Prevalence of Diabetes Mellitus in Pancreatic Cancer Compared to Common Cancers
Open accessAbstract
OBJECTIVES: In pancreatic cancer (PaC), the prevalence of diabetes mellitus (DM), especially new-onset DM (≤36 months of PaC diagnosis), is high. To determine if this observation is unique to PaC, we compared the prevalence and characteristics of DM in lung, breast, prostate, and colorectal cancers with PaC and noncancer controls. METHODS: We retrospectively reviewed the medical records of 500 consecutive patients with cancer (100 each with lung, breast, prostate, and colorectal cancers and PaC) and 100 noncancer controls. RESULTS: Patients with PaC (mean age ± SD, 71.6 ± 9.4 years; 53% men) had a significantly (P < 0.0001) higher prevalence of DM (68%) compared to age-matched patients with lung (mean age ± SD, 71.6 ± 9.4 years; 59% men; and 19.6% DM), breast (mean age ± SD, 71.6 ± 9.6 years; 100% women; and 19.4% DM), prostate (mean age ± SD, 71.3 ± 9.4 years; 100% men; and 14.8% DM), and colorectal cancer (mean age ± SD, 71.6 ± 9.5 years; 56% men; and 20.7% DM), and noncancer controls (mean age ± SD, 70.7 ± 9.2 years; 57% men; and 23.5% DM). Among the patients with PaC, 40% developed DM in the 36 months preceding the diagnosis of PaC compared with 3.3% to 5.7% in the other groups (P < 0.0001). CONCLUSIONS: Whereas the prevalence of DM in PaC is very high, DM prevalence in other common cancers is no different from that in noncancer controls. In particular, new-onset DM is a phenomenon that is unique to PaC.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Prevalence of diabetes among patients diagnosed with PDAC is remarkably higher than for any other solid tumor.
“The prevalence of diabetes among patients diagnosed with PDAC is remarkably higher than for any other solid tumor,211”
From Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review (2021) · cites this paper as [211]
The Results (Prevalence of Diabetes Mellitus; page not provided) report diabetes in 68% of pancreatic cancer patients, significantly higher than in patients with lung, breast, prostate, or colorectal cancer. The study compared only those four other cancers, so it does not establish the claim for any other solid tumor. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Wild, S., Roglic, G., Green, A., Sicree, R., & King, H. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1047 · Cited by 15,297 · see citing works
Diagnosis and Classification of Diabetes Mellitus
American Diabetes Association (2010) · Diabetes Care · doi:10.2337/dc11-s062 · Cited by 14,019 · see citing works
Diagnosis and Classification of diabetes mellitus
Rossi, G. (2014) · Diapedia.org eBooks · doi:10.14496/dia..20 · Cited by 3,212 · see citing works
Giovannucci, E., Harlan, D. M., Archer, M. C., Bergenstal, R. M., Gapstur, S. M., Habel, L. A., Pollak, M., Regensteiner, J. G., & Yee, D. (2010) · Diabetes Care · doi:10.2337/dc10-0666 · Cited by 2,366 · see citing works
Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies
Huxley, R., Ansary-Moghaddam, A., Berrington de González, A., Barzi, F., & Woodward, M. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602619 · Cited by 1,105 · see citing works
Diagnosis and Classification of Diabetes Mellitus
American Diabetes Association (2008) · Diabetes Care · doi:10.2337/dc08-s055 · Cited by 1,062 · see citing works
Vigneri, P., Frasca, F., Sciacca, L., Pandini, G., & Vigneri, R. (2009) · Endocrine Related Cancer · doi:10.1677/erc-09-0087 · Cited by 1,009 · see citing works
Prevalence and Clinical Profile of Pancreatic Cancer–Associated Diabetes Mellitus
Pannala, R., Leirness, J. B., Bamlet, W. R., Basu, A., Petersen, G. M., & Chari, S. T. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.039 · Cited by 621 · see citing works
Self-citationProbability of Pancreatic Cancer Following Diabetes: A Population-Based Study
Chari, S. T., Leibson, C. L., Rabe, K. G., Ransom, J., de Andrade, M., & Petersen, G. M. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.007 · Cited by 603 · see citing works
Self-citationProbability of Pancreatic Cancer Following Diabetes: A Population-Based Study
CHARI, S., LEIBSON, C., RABE, K., RANSOM, J., DEANDRADE, M., & PETERSEN, G. (2005) · Gastroenterology · doi:10.1016/j.gastro.2005.05.007 · Cited by 603 · see citing works
Self-citationNew-onset diabetes: a potential clue to the early diagnosis of pancreatic cancer
Pannala, R., Basu, A., Petersen, G. M., & Chari, S. T. (2008) · The Lancet Oncology · doi:10.1016/s1470-2045(08)70337-1 · Cited by 562 · see citing works
Self-citationDoes diabetes therapy influence the risk of cancer?
