The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index; 1 of the 20 sources its claims cite were checked for support.
Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy
Open accessAbstract
BACKGROUND: Diabetic nephropathy is the leading cause of end-stage renal disease. Interruption of the renin-angiotensin system slows the progression of renal disease in patients with type 1 diabetes, but similar data are not available for patients with type 2, the most common form of diabetes. We assessed the role of the angiotensin-II-receptor antagonist losartan in patients with type 2 diabetes and nephropathy. METHODS: A total of 1513 patients were enrolled in this randomized, double-blind study comparing losartan (50 to 100 mg once daily) with placebo, both taken in addition to conventional antihypertensive treatment (calcium-channel antagonists, diuretics, alpha-blockers, beta-blockers, and centrally acting agents), for a mean of 3.4 years. The primary outcome was the composite of a doubling of the base-line serum creatinine concentration, end-stage renal disease, or death. Secondary end points included a composite of morbidity and mortality from cardiovascular causes, proteinuria, and the rate of progression of renal disease. RESULTS: A total of 327 patients in the losartan group reached the primary end point, as compared with 359 in the placebo group (risk reduction, 16 percent; P=0.02). Losartan reduced the incidence of a doubling of the serum creatinine concentration (risk reduction, 25 percent; P=0.006) and end-stage renal disease (risk reduction, 28 percent; P=0.002) but had no effect on the rate of death. The benefit exceeded that attributable to changes in blood pressure. The composite of morbidity and mortality from cardiovascular causes was similar in the two groups, although the rate of first hospitalization for heart failure was significantly lower with losartan (risk reduction, 32 percent; P=0.005). The level of proteinuria declined by 35 percent with losartan (P<0.001 for the comparison with placebo). CONCLUSIONS: Losartan conferred significant renal benefits in patients with type 2 diabetes and nephropathy, and it was generally well tolerated.
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In the paper
“In this regard, it should be noted that in related studies in patients with type 1 and type 2 diabetes, 1,28,29 the benefits of captopril or irbesartan were not tested in the presence of concurrent calcium-channel-antagonist therapy.”
What the sources say
- Not checked — no full text of the sourcecites [1] source
- Supportedcites [28] source
The Randomization and Treatment Plan states that calcium-channel blockers were discontinued before screening and excluded as additional antihypertensive treatment. Irbesartan and the calcium-channel blocker amlodipine were assigned as separate regimens, so this type 2 diabetes study did not test irbesartan's benefit with concurrent calcium-channel-blocker therapy. The captopril study in type 1 diabetes is covered by the sentence's other citations, not this source. (LLM, conf=0.92)
- Not checked — no full text of the sourcecites [29] source
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The level of proteinuria declined by 35 percent with losartan (P<0.001 for the comparison with placebo).”
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Losartan also reduced the risk of end-stage renal disease by 28 percent (P=0.002)”
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“according to the per-protocol analysis, among the patients who continued to receive their assigned study treatment, losartan conferred a 22 percent reduction in the risk of the primary composite end point (P=0.008).”
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“We did find a significant difference in favor of losartan with regard to the rate of a first hospitalization for heart failure, a component of this secondary composite end point.”
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The risk of the combined end point of end-stage renal disease or death was 20 percent lower in the losartan group than in the placebo group (P=0.01)”
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In this population, losartan (plus conventional antihypertensive therapy) demonstrated excellent tolerability, similar to that of placebo (plus conventional antihypertensive therapy), as evidenced by the similar numbers of patients in the two groups in whom the study treatment was discontinued because of adverse events.”
Strength:boosted· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Treatment with losartan resulted in a 16 percent reduction in the risk of the primary composite end point (P= 0.02)”
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesThe paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Similarly, simultaneous therapy with calcium-channel antagonists did not detract from the beneficial effects of losartan, despite the recent controversy regarding the role of calcium-channel antagonists in the protection of the kidneys and the heart. 25-27”
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Approximately one third of the patients had a fatal or nonfatal cardiovascular event (247 in the losartan group [32.9 percent] and 268 in the placebo group [35.2 percent]; risk reduction, 10 percent; P=0.26).”
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes
- It may state two separate claims as one. 14
- Probably not a substantial claim. 16
- The quote only partly states this claim. 1
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“There was a difference between the number of myocardial infarctions in the losartan group (50 patients [6.7 percent]) and the number in the placebo group (68 patients [8.9 percent]; risk reduction, 28 percent), but this difference was not statistically significant (P=0.08).”
Strength:plain· not yet calibratedn = 50Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“There was a small, time-averaged difference in the trough blood pressure between the losartan group”
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. The quote only partly states this claim.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Approximately 20 percent of the patients died, but there was no significant difference in mortality between the two groups (P=0.88).”
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Losartan also led to an average reduction in the level of proteinuria (the urinary albumin-to-creatinine ratio) of 35 percent, whereas in the patients in the placebo group, the urinary albumin-to-creatinine ratio tended to increase (P<0.001 for the overall treatment effect) (Fig. 3).”
