Cited by 2,300Thyroid Disorders and TreatmentsHormonal and reproductive studiesCardiovascular Function and Risk Factors

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Thyroid hormone and the cardiovascular system.

Klein, Irwin, Ojamaa, Kaie·2001·New England Journal of Medicine

DOI 10.1056/nejm200102153440707

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Abstract

Thyroid hormone has many effects on the heart and vascular system.1 Many of the clinical manifestations of hyperthyroidism are due to the ability of thyroid hormone to alter cardiovascular hemodynamics.2 The hemodynamic effects of hypothyroidism are opposite to those of hyperthyroidism, although the clinical manifestations are less obvious. This review will integrate what is known about the mechanisms of thyroid hormone action on the heart25 with recent observations from both experimental and clinical studies of hyperthyroidism and hypothyroidism. We will also address the potential role of thyroid hormone treatment in patients with acute or chronic cardiac disease.Effects of . . .

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Authors: Klein, I., & Ojamaa, K.
Affiliations: North Shore University Hospital (US)
ORCID: Ojamaa, Kaie
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2001-02-15
Volume: 344
Issue: 7
Pages: 501-509
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm200102153440707
OpenAlex: W2325705904
Cited by: 2,300
References: 12
Citations by year: 2026: 48 · 2025: 61 · 2024: 92 · 2023: 101 · 2022: 96 · 2021: 79 · 2020: 105 · 2019: 89 · 2018: 87 · 2017: 117 · 2016: 96 · 2015: 132 · 2014: 103 · 2013: 112 · 2012: 87
FWCI: 10.00
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords: thyroid hormones, cardiovascular system, hyperthyroidism, hypothyroidism, cardiac hemodynamics, vascular system, heart disease, thyroid hormone replacement
MeSH terms: Amiodarone, Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Atrial Fibrillation, Heart, Heart Diseases, Heart Failure, Hemodynamics, Humans, Hyperthyroidism, Hypothyroidism, Myocardial Contraction, Thyroid Hormones, Thyroxine, Triiodothyronine

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Thyroid hormone and the cardiovascular system.

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