Smith, U., & Gale, E. A. M. (2009) · Diabetologia · doi:10.1007/s00125-009-1441-5 · Cited by 316 · see citing works
Carbohydrate Metabolism in Non-Insulin-Dependent Diabetes Mellitus
Dinneen, S., Gerich, J., & Rizza, R. (1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271007 · Cited by 279 · see citing works
Improved glucose metabolism after subtotal pancreatectomy for pancreatic cancer
Permert, J., Ihse, I., Jorfeldt, L., von Schenck, H., Arnquist, H. J., & Larsson, D. G. J. (1993) · British journal of surgery · doi:10.1002/bjs.1800800841 · Cited by 241 · see citing works
Pelaez-Luna, M., Takahashi, N., Fletcher, J. G., & Chari, S. T. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01480.x · Cited by 180 · see citing works
Self-citationPermert, J., Adrian, T. E., Jacobsson, P., Jorfelt, L., Fruin, A. B., & Larsson, J. (1993) · The American Journal of Surgery · doi:10.1016/s0002-9610(05)80405-2 · Cited by 138 · see citing works
Islet amyloid polypeptide is not a satisfactory marker for detecting pancreatic cancer
Chari, S. T., Klee, G. G., Miller, L. J., Raimondo, M., & DiMagno, E. P. (2001) · Gastroenterology · doi:10.1053/gast.2001.27210 · Cited by 87 · see citing works
Self-citationDiabetes mellitus in pancreatic cancer follow-up.
Fogar, P., Pasquali, C., Basso, D., Sperti, C., Panozzo, M. P., Tessari, G., D'Angeli, F., Favero, G. D., & Plebani, M. (1994) · PubMed · Cited by 72 · see citing works
Islet Hormone Secretion in Pancreatic Cancer Patients with Diabetes
Permert, J., Larsson, D. G. J., Fruin, A. B., Tatemoto, K., Herrington, M. K., von Schenck, H., & Adrian, T. E. (1997) · Pancreas · doi:10.1097/00006676-199707000-00009 · Cited by 61 · see citing works
Isaksson, B., Strömmer, L., Friess, H., Büchler, M. W., Herrington, M. K., Wang, F., Zierath, J. R., Wallberg‐Henriksson, H., Larsson, J., & Permert, J. (2003) · Pancreas · doi:10.1097/00006676-200303000-00014 · Cited by 44 · see citing works
β-Cell Function in Pancreatic Adenocarcinoma
Basso, D., Plebani, M., Fogar, P., Favero, G. D., Briani, G., Meggiato, T., Panozzo, M. P., Ferrara, C., D'Angeli, F., & Burlina, A. (1994) · Pancreas · doi:10.1097/00006676-199405000-00008 · Cited by 37 · see citing works
The gastrointestinal tract and glucose tolerance
Vella, A. V., Camilleri, M., & Rizza, R. A. (2004) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000134375.01310.97 · Cited by 36 · see citing works
Diabetes Diagnostic Criteria and Impaired Glycemic States: Evolving Evidence Base
Engelgau, M. M. (2004) · Clinical Diabetes · doi:10.2337/diaclin.22.2.69 · Cited by 18 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [3]Altekruse SF Kosary CL Krapcho M Accessed on June 1, 2011 SEER Cancer Statistics Review, 1976-2007 2010 National Cancer Institute Bethesda, MD based on November 2009 SEER data submission, posted to the SEER Web site Available at: http://www.cancer.org/cancer/cancerbasics/cancer-prevalence
Cited by
Sorted by citations
The Epidemiology of Pancreatitis and Pancreatic Cancer
Yadav, D., & Lowenfels, A. B. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.068 · Cited by 1,974 · see citing works
Type 3c (pancreatogenic) diabetes mellitus secondary to chronic pancreatitis and pancreatic cancer
Hart, P. A., Bellin, M. D., Andersen, D. K., Bradley, D., Cruz-Monserrate, Z., Forsmark, C. E., Goodarzi, M. O., Habtezion, A., Korc, M., Kudva, Y. C., et al. (2016) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(16)30106-6 · Cited by 551 · see citing works
Self-citationDiabetes, pancreatogenic diabetes, and pancreatic cancer
Andersen, D. K., Korc, M., Petersen, G. M., Eibl, G., Li, D., Rickels, M. R., Chari, S. T., & Abbruzzese, J. L. (2017) · Diabetes · doi:10.2337/db16-1477 · Cited by 516 · see citing works