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“mean arterial pressure, 95.9 mm Hg and 96.8 mm Hg, respectively [P=0.59]; pulse pressure, 66.7 mm Hg and 67 .4 mm Hg, respectively [P= 0.77]”
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“mean arterial pressure, 99.1 mm Hg and 99.7 mm Hg, respectively [P= 0.38]; pulse pressure, 66.2 mm Hg and 67 .1 mm Hg, respectively [P=0.37]”
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“mean arterial pressure, 100.9 mm Hg and 103.1 mm Hg, respectively [P<0.001]; pulse pressure, 67 .8 mm Hg and 69.8 mm Hg, respectively [P=0.05]”
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“There were no significant differences in the rates of most of the cardiovascular end points; the exception was the first hospitalization with heart failure (89 patients in the losartan group [11.9 percent], as compared with 127 in the placebo group [16.7 percent]), for which the risk was reduced by 32 percent (P=0.005)”
- Also stated in: § A BSTRACT · p. 1 · plain
“although the rate of first hospitalization for heart failure was significantly lower with losartan (risk reduction, 32 percent; P=0.005)”
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
- Also stated in: § A BSTRACT · p. 1 · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“At base line, 93.5 percent of the patients (92.3 percent in the losartan group and 94.6 percent in the placebo group) were receiving antihypertensive therapy.”
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The benefits of losartan were observed among our patients, many of whom were already receiving other therapies, such as aspirin, beta-blockers, and lipidlowering agents, as part of sound medical practice.”
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Increased serum concentrations of creatinine or potassium led to the discontinuation of the study medication in 1.5 percent and 1.1 percent, respectively, of the patients in the losartan group, as compared with 1.2 percent and 0.5 percent of the patients in the placebo group.”
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Analyses of the primary and secondary end points were performed according to the intention-to-treat principle; we included data from all randomized patients (with the exception of three patients who were lost to follow-up), from the time of randomization through the date of study termination.”
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“An independent end-points committee whose members were unaware of the patients' treatment assignments reviewed the data to determine which patients had reached the end points.”
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“More patients discontinued the study treatment in the placebo group (53.5 percent) than in the losartan group (46.5 percent).”
Strength:plain· not yet calibratedn = 1,513Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan Study was an investigator-initiated, multinational, double-blind, randomized, placebo-controlled study designed to evaluate the renoprotective effects of losartan in 1513 patients with type 2 diabetes and nephropathy.”
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“Because one interim analysis used a stopping boundary that was based on an alpha spending function of the O'Brien-Fleming type, 10 a critical P value of 0.048 was required for the primary hypothesis.”
What the sources say
- Not checked — no full text of the sourcecites [10] source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“In a second, per-protocol analysis, we excluded patients who violated the criteria for inclusion and exclusion and censored patients' data 14 days after they permanently discontinued the study medication.”
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The study protocol was approved by the institutional review board of each center, and all patients gave written informed consent.”
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“However, the study was discontinued early (February 10, 2001) by a unanimous vote of the steering committee, whose members were unaware of the treatment assignments.”
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“We cannot exclude the possibility that this small difference had a beneficial effect on the renal outcomes.”
Strength:hedged· not yet calibratedCausal:conditional· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“The Heart Outcomes Prevention Evaluation (HOPE) Study 32 and its substudy of patients with diabetes, MICRO-HOPE, 20 showed benefits of angiotensin-I-converting enzyme inhibition in terms of the signs and symptoms of heart failure but failed to show significant differences in hospitalizations for heart failure.”
What the sources say
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Previous studies involving angiotensin-I-converting enzyme inhibitors have demonstrated beneficial effects on proteinuria but have not demonstrated the superiority of blockade of the renin-angiotensin system in slowing the progression to end-stage renal disease over nonblockade forms of therapy. 14-20”
What the sources say
- Not matchedcites [14] Walker WG, 1992, J Am Soc Nephrol
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites [15] source
- Not checked — no full text of the sourcecites [16] source
- Not checked — no full text of the sourcecites [17] source
- Not checked — no full text of the sourcecites [18] source
- Not checked — no full text of the sourcecites [19] Estacio RO, 2000, Diabetes Care
- Not checked — no full text of the sourcecites [20] source
Load-bearingStrength:boosted· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Not matched
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, in the absence of a direct comparison between angiotensin-I-converting enzyme inhibitors and angiotensin II antagonists, any extrapolation from the results obtained with different classes of drugs is speculative at best.”
Strength:plain· not yet calibratedTests✓ Asserted: passes✗ Checkable: fails✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. It may be too vague to check against evidence. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“We were able to determine the status of all patients (except for three patients in the losartan group who could not be contacted) with respect to dialysis, transplantation, and death.”
Strength:plain· not yet calibratedn = 3Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Subsequent hospitalizations for heart failure were not assessed.”
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“In addition, the Cox model accounts for the base-line level of proteinuria (which was a stratification factor) and the geographic region, as prespecified in the data analysis plan.”
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The difference results in part from the fact that the Cox regression model accounts for the time at risk - i.e., the longer average follow-up in the losartan group than in the placebo group.”
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
The paper relies on this without support.
Diabetic nephropathy is the leading cause of end-stage renal disease.
“Diabetic nephropathy is the leading cause of end-stage renal disease.”
The paper relies on this without support.
Type 2 diabetes is the most common form of diabetes.
“type 2, the most common form of diabetes”
The paper relies on this without support.
Similar data on interruption of the renin-angiotensin system are not available for patients with type 2 diabetes.
