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Cited by 2,300Thyroid Disorders and TreatmentsHormonal and reproductive studiesCardiovascular Function and Risk Factors

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Thyroid hormone and the cardiovascular system.

Klein, Irwin, Ojamaa, Kaie·2001·New England Journal of Medicine
DOI 10.1056/nejm200102153440707
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Abstract

Thyroid hormone has many effects on the heart and vascular system.1 Many of the clinical manifestations of hyperthyroidism are due to the ability of thyroid hormone to alter cardiovascular hemodynamics.2 The hemodynamic effects of hypothyroidism are opposite to those of hyperthyroidism, although the clinical manifestations are less obvious. This review will integrate what is known about the mechanisms of thyroid hormone action on the heart25 with recent observations from both experimental and clinical studies of hyperthyroidism and hypothyroidism. We will also address the potential role of thyroid hormone treatment in patients with acute or chronic cardiac disease.Effects of . . .

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Crossref · 10.1056/nejm200102153440707

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  1. Graves RJ, 1835, Lond Med Surg J, 7, 517
  2. 10.1016/0002-9343(90)90530-Q · DOI · Paper page
  3. 10.1016/S0033-0620(96)80017-X · DOI
  4. Klein I, Levey GS. The cardiovascular system in thyrotoxicosis. In: Braverman LE, Utiger RD, eds. Werner & Ingbar's the thyroid: a fundamental and clinical text. 8th ed. Philadelphia: Lippincott Williams & Wilkins, 2000:596-604.
  5. 10.1172/JCI103906 · DOI
  6. 10.1210/jcem-73-1-146 · DOI
  7. 10.1210/jc.78.5.1028 · DOI · Paper page
  8. 10.1139/y89-158 · DOI
  9. 10.1056/NEJM198211043071901 · DOI
  10. 10.1016/S0735-1097(86)80213-3 · DOI
  11. 10.1097/00000539-199710000-00005 · DOI
  12. 10.1089/thy.1996.6.505 · DOI
  13. 10.1056/NEJM199512073332302 · DOI
  14. 10.1016/0024-3205(82)90273-9 · DOI
  15. 10.1210/en.137.10.4235 · DOI
  16. 10.1056/NEJM199409293311306 · DOI
  17. 10.1210/en.137.3.802 · DOI
  18. Morkin E, 1993, Circulation, 87, 1451, 10.1161/01.CIR.87.5.1451 · DOI · Paper page
  19. Magner J, 1988, West J Med, 110, 759
  20. 10.1073/pnas.89.12.5251 · DOI
  21. Klein I, Ojamaa K. The cardiovascular system in hypothyroidism. In: Braverman LE, Utiger RD, eds. Werner & Ingbar's the thyroid: a fundamental and clinical text. 8th ed. Philadelphia: Lippincott Williams & Wilkins, 2000:777-82.
  22. Kiss E, 1994, Circ Res, 75, 245, 10.1161/01.RES.75.2.245 · DOI · Paper page
  23. 10.1210/en.141.6.2139 · DOI · Paper page
  24. Kiss E, 1998, Circ Res, 83, 608, 10.1161/01.RES.83.6.608 · DOI
  25. 10.1016/0002-9343(90)90533-J · DOI
  26. Hoit BD, 1997, Circulation, 96, 592, 10.1161/01.CIR.96.2.592 · DOI
  27. 10.1016/S0026-0495(00)92262-5 · DOI
  28. 10.1007/BF01868642 · DOI
  29. 10.1210/en.140.7.3170 · DOI
  30. 10.1016/0003-4975(93)90550-2 · DOI
  31. Walker JD, 1994, J Thorac Cardiovasc Surg, 108, 672, 10.1016/S0022-5223(94)70292-6 · DOI
  32. 10.1016/S0889-8529(05)70297-8 · DOI
  33. 10.1210/jc.81.8.2828 · DOI
  34. 10.1001/archinte.148.3.626 · DOI
  35. 10.1172/JCI105212 · DOI
  36. Theilen EO, 1967, J Appl Physiol, 22, 207, 10.1152/jappl.1967.22.2.207 · DOI
