Cited by 1,101Smoking Behavior and CessationBlood Pressure and Hypertension StudiesReceptor Mechanisms and Signaling

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Norepinephrine and Epinephrine Release and Adrenergic Mediation of Smoking-Associated Hemodynamic and Metabolic Events

Cryer, Philip E., Haymond, Morey W., Santiago, Julio V., Shah, Suresh D.·1976·New England Journal of Medicine

DOI 10.1056/nejm197609092951101

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Abstract

We studied the effects of cigarette smoking, sham smoking and smoking during adrenergic blockade in 10 subjects to determine whether smoking released the sympathetic neurotransmitter norepinephrine, as well as the adrenomedullary hormone epinephrine, and whether smoking-associated hemodynamic and metabolic changes were mediated through adrenergic mechanisms. Smoking-associated increments in mean (+/- S.E.M.) plasma norepinephrine (227 +/- 23 to 324 +/- 39 pg per milliliter, P less than 0.01) and epinephrine (44 +/- to 113 +/- 27 pg per milliliter, P less than 0.05) were demonstrated. Smoking-associated increments in pulse rate, blood pressure, blood glycerol and blood lactate/pyruvate ratio were prevented by adrenergic blockade; increments in plasma growth hormone and cortisol were not. Since significant smoking-associated increments, in pulse rate, blood pressure and blood lactate/pyruvate ratio, preceded measurable increments in plasma catecholamine concentrations, but were adrenergically mediated, these changes should be attributed to norepinephrine released locally from adrenergic axon terminals within the tissues rather than to increments in circulating catecholamines.

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Effect of Ischemia on Known Substrates and Cofactors of the Glycolytic Pathway in Brain
Lowry, O. H., Passonneau, J. V., Hasselberger, F. X., & Schulz, D. W. (1964) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51740-3 · Cited by 2,222
Immunoassay of Insulin: Two Antibody System: Plasma Insulin Levels of Normal, Subdiabetic and Diabetic Rats
Morgan, C. R., & Lazarow, A. (1963) · Diabetes · doi:10.2337/diab.12.2.115 · Cited by 2,197
Hormone-fuel interrelationships during fasting.
Cahill, G. F., Herrera, M. G., Morgan, A. P., Soeldner, J. S., Steinke, J., Levy, P. L., Reichard, G. A., & Kipnis, D. M. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105481 · Cited by 1,036
A simplified radiometric assay for plasma norepinephrine and epinephrine
Passon, P. G., & Peuler, J. D. (1973) · Analytical Biochemistry · doi:10.1016/0003-2697(73)90517-4 · Cited by 637
A Sensitive Double Antibody Immunoassay for Human Growth Hormone in Plasma
Schalch, P., & PARKER, M. L. (1964) · Nature · doi:10.1038/2031141a0 · Cited by 635
DEATH AND CORONARY ATTACKS IN MEN AFTER GIVING UP CIGARETTE SMOKING
Gordon, T., Kannel, W., McGee, D., & Dawber, T. (1974) · The Lancet · doi:10.1016/s0140-6736(74)92214-4 · Cited by 307
SMOKING AND MYOCARDIAL INFARCTION
Wilhelmsson, C., Elmfeldt, D., Vedin, J. A., Tibblin, G., & Wilhelmsen, L. (1975) · The Lancet · doi:10.1016/s0140-6736(75)91488-9 · Cited by 276
Smoking and Myocardial Infarction
FRANK, M. J. (1977) · Annals of Internal Medicine · doi:10.7326/0003-4819-86-4-509_1 · Cited by 274
Enzymic assay of glycerol, dihydroxyacetone, and glyceraldehyde
Pinter, J. K., Hayashi, J. A., & Watson, J. A. (1967) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(67)90094-x · Cited by 190
Measurement of Norepinephrine and Epinephrine in Small Volumes of Human Plasma by a Single Isotope Derivative Method: Response to the Upright Posture
CRYER, P. E., SANTIAGO, J. V., & SHAH, S. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-39-6-1025 · Cited by 155
Self-citation

