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Infection and Vaccine-Induced Neutralizing-Antibody Responses to the SARS-CoV-2 B.1.617 Variants
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To assess infection and vaccine-Induced Neutralizing-Antibody activity against the SARS-CoV-2 B.1.617.1 (or kappa) and B.1.617.2 (or delta) variants.
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“Of convalescent plasma samples, about 40% had 3-fold to 10-fold and 15% had >10-fold reduced neutralizing activity 100,122,234 .”
From The biological and clinical significance of emerging SARS-CoV-2 variants (2021) · cites this paper as [122]
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“Of plasma samples from recipients of an mRNA vaccine, approximately 55% had 3-fold to 10-fold and 5% had >10-fold reduced neutralizing activity 100,118,122,234 .”
From The biological and clinical significance of emerging SARS-CoV-2 variants (2021) · cites this paper as [122]
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Metadata
- Authors
- Edara, V.-V., Pinsky, B. A., Suthar, M. S., Lai, L., Davis-Gardner, M. E., Floyd, K., Flowers, M. W., Wrammert, J., Hussaini, L., Ciric, C. R., Bechnak, S., Stephens, K., Graham, B. S., Bayat Mokhtari, E., Mudvari, P., Boritz, E., Creanga, A., Pegu, A., Derrien-Colemyn, A., Henry, A. R., Gagne, M., Douek, D. C., Sahoo, M. K., Sibai, M., Solis, D., Webby, R. J., Jeevan, T., & Fabrizio, T. P.
- Affiliations
- Emory University (US)
- Stanford Medicine (US)
- National Institute of Allergy and Infectious Diseases (US)
- National Institute of Allergy and Infectious Diseases, Bethesda, MD
- St. Jude Children's Research Hospital (US)
- Corresponding author
- Suthar, Mehul S.
- ORCID
- Edara, Venkata-Viswanadh
- Pinsky, Benjamin A.
- Suthar, Mehul S.
- Lai, Lilin
- Davis-Gardner, Meredith E.
- Floyd, Katharine
- Flowers, Maria W.
- Wrammert, Jens
- Graham, Barney S.
- Mudvari, Prakriti
- Boritz, Eli
- Creanga, Adrian
- Pegu, Amarendra
- Derrien-Colemyn, Alexandrine
- Gagne, Matthew
- Douek, Daniel C.
- Sahoo, Malaya K.
- Solis, Daniel
- Webby, Richard J.
- Fabrizio, Thomas P.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2021-08-12
- Volume
- 385
- Issue
- 7
- Pages
- 664-666
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC8279090
- OpenAlex
- W3182882252
- Cited by
- 328
- References
- 5
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 31 · 2023: 62 · 2022: 129 · 2021: 95
- FWCI
- 25.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ImmPort
- Funders
- Massachusetts General Hospital
- National Institutes of Health (NIH P51 OD011132, P51OD011132)
- National Cancer Institute (U54CA260563)
- National Institute of Allergy and Infectious Diseases (75N93021C00016, HHSN272201400004C, U19AI057266)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- SARS-CoV-2, Delta variant, Omicron variant, neutralizing antibodies, vaccine-induced immunity, natural infection, COVID-19 vaccines
- MeSH terms
- Immunogenicity, Vaccine, COVID-19, SARS-CoV-2, COVID-19 Vaccines, BNT162 Vaccine, 2019-nCoV Vaccine mRNA-1273, Antibodies, Viral, Humans, Antibodies, Neutralizing
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