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The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes
Abstract
IN the 19th century there were two major hypotheses to explain the pathogenesis of atherosclerosis: the "incrustation" hypothesis and the "lipid" hypothesis. The incrustation hypothesis of von Rokitansky,1 proposed in 1852 and modified by Duguid,2 suggested that intimal thickening resulted from fibrin deposition, with subsequent organization by fibroblasts and secondary lipid accumulation. The lipid hypothesis, proposed by Virchow3 in 1856, suggested that lipid in the arterial wall represented a transduction of blood lipid, which subsequently formed complexes with acid mucopolysaccharides; lipid accumulated in arterial walls because mechanisms of lipid deposition predominated over those of removal. The two hypotheses are now . . .
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Cited by
(1996) · The Lancet · doi:10.1016/s0140-6736(96)09457-3 · Cited by 6,503
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504
Falk, E., Shah, P. K., & Fuster, V. (1995) · Circulation · doi:10.1161/01.cir.92.3.657 · Cited by 3,536
Self-citationAntman, E. M., Tanasijevic, M. J., Thompson, B., Schactman, M., McCabe, C. H., Cannon, C. P., Fischer, G. A., Fung, A. Y., Thompson, C., Wybenga, D., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610313351802 · Cited by 1,749
Davies, M. J., Richardson, P. D., Woolf, N., Katz, D. R., & Mann, J. (1993) · Heart · doi:10.1136/hrt.69.5.377 · Cited by 1,127
Prognostic Significance of Endothelial Dysfunction in Hypertensive Patients
Perticone, F., Ceravolo, R., Pujia, A., Ventura, G., Iacopino, S., Scozzafava, A., Ferraro, A., Chello, M., Mastroroberto, P., Verdecchia, P., et al. (2001) · Circulation · doi:10.1161/01.cir.104.2.191 · Cited by 1,059
Early versus delayed invasive intervention in acute coronary syndromes
Mehta, S. R., Granger, C. B., Boden, W. E., Steg, P. G., Bassand, J.-P., Faxon, D. P., Afzal, R., Chrolavicius, S., Jolly, S. S., Widimsky, P., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0807986 · Cited by 925
Tracy, R. P., Lemaitre, R. N., Psaty, B. M., Ives, D. G., Evans, R. W., Cushman, M., Meilahn, E. N., & Kuller, L. H. (1997) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.17.6.1121 · Cited by 836
Cardiovascular Reactivity and Development of Preclinical and Clinical Disease States
Treiber, F. A., Kamarck, T., Schneiderman, N., Sheffield, D., Kapuku, G., & Taylor, T. (2003) · Psychosomatic Medicine · doi:10.1097/00006842-200301000-00007 · Cited by 683
JCS 2018 Guideline on Diagnosis and Treatment of Acute Coronary Syndrome
Kimura, K., Kimura, T., Ishihara, M., Nakagawa, Y., Nakao, K., Miyauchi, K., Sakamoto, T., Tsujita, K., Hagiwara, N., Miyazaki, S., et al. (2019) · Circulation Journal · doi:10.1253/circj.cj-19-0133 · Cited by 565
Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes.
Liuzzo, G., Goronzy, J. J., Yang, H., Kopecky, S. L., Holmes, D. R., Frye, R. L., & Weyand, C. M. (2000) · Circulation · doi:10.1161/01.cir.101.25.2883 · Cited by 552
Pathophysiology of native coronary, vein graft, and in-stent atherosclerosis
Yahagi, K., Kolodgie, F. D., Otsuka, F., Finn, A. V., Davis, H. R., Joner, M., & Virmani, R. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.164 · Cited by 548
Perturbation of the T-cell repertoire in patients with unstable angina.