Show all 29 references

Research works printed but not linked: 3

Raab, 1943, Exp Med Surg, 1, 402
Karl, 1972, J Lab Clin Med, 80, 434
Snedecor GW: Statistical Methods. Fifth edition. Ames, Iowa, Iowa State College Press, 1956

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Zvolensky, M. J., Schmidt, N. B., & McCreary, B. T. (2002) · Journal of Anxiety Disorders · doi:10.1016/s0887-6185(02)00222-0 · Cited by 92
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“[42] Cryer PE, Haymond MW, Santiago JV, et al.”
Background
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Walker, J. F., Collins, L. C., Rowell, P., Goldsmith, L. J., Moffatt, R. J., & STAMFORD, B. A. (1999) · Nicotine & Tobacco Research · doi:10.1080/14622299050011501 · Cited by 84
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Hunter, K. A., Garlick, P. J., BROOM, I., Anderson, S. E., & McNurlan, M. A. (2001) · Clinical Science · doi:10.1042/cs1000459 · Cited by 85
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Yu, P. H., Lai, C., & Zuo, D.-M. (1997) · Neurochemical Research · doi:10.1023/a:1022478221421 · Cited by 85
“It is cytotoxic and has been considered to be potentially carcinogenic and is a subject of major environmental concern (19,29).”
Background
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Wager-Srdar, S. A., Levine, A. S., Morley, J. E., Hoidal, J. R., & Niewoehner, D. E. (1984) · Physiology & Behavior · doi:10.1016/0031-9384(84)90252-x · Cited by 83
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Background
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Yu, P. H. (1998) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6499-0_19 · Cited by 83
Galactose cataract prevention with sorbinil, an aldose reductase inhibitor: a light microscopic study.
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Amir, L. H. (2001) · Early Human Development · doi:10.1016/s0378-3782(01)00170-0 · Cited by 82
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Background
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Dochi, M., Sakata, K., Oishi, M., Tanaka, K., Kobayashi, E., & Suwazono, Y. (2009) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.217.37 · Cited by 81
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Background
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Background
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“and long term cardiac damage caused by stimulation of catecholamine by lifelong smoking.”
Background
Nicotine, resorption and fate
Schievelbein, H. (1982) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(82)90068-7 · Cited by 78
Catecholamine-mediated reduction in uterine blood flow after nicotine infusion in the pregnant ewe.
Resnik, R. R., Brink, G. W., & Wilkes, M. M. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109406 · Cited by 79
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Baer, L., & Radichevich, I. (1985) · The American Journal of Medicine · doi:10.1016/0002-9343(85)90396-1 · Cited by 78
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Forrest, C. R., Pang, C. Y., & Lindsay, W. K. (1987) · British Journal of Plastic Surgery · doi:10.1016/0007-1226(87)90126-3 · Cited by 78
Epinephrine sensitivity with respect to metabolic rate and other variables in women
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Cardiac function in smokers and nonsmokers: The CARDIA study
Gidding, S. S., Xie, X., Liu, K., Manolio, T. A., Flack, J. M., & Gardin, J. M. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00118-j · Cited by 77
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Background
Effects of Smoking Marihuana on Left Ventricular Performance and Plasma Norepinephrine
Gash, A. K., KARLINER, J. S., JANOWSKY, D., et al. (1978) · Annals of Internal Medicine · doi:10.7326/0003-4819-89-4-448 · Cited by 77
Effect of breathing 100% oxygen on retinal and optic nerve head capillary blood flow in smokers and non-smokers
Langhans, M. J., Michelson, G., & Groh, M. J. M. (1997) · British Journal of Ophthalmology · doi:10.1136/bjo.81.5.365 · Cited by 77
Acute influence of smoking on platelet behaviour, endothelium and plasma lipids and normalization by aspirin
Blache, D., Bouthillier, D., & Davignon, J. (1992) · Atherosclerosis · doi:10.1016/0021-9150(92)90254-e · Cited by 77
Sodium intake alters the effects of norepinephrine on blood pressure.
