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Cited by 2,300Thyroid Disorders and TreatmentsHormonal and reproductive studiesCardiovascular Function and Risk Factors

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Thyroid hormone and the cardiovascular system.

Klein, Irwin, Ojamaa, Kaie·2001·New England Journal of Medicine
DOI 10.1056/nejm200102153440707
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Abstract

Thyroid hormone has many effects on the heart and vascular system.1 Many of the clinical manifestations of hyperthyroidism are due to the ability of thyroid hormone to alter cardiovascular hemodynamics.2 The hemodynamic effects of hypothyroidism are opposite to those of hyperthyroidism, although the clinical manifestations are less obvious. This review will integrate what is known about the mechanisms of thyroid hormone action on the heart25 with recent observations from both experimental and clinical studies of hyperthyroidism and hypothyroidism. We will also address the potential role of thyroid hormone treatment in patients with acute or chronic cardiac disease.Effects of . . .

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Metadata

Authors
Klein, I., & Ojamaa, K.
Affiliations
North Shore University Hospital (US)
ORCID
Ojamaa, Kaie
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2001-02-15
Volume
344
Issue
7
Pages
501-509
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm200102153440707
OpenAlex
W2325705904
Cited by
2,300
References
12
Citations by year
2026: 48 · 2025: 61 · 2024: 92 · 2023: 101 · 2022: 96 · 2021: 79 · 2020: 105 · 2019: 89 · 2018: 87 · 2017: 117 · 2016: 96 · 2015: 132 · 2014: 103 · 2013: 112 · 2012: 87
FWCI
10.00
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
thyroid hormones, cardiovascular system, hyperthyroidism, hypothyroidism, cardiac hemodynamics, vascular system, heart disease, thyroid hormone replacement
MeSH terms
Amiodarone, Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Atrial Fibrillation, Heart, Heart Diseases, Heart Failure, Hemodynamics, Humans, Hyperthyroidism, Hypothyroidism, Myocardial Contraction, Thyroid Hormones, Thyroxine, Triiodothyronine

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