“similar data are not available for patients with type 2, the most common form of diabetes”
The paper relies on this without support.
Postponing end-stage renal disease in patients with type 2 diabetes remains an elusive goal.
“postponing end-stage renal disease in patients with type 2 diabetes, the leading cause of chronic renal failure in many countries, remains an elusive goal”
The paper relies on this without support.
Type 2 diabetes is the leading cause of chronic renal failure in many countries.
“type 2 diabetes, the leading cause of chronic renal failure in many countries”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“In the IDNT trial, treatment with irbesartan compared with placebo resulted in a 33% decrease in the risk of doubling of serum creatinine concentration and was associated with a nonsigni fi cant reduction in the incidence of kidney failure, which was independent of blood pressure.”
From KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease (2022) · cites this paper as [13]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Antihypertensive therapy reduces the risk of albuminuria (67)(68)(69)(70), and among people with type 1 or 2 diabetes with established CKD (eGFR <60 mL/min/1.73m 2 and UACR $300 mg/g creatinine), ACE inhibitor or ARB therapy reduces the risk of progression to ESKD (71)(72)(73)(74)(75)(76)(77)(78)(79)(80).”
From 11. Chronic Kidney Disease and Risk Management: Standards of Care in Diabetes—2025 (2025) · cites this paper as [71]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Treatment with angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) has been shown to prevent major adverse kidney outcomes in people with diabetes, and these drugs are recommended by clinical practice guidelines for the treatment of people with type 2 diabetes who have, or are at high risk of, kidney disease.[4][5][6][7][8]”
From SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis (2019) · cites this paper as [6]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The only currently approved treatment for renoprotection in patients with type 2 diabetes is reninangiotensin system blockade, which was first shown to be effective 18 years ago.3,4”
From Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy (2019) · cites this paper as [3]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“However, a sustained ≥57% decrease in eGFR (equivalent to doubling of serum creatinine) was selected in FIDELITY because it is a classic outcome in diabetic nephropathy studies2 , 12–14 and is a more robust kidney failure surrogate outcome than a ≥40% decrease in eGFR, particularly when initial changes in eGFR occur.14 , 15”
From Cardiovascular and kidney outcomes with finerenone in patients with type 2 diabetes and chronic kidney disease: the FIDELITY pooled analysis (2022) · cites this paper as [13]
Experimental — accuracy not yet measured
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Antihypertensive therapy reduces the risk of albuminuria (68-71), and among people with type 1 or 2 diabetes with established CKD (eGFR <60 mL/min/1.73m 2 and UACR ≥300 mg/g creatinine), ACE inhibitor or ARB therapy reduces the risk of progression to kidney failure (72)(73)(74)(75)(76)(77)(78)(79)(80)(81).”
From 11. Chronic Kidney Disease and Risk Management: Standards of Care in Diabetes—2026 (2026) · cites this paper as [72]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“ACE inhibitors or ARBs are the preferred first-line agents for blood pressure treatment among people with diabetes, hypertension, eGFR <60 mL/min/1.73m 2 , and UACR ≥300 mg/g creatinine because of their proven benefits for prevention of CKD progression (72,73,75).”
From 11. Chronic Kidney Disease and Risk Management: Standards of Care in Diabetes—2026 (2026) · cites this paper as [72]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This recommendation is based on RCTs where findings demonstrated decreased risk of CKD progression, for which patients with albuminuria are at elevated risk, with a maximally dosed RAS inhibitor compared with placebo or an active antihypertensive drug comparator (42–44).”
From Diabetes management in chronic kidney disease: a consensus report by the American Diabetes Association (ADA) and Kidney Disease: Improving Global Outcomes (KDIGO) (2022) · cites this paper as [42]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“In patients with diabetic kidney disease with increased levels of albuminuria, large placebo-controlled trials have shown that renin-angiotensin system (RAS) inhibitors,3–5 sodium-glucose cotransporter 2 (SGLT2) inhibitors,6,7 and the non-steroidal mineralocorticoid receptor antagonist finerenone8,9 all reduced the risk of progression to kidney failure.”
From Empagliflozin in Patients with Chronic Kidney Disease (2023) · cites this paper as [3]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“In the IDNT trial, treatment with irbesartan compared with placebo resulted in a 33% decrease in the risk of doubling of serum creatinine concentration and was associated with a nonsigni fi cant reduction in the incidence of kidney failure, which was independent of blood pressure.”
From KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease (2022) · cites this paper as [13]
Experimental — accuracy not yet measuredIn the citing paper
“For many years, the only agents that had demonstrated benefit in slowing kidney disease progression were the renin angiotensin aldosterone system blockers of angiotensin-converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARBs) [11], [12], [13].”