Self-citationEarly detection of pancreatic cancer
Pereira, S. P., Oldfield, L., Ney, A., Hart, P. A., Keane, M. G., Pandol, S. J., Li, D., Greenhalf, W., Jeon, C. Y., Koay, E. J., et al. (2020) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(19)30416-9 · Cited by 482 · see citing works
New insights into pancreatic cancer-induced paraneoplastic diabetes
Sah, R. P., Nagpal, S. J. S., Mukhopadhyay, D., & Chari, S. T. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.49 · Cited by 336 · see citing works
Self-citationAmerican Diabetes Association Professional Practice Committee (2022) · Diabetes Care · doi:10.2337/dc22-s004 · Cited by 285 · see citing works
ElSayed, N. A., Aleppo, G., Aroda, V. R., Bannuru, R. R., Brown, F. M., Bruemmer, D., Collins, B. S., Cusi, K. J., Hilliard, M. E., Isaacs, D. M., et al. (2022) · Diabetes Care · doi:10.2337/dc23-s004 · Cited by 233 · see citing works
Lee, J. W., Kang, C. M., Choi, H. J., Lee, W. J., Song, S. Y., Lee, J., & Lee, J.-D. (2014) · Journal of Nuclear Medicine · doi:10.2967/jnumed.113.131847 · Cited by 210 · see citing works
ElSayed, N. A., McCoy, R. G., Aleppo, G., Bajaj, M. S., Balapattabi, K., Beverly, E. A., Early, K. B., Bruemmer, D., Cusi, K. J., Echouffo-Tcheugui, J. B., et al. (2024) · Diabetes Care · doi:10.2337/dc25-s004 · Cited by 222 · see citing works
American Diabetes Association (2019) · Diabetes Care · doi:10.2337/dc20-s004 · Cited by 207 · see citing works
Association of Diabetes Mellitus and Pancreatic Adenocarcinoma: A Meta-Analysis of 88 Studies
Batabyal, P., Hoorn, S. V., Christophi, C., & Nikfarjam, M. (2014) · Annals of Surgical Oncology · doi:10.1245/s10434-014-3625-6 · Cited by 186 · see citing works
American Diabetes Association (2018) · Diabetes Care · doi:10.2337/dc19-s004 · Cited by 183 · see citing works
Liao, W., Tu, Y., Wu, M., Lin, J.-T., Wang, C., & Chien, K. (2015) · BMJ · doi:10.1136/bmj.g7371 · Cited by 171 · see citing works
Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review
Kenner, B., Chari, S. T., Kelsen, D., Klimstra, D. S., Pandol, S. J., Rosenthal, M., Rustgi, A. K., Taylor, J. A., Yala, A., Abul-Husn, N., et al. (2021) · Pancreas · doi:10.1097/mpa.0000000000001762 · Cited by 158 · see citing works
Self-citationElSayed, N. A., Aleppo, G., Bannuru, R. R., Bruemmer, D., Collins, B. S., Cusi, K. J., Ekhlaspour, L., Fleming, T. K., Hilliard, M. E., Johnson, E. L., et al. (2023) · Diabetes Care · doi:10.2337/dc24-s004 · Cited by 167 · see citing works
American Diabetes Association (2020) · Diabetes Care · doi:10.2337/dc21-s004 · Cited by 149 · see citing works
Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer
Eibl, G., Cruz‐Monserrate, Z., Korc, M., Petrov, M. S., Goodarzi, M. O., Fisher, W. E., Habtezion, A., Lugea, A., Pandol, S. J., Hart, P. A., et al. (2017) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2017.07.005 · Cited by 138 · see citing works
Pancreatic cancer in 2021: What you need to know to win
Tonini, V., & Zanni, M. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i35.5851 · Cited by 126 · see citing works
Hu, C.-M., Tien, S.-C., Hsieh, P.-K., Jeng, Y.-M., Chang, M.-C., Chang, Y.-T., Chen, Y.-J., Chen, Y.-J., Lee, E. Y.-H. P., & Lee, W.-H. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.02.005 · Cited by 123 · see citing works
Peng, Y.-C., Wu, C., Tien, Y., Lu, T., Wang, Y.-H., & Chen, B. (2020) · European Radiology · doi:10.1007/s00330-020-07294-7 · Cited by 104 · see citing works
Diabetes and pancreatic cancer: Exploring the two-way traffic
Roy, A., Sahoo, J., Kamalanathan, S., Naik, D., Mohan, P., & Kalayarasan, R. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i30.4939 · Cited by 104 · see citing works