Rankin, L. I., Luft, F. C., Henry, D. P., Gibbs, P. S., & Weinberger, M. H. (1981) · Hypertension · doi:10.1161/01.hyp.3.6.650 · Cited by 77
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Adamopoulos, D. N., van de Borne, P., & Argacha, J. (2008) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2008.04896.x · Cited by 77
Effects of nicotine on finger tapping rate in non-smokers
West, R., & Jarvis, M. J. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90377-1 · Cited by 76
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Tse, T. F., Clutter, W. E., Shah, S. D., & Cryer, P. E. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110967 · Cited by 73
Self-citation
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Okubo, Y., Miyamoto, T., Suwazono, Y., et al. (2002) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001303 · Cited by 74
Epinephrine and norepinephrine are cleared through beta-adrenergic, but not alpha-adrenergic, mechanisms in man
Cryer, P. E., Rizza, R. A., Haymond, M. W., & Gerich, J. E. (1980) · Metabolism · doi:10.1016/0026-0495(80)90019-0 · Cited by 115
Self-citation
Cortisol levels decrease after acute tobacco abstinence in regular smokers
Wong, J. A., Pickworth, W. B., Waters, A. J., Al’Absi, M., & Leventhal, A. M. (2014) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2382 · Cited by 78
“…1983; Kirschbaum et al., 1992; Mendelson et al., 2005), with evidence of a nicotine dose-related increase in cortisol—a key hormone involved in the HPA axis— acutely following nicotine administration (Cryer et al., 1976, Winternitz and Quillen, 1977; Seyler et al., 1984; Mendelson et al., 2005).”
BackgroundInfluential
Parametric Mediational g-Formula Approach to Mediation Analysis with Time-varying Exposures, Mediators, and Confounders
Lin, S., Young, J. G., Logan, R. W., Tchetgen, E. J. T., & VanderWeele, T. J. (2016) · Epidemiology · doi:10.1097/ede.0000000000000609 · Cited by 77
Cardiac Arrhythmias Following Intravenous Nicotine: Experimental Study in Dogs
Mehta, M. C., Jain, A. C., Mehta, A., & Billie, M. (1997) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/107424849700200407 · Cited by 73
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Background
An association between smoking habits and blood pressure in normotensive Japanese men: a 5-year follow-up study
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“Smoking has been shown to raise blood pressure (BP) by vasoconstriction and accelerated heart rate as an acute effect (Aronow et al., 1971; Cryer et al., 1976; Benowitz et al., 1982; Benowitz et al., 1984; De Cesaris et al., 1992), while the chronic effect of addictive smoking has not been elucidated in epidemiologica…”
Background
Cigarette smoking may reduce plasma leptin concentration via catecholamines
Reseland, J. E., Mundal, H. H., Hollung, K., Haugen, F., Naeem, Z., Anderssen, S. A., & Drevon, C. A. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.04.006 · Cited by 72
Does Smoking Affect Blood Pressure and Heart Rate?
Al-Safi, S. A. (2005) · European Journal of Cardiovascular Nursing · doi:10.1016/j.ejcnurse.2005.03.004 · Cited by 71
“Thus, nicotine of cigarettes acts as an adrenergic agonist, enhances local and systemic catecholamine release, and it may also stimulate vasopressin release [7].”
Background
Family History of Hypertension and Blood Pressure in a Screened Cohort.
Tozawa, M., Oshiro, S., Iseki, C., et al. (2001) · Hypertension Research · doi:10.1291/hypres.24.93 · Cited by 71
Exposure to cadmium and conventional and ambulatory blood pressures in a prospective population study
Staessen, J. A., Kuznetsova, T., Roels, H. A., et al. (2000) · American Journal of Hypertension · doi:10.1016/s0895-7061(99)00187-9 · Cited by 71
Basic and Clinical Psychopharmacology of Nicotine
Houezec, J. L., & Benowitz, N. L. (1991) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(21)00817-0 · Cited by 71
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Kim, H., Chung, J., Kim, K.-J., Kim, H., Seo, W., Jeon, K., Cho, I., Park, J. J., Lee, M., Suh, J., et al. (2021) · Korean Circulation Journal · doi:10.4070/kcj.2021.0328 · Cited by 76
Smoking cessation and change in diastolic blood pressure, body weight, and plasma lipids
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High blood pressure. A side effect of drugs, poisons, and food
