The DOI matches its Crossref record.
The Effects of Antihypertensive Therapy on the Quality of Life
Abstract
We conducted a multicenter randomized double-blind clinical trial among 626 men with mild to moderate hypertension to determine the effects of captopril, methyldopa, and propranolol on their quality of life. Hydrochlorothiazide was added if needed to control blood pressure. After a 24-week treatment period, all three groups had similar blood-pressure control, although fewer patients taking propranolol required hydrochlorothiazide. Patients taking captopril alone or in combination with a diuretic were least likely to withdraw from treatment because of adverse effects (8 percent vs. 20 percent for methyldopa and 13 percent for propranolol). The treatment groups were similar in scores for sleep dysfunction, visual memory, and social participation. However, patients taking captopril, as compared with patients taking methyldopa, scored significantly higher (P less than 0.05 to less than 0.01) on measures of general well-being, had fewer side effects, and had better scores for work performance, visual-motor functioning, and measures of life satisfaction. Patients taking propranolol also reported better work performance than patients taking methyldopa. Patients taking captopril reported fewer side effects and less sexual dysfunction than those taking propranolol and had greater improvement (P less than 0.05 to less than 0.01) on measures of general well-being. Our findings show that antihypertensive agents have different effects on the quality of life and that these can be meaningfully assessed with available psychosocial measures.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
McHorney, C. A., Ware, J. E., Rachel Lu, J. F., & Sherbourne, C. D. (1994) · Medical Care · doi:10.1097/00005650-199401000-00004 · Cited by 4,458
Core outcome domains for chronic pain clinical trials: IMMPACT recommendations
Turk, D. C., Dworkin, R. H., Allen, R. R., Bellamy, N., Brandenburg, N., Carr, D. B., Cleeland, C., Dionne, R., Farrar, J. T., Galer, B. S., et al. (2003) · Pain · doi:10.1016/j.pain.2003.08.001 · Cited by 3,510
The Validity and Reproducibility of a Work Productivity and Activity Impairment Instrument
Reilly, M. C., Zbrozek, A. S., & Dukes, E. M. (1993) · PharmacoEconomics · doi:10.2165/00019053-199304050-00006 · Cited by 3,071
Effect Sizes for Interpreting Changes in Health Status
Kazis, L. E., Anderson, J. J., & Meenan, R. F. (1989) · Medical Care · doi:10.1097/00005650-198903001-00015 · Cited by 2,401
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)
Umemura, S., Arima, H., Arima, S., Asayama, K., Dohi, Y., Hirooka, Y., Horio, T., Hoshide, S., Ikeda, S., Ishimitsu, T., et al. (2019) · Hypertension Research · doi:10.1038/s41440-019-0284-9 · Cited by 1,880
The Arizona Sexual Experience Scale (ASEX): Reliability and Validity
A. McGahuey, A. J. G. (2000) · Journal of Sex & Marital Therapy · doi:10.1080/009262300278623 · Cited by 1,155
Oparil, S., Acelajado, M. C., Bakris, G. L., Berlowitz, D. R., Cífková, R., Dominiczak, A. F., Grassi, G., Jordan, J., Poulter, N. R., Rodgers, A., et al. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.14 · Cited by 1,167
Quality of Life in Individuals With Anxiety Disorders
Mendlowicz, M. V., & Stein, M. B. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.669 · Cited by 955
(2005) · doi:10.1016/j.ucl.2005.08.007 · Cited by 759
Problems in the “Evidence” of “Evidence-Based Medicine”
Feinstein, A. R., & Horwitz, R. I. (1997) · The American Journal of Medicine · doi:10.1016/s0002-9343(97)00244-1 · Cited by 653
Development of the Quality of Life in Epilepsy Inventory
Devinsky, O., Vickrey, B. G., Cramer, J., Perrine, K., Hermann, B., Meador, K., & Hays, R. D. (1995) · Epilepsia · doi:10.1111/j.1528-1157.1995.tb00467.x · Cited by 634