Setiawan, V. W., Stram, D. O., Porcel, J., Chari, S. T., Maskarinec, G., Le Marchand, L., Wilkens, L. R., Haiman, C. A., Pandol, S. J., & Monroe, K. R. (2019) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djy090 · Cited by 91 · see citing works
Self-citationDiabetes of the exocrine pancreas
Wynne, K., Devereaux, B., & Dornhorst, A. (2018) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.14451 · Cited by 87 · see citing works
KRAS, YAP, and obesity in pancreatic cancer: A signaling network with multiple loops
Eibl, G., & Rozengurt, E. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.10.007 · Cited by 87 · see citing works
Weight Loss, Diabetes, Fatigue, and Depression Preceding Pancreatic Cancer
Olson, S. H., Xu, Y., Herzog, K., Saldia, A., DeFilippis, E. M., Li, P. C.-W., Allen, P. J., O'Reilly, E. M., & Kurtz, R. C. (2015) · Pancreas · doi:10.1097/mpa.0000000000000590 · Cited by 85 · see citing works
for the European Study Group for Pancreatic Cancer, Kleeff, J. H., Costello, E., Jackson, R., Halloran, C. M., Greenhalf, W., Ghaneh, P., Lamb, R. F., Lerch, M. M., Mayerle, J. V., et al. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.277 · Cited by 78 · see citing works
Molina‐Montes, E., Coscia, C., Gómez-Rubio, P., Fernández, A. M., Boenink, R., Rava, M., Márquez, M., Molero, X., Löhr, M. J., Sharp, L., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-319990 · Cited by 75 · see citing works
Bajaj, M. S., McCoy, R. G., Balapattabi, K., Bannuru, R. R., Bellini, N. J., Bennett, A. K., Beverly, E. A., Early, K. B., ChallaSivaKanaka, S., Echouffo-Tcheugui, J. B., et al. (2025) · Diabetes Care · doi:10.2337/dc26-s004 · Cited by 86 · see citing works
Diabetes, pancreatic cancer, and metformin therapy
Gong, J., Robbins, L., Lugea, A., Waldron, R. T., Jeon, C. Y., & Pandol, S. J. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00426 · Cited by 67 · see citing works
Interplays of glucose metabolism and KRAS mutation in pancreatic ductal adenocarcinoma
Liu, Y.-H., Hu, C., Hsu, Y.-S., & Lee, W. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05259-w · Cited by 66 · see citing works
Yao, K., Wang, Q., Jia, J., & Zhao, H. (2017) · Tumor Biology · doi:10.1177/1010428317707882 · Cited by 61 · see citing works
Guideline for the Management of Diabetes Mellitus in the Elderly in China (2024 Edition)
Guo, L., & Xiao, X. (2024) · Aging Medicine · doi:10.1002/agm2.12294 · Cited by 65 · see citing works
A tale of two pancreases: exocrine pathology and endocrine dysfunction
Rickels, M. R., Norris, A. W., & Hull, R. L. (2020) · Diabetologia · doi:10.1007/s00125-020-05210-8 · Cited by 60 · see citing works
The Role of Mitochondria in the Chemoresistance of Pancreatic Cancer Cells
Fu, Y., Ricciardiello, F., Yang, G., Qiu, J., Huang, H., Xiao, J., Cao, Z., Zhao, F., Liu, Y., Luo, W., et al. (2021) · Cells · doi:10.3390/cells10030497 · Cited by 57 · see citing works
Illés, D., Terzin, V., Holzinger, G., Kosár, K., Róka, R., Zsóri, G., Ábrahám, G., & Czakó, L. (2015) · Pancreatology · doi:10.1016/j.pan.2015.12.005 · Cited by 54 · see citing works
The relationship between pancreatic cancer and type 2 diabetes: cause and consequence
Li, Y., Bian, X., Wei, S., He, M., & Yang, Y. (2019) · Cancer Management and Research · doi:10.2147/cmar.s211972 · Cited by 47 · see citing works
Hank, T. P., Sandini, M., Qadan, M., Weniger, M., Ciprani, D., Li, A., Ferrone, C. R., Warshaw, A. L., Lillemoe, K. D., & Castillo, C. F. F.-D. (2019) · Pancreatology · doi:10.1016/j.pan.2019.10.007 · Cited by 45 · see citing works
Activation of GLP-1 receptor enhances the chemosensitivity of pancreatic cancer cells
