schalch, P., & PARKER, M. L. (1964) · Nature · doi:10.1038/2031141a0 · Cited by 635
DEATH AND CORONARY ATTACKS IN MEN AFTER GIVING UP CIGARETTE SMOKING
Gordon, T., Kannel, W., McGee, D., & Dawber, T. (1974) · The Lancet · doi:10.1016/s0140-6736(74)92214-4 · Cited by 307
SMOKING AND MYOCARDIAL INFARCTION
Wilhelmsson, C., Elmfeldt, D., Vedin, J. A., Tibblin, G., & Wilhelmsen, L. (1975) · The Lancet · doi:10.1016/s0140-6736(75)91488-9 · Cited by 276
Smoking and Myocardial Infarction
FRANK, M. J. (1977) · Annals of Internal Medicine · doi:10.7326/0003-4819-86-4-509_1 · Cited by 274
Enzymic assay of glycerol, dihydroxyacetone, and glyceraldehyde
Pinter, J. K., Hayashi, J. A., & Watson, J. A. (1967) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(67)90094-x · Cited by 190
Measurement of Norepinephrine and Epinephrine in Small Volumes of Human Plasma by a Single Isotope Derivative Method: Response to the Upright Posture
CRYER, P. E., SANTIAGO, J. V., & SHAH, S. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-39-6-1025 · Cited by 155
Self-citation

Show all 29 references

Research works printed but not linked: 3

Raab, 1943, Exp Med Surg, 1, 402
Karl, 1972, J Lab Clin Med, 80, 434
Snedecor GW: Statistical Methods. Fifth edition. Ames, Iowa, Iowa State College Press, 1956