From Glucagon-like peptide-1 receptor agonists in diabetic kidney disease: a review of their kidney and heart protection (2023) · cites this paper as [11]
In the citing paper
“ARBs (irbesartan/telmisartan) also slowed progression from microalbuminuria (albuminuria stage A2) to overt nephropathy.708,709”
From 2023 ESC guidelines for the management of cardiovascular disease in patients with diabetes. (2023) · cites this paper as [708]
In the citing paper
“Antagonism of the RAAS with ACE inhibitors or AngII receptor blockers also attenuates, but may not completely halt, the progression of kidney injury in patients with obesity, hypertension and T2DM67,68.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [67]
In the citing paper
“Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARB)s improve endothelium-dependent vasodilation and reduce morbidity and mortality in heart failure and nephropathy, including diabetic nephropathy.218-221”
From The Vasculature in Prediabetes (2018) · cites this paper as [219]
In the citing paper
“Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARB)s improve endothelium-dependent vasodilation and reduce morbidity and mortality in heart failure and nephropathy, including diabetic nephropathy.218-221”
From The Vasculature in Prediabetes (2018) · cites this paper as [219]
In the citing paper
“ARBs have also been shown to reduce the rate of progression from micro- to macroalbuminuria as well as ESRD in patients with type 2 diabetes (234–236).”
From Standards of Medical Care in Diabetes—2009 (2009) · cites this paper as [235]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Mean follow-up of 3.4 years is not 42 months
MinorAt 12 months per year, 3.4 years is 40.8 months, not 42 months. Forty-two months is 3.5 years.
Reported 42 · recomputed 40.8
“The mean follow-up time was 3.4 years (42 months).”
Patients with prior heart failure were both excluded and included
MinorThe eligibility criteria excluded anyone with a history of heart failure before enrollment, but the paper later says 88 patients had preexisting heart failure at randomization. This affects the description of the population used for the heart-failure analysis.
“who had any history of heart failure before enrollment.”
“There were 88 patients (44 in each group) who had preexisting heart failure at the time of randomization.”
Citations
Cites
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer series in statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,239
Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
Regression Models and Life-Tables
Cox, D. R. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_37 · Cited by 26,297
Levey, A. S., Bosch, J. P., Lewis, J. B., Greene, T., Rogers, N., Roth, D., & for the Modification of Diet in Renal Disease Study Group* (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-6-199903160-00002 · Cited by 15,079
(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420301 · Cited by 8,663
The SOLVD Investigators* (1991) · New England Journal of Medicine · doi:10.1056/nejm199108013250501 · Cited by 8,029
Lewis, E. J., Hunsicker, L. G., Clarke, W. R., Berl, T., Pohl, M. A., Lewis, J. B., Ritz, E., Atkins, R. C., Rohde, R., & Raz, I. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011303 · Cited by 5,987
The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy
Lewis, E. J., Hunsicker, L. G., Bain, R. P., & Rohde, R. D. (1993) · New England Journal of Medicine · doi:10.1056/nejm199311113292004 · Cited by 5,394
(1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271003 · Cited by 3,725
Flagged first, then by citations
Research works printed but not linked: 5
- Black HR, 1999, J Hypertens, 17, S3
- Levey AS, 2000, J Am Soc Nephrol, 11, 155A
- Walker WG, 1992, J Am Soc Nephrol, 3, 339
- Estacio RO, 2000, Diabetes Care, 23, B54
- Bauer JH, Reams GP. Antihypertensive drugs. In: Brenner BM, ed. The kidney. 6th ed. Philadelphia: W.B. Saunders, 2000:2253-97.
Cited by
Sorted by citations
Items 1,201–1,300 of 7,495
Battisti, W. P., Palmisano, J. J., & Keane, W. F. (2003) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2003.181 · Cited by 78
Self-citationSome issues with composite endpoints in clinical trials
Chi, G. Y. H. (2005) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2005.00370.x · Cited by 79
Systems biology of kidney diseases
He, C., Chuang, P. Y., Ma’ayan, A., & Iyengar, R. (2011) · Kidney International · doi:10.1038/ki.2011.314 · Cited by 81
Somaratne, J., WHALLEY, G. A., Poppe, K., ter Bals, M. M., Wadams, G., Pearl, A., Bagg, W., & Doughty, R. N. (2011) · Cardiovascular Diabetology · doi:10.1186/1475-2840-10-29 · Cited by 78
Guías de práctica clínica para el tratamiento de la hipertensión arterial 2007
(ESH), G. D. T. P. E. T. D. L. H. A. D. L. S. E. D. H., & de Cardiología, D. L. S. E. (2007) · Revista Española de Cardiología · doi:10.1157/13109650 · Cited by 79
Antifibrotic Effect of Tamoxifen in a Model of Progressive Renal Disease
Dellê, H., da Rocha, J. R. C., Cavaglieri, R. C., Vieira, J. M., Malheiros, D. M. A. C., & Noronha, I. L. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011010046 · Cited by 81
Chang, C., Lin, J., Wu, L., & Lai, M. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.35.1908 · Cited by 80