Zhao, H.-J., Jiang, X., Hu, L., Yang, L., Deng, L.-D., Wang, Y.-P., & Ren, Z. (2019) · Journal of Molecular Endocrinology · doi:10.1530/jme-19-0186 · Cited by 45 · see citing works
Obesity, obesities and gastrointestinal cancers
Zou, Y., & Pitchumoni, C. S. (2023) · Disease-a-Month · doi:10.1016/j.disamonth.2023.101592 · Cited by 44 · see citing works
Mannucci, A., & Goel, A. (2025) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.70035 · Cited by 53 · see citing works
Ose, D. J., Viskochil, R. H., Holowatyj, A. N., Larson, M., Wilson, D., Dunson, W. A., Deshmukh, V. G., Butcher, J. R., Taylor, B., Svoboda, K., et al. (2021) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2020.7653 · Cited by 43 · see citing works
Oldfield, L. S., Evans, A., Rao, R. G., Jenkinson, C., Purewal, T. S., Psarelli, E. E., Menon, U., Timms, J. F., Pereira, S. P., Ghaneh, P., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2021.103802 · Cited by 42 · see citing works
Gaps and Opportunities in the Diagnosis and Treatment of Pancreatic Cancer
Caban, M., & Małecka-Wojciesko, E. (2023) · Cancers · doi:10.3390/cancers15235577 · Cited by 41 · see citing works
Metformin with Everolimus and Octreotide in Pancreatic Neuroendocrine Tumor Patients with Diabetes
Pusceddu, S., Buzzoni, R., Vernieri, C., Concas, L., Marceglia, S. R. F., Giacomelli, L., Milione, M., Leuzzi, L., Femia, D., Formisano, B., et al. (2016) · Future Oncology · doi:10.2217/fon-2015-0077 · Cited by 38 · see citing works
Galectin-3 and S100A9: Novel Diabetogenic Factors Mediating Pancreatic Cancer–Associated Diabetes
Liao, W., Huang, B., Yu, Y., Yang, H.-H., Chen, P., Huang, C., Huang, H., Wu, M., & Chow, L. (2019) · Diabetes Care · doi:10.2337/dc19-0217 · Cited by 37 · see citing works
Pang, W., Yao, W., Dai, X., Zhang, A., Hou, L., Wang, L., Wang, Y., Huang, X. Y., Meng, X., & Li, L. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.56271 · Cited by 37 · see citing works
Wang, Y., HUANG, S. H., Zhong, J., Yang, K., Guo, Z., Liu, J., Ma, L., Li, H., Ou, B.-N., & Li, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113858 · Cited by 36 · see citing works
Cheng, Y., Diao, D., Zhang, H., Guo, Q., Wu, X., Song, Y., & Dang, C. (2013) · Biomedical Reports · doi:10.3892/br.2013.211 · Cited by 36 · see citing works
Park, W. G., Li, L., Appana, S. N., Wei, W., Stello, K. M., Andersen, D. K., Hughes, S. J., Whitcomb, D. C., Brand, R. E., Yadav, D. K., et al. (2019) · Pancreatology · doi:10.1016/j.pan.2019.11.008 · Cited by 36 · see citing works
Relationship between pancreatic cancer‐associated diabetes and cachexia
Liao, W., Chen, P., Huang, C., Chang, Y., Huang, B., Chang, C., Wu, M., & Chow, L. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12553 · Cited by 32 · see citing works
Sheth, S. G., Conwell, D. L., Whitcomb, D. C., Alsante, M., Anderson, M. A., Barkin, J. S., Brand, R. E., Coté, G. A., Freedman, S. D., Gelrud, A., et al. (2017) · Pancreatology · doi:10.1016/j.pan.2017.02.015 · Cited by 31 · see citing works
Deng, J., Guo, Y., Du, J., Gu, J., Kong, L., Tao, B., Li, J., & Fu, D. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.844028 · Cited by 31 · see citing works
Chovsepian, A., Prokopchuk, O., Petrova, G., Gjini, T., Kuzi, H., Heisz, S., Janssen, K., Martignoni, M. E., Friess, H., Hauner, H., et al. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101729 · Cited by 30 · see citing works
Diabetes Mellitus and Pancreatic Cancer
Hart, P. A., & Chari, S. T. (2013) · Pancreas · doi:10.1097/mpa.0b013e3182a7c963 · Cited by 30 · see citing works
Self-citationImmune-related somatic mutation genes are enriched in PDACs with diabetes
