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Cited by 430

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Body Iron Stores and the Risk of Cancer

Stevens, Richard G., Jones, D. Yvonne, Micozzi, Marc S., Taylor, Philip R.·1988·New England Journal of Medicine
DOI 10.1056/nejm198810203191603
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Abstract

Because of evidence that increased body iron stores are associated with an increased risk of cancer, we examined iron status and cancer risk in the first National Health and Nutrition Examination Survey, a survey of more than 14,000 adults begun in 1971, with follow-up between 1981 and 1984. Among 242 men in whom cancer developed, the mean total iron-binding capacity was significantly lower (61.4 vs. 62.9 mumol per liter; P = 0.01) and transferrin saturation was significantly higher (33.1 vs. 30.7 percent; P = 0.002) than among 3113 men who remained free of cancer. The risk of cancer in men in each quartile of transferrin-saturation level relative to the lowest quartile was 1.00, 1.01, 1.10, and 1.37 (P = 0.02 for trend). The serum albumin level was significantly lower in men in whom cancer developed than in those who remained cancer-free. Among women, those in whom cancer developed did not have significantly lower total iron-binding capacity or higher transferrin saturation than those who remained cancer-free. However, a post hoc examination of 5367 women (203 with cancer) yielded a relative risk of 1.3 (95 percent confidence interval, 0.9 to 1.9) associated with a very high transferrin saturation (greater than or equal to 36.8 percent, a value in the highest quartile among men); in 5228 women with at least six years of follow-up (149 with cancer), the relative risk associated with transferrin saturation above this level was 1.5 (1.0 to 2.2). These results are consistent wit…

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Crossref · 10.1056/nejm198810203191603

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Citations

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Research works printed but not linked: 25

  1. Stevens, 1986, JNCI, 76, 605, 10.1093/jnci/76.4.605 · DOI
  2. 10.1002/ijc.2910410507 · DOI
  3. Stevens, 1983, Am J Epidemiol, 118, 550, 10.1093/oxfordjournals.aje.a113660 · DOI
  4. 10.1016/0003-9861(86)90305-X · DOI · Paper page
  5. 10.1126/science.6351251 · DOI
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  7. Weinberg, 1984, Physiol Rev, 64, 65, 10.1152/physrev.1984.64.1.65 · DOI · Paper page
  8. Bergeron, 1985, J Nutr, 115, 369, 10.1093/jn/115.3.369 · DOI
  9. Cook, 1974, Am J Clin Nutr, 27, 681, 10.1093/ajcn/27.7.681 · DOI
  10. Cook, 1976, Blood, 48, 449, 10.1182/blood.V48.3.449.449 · DOI
  11. 10.1056/NEJM197405302902201 · DOI
  12. Madans, 1986, Public Health Rep, 101, 464
  13. McLaughlin, 1987, Am J Epidemiol, 126, 144, 10.1093/oxfordjournals.aje.a114647 · DOI
  14. 10.1097/00043764-198411000-00012 · DOI
  15. 10.1016/0021-9681(74)90093-9 · DOI
  16. Chandra RK, Newberne PM. Nutrition, immunity, and infection: mechanisms of interactions. New York: Plenum Press, 1977.
  17. 10.1136/bmj.292.6526.969 · DOI
  18. 10.1136/bmj.293.6546.518 · DOI
  19. Murray, 1980, Am J Clin Nutr, 33, 697, 10.1093/ajcn/33.3.697 · DOI
  20. 10.1001/jama.239.19.2026 · DOI
  21. 10.1001/jama.239.19.1999 · DOI
  22. 10.1080/01635588109513684 · DOI
  23. 10.1021/bi00305a003 · DOI
  24. 10.1056/NEJM198403083101006 · DOI
  25. 10.1016/S0140-6736(76)91434-3 · DOI

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Metadata

Authors
Stevens, R. G., Jones, D. Y., Micozzi, M. S., & Taylor, P. R.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1988-10-20
Volume
319
Issue
16
Pages
1047-1052
ISSN
  • 0028-4793
  • 1533-4406
DOI
10.1056/nejm198810203191603
Cited by
430
References
2
Language
en

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