Cerasola, G., Cottone, S., & Mulè, G. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e32833ec377 · Cited by 79
Croom, K. F., Curran, M. P., Goa, K. L., & Perry, C. M. (2004) · Drugs · doi:10.2165/00003495-200464090-00011 · Cited by 80
Şengül, A. M., Altuntaş, Y., Kürklü, A., & Aydın, L. (2005) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2005.06.010 · Cited by 79
Cytosine methylation predicts renal function decline in American Indians
Qiu, C., Hanson, R. L., Fufaa, G. D., Kobes, S., Gluck, C. A., Huang, J. Y., Chen, Y., Raj, D. S., Nelson, R. G., Knowler, W. C., et al. (2018) · Kidney International · doi:10.1016/j.kint.2018.01.036 · Cited by 78
The Story of the Silent Killer
Kalehoff, J. P., & Oparil, S. (2020) · Current Hypertension Reports · doi:10.1007/s11906-020-01077-7 · Cited by 89
Nelson, A. J., O’Brien, E. C., Kaltenbach, L. A., Green, J. B., Lopes, R. D., Morse, C. G., Al-Khalidi, H. R., Aroda, V. R., Cavender, M. A., Gaynor, T., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.48030 · Cited by 78
Satirapoj, B. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5441-0_11 · Cited by 79
Trends in advanced glycation end products research in diabetes mellitus and its complications
Méndez, J. D., Xie, J., Aguilar-Hernández, M., & Méndez-Valenzuela, V. (2010) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-010-0434-5 · Cited by 81
Cardiovascular disease in chronic kidney disease from a cardiologistʼs perspective
McCullough, P. A. (2004) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200411000-00003 · Cited by 78
Lercanidipine in Patients with Chronic Renal Failure: The ZAFRA Study
Robles, N. R., Ocón, J., Gomez, C. F., Manjón, M., Pastor, L., Herrera, J., Villatoro, J., Calls, J., Torrijos, J., Rodríguez, V. I., et al. (2005) · Renal Failure · doi:10.1081/jdi-200042801 · Cited by 78
The Protective Effect of Fucoidan in Rats with Streptozotocin-Induced Diabetic Nephropathy
Wang, J., Liu, H., Li, N., Zhang, Q., & Zhang, H. (2014) · Marine Drugs · doi:10.3390/md12063292 · Cited by 78
Sarafidis, P. A., & Ruilope, L. M. (2013) · Kidney International · doi:10.1038/ki.2013.355 · Cited by 75
Kramer, A. B., van den Hoven, M. J. W., Rops, A. L. W. M. M., Wijnhoven, T. J. M., van den Heuvel, L., Lensen, J. F. M., Kuppevelt, T. H. V., van Goor, H., van der Vlag, J., Navis, G. J., et al. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006020184 · Cited by 78
Update on microalbuminuria as a biomarker in renal and cardiovascular disease
Heerspink, H. J. L., Brinkman, J. W., Bakker, S. J. L., Gansevoort, R. T., & de Zeeuw, D. (2006) · Current Opinion in Nephrology & Hypertension · doi:10.1097/01.mnh.0000247496.54882.3f · Cited by 78
Effects of dual blockade of the renin-angiotensin system in primary proteinuric nephropathies
Luño, J., Barrio, V., Goicoechea, M. Á., González, C., de Vinuesa, S. G., Gómez-Preciado, F., Bernis, C., Espinosa, M., Ahijado, F. J., Gómez, J., et al. (2002) · Kidney International · doi:10.1046/j.1523-1755.62.s82.10.x · Cited by 78
Riedl, E., Koeppel, H., Brinkkoetter, P. T., Sternik, P., Steinbeißer, H., Sauerhoefer, S., Janssen, B. J., van der Woude, F. J., & Yard, B. A. (2007) · Diabetes · doi:10.2337/db07-0128 · Cited by 78
McBrien, K., Manns, B., Chui, B. K., Klarenbach, S. W., Rabi, D. M., Ravani, P., Hemmelgarn, B. R., Wiebe, N., Au, F., & Clement, F. M. (2012) · Diabetes Care · doi:10.2337/dc12-0862 · Cited by 77
Human Kidney Tubule-Specific Gene Expression Based Dissection of Chronic Kidney Disease Traits
Beckerman, P., Qiu, C., Park, J., Ledó, N., Ko, Y.-A., Park, A. S. D., Han, S. Y., Choi, P., Palmer, M., & Suszták, K. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.09.014 · Cited by 77
Khodja, I. A., Boulebd, H., Bensouıcı, C., & Ali Belfaitah, A. (2020) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2020.128527 · Cited by 77
Nagaraj, S. B., Pena, M. J., Ju, W., & Heerspink, H. J. L. (2020) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14178 · Cited by 80
Thomson, S. C., & Vallon, V. (2021) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00552.2020 · Cited by 75
González‐Pérez, A., Sáez, M. E., Vizcaya, D., Lind, M., & Rodríguez, L. G. (2021) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2021-002146 · Cited by 83
Cardiovascular Disease in Diabetes and Chronic Kidney Disease
Swamy, S., Noor, S. M., & Mathew, R. O. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12226984 · Cited by 88
Contemporary pharmacological treatment and management of heart failure
Bozkurt, B. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-024-00997-0 · Cited by 86
Judge, P. K., Tuttle, K. R., Staplin, N., Hauske, S. J., Zhu, D., Sardell, R. J., Cronin, L., Green, J. B., Agrawal, N., Arimoto, R., et al. (2024) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfae263 · Cited by 84
Microalbuminuria in Type 2 Diabetics: An Important, Overlooked Cardiovascular Risk Factor
Weir, M. R. (2004) · Journal of Clinical Hypertension · doi:10.1111/j.1524-6175.2004.02524.x · Cited by 77
Yokota, K., Fukuda, M., Matsui, Y., Hoshide, S., Shimada, K., & Kario, K. (2012) · Hypertension Research · doi:10.1038/hr.2012.145 · Cited by 77
Does the use of ACE inhibitors or angiotensin receptor blockers affect bone loss in older men?