Wang, K., Zhou, W., Meng, P., Wang, P., Zhou, C., Yao, Y., Wu, S., Wang, Y., Zhao, J., Zou, D., et al. (2019) · Translational Oncology · doi:10.1016/j.tranon.2019.03.006 · Cited by 29 · see citing works
Lee, H. S., Chae, W., Sung, M. J., Keum, J., Jo, J. H., Chung, M. J., Park, J. Y., Park, S. W., Song, S. Y., Park, E., et al. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac728 · Cited by 30 · see citing works
A Serum Marker for Early Pancreatic Cancer With a Possible Link to Diabetes
Nam, H., Hong, S., Jung, K. H., Kang, S., Park, M. S., Kang, S., Kim, H. S., Mai, V.-H., Kim, J., Lee, H., et al. (2021) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djab191 · Cited by 29 · see citing works
Surveillance for neoplasia in the pancreas
Overbeek, K. A., Cahen, D. L., Canto, M. I., & Bruno, M. J. (2016) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2016.10.013 · Cited by 28 · see citing works
Paraneoplastic β Cell Dedifferentiation in Nondiabetic Patients with Pancreatic Cancer
Wang, Y., Ni, Q., Sun, J., Xu, M., Xie, J., Zhang, J., Fang, Y., Ning, G., & Wang, Q. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz224 · Cited by 27 · see citing works
Neural innervation in adipose tissue, gut, pancreas, and liver
Sun, M., Wan, Y., Shi, M., Meng, Z., & Zeng, W. (2023) · Life Metabolism · doi:10.1093/lifemeta/load022 · Cited by 28 · see citing works
Hart, P. A., Law, R. J., Frank, R. D., Bamlet, W. R., Burch, P. A., Petersen, G. M., Rabe, K. G., & Chari, S. T. (2014) · The American Journal of Gastroenterology · doi:10.1038/ajg.2014.193 · Cited by 27 · see citing works
Self-citationInsulin resistance and cancer: molecular links and clinical perspectives
Caturano, A., Erul, E., Nilo, R., Nilo, D., Russo, V., Rinaldi, L., Acierno, C., Gemelli, M., Ricotta, R., Sasso, F. C., et al. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05245-8 · Cited by 26 · see citing works
Is diabetes mellitus a risk factor for pancreatic cancer?
Pezzilli, R. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i30.4861 · Cited by 24 · see citing works
Perera, C. J., Falasca, M., Chari, S. T., Greenfield, J. R., Xu, Z., Pirola, R. C., Wilson, J. S., & Apte, M. V. (2021) · Cancers · doi:10.3390/cancers13205224 · Cited by 24 · see citing works
Self-citationLee, S., Hwang, H. K., Kang, C. M., & Lee, W. J. (2018) · Pancreas · doi:10.1097/mpa.0000000000001099 · Cited by 24 · see citing works
Park, B. K., Seo, J. H., Chung, J. B., & Choi, J. K. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01807-5 · Cited by 23 · see citing works
Baseline Hemoglobin-A1c Impacts Clinical Outcomes in Patients With Pancreatic Cancer
Fan, K. Y., Dholakia, A. S., Wild, A. T., Su, Z., Hacker‐Prietz, A., Kumar, R., Hodgin, M. B., Hsu, C. C.-C., Le, D. T., Jesus‐Acosta, A. D., et al. (2014) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2014.0006 · Cited by 23 · see citing works
Small Molecules and Pancreatic Cancer Trials and Troubles
Govardhanagiri, S., Bethi, S. R., & Nagaraju, G. P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-817661-0.00008-1 · Cited by 22 · see citing works
Duvillié, B., Kourdoughli, R., Druillennec, S., Eychène, A., & Pouponnot, C. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.563267 · Cited by 22 · see citing works
CA19-9 capability as predictor of pancreatic cancer resectability in a Spanish cohort
Herreros‐Villanueva, M., Ruiz-Rebollo, L., Montes, M., Rodriguez-Lopez, M., Francisco, M., Cubiella, J., Iyo, E., Garabitos, E., Moneo, E. M., Martos, M., et al. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05245-5 · Cited by 22 · see citing works