Grossman, E. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.155.5.450 · Cited by 70
Effects of Smoking Successive Low- and High-Nicotine Cigarettes on Hypothalamic–Pituitary–Adrenal Axis Hormones and Mood in Men
Mendelson, J. H., Goletiani, N. V., Sholar, M. B., Siegel, A. J., & Mello, N. K. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301455 · Cited by 69
Risk Factors for Diabetes Mellitus in Chronic Pancreatitis
Pan, J., Xin, L., Wang, D., Liao, Z., Lin, J., Li, B., Du, T., Ye, B., Zou, W., Chen, H., et al. (2016) · Medicine · doi:10.1097/md.0000000000003251 · Cited by 68
“Experimental results revealed that smoking might lead to insulin resistance in peripheral tissues,(31) and elevated level of catecholamines due to smoking might also cause insulin resistance.(32) However, Imoto et al concluded that smoking did not affect DM development.”
Background
Tobacco and Cardiovascular Disease: A Summary of Evidence
Roy, A., Rawal, I., Jabbour, S., & Prabhakaran, D. (2017) · World Bank, Washington, DC eBooks · doi:10.1596/978-1-4648-0518-9_ch4 · Cited by 73
E-Cigarettes and Cancer Risk
Mravec, B., Tibenský, M., Horváthová, Ľ., & Babál, P. (2019) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-19-0346 · Cited by 74
“The net stimulatory effect of nicotine on the sympathoadrenal system is documented by the significantly increased plasma norepinephrine and epinephrine levels found in smokers (89).”
Background
Pharmacological treatment of tobacco dependence
Jarvik, M. E., & Henningfield, J. E. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90456-x · Cited by 69
Cigarette Smoking
Love, B. B. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530060107027 · Cited by 68
Interrelationships of cigarette smoking, testicular varicoceles, and seminal fluid indexes
Klaiber, E. L., Broverman, D. M., Pokoly, T. B., et al. (1987) · Fertility and Sterility · doi:10.1016/s0015-0282(16)59059-1 · Cited by 68
Vasoactive and atherogenic effects of cigarette smoking: a study of monozygotic twins discordant for smoking.
Lassila, R., Seyberth, H. W., Haapanen, A., et al. (1988) · BMJ · doi:10.1136/bmj.297.6654.955 · Cited by 68
Current Strategies in Prevention of Postoperative Infections in Spine Surgery
Ateşok, K., Papavassiliou, E. D., Heffernan, M. J., et al. (2019) · Global Spine Journal · doi:10.1177/2192568218819817 · Cited by 67
Acute Effects of Smoking during Modified Sham Feeding in Duodenal Ulcer Patients: An Analysis of Nicotine, Acid Secretion, Gastrin, Catecholamines, Epidermal Growth Factor, Prostaglandin E2, and Bile Acids
Lindell, G., Farnebo, L. O., Chen, D., et al. (1993) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529309098254 · Cited by 67
Does Smoking Act as a Friend or Enemy of Blood Pressure? Let Release Pandora's Box
Leone, A. (2011) · Cardiology Research and Practice · doi:10.4061/2011/264894 · Cited by 67
The Association of Cigarette Smoking and Alcohol Consumption with Other Cardiovascular Risk Factors in Men from Seoul, Korea
Lee, K., Park, C.-Y., Meng, K.-H., Bush, A., Lee, S. K., Lee, W. C., Koo, J., & Chung, C.-K. (1998) · Annals of Epidemiology · doi:10.1016/s1047-2797(97)00113-0 · Cited by 65
Acute effects of cigarette smoking on the heart rate variability of taxi drivers during work
Kobayashi, F., Watanabe, T., Akamatsu, Y., et al. (2005) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.919 · Cited by 67
Proteinuria in Diabetes
Klein, R. (1988) · Archives of Internal Medicine · doi:10.1001/archinte.148.1.181 · Cited by 68
Acute Effects of Electronic and Tobacco Cigarette Smoking on Sympathetic Nerve Activity and Blood Pressure in Humans
Dimitriadis, K. S., Narkiewicz, K., Leontsinis, I., Konstantinidis, D., Mihas, C. C., Andrikou, I., Thomopoulos, C., Tousoulis, D. M., & Tsioufis, K. P. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19063237 · Cited by 66
Association of Cigarette Smoking With Chronotropic Incompetence and Prognosis in the Framingham Heart Study
Lauer, M. S., Pashkow, F. J., Larson, M. G., & Levy, D. A. (1997) · Circulation · doi:10.1161/01.cir.96.3.897 · Cited by 66
Evaluation of plasma norepinephrine as an index of sympathetic neuron function in the conscious, unrestrained rat
Micalizzi, E. R., & Pals, D. T. (1979) · Life Sciences · doi:10.1016/0024-3205(79)90080-8 · Cited by 66
Serum estradiol levels in male cigarette smokers
