Cited by 232Pain Management and Opioid UseOpioid Use Disorder TreatmentAnesthesia and Pain Management

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Alleviating Suffering 101 — Pain Relief in the United States

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Pizzo, Philip A., Clark, Noreen M.·2012·New England Journal of Medicine

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Abstract

An Institute of Medicine committee has found that the magnitude of pain in the United States is vast — and costly. It concluded that relieving acute and chronic pain is a significant overlooked problem and that education is key to the cultural transformation required.

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Oxycodone, fentanyl, and morphine amplify established neuropathic pain in male rats
Green‐Fulgham, S. M., Ball, J. B., Kwilasz, A. J., Fabisiak, T., Maier, S. F., Watkins, L. R., & Grace, P. M. (2019) · Pain · doi:10.1097/j.pain.0000000000001652 · Cited by 27
“Approximately one-third of Americans suffer from chronic pain, and this proportion is increasing.(41,43) Chronic pain, including neuropathic pain fromperipheral nerve injury, is frequently treated with opioids.”
Background
Priorities to improve the care for chronic conditions and multimorbidity: a survey of patients and stakeholders nested within the ComPaRe e-cohort
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“[18] Inadequate knowledge concerning managerial skills and pain assessment[19] and wrong understanding of various professional health caregivers, especially the nurses, have been mentioned as efficient managerial barriers in adequate pain management.[20] Therefore, as pain management is essential for appropriate care…”
Background
RIP3 Inhibition ameliorates chronic constriction injury-induced neuropathic pain by suppressing JNK signaling
He, N., Qu, Y., Li, D., & Yue, S. (2021) · Aging · doi:10.18632/aging.203691 · Cited by 22
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Influential
Kynurenine Pathway Metabolites as Potential Biomarkers in Chronic Pain
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“The economic burden that chronic pain places on the United States exceeds the amount spent on the country’s preeminent health conditions of diabetes, cancer, and cardiovascular disease combined [5].”
Background
Continuing War on Pain: A Personalized Approach to the Therapy with Nonsteroidal Anti-Inflammatory Drugs and Opioids
Bach‐Rojecky, L., Vađunec, D., Žunić, K., Kurija, J., Šipicki, S., Gregg, R. A., Mikula, I., & Primorac, D. (2018) · Personalized Medicine · doi:10.2217/pme-2018-0116 · Cited by 23
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“Only in the United States, more than half of patients with pain have reported inadequate treatment of their condition [55], and this percentage is even higher in low- and middle-income countries [9].”
Background
Future Directions for Pain Management
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Interprofessional pain education: definitions, exemplars and future directions
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Neoclerodanes as Atypical Opioid Receptor Ligands
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“divinorum leaves identified salvinicins A (6) and B (7).”
Postoperative Pain: Management and Documentation by Iranian Nurses
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“Negative misperceptions and biases was introduced a preventive factor for the provision of adequate pain control in other studies as well (22) analgesic Drugs Admissions Oral Analgesics Suppository Parenteral parasetamol Intramuscular opioid analgesics Parenteral opioid analgesics Total”
Background
Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing
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The Effect of Postoperative Opioid Prescription Refills on Achieving Meaningful Clinical Outcomes After Hip Arthroscopy for Femoroacetabular Impingement Syndrome
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Chronic Pain Increases the Risk for Major Adverse Cardiac and Cerebrovascular Events: A Nationwide Population-Based Study in Asia.
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Dimethyl itaconate inhibits neuroinflammation to alleviate chronic pain in mice
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Transporter-Mediated Disposition of Opioids: Implications for Clinical Drug Interactions
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Authors: Pizzo, P. A., & Clark, N. M.
Affiliations: Stanford Medicine (US)
University of Michigan (US)
ORCID: Pizzo, Philip A.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2012-01-19
Volume: 366
Issue: 3
Pages: 197-199
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmp1109084
OpenAlex: W2072724964
Cited by: 231
References: 0
Citations by year: 2026: 5 · 2025: 8 · 2024: 9 · 2023: 13 · 2022: 10 · 2021: 16 · 2020: 16 · 2019: 12 · 2018: 17 · 2017: 16 · 2016: 16 · 2015: 25 · 2014: 20 · 2013: 21 · 2012: 27
FWCI: 40.26
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Pain Management
Keywords: analgesia, chronic pain, acute pain, pain management, Institute of Medicine report, pain education, cultural change, health care costs, United States
MeSH terms: Clinical Competence, Education, Medical, Humans, United States, National Academies of Science, Engineering, and Medicine, U.S., Health and Medicine Division, Advisory Committees, Chronic Pain, Pain Management

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Alleviating Suffering 101 — Pain Relief in the United States

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