Liuzzo, G., Kopecky, S. L., Frye, R. L., Fallon, W. M. O., Maseri, A., Goronzy, J. J., & Weyand, C. M. (1999) · Circulation · doi:10.1161/01.cir.100.21.2135 · Cited by 398
Body Iron Stores and the Risk of Carotid Atherosclerosis: Prospective Results From the Bruneck Study
Kiechl, S., Willeit, J., Egger, G., Poewe, W., & Oberhollenzer, F. (1997) · Circulation · doi:10.1161/01.cir.96.10.3300 · Cited by 390
Konstantinidou, V., Covas, M., Muñoz‐Aguayo, D., Khymenets, O., de la Torre, R., Saez, G., del Carmen Tormos, M., Toledo, E., Marti, A., Ruiz‐Gutiérrez, V., et al. (2010) · The FASEB Journal · doi:10.1096/fj.09-148452 · Cited by 274
Sawayama, Y., Shimizu, C., Maeda, N., Tatsukawa, M., Kinukawa, N., Koyanagi, S., Kashiwagi, S., & Hayashi, J. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01783-1 · Cited by 226
Circadian variation in stroke onset: identical temporal pattern in ischemic and hemorrhagic events
Manfredini, R., Boari, B., Smolensky, M. H., Salmi, R., la Cecilia, O., Maria Malagoni, A., Haus, E., & Manfredini, F. (2005) · Chronobiology International · doi:10.1081/cbi-200062927 · Cited by 197
Miller, M., Seidler, A., Moalemi, A., & Pearson, T. A. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00083-7 · Cited by 193
Beyond the CNS: The many peripheral roles of APOE
Martínez-Martínez, A. B., Torres-Perez, E., Devanney, N., Del Moral, R., Johnson, L. A., & Arbones-Mainar, J. M. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104809 · Cited by 149
Physical activity, physical fitness and longevity
Lee, I. M., Paffenbarger, R. S., & Hennekens, C. H. (1997) · Aging Clinical and Experimental Research · doi:10.1007/bf03340123 · Cited by 146
Effect of smoking cessation on the risk of dementia: a longitudinal study
Choi, D., Choi, S., & Park, S. M. (2018) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.633 · Cited by 134
Liao, D., Heiss, G., Chinchilli, V. M., Duan, Y., Folsom, A. R., Lin, H.-M., & Salomaa, V. (2005) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/sj.jea.7500408 · Cited by 129
Holy, E. W., Forestier, M., Richter, E. K., Akhmedov, A., Leiber, F., Camici, G. G., Mocharla, P., Lüscher, T. F., Beer, J. H., & Tanner, F. C. (2011) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.111.226118 · Cited by 88
Birth Weight and Cardiac Structure in Children
Jiang, B., Godfrey, K. M., Martyn, C. N., & Gale, C. R. (2006) · Pediatrics · doi:10.1542/peds.2005-1325 · Cited by 72
Surks, H. K., Riddick, N., & Ohtani, K.-I. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506863200 · Cited by 71
Why Do South Asians Have High Risk for CAD?
Nair, M., & Prabhakaran, D. (2012) · Global Heart · doi:10.1016/j.gheart.2012.09.001 · Cited by 58
Medicinal Plants with Antiplatelet Activity
El Haouari, M., & Rosado, J. A. (2016) · Phytotherapy Research · doi:10.1002/ptr.5619 · Cited by 54
Muendlein, A., Geller-Rhomberg, S., Saely, C. H., Winder, T., Sonderegger, G., Rein, P., Beer, S., Vonbank, A., & Drexel, H. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.02.040 · Cited by 38
Cabello-Moruno, R., Perona, J. S., Osada, J., Garcia, M., & Ruiz-Gutierrez, V. (2007) · Journal of the American College of Nutrition · doi:10.1080/07315724.2007.10719582 · Cited by 22
Josef, P., Ali, I., Ariel, P., Alon, M., & Nimer, A. (2013) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph10083409 · Cited by 22
Therapeutic potential of thymosin β4 in myocardial infarct and heart failure.
Stark, C., Taimen, P., Tarkia, M., Pärkkä, J., Saraste, A., Alastalo, T., Savunen, T., & Koskenvuo, J. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06695.x · Cited by 5
Metadata
- Authors
- Epstein, F. H., Fuster, V., Badimon, L., Badimon, J. J., & Chesebro, J. H.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1992-01-23
- Volume
- 326
- Issue
- 4
- Pages
- 242-250
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W3194355700
- Cited by
- 2,717
- References
- 0
- FWCI
- 36.87
- Type
- journal article
- Language
- en
- Open access
- closed
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