Klaiber, E. L., Broverman, D. M., & Dalen, J. E. (1984) · The American Journal of Medicine · doi:10.1016/0002-9343(84)90524-2 · Cited by 66
How do smokers differ from nonsmokers in their response to thrombolysis? (The TIMI-4 trial)
Zahger, D., Cercek, B., Cannon, C. P., et al. (1995) · The American Journal of Cardiology · doi:10.1016/0002-9149(95)80026-o · Cited by 64
Effects of alcohol and nicotine on cytotoxic functions of human lymphocytes
Nair, M., Kronfol, Z., & Schwartz, S. A. (1990) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(90)90053-s · Cited by 64
Smoking-Induced Elevations in Blood Carboxyhaemoglobin Levels
McDonough, P., & Moffatt, R. J. (1999) · Sports Medicine · doi:10.2165/00007256-199927050-00001 · Cited by 63
Cigarette smoke condensate aggravates renal injury in the renal ablation model
Odoni, G., Ogata, E., Viedt, C., Amann, K., Ritz, E., & Orth, S. R. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00382.x · Cited by 63
“The sympathetic nerve system was selected, because smoking causes intense sympathetic activatio”
Background
Common risk factors of dry socket (alveolitis osteitis) following dental extraction: A brief narrative review
Rakhshan, V. (2018) · Journal of Stomatology Oral and Maxillofacial Surgery · doi:10.1016/j.jormas.2018.04.011 · Cited by 63
Effects of cigarette smoking on resting EEG, visual evoked potentials and photic driving
Golding, J. F. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90268-7 · Cited by 63
Acute coronary vasoconstrictive effects of cigarette smoking in coronary heart disease
Martin, J. L., Wilson, J. R., Ferraro, N., et al. (1984) · The American Journal of Cardiology · doi:10.1016/0002-9149(84)90303-5 · Cited by 63
Effect of cigarette smoking upon in vivo platelet function in man
Bierenbaum, M. L., Fleischman, A. I., Stier, A., et al. (1978) · Thrombosis Research · doi:10.1016/0049-3848(78)90060-9 · Cited by 63
Norepinephrine: hormone and neurotransmitter in man.
Silverberg, A. B., Shah, S. D., Haymond, M. W., & Cryer, P. E. (1978) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1978.234.3.e252 · Cited by 338
Self-citation
Analysis of Active and Passive Tobacco Exposures and Blood Pressure in US Children and Adolescents
Levy, R. V., Brathwaite, K. E., Sarathy, H., Reidy, K. J., Kaskel, F. J., & Melamed, M. L. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.37936 · Cited by 64
“001 Overweight 23 (22-24) 22 (21-24) 24 (22-25) Obese 17 (16-18) 14 (13-16) 20 (18-22) Poverty-income ratio <130% 31 (29-34) 23 (20-26) 43 (40-47)”
Smoking and plastic surgery, part I. Pathophysiological aspects: Update and proposed recommendations
Pluvy, I., Garrido, I., Pauchot, J., Saboye, J., Chavoin, J.-P., Tropet, Y., Grolleau, J. ‐., & Chaput, B. (2014) · Annales de Chirurgie Plastique Esthétique · doi:10.1016/j.anplas.2014.06.011 · Cited by 62
Dietary patterns and blood pressure among middle-aged and elderly Chinese men in Shanghai
Lee, S., Cai, H., Yang, G., Xu, W., Zheng, W., Li, H., Gao, Y., Xiang, Y., & Shu, X. O. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510000383 · Cited by 61
“Smoking causes an acute increase in BP and heart rate and possibly malignant hypertension (41) , which could be explained by nicotine acting as an adrenergic agonist, mediating local and systemic catecholamine release of vaso-pressin (11) .”
Alterations of lipolysis and lipoprotein lipase in chronically nicotine-treated rats
Sztalryd, C., Hamilton, J. S., Horwitz, B. A., et al. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.2.e215 · Cited by 62
Glucoregulation during exercise: hypoglycemia is prevented by redundant glucoregulatory systems, sympathochromaffin activation, and changes in islet hormone secretion.
Hoelzer, D. R., Dalsky, G. P., Clutter, W. E., SHAH, S. D., Holloszy, J. O., & Cryer, P. E. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112279 · Cited by 61
Self-citation
Retracted
Multivariate correlates of adult blood pressures in nine North American populations: The lipid research clinics prevalence study
Criqui, M. H., Mebane, I., Wallace, R. B., HEISS, G. M., & Holdbrook, M. J. (1982) · Preventive Medicine · doi:10.1016/0091-7435(82)90043-3 · Cited by 62
Acute and chronic sympathetic reflex activation and antihypertensive response to nifedipine
Kiowski, W., Erné, P., Bertel, O., Bolli, P., & Bühler, F. R. (1986) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(86)80503-4 · Cited by 62