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“In addition, smoking increases heart rate and blood pressure by stimulating sympathetic nerves [14], in addition to coagulation factors and platelet function [15].”
Background
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DiFrancisco‐Donoghue, J., Jung, M., & Leder, A. N. (2017) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntx263 · Cited by 7
Current Smoking: An Independent Predictor of Elevated A1C in Persons With Type 2 Diabetes
DiNardo, M. M., Sereika, S. M., Korytkowski, M. T., Baniak, L. M., Weinzierl, V., Hoenstine, A. L., & Chasens, E. R. (2019) · The Science of Diabetes Self-Management and Care · doi:10.1177/0145721719829068 · Cited by 7
“A temporary increase of blood glucose occurring within 30 minutes of cigarette smoking was reported in persons with and without diabetes,(10) but other research reported no effect.(11,12) There has been little further experimental inquiry in this area for almost 40 years.”
Influence of smoking and other cardiovascular risk factors on heart rate circadian rhythm in normotensive and hypertensive subjects
Accardo, A., Silveri, G., Ajčević, M., Miladinović, A., & Pascazio, L. (2021) · PLoS ONE · doi:10.1371/journal.pone.0257660 · Cited by 7
“In healthy subjects, the smoking, inducing an acute rise in heart rate in smokers over 15 min after smoking one cigarette [24], is one of the major risk factor for cardiovascular morbidity and mortality.”
Background
Changes in Choroidal Blood Flow by Diurnal Variation in Healthy Young Adults
Hashimoto, Y., Ishimaru, Y., Chiyozono, M., Imabayashi, S., Umemoto, R., Yamanokuchi, T., & Yoshitomi, T. (2023) · The Open Ophthalmology Journal · doi:10.2174/18743641-v17-e230214-2022-53 · Cited by 7
Family history of hypertension and its relation to other variables in hypertensive patients: a cross-sectional study from a tertiary care hospital
Kanchan, K. C., Katwal, S., Yadav, G. K., Adhikari, A., Thapa, R. K., Jha, S. K., Sharma, A., Rijal, T., Giri, S., & Khadka, S. (2023) · International Journal of Surgery Global Health · doi:10.1097/gh9.0000000000000235 · Cited by 7
“Smoking temporarily raises blood pressure due to an increase in sympathetic outflow mediated by nicotine, but the long-term impact on blood pressure is debatable([28]).”
Background
Documento de consenso sobre tabaquismo y riesgo vascular
Alemán, J. A., Sabarís, R. C., Pardo, D. E., Donaire, J. A. G., Romanos, F. G., Iturralde-Iriso, J., Penagos, L. M., Iglesias, L. J. N., de Salinas, A. P. M., Robles, N. R., et al. (2024) · Hipertensión y Riesgo Vascular · doi:10.1016/s1889-1837(24)00075-8 · Cited by 9
Methodology of Studying the Catecholamine Response to Stress
Ward, M. M., & Mefford, I. N. (1985) · Springer eBooks · doi:10.1007/978-3-642-70655-4_13 · Cited by 7
In vitro effect of nicotine on red blood cell deformability in untreated and treated essential hypertension
Salbaş, K., Gürlek, A., & Akyol, T. (1994) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365519409087547 · Cited by 7
Lifestyle diseases and cardiovascular risk factors are interrelated to deficiencies of major substrates in ATP synthesis
Lervang, H.-H., & Ditzel, J. (2010) · Vascular Health and Risk Management · doi:10.2147/vhrm.s13368 · Cited by 7
“Smoking also releases the sympathetic neurotransmitter norepinephrine and the adrenomedullary hormone epinephrine and may thereby increase tissue oxygen demand.(38) The oxygen availability or demand ratio will, therefore, decrease and the oxygen deficit may participate in adverse changes in the cardiovascular system.”
The effect of cigarette smoking on blood sugar, serum insulin and non esterified fatty acids in diabetic and non diabetic subjects
Walsh, C. H., Wright, A. D., Allbutt, E., et al. (1977) · Diabetologia · doi:10.1007/bf01234502 · Cited by 7
“Indeed, the few studies which have been carried out are contradictory and incomplete [2, 3, 4, 5, 6].”
Background
Effects of potentially modifiable risk factors on the health of adults in the Eastern Province of KSA
Al-Hariri, M. T., Elkilany, A. M., & Alkahtani, S. A. (2017) · Journal of Taibah University Medical Sciences · doi:10.1016/j.jtumed.2017.08.002 · Cited by 7
Cardiovascular Diseases
Peek, S. F. (2008) · Elsevier eBooks · doi:10.1016/b978-141603137-6.50006-5 · Cited by 7
Habitual cigarette smoking raises pressor responses to spontaneous bursts of muscle sympathetic nerve activity
Cui, J. G., Drew, R. C., Muller, M. D., Blaha, C., Gonzalez, V., & Sinoway, L. I. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00293.2018 · Cited by 7
“Another prior study (3) showed that smoking raises BP via -adrenergic receptor-mediated vasoconstriction.”
Background
Smoking and Atherosclerotic Cardiovascular Disease: Part III: Functional Biomarkers Influenced by Smoking
Unverdorben, M., von Holt, K., & Winkelmann, B. R. (2009) · Biomarkers in Medicine · doi:10.2217/bmm.09.69 · Cited by 8
80-year-old men have elevated plasma concentrations of catecholamines but decreased plasma renin activity and aldosterone as compared to young men
Hallengren, B., Elmståhl, S., Galvard, H., Jerntorp, P., Manhem, P., Pessah-Rasmussen, H., & Stavenow, L. (1992) · Aging Clinical and Experimental Research · doi:10.1007/bf03324116 · Cited by 7
Effects of chronic smoke exposure on the cardiovascular responses to acute nicotine infusion in the rat
Barron, K. W., Heesch, C. M., Fleming, B. P., et al. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90298-1 · Cited by 7
Consommation de tabac et risque cardiovasculaire
Veyssier-Belot, C. (1997) · La Revue de Médecine Interne · doi:10.1016/s0248-8663(97)83749-6 · Cited by 7
Epinephrine and the genesis of hypertension.
Frankl, O. (1992) · Hypertension · doi:10.1161/01.hyp.20.4.583 · Cited by 7
Cigarette Smoke, LDL and Cholesteryl Ester Accumulation in Macrophages Implications for Atherosclerosisa
Kita, T., Yokode, M., Arai, H., et al. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb39159.x · Cited by 7
Cigarette smoking: Acute main and small vessel hemodynamic responses in patients with arterial disease
Lusby, R. J., Bauminger, B. B., Woodcock, J. P., Skidmore, R., & Baird, R. N. (1981) · The American Journal of Surgery · doi:10.1016/0002-9610(81)90269-5 · Cited by 7
Insulin Resistance in Smokers and Other Long-Term Users of Nicotine
Eliasson, B., & Smith, U. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-716-1_7 · Cited by 6
Smoking attenuates the vasoconstrictor response to noradrenaline in type I diabetic patients and normal subjects: possible relevance to diabetic nephropathy
Bodmer, C. W., VALENTINE, D. T., Masson, E. A., SAVAGE, M. W., LAKE, D., & Williams, G. (1994) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1994.tb01093.x · Cited by 7

Authors: Cryer, P. E., Haymond, M. W., Santiago, J. V., & Shah, S. D.
Affiliations: Washington University in St. Louis (US)
ORCID: Haymond, Morey W.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1976-09-09
Volume: 295
Issue: 11
Pages: 573-577
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm197609092951101
OpenAlex: W2341712066
Semantic Scholar: 61a71636dc3f81cda5208adbb0e928b8f3d3f442
Cited by: 1,101
References: 29
Citations by year: 2026: 6 · 2025: 6 · 2024: 10 · 2023: 14 · 2022: 18 · 2021: 19 · 2020: 22 · 2019: 20 · 2018: 14 · 2017: 22 · 2016: 24 · 2015: 13 · 2014: 23 · 2013: 15 · 2012: 19
FWCI: 19.23
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: cigarette smoking, norepinephrine, epinephrine, sympathetic nervous system, adrenergic blockade, plasma catecholamines, hemodynamic response, blood pressure, pulse rate, blood lactate, growth hormone, cortisol, adrenergic neurotransmission
MeSH terms: Adult, Blood Pressure, Epinephrine, Glycerol, Hemodynamics, Humans, Hydrocortisone, Lactates, Male, Norepinephrine, Phentolamine, Propranolol, Pulse, Pyruvates, Smoking, Growth Hormone, Sympathetic Nervous System, Sympatholytics

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Norepinephrine and Epinephrine Release and Adrenergic Mediation of Smoking-Associated Hemodynamic and Metabolic Events

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