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Effect of Mutation Order on Myeloproliferative Neoplasms
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“Among the mutated genes driving competitive advantage and enhanced self-renewal is TET2, an epigenetic regulator commonly mutated in both CH and a wide range of myeloid malignancies”
From A scalable in vitro cell competition model identifies preleukemic super competitor clones (2026) · cites this paper as Ortmann et al, 2015
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Cites
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Mutation in TET2 in Myeloid Cancers
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Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2
Nangalia, J., Massie, C. E., Baxter, E. J., Nice, F. L., Gundem, G., Wedge, D. C., Avezov, E., Li, J., Kollmann, K., Kent, D. G., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1312542 · Cited by 1,756
Self-citationTet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
Moran-Crusio, K., Reavie, L., Shih, A., Abdel-Wahab, O., Ndiaye-Lobry, D., Lobry, C., Figueroa, M. E., Vasanthakumar, A., Patel, J., Zhao, X., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.06.001 · Cited by 1,339
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Williams, N., Lee, J., Mitchell, E., Moore, L., Baxter, E. J., Hewinson, J., Dawson, K. J., Menzies, A., Godfrey, A. L., Green, A. R., et al. (2022) · Nature · doi:10.1038/s41586-021-04312-6 · Cited by 285
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High prevalence of focal and multi-focal somatic genetic variants in the human brain
Keogh, M. J., Wei, W., Aryaman, J., Walker, L., van den Ameele, J., Coxhead, J., Wilson, I., Bashton, M., Beck, J., West, J., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06331-w · Cited by 74
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A scalable in vitro cell competition model identifies preleukemic super competitor clones
Cabrera-Cosme, L., Rubio-Lara, J. A., Bennett, E., Miłek, J., Baldreki, C., Dowle, A., Vijayabaskar, M. S., Davies, S. J., Taylor-Smith, E., Bain, F. M., et al. (2026) · doi:10.64898/2026.10.21.760611
Self-citation
Metadata
- Authors
- Ortmann, C. A., Kent, D. G., Nangalia, J., Silber, Y., Wedge, D. C., Grinfeld, J., Baxter, E. J., Massie, C. E., Papaemmanuil, E., Menon, S., Godfrey, A. L., Dimitropoulou, D., Guglielmelli, P., Bellosillo, B., Besses, C., Döhner, K., Harrison, C. N., Vassiliou, G. S., Vannucchi, A., Campbell, P. J., & Green, A. R.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2015-02-12
- Volume
- 372
- Issue
- 7
- Pages
- 601-612
- ISSN
- 0028-4793
- 1533-4406
- PMC
- PMC4660033
- Cited by
- 562
- References
- 7
- Language
- en
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