Hsueh, H., Pita-Grisanti, V., Gumpper, K., Lahooti, A., Chavez-Tomar, M., Schadler, K., & Cruz‐Monserrate, Z. (2021) · Pancreatology · doi:10.1016/j.pan.2021.10.004 · Cited by 19 · see citing works
Škrha, P., Hořínek, A., Pazourková, E., Hajer, J., Fric, P., Škrha, J., & Anděl, M. (2016) · Pancreatology · doi:10.1016/j.pan.2016.05.005 · Cited by 20 · see citing works
Prediction of Pancreatic Cancer in Diabetes Patients with Worsening Glycemic Control
Jeon, C. Y., Kim, S., Lin, Y., Risch, H. A., Goodarzi, M. O., Nuckols, T. K., Freedland, S. J., Pandol, S. J., & Pisegna, J. R. (2021) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-21-0712 · Cited by 19 · see citing works
Takeda, T., Sasaki, T., Okamoto, T., Ishitsuka, T., Yamada, M., Nakagawa, H., Mie, T., Furukawa, T., Kasuga, A., Matsuyama, M., et al. (2022) · Internal Medicine · doi:10.2169/internalmedicine.0730-22 · Cited by 19 · see citing works
Moz, S., Basso, D., Padoan, A., Bozzato, D., Fogar, P., Zambon, C., Pelloso, M., Sperti, C., de Kreutzenberg, S. V., Pasquali, C., et al. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2016.02.018 · Cited by 19 · see citing works
Pathogenesis of Pancreatic Cancer-Related Diabetes Mellitus
Korc, M. (2019) · Pancreas · doi:10.1097/mpa.0000000000001300 · Cited by 19 · see citing works
Su, J., Pang, W., Zhang, A., Li, L., Yao, W., & Dai, X. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06980-z · Cited by 18 · see citing works
Wu, K., Wang, W., Chen, H., Gao, W., & Yu, C. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.12.182 · Cited by 17 · see citing works
Early detection of sporadic pancreatic cancer: time for change
Fric, P., Šedo, A., Škrha, J., Bušek, P., Laclav, M., Škrha, P., & Zavoral, M. (2017) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000904 · Cited by 16 · see citing works
Pancreatic cancer trends in Europe: epidemiology and risk factors
Hawksworth, G., Hales, J., Martinez, F., Hynes, A., Hamilton, A., & Fernández, V. (2019) · Medical Studies · doi:10.5114/ms.2019.86336 · Cited by 16 · see citing works
Carnie, L. E., Lamarca, Á., McNamara, M. G., Bibby, N., O'Reilly, D. A., & Valle, J. W. (2020) · Pancreatology · doi:10.1016/j.pan.2020.03.020 · Cited by 16 · see citing works
Oldfield, L. S., Stott, M. C., Hanson, R., Jackson, R., Reynolds, W. F., Chandran-Gorner, V., Meer, R. V. D., Alison, L. J., Tejeiro, R. A., Purewal, T. S., et al. (2022) · BMJ Open · doi:10.1136/bmjopen-2022-068010 · Cited by 16 · see citing works
Wu, B. U. (2021) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000763 · Cited by 14 · see citing works
Ding, F., Guo, Y., Zhang, H., Zhong, Y., Zhang, D., Huang, Q., Zhou, Z., Liu, G., Zhang, X., & Weng, S. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.112027 · Cited by 13 · see citing works
Thonsri, U., Wongkham, S., Wongkham, C., Hino, S., Nakao, M., Roytrakul, S., Koga, T., & Seubwai, W. (2020) · Cancer Science · doi:10.1111/cas.14719 · Cited by 13 · see citing works
A Decade Later: Revisiting the TGFβ Family’s Role in Diabetes
Brown, M., & Schneyer, A. L. (2020) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2020.11.006 · Cited by 13 · see citing works
Sohn, S. Y., Lee, E. K., Han, S., Lee, Y. J., Hwangbo, Y., Kang, Y. H., Lee, S. D., Kim, S., Woo, S. M., Lee, W. J., et al. (2018) · Medicine · doi:10.1097/md.0000000000010590 · Cited by 12 · see citing works
White, M. J., Sheka, A. C., LaRocca, C. J., Irey, R., Ma, S., Wirth, K. M., Benner, A., Denbo, J. W., Jensen, E. H., Ankeny, J. S., et al. (2022) · Journal of Public Health · doi:10.1093/pubmed/fdac118 · Cited by 11 · see citing works
Yang, K., Doege, D., Thong, M. S. Y., Koch‐Gallenkamp, L., Weißer, L., Bertram, H., Eberle, A., Holleczek, B., Nennecke, A., Waldmann, A., et al. (2023) · Cancer · doi:10.1002/cncr.35133 · Cited by 11 · see citing works
