CoChat
Sign Up
Cited by 272Thyroid Disorders and TreatmentsGrowth Hormone and Insulin-like Growth FactorsHypothalamic control of reproductive hormones

Long-Term Growth in Juvenile Acquired Hypothyroidism:

Rivkees, Scott A., Bode, Hans H., Crawford, John D.·1988·New England Journal of Medicine
DOI 10.1056/nejm198803103181003
Open this paper in CoChat — free account

Abstract

It has been suggested that complete catch-up growth is achieved with treatment in patients with juvenile acquired hypothyroidism. We tested this assumption by examining long-term growth in 18 girls (mean [+/- SD] age, 11.4 +/- 2.7 years; bone age, 6.2 +/- 3.1 years) and 6 boys (age, 10.6 +/- 4.7 years; bone age, 6.4 +/- 2.7 years) with severe primary hypothyroidism (serum thyroxine level 1.1 +/- 0.3 micrograms per deciliter [13 +/- 4 nmol per liter]). At diagnosis, heights were 4.04 +/- 0.5 and 3.15 +/- 0.4 SD below the mean heights for age of normal girls and boys, respectively. The patients were treated with levothyroxine (3.4 +/- 0.3 micrograms per kilogram of body weight per day) to maintain normal thyroid function. During the first 18 months of therapy, the children's skeletal maturation exceeded the maturation expected for their statural growth, regardless of whether or not they were undergoing pubertal development. Predictions of decreased adult height were based on these observations. At maturity, girls and boys stood approximately 2 SD below normal adult stature, at 149 +/- 5.0 cm and 168 +/- 5.1 cm, respectively. Heights at maturity were also lower than midparental heights (P less than 0.01) and lower than pre-illness standard-deviation scores for height (P less than 0.01). The deficit in adult stature was significantly related to the duration of hypothyroidism before treatment (P less than 0.01). We conclude that despite treatment, prolonged juvenile acquired hypothyroidism results in a permanent height deficit related to the duration of thyroxine deficiency before treatment.

Integrity signals

Registry

Crossref · 10.1056/nejm198803103181003

Cites

17 of 17 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Thyroid hormone replacement stimulates catch-up growth and bone maturation, but recovery may be incomplete dependent on the duration and severity of hypothyroidism prior to treatment.

    “Thyroid hormone replacement stimulates catch-up growth and bone maturation, but recovery may be incomplete dependent on the duration and severity of hypothyroidism prior to treatment.”

    From Thyroid diseases and bone health (2018) · cites this paper as [17]

Cites

Flagged first, then by citations

1 of the 18 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Rivkees, S. A., Bode, H. H., & Crawford, J. D.
Affiliations
Massachusetts General Hospital (US)
ORCID
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1988-03-10
Volume
318
Issue
10
Pages
599-602
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm198803103181003
OpenAlex
W2326819552
Cited by
272
References
18
Citations by year
2026: 5 · 2025: 15 · 2024: 8 · 2023: 7 · 2022: 5 · 2021: 8 · 2020: 14 · 2019: 12 · 2018: 10 · 2017: 13 · 2016: 19 · 2015: 10 · 2014: 10 · 2013: 9 · 2012: 13
FWCI
2.07
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
catch-up growth, levothyroxine therapy, adult height prediction, height deficit, skeletal maturation, bone age, pubertal development, mid-parental height
MeSH terms
Age Factors, Body Weight, Child, Female, Follow-Up Studies, Growth, Humans, Hypothyroidism, Male, Sexual Maturation, Thyroxine, Time Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review