Comparative responsiveness of generic and specific quality-of-life instruments
Wiebe, S., Guyatt, G., Weaver, B., Matijevic, S., & Sidwell, C. (2003) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(02)00537-1 · Cited by 573
Quality of life of adults with chronic illness: A psychometric study
Burckhardt, C. S., Woods, S. L., Schultz, A. A., & Ziebarth, D. M. (1989) · Research in Nursing & Health · doi:10.1002/nur.4770120604 · Cited by 361
The Quality of Well-Being Scale: Applications in AIDS, Cystic Fibrosis, and Arthritis
Kaplan, R. M., Anderson, J. P., Wu, A. W., Mathews, W. C., Kozin, F., & Orenstein, D. (1989) · Medical Care · doi:10.1097/00005650-198903001-00003 · Cited by 344
Antihypertensive classes, cognitive decline and incidence of dementia: a network meta-analysis
Levi Marpillat, N., Macquin-Mavier, I., Tropeano, A.-I., Bachoud-Levi, A.-C., & Maison, P. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e3283603f53 · Cited by 254
Niskanen, L., Hedner, T., Hansson, L., Lanke, J., Niklason, A., & for the CAPPP study group (2001) · Diabetes Care · doi:10.2337/diacare.24.12.2091 · Cited by 219
Drug-Induced Cognition Disorders in the Elderly: Incidence, Prevention and Management
Gray, S. L., Lai, K. V., & Larson, E. B. (1999) · Drug Safety · doi:10.2165/00002018-199921020-00004 · Cited by 190
The Effects of Psychological Distress and Psychological Well-Being on Use of Medical Services
Manning, W. G., & Wells, K. B. (1992) · Medical Care · doi:10.1097/00005650-199206000-00007 · Cited by 167
Carmack Taylor, C. L., Badr, H., Lee, J. H., Fossella, F., Pisters, K., Gritz, E. R., & Schover, L. (2008) · Annals of Behavioral Medicine · doi:10.1007/s12160-008-9062-7 · Cited by 99
PANSS syndromes and quality of life in schizophrenia.
Karow, A., Moritz, S., Lambert, M., Schoder, S., & Krausz, M. (2005) · Psychopathology · doi:10.1159/000088921 · Cited by 97
Lambert, G. W., Hering, D., Esler, M. D., Marusic, P., Lambert, E. A., Tanamas, S. K., Shaw, J., Krum, H., Dixon, J. B., Barton, D. A., et al. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.200865 · Cited by 80
Nootropic effects of ACE inhibitors in mice
Mondadori, C., & Etienne, P. (1990) · Psychopharmacology · doi:10.1007/bf02244597 · Cited by 53
Brownstein, D. J., Salagre, E., Köhler, C., Stubbs, B., Vian, J., Pereira, C., Chavarria, V., Karmakar, C., Turner, A., Quevedo, J., et al. (2018) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867417721654 · Cited by 46
“Twenty studies did not use a validated scale for measuring QoL and were hence excluded (Bracchetti et al., 1990; Conlin et al., 1998; Croog et al., 1986; Ebert and Kirch, 1999; Fagher et al., 1991; Fletcher et al., 1992; Freytag et al., 2001; Hu and Zhu, 1999; Lacourciere, 1988; Lewis et al., 1996; McMahon et al., 199…”
MethodCunningham, E. L., Todd, S. A., Passmore, P., Bullock, R., & McGuinness, B. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004034.pub4 · Cited by 45
Thomson, P., Howie, K., Leslie, S. J., Angus, N. J., Andreis, F., Thomson, R., Mohan, A. R. M., Mondoa, C., & Chung, M. L. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227129 · Cited by 28
Williams, S. N., Parkins, M. M., Benedict, B., & Waelde, L. C. (2020) · Journal of Forensic Psychology Research and Practice · doi:10.1080/24732850.2020.1677108 · Cited by 2
Metadata
- Authors
- Croog, S. H., Levine, S., Testa, M. A., Brown, B., Bulpitt, C. J., Jenkins, C. D., Klerman, G. L., & Williams, G. H.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1986-06-26
- Volume
- 314
- Issue
- 26
- Pages
- 1657-1664
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2332694193
- Cited by
- 1,325
- References
- 0
- FWCI
- 80.14
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