New onset diabetes predicts progression of low risk pancreatic mucinous cysts
Schweber, A. B., Brooks, C., Agarunov, E., Sethi, A., Poneros, J. M., Schrope, B., Kluger, M. D., Chabot, J. A., & Gonda, T. A. (2020) · Pancreatology · doi:10.1016/j.pan.2020.09.015 · Cited by 11 · see citing works
Park, S. H., Kang, I., Hong, S. S., Kim, H.-Y., Hwang, H. K., & Kang, C. M. (2024) · Cancers · doi:10.3390/cancers16101844 · Cited by 10 · see citing works
Zhao, H., Jiang, X., Duan, L., Yang, L., Wang, W., & Ren, Z. (2019) · Endocrine Journal · doi:10.1507/endocrj.ej19-0215 · Cited by 10 · see citing works
Screening Strategy of Pancreatic Cancer in Patients with Diabetes Mellitus
Mizuno, S., Nakai, Y., Ishigaki, K., Saito, K., Oyama, H., Hamada, T., Suzuki, Y., Inokuma, A., Kanai, S., Noguchi, K., et al. (2020) · Diagnostics · doi:10.3390/diagnostics10080572 · Cited by 10 · see citing works
Carrato, A., Melisi, D., Prager, G. W., Westphalen, C. B., Ferreras, A., D’Esquermes, N., Taı̈eb, J., & Macarulla, T. M. (2021) · Future Oncology · doi:10.2217/fon-2020-0749 · Cited by 9 · see citing works
Bitterman, D. S., Winter, K. A., Hong, T. S., Fuchs, C. S., Regine, W. F., Abrams, R. A., Safran, H. P., Hoffman, J. P., Benson, A. B., Kasunic, T., et al. (2020) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2020.08.042 · Cited by 8 · see citing works
Wang, C., Tseng, M., Wu, S., Yang, T., Chen, H., Sung, W., Su, C., Wang, Y., Chen, W., Lai, H., et al. (2020) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15234 · Cited by 8 · see citing works
Individualized diabetes care: Lessons from the real-world experience
Khor, X. Y., Pappachan, J. M., & Jeeyavudeen, M. S. (2023) · World Journal of Clinical Cases · doi:10.12998/wjcc.v11.i13.2890 · Cited by 8 · see citing works
Early pancreatic carcinogenesis – risk factors, early symptoms, and the impact of antidiabetic drugs
Fric, P., Škrha, J., Šedo, A., Bušek, P., Kmochová, K., Laclav, M., Solař, S., Bunganič, B., & Zavoral, M. (2016) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000646 · Cited by 7 · see citing works
Feingold, K. R. (2015) · Europe PMC (PubMed Central) · Cited by 7 · see citing works
Zhou, Y., Wu, Z. K., Zeng, L., & Chen, R. (2025) · BMC Medicine · doi:10.1186/s12916-025-04048-4 · Cited by 6 · see citing works
- Authors
- Aggarwal, G., Kamada, P., & Chari, S. T.
- Affiliations
- Mayo Clinic (US)
- University Medical Center Brackenridge (US)
- Corresponding author
- Aggarwal, Gaurav
- Chari, Suresh T.
- Venue
- Pancreas
- Published
- 2013-03
- Volume
- 42
- Issue
- 2
- Pages
- 198-201
- ISSN
- 0885-3177 (ISSN-L)
- PMC
- PMC3896296
- OpenAlex
- W2045036543
- Cited by
- 167
- References
- 21
- Citations by year
- 2026: 11 · 2025: 16 · 2024: 7 · 2023: 11 · 2022: 14 · 2021: 23 · 2020: 19 · 2019: 17 · 2018: 10 · 2017: 10 · 2016: 9 · 2015: 4 · 2014: 7 · 2013: 9
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Pancreas (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P50CA102701, R01CA100685)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- diabetes mellitus, pancreatic cancer, new-onset diabetes, cancer-associated diabetes, lung cancer, breast cancer, prostate cancer, colorectal cancer, diabetes prevalence, cancer patients
- MeSH terms
- Aged, Aged, 80 and over, Blood Glucose, Breast Neoplasms, Diabetes Mellitus, Female, Humans, Lung Neoplasms, Male, Middle Aged, Minnesota, Pancreatic Neoplasms, Prostatic Neoplasms, Retrospective Studies, Risk Factors, Time Factors, Colorectal Neoplasms, Biomarkers, Prevalence, Chi-Square Distribution
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
