Cited by 556Physical Activity and HealthNutritional Studies and DietHealth and Lifestyle Studies

Effects of exercise and diet on chronic disease

Roberts, Christian K., Barnard, R. James·2005·Journal of Applied Physiology

Abstract

Currently, modern chronic diseases, including cardiovascular diseases, Type 2 diabetes, metabolic syndrome, and cancer, are the leading killers in Westernized society and are increasing rampantly in developing nations. In fact, obesity, diabetes, and hypertension are now even commonplace in children. Clearly, however, there is a solution to this epidemic of metabolic disease that is inundating today’s societies worldwide: exercise and diet. Overwhelming evidence from a variety of sources, including epidemiological, prospective cohort, and intervention studies, links most chronic diseases seen in the world today to physical inactivity and inappropriate diet consumption. The purpose of this review is to 1) discuss the effects of exercise and diet in the prevention of chronic disease, 2) highlight the effects of lifestyle modification for both mitigating disease progression and reversing existing disease, and 3) suggest potential mechanisms for beneficial effects.

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Crossref · 10.1152/japplphysiol.00852.2004

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440 of 440 references verified0 citation errors · 0 not checkable

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Authors
Roberts, C. K., & Barnard, R. J.
Affiliations
University of California, Los Angeles (US)
Venue
Journal of Applied Physiology
Published
2005-01
Volume
98
Issue
1
Pages
3-30
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
OpenAlex
W2166309615
Cited by
556
References
440
Citations by year
2026: 4 · 2025: 11 · 2024: 21 · 2023: 27 · 2022: 22 · 2021: 22 · 2020: 30 · 2019: 22 · 2018: 21 · 2017: 22 · 2016: 20 · 2015: 26 · 2014: 32 · 2013: 43 · 2012: 46
FWCI
14.84
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (HL 68406-01, F32HL068406)
  • National Cancer Institute (CA42710, CA 100938, R01CA100938)
Topics
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Health Professions › General Health Professions › Health and Lifestyle Studies
Keywords
physical activity, diet, chronic disease prevention, physical inactivity, lifestyle modification, cardiovascular disease, type 2 diabetes, metabolic syndrome, cancer, obesity, hypertension, disease progression, disease reversal
MeSH terms
Animals, Chronic Disease, Clinical Trials as Topic, Coronary Artery Disease, Diabetes Mellitus, Diet Therapy, Exercise Therapy, Humans, Hypertension, Neoplasms, Treatment Outcome, Metabolic Syndrome

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