  37. 10.1016/0002-9149(79)90243-1 · DOI
  38. 10.1016/S0002-9343(96)00194-5 · DOI
  39. 10.1001/archinte.156.19.2221 · DOI
  40. 10.1161/01.STR.19.1.15 · DOI
  41. 10.1016/0002-9343(82)90850-6 · DOI
  42. Sandler G, 1959, QJM, 28, 347
  43. 10.1056/NEJM199803123381103 · DOI
  44. 10.1210/jc.83.7.2607 · DOI
  45. 10.1210/jc.85.1.159 · DOI
  46. 10.1056/NEJM197701062960101 · DOI
  47. 10.1210/jc.85.5.1822 · DOI
  48. 10.1111/j.0954-6820.1983.tb03724.x · DOI
  49. 10.1016/S0033-0620(61)90004-4 · DOI
  50. Vanderpump MPJ, Tunbridge WMG. The epidemiology of thyroid diseases. In: Braverman LE, Utiger RD, eds. Werner & Ingbar's the thyroid: a fundamental and clinical text. 8th ed. Philadelphia: Lippincott Williams & Wilkins, 2000:467-73.
  51. Forfar JC, 1985, QJM, 224, 857
  52. 10.1210/jc.84.6.2064 · DOI · Paper page
  53. Hak AE, 2000, Ann Intern Med, 132, 270, 10.7326/0003-4819-132-4-200002150-00004 · DOI · Paper page
  54. Wiersinga WM. Amiodarone and the thyroid: In: Weetmen AP, Grossman A, eds. Pharmacotherapeutics of the thyroid gland. Vol. 128 of Handbook of experimental pharmacology. Berlin, Germany: Springer-Verlag, 1997:225-87. · DOI
  55. Harjai KJ, 1997, Ann Intern Med, 126, 63, 10.7326/0003-4819-126-1-199701010-00009 · DOI
  56. 10.1210/jc.81.8.2930 · DOI
  57. 10.1001/archinte.144.3.487 · DOI
  58. Franklyn JA, 1984, Clin Sci (Colch), 67, 585, 10.1042/cs0670585 · DOI
  59. 10.1016/0735-1097(90)90462-X · DOI
  60. 10.1016/S0002-9149(97)00940-5 · DOI
  61. 10.1016/S0002-9149(97)00950-8 · DOI
  62. 10.1210/jc.84.1.151 · DOI · Paper page
  63. Katzeff HL, 1997, Am J Physiol, 273, E951
  64. 10.1016/0003-4975(91)91416-S · DOI
  65. 10.1159/000177147 · DOI
  66. 10.1016/S0022-5223(97)70222-8 · DOI
  67. 10.1016/0003-4975(96)00102-6 · DOI
  68. 10.1016/S0022-5223(99)70249-7 · DOI
  69. 10.1001/jama.275.9.687 · DOI
  70. 10.1203/00006450-199703000-00012 · DOI
  71. 10.3109/14017439609107243 · DOI
  72. 10.1111/j.1540-8191.1994.tb00851.x · DOI
  73. Mainwaring RD, 2000, Circulation, 101, 1423, 10.1161/01.CIR.101.12.1423 · DOI
  74. 10.1067/mtc.2000.108900 · DOI
  75. 10.1016/S0140-6736(00)02576-9 · DOI
  76. 10.1016/S0002-9149(99)00513-5 · DOI

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Metadata

Authors
Klein, I., & Ojamaa, K.
Affiliations
North Shore University Hospital (US)
ORCID
Ojamaa, Kaie
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2001-02-15
Volume
344
Issue
7
Pages
501-509
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm200102153440707
OpenAlex
W2325705904
Cited by
2,300
References
12
Citations by year
2026: 48 · 2025: 61 · 2024: 92 · 2023: 101 · 2022: 96 · 2021: 79 · 2020: 105 · 2019: 89 · 2018: 87 · 2017: 117 · 2016: 96 · 2015: 132 · 2014: 103 · 2013: 112 · 2012: 87
FWCI
10.00
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
thyroid hormones, cardiovascular system, hyperthyroidism, hypothyroidism, cardiac hemodynamics, vascular system, heart disease, thyroid hormone replacement
MeSH terms
Amiodarone, Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Atrial Fibrillation, Heart, Heart Diseases, Heart Failure, Hemodynamics, Humans, Hyperthyroidism, Hypothyroidism, Myocardial Contraction, Thyroid Hormones, Thyroxine, Triiodothyronine

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