Kwok, T. C. Y., Leung, J. C. S., Zhang, Y. F., et al. (2011) · Osteoporosis International · doi:10.1007/s00198-011-1831-7 · Cited by 77
Haynes, R., Staplin, N., Emberson, J., Herrington, W. G., Tomson, C., Agodoa, L. Y. C., Tesař, V., Levin, A., Lewis, D., Reith, C. A., et al. (2014) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2013.12.013 · Cited by 82
McMullan, C. J., Heerspink, H. J. L., Parving, H., Dwyer, J. P., Forman, J. P., & de Zeeuw, D. (2014) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2014.06.008 · Cited by 78
Self-citationCo-clustering phenome–genome for phenotype classification and disease gene discovery
Hwang, T., Atluri, G., Xie, M., Dey, S., Hong, C., Kumar, V., & Kuang, R. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks615 · Cited by 77
Nutahara, K., Higashihara, E., Horie, S., et al. (2005) · Nephron Clinical Practice · doi:10.1159/000081790 · Cited by 77
Mima, A., Arai, H., Matsubara, T., Abe, H., Nagai, K., Tamura, Y., Torikoshi, K., Araki, M., Kanamori, H., Takahashi, T., et al. (2008) · Diabetes · doi:10.2337/db07-1726 · Cited by 77
Xie, D., Joffe, M. M., Brunelli, S. M., Beck, G. J., Chertow, G. M., Fink, J. C., Greene, T., Hsu, C., Kusek, J. W., Landis, J. R., et al. (2008) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.05631207 · Cited by 77
Revisiting RAAS blockade in CKD with newer potassium-binding drugs
Georgianos, P. I., & Agarwal, R. (2017) · Kidney International · doi:10.1016/j.kint.2017.08.038 · Cited by 78
Histone Deacetylase Inhibitors and Diabetic Kidney Disease
Hadden, M. J., & Advani, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092630 · Cited by 79
on behalf of the ADVANCE Collaborative Group, Oshima, M., Jun, M., Ohkuma, T., Toyama, T., Wada, T., Cooper, M. E., Hadjadj, S., Hamet, P., Harrap, S. B., et al. (2019) · Diabetologia · doi:10.1007/s00125-019-4948-4 · Cited by 82
Self-citationEllis, D., Vats, A. N., Moritz, M. L., Reitz, S., Grosso, M. J., & Janosky, J. E. (2003) · The Journal of Pediatrics · doi:10.1016/s0022-3476(03)00279-8 · Cited by 77
Aranda, P. J., Segura, J., Ruilope, L. M., Aranda, F. J., Frutos, M. Á., López, V., & de Novales, E. L. (2005) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2005.08.034 · Cited by 76
Hypertension and cardiovascular risk assessment in dialysis patients
Locatelli, F., Covic, A. C., Chazot, C., Leunissen, K. M. L., Luño, J., & Yaqoob, M. (2004) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfh103 · Cited by 76
Therapeutic Potential of Renin Inhibitors in the Management of Cardiovascular Disorders
Stanton, A. V. (2003) · American Journal of Cardiovascular Drugs · doi:10.2165/00129784-200303060-00002 · Cited by 79
Damman, K., Solomon, S. D., Pfeffer, M. A., Swedberg, K., Yusuf, S., Young, J. B., Rouleau, J. L., Granger, C. B., & McMurray, J. J. V. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.609 · Cited by 75
“Thus, it seems clear from Val-HeFT, I-Preserve and CHARM that ARBs do not preserve renal function in patients with HFREF or HFPEF in contradistinction to patients with diabetic nephropathy.(15,16)”
ResultThe Kidney in Type 2 Diabetes Therapy
Heerspink, H. J. L., & de Zeeuw, D. (2011) · The Review of Diabetic Studies · doi:10.1900/rds.2011.8.392 · Cited by 71
Impact of kinins in the treatment of cardiovascular diseases
Regoli, D. C., Plante, G. E., & Gobeil, F. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.04.002 · Cited by 80
Sipahi, İ., Swaminathan, A. C., Natesan, V., Debanne, S. M., Simon, D. I., & Fang, J. C.-T. (2011) · Stroke · doi:10.1161/strokeaha.111.636829 · Cited by 77
Understanding the Mechanisms of Proteinuria: Therapeutic Implications
Toblli, J. E., Bevione, P., Gennaro, F. D., Madalena, L. B., Cao, G., & Angerosa, M. (2012) · International Journal of Nephrology · doi:10.1155/2012/546039 · Cited by 84
Treatment of hypertension in patients with coronary artery disease
Rosendorff, C., Lackland, D. T., Allison, M., Aronow, W. S., Black, H. R., Blumenthal, R. S., Cannon, C. P., de Lemos, J. A., Elliott, W. J., Findeiss, L., et al. (2015) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2015.03.002 · Cited by 79
Iino, Y., Hayashi, M., Kawamura, T., Shiigai, T., Tomino, Y., Yamada, K., KITAJIMA, T., Ideura, T., Kôyama, A., Sugisaki, T., et al. (2004) · Hypertension Research · doi:10.1291/hypres.27.21 · Cited by 76
Mizuno, M., Sada, T., Kato, M., & Koike, H. (2002) · Hypertension Research · doi:10.1291/hypres.25.271 · Cited by 76