Authors: Cryer, P. E., Haymond, M. W., Santiago, J. V., & Shah, S. D.
Affiliations: Washington University in St. Louis (US)
ORCID: Haymond, Morey W.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1976-09-09
Volume: 295
Issue: 11
Pages: 573-577
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm197609092951101
OpenAlex: W2341712066
Semantic Scholar: 61a71636dc3f81cda5208adbb0e928b8f3d3f442
Cited by: 1,101
References: 29
Citations by year: 2026: 6 · 2025: 6 · 2024: 10 · 2023: 14 · 2022: 18 · 2021: 19 · 2020: 22 · 2019: 20 · 2018: 14 · 2017: 22 · 2016: 24 · 2015: 13 · 2014: 23 · 2013: 15 · 2012: 19
FWCI: 19.23
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: cigarette smoking, norepinephrine, epinephrine, sympathetic nervous system, adrenergic blockade, plasma catecholamines, hemodynamic response, blood pressure, pulse rate, blood lactate, growth hormone, cortisol, adrenergic neurotransmission
MeSH terms: Adult, Blood Pressure, Epinephrine, Glycerol, Hemodynamics, Humans, Hydrocortisone, Lactates, Male, Norepinephrine, Phentolamine, Propranolol, Pulse, Pyruvates, Smoking, Growth Hormone, Sympathetic Nervous System, Sympatholytics

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Norepinephrine and Epinephrine Release and Adrenergic Mediation of Smoking-Associated Hemodynamic and Metabolic Events

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