A positive effect of AII inhibitors on peritoneal membrane function in long-term PD patients
Kolesnyk, I., Noordzij, M., Dekker, F. W., Boeschoten, E. W., & Krediet, R. T. (2008) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfn421 · Cited by 76
Tan, X., He, W., & Liu, Y. (2009) · Kidney International · doi:10.1038/ki.2009.346 · Cited by 75
The renin–angiotensin system contributes to renal fibrosis through regulation of fibrocytes
Sakai, N., Wada, T., Matsushima, K., Bucala, R., Iwai, M., Horiuchi, M., & Kaneko, S. (2008) · Journal of Hypertension · doi:10.1097/hjh.0b013e3282f3e9e6 · Cited by 75
Sourris, K. C., Morley, A. L., Koı̈tka, A., Samuel, P., Coughlan, M. T., Penfold, S. A., Thomas, M. C., Bierhaus, A., Nawroth, P. P., Yamamoto, H., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-1837-2 · Cited by 75
Self-citationShoji, T., Wada, A., Inoue, K., Hayashi, D., Tomida, K., Furumatsu, Y., Kaneko, T., Okada, N., Fukuhara, Y., Imai, E., et al. (2006) · Nephron Clinical Practice · doi:10.1159/000097985 · Cited by 75
Lai, P.-B., Zhang, L., & Yang, L. (2011) · Renal Failure · doi:10.3109/0886022x.2011.623564 · Cited by 75
Cardiovascular risk factors in patients with chronic kidney disease
van der Zee, S. A., Baber, U., Elmariah, S., Winston, J. A., & Fuster, V. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.121 · Cited by 82
Phisitkul, K., Hegazy, K., Chuahirun, T., Hudson, C., Wesson, D. E., Simoni, J. M., & Rajab, H. (2008) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e318156b799 · Cited by 75
Horita, Y., Taura, K., Taguchi, T., Furusu, A., & Kohno, S. (2006) · Nephrology · doi:10.1111/j.1440-1797.2006.00665.x · Cited by 75
Diabetes and Drug-Associated Hyperkalemia: Effect of Potassium Monitoring
Raebel, M. A., Ross, C. A., Xu, S., Roblin, D. W., Cheetham, C., Blanchette, C. M., Saylor, G., & Smith, D. H. (2010) · Journal of General Internal Medicine · doi:10.1007/s11606-009-1228-x · Cited by 75
Ceriello, A. (2006) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000245256.17764.fb · Cited by 75
Agarwal, R., Duffin, K. L., Laska, D. A., Voelker, J. R., Breyer, M. D., & Mitchell, P. G. (2014) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfu255 · Cited by 75
Increased urinary excretion of angiotensinogen is associated with risk of chronic kidney disease
Mills, K. T., Kobori, H., Hamm, L. L., Alper, A., Khan, I. E., Rahman, M., Navar, L. G., Liu, Y., Browne, G. M., Batuman, V., et al. (2012) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfs011 · Cited by 79
Twenty years after ACEIs and ARBs: emerging treatment strategies for diabetic nephropathy
Johnson, S. A., & Spurney, R. F. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00266.2015 · Cited by 76
Cardiorenal Syndrome in Western Countries: Epidemiology, Diagnosis and Management Approaches
Ronco, C., & Lullo, L. D. (2016) · Kidney Diseases · doi:10.1159/000448749 · Cited by 75
Recent advances in management of type 2 diabetes and nephropathy: Lessons from the RENAAL study
Keane, W. F., & Lyle, P. A. (2003) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2003.50078 · Cited by 75
Self-citationYamagishi, S., Takeuchi, M., Matsui, T., Nakamura, K., Imaizumi, T., & Inoue, H. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.06.058 · Cited by 76
Role of Anemia in Progression of Chronic Kidney Disease
Rossert, J., & Froissart, M. (2006) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2006.05.004 · Cited by 75
Wang, X., Lewis, J. B., Appel, L. J., Cheek, D., Contreras, G. N., Faulkner, M. L., Feldman, H. I., Gassman, J., Lea, J. P., Kopple, J. D., et al. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005101106 · Cited by 78
Fairbanks, L. D. (2002) · QJM · doi:10.1093/qjmed/95.9.597 · Cited by 75
Retarding the progression of renal disease
Brenner, B. M. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.t01-2-00052.x · Cited by 74
Self-citationImprovement of albuminuria after renal denervation
Ott, C., Mahfoud, F., Schmid, A., Ditting, T., Veelken, R., Ewen, S., Ukena, C., Uder, M., Böhm, M., & Schmieder, R. E. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.03.017 · Cited by 75
Chronic angiotensin (17) injection accelerates STZ-induced diabetic renal injury1
Shao, Y., He, M., Li, Z. H. O. U., Yao, T., Huang, Y., & Lü, L. (2008) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2008.00812.x · Cited by 74
Achievement of target blood pressure levels in chronic kidney disease: a salty question?
Nicola, L. D., Minutolo, R., Bellizzi, V., Zoccali, C., Cianciaruso, B., Andreucci, V. E., Fuíano, G., & Conte, G. (2004) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2004.01.009 · Cited by 74
Pavkov, M. E., Knowler, W. C., Bennett, P. H., Looker, H. C., Krakoff, J. A., & Nelson, R. G. (2006) · Kidney International · doi:10.1038/sj.ki.5001882 · Cited by 74
Yıldırım, T., Arıcı, M., Pişkinpaşa, S., Kutlugün, A. A., Yılmaz, R., Altun, B., Erdem, Y., & Turgan, Ç. (2012) · Renal Failure · doi:10.3109/0886022x.2012.717478 · Cited by 75
Kojima, S., Shida, M., & Yokoyama, H. (2004) · Hypertension Research · doi:10.1291/hypres.27.379 · Cited by 73
Calcineurin (CN) Activation Promotes Apoptosis of Glomerular Podocytes Both in Vitro and in Vivo
Wang, L., Chang, J., Paik, S.-Y., Tang, Y., Eisner, W., & Spurney, R. F. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-0029 · Cited by 74
The renin-angiotensin system and insulin resistance
Liu, Z. (2007) · Current Diabetes Reports · doi:10.1007/s11892-007-0007-5 · Cited by 76
Rodríguez-Ortiz, M. E., Pontillo, C., Rodríguez, M., Zürbig, P., Mischak, H., & Ortíz, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-34386-8 · Cited by 77
Angiotensin II stimulation of VEGF mRNA translation requires production of reactive oxygen species
Féliers, D., Gorin, Y. C., Ghosh-Choudhury, G., Abboud, H. E., & Kasinath, B. S. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00331.2005 · Cited by 75
Optimal Dose of Candesartan for Renoprotection in Type 2 Diabetic Patients With Nephropathy
Rossing, K., Christensen, P. K., Hansen, B. V., Carstensen, B., & Parving, H. (2003) · Diabetes Care · doi:10.2337/diacare.26.1.150 · Cited by 72
Self-citationEffects of Paricalcitol and Enalapril on Atherosclerotic Injury in Mouse Aortas
Husain, K. M., Suárez, E., Isidro, A., & Ferder, L. (2010) · American Journal of Nephrology · doi:10.1159/000319445 · Cited by 73
Comparison of Angiotensin II Type 1 Receptor Antagonists in the Treatment of Essential Hypertension
Smith, D. H. G. (2008) · Drugs · doi:10.2165/00003495-200868090-00003 · Cited by 72
Assogba, G. F. A., Couchoud, C., Roudier, C., Pornet, C., Fosse‐Edorh, S., Romon, I., Druet, C., Stengel, B., & Fagot‐Campagna, A. (2012) · Diabetes & Metabolism · doi:10.1016/j.diabet.2012.08.004 · Cited by 73
Association of heart rate with microalbuminuria in cardiovascular risk patients: data from I-SEARCH
Böhm, M., Reil, J., Danchin, N., Thoenes, M., Bramlage, P., & Volpe, M. (2008) · Journal of Hypertension · doi:10.1097/hjh.0b013e3282f05c8a · Cited by 73
Emerging therapies for chronic kidney disease: what is their role?
Vilayur, E., & Harris, D. C. H. (2009) · Nature Reviews Nephrology · doi:10.1038/nrneph.2009.76 · Cited by 73
Cardiovascular Disease and Diabetic Kidney Disease
Maqbool, M., Cooper, M. E., & Jandeleit-Dahm, K. A. M. (2018) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2018.02.003 · Cited by 73
Self-citationHostetter, T. H., Rosenberg, M. E., Ibrahim, H. N., & Juknevicius, I. (2001) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200101000-00016 · Cited by 72
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Metadata
- Authors
- Brenner, B. M., Cooper, M. E., de Zeeuw, D., Keane, W. F., Mitch, W. E., Parving, H.-H., Remuzzi, G., Snapinn, S. M., Zhang, Z., & Shahinfar, S.
- Affiliations
- Brigham and Women's Hospital (US)
- The University of Melbourne (AU)
- Hennepin County Medical Center (US)
- Emory University (US)
- Mario Negri Institute for Pharmacological Research (IT)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2001-09-20
- Volume
- 345
- Issue
- 12
- Pages
- 861-869
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2056976690
- Semantic Scholar
- 842bf4da2a50ee13464536c9dfa502f4eb80c5f1
- Cited by
- 7,493
- References
- 37
- Citations by year
- 2026: 180 · 2025: 233 · 2024: 211 · 2023: 248 · 2022: 235 · 2021: 240 · 2020: 263 · 2019: 204 · 2018: 212 · 2017: 233 · 2016: 243 · 2015: 249 · 2014: 289 · 2013: 288 · 2012: 341
- FWCI
- 280.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, public-domain)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Keywords
- losartan, type 2 diabetes, diabetic nephropathy, angiotensin receptor blockers, renin-angiotensin system blockade, end-stage renal disease, kidney disease progression, proteinuria, cardiovascular morbidity and mortality, heart failure hospitalization, serum creatinine doubling, antihypertensive therapy
- MeSH terms
- Adult, Aged, Antihypertensive Agents, Cardiovascular Diseases, Creatine, Creatinine, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Double-Blind Method, Female, Humans, Hypertension, Kidney Failure, Chronic, Male, Middle Aged, Proteinuria, Disease Progression, Losartan, Angiotensin Receptor Antagonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-16, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-16 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Cited sources are checked with a language model’s help (gpt-6-sol).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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