Heat Stroke

Acute-Phase Proteins and Other Systemic Responses to Inflammation

Gabay, C., & Kushner, I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400607 · Cited by 6,734

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

Bernard, G. R., Vincent, J., Laterre, P., LaRosa, S. P., Dhainaut, J.-F., Lopez-Rodriguez, A., Steingrub, J. S., Garber, G. E., Helterbrand, J. D., Ely, E. W., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103083441001 · Cited by 6,124

Climate Extremes: Observations, Modeling, and Impacts

Easterling, D. R., Meehl, G. A., Parmesan, C., Changnon, S. A., Karl, T. R., & Mearns, L. O. (2000) · Science · doi:10.1126/science.289.5487.2068 · Cited by 4,945

NF-κB: a key role in inflammatory diseases

Tak, P. P., & Firestein, G. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11830 · Cited by 3,918

Exercise and the immune system: regulation, integration, and adaptation

Pedersen, B. K., & Hoffman-Goetz, L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.1055 · Cited by 1,710

IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses.

Xing, Z., Gauldie, J., Cox, G., Baumann, H., Jordana, M., Lei, X.-F., & Achong, M. K. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1368 · Cited by 1,578

Heat-Related Deaths during the July 1995 Heat Wave in Chicago

Semenza, J. C., Rubin, C., Falter, K. H., Selanikio, J., Flanders, W. D., Howe, H. L., & Wilhelm, J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199607113350203 · Cited by 1,381

Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease

Welch, W. J. (1992) · Physiological Reviews · doi:10.1152/physrev.1992.72.4.1063 · Cited by 1,190

Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running

Ostrowski, K., Rohde, T., Zacho, M., Asp, S., & Pedersen, B. K. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.949bp.x · Cited by 673

Heat Shock Is Lethal to Fibroblasts Microinjected with Antibodies Against hsp70

Riabowol, K. T., Mizzen, L., & Welch, W. J. (1988) · Science · doi:10.1126/science.3175665 · Cited by 631

Microvascular Injury, Thrombosis, Inflammation, and Apoptosis in the Pathogenesis of Heatstroke

Roberts, G. T., Ghebeh, H., Chishti, M. A., Almohanna, F., El-Sayed, R., Al-Mohanna, F. A., & Bouchama, A. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.158709 · Cited by 174

ACSM Expert Consensus Statement on Exertional Heat Illness: Recognition, Management, and Return to Activity

Roberts, W. O., Armstrong, L. E., Sawka, M. N., Yeargin, S. W., Heled, Y., & O’Connor, F. G. (2021) · Current Sports Medicine Reports · doi:10.1249/jsr.0000000000000878 · Cited by 168

Consensus Statement- Prehospital Care of Exertional Heat Stroke

Belval, L. N., Casa, D. J., Adams, W. M., Chiampas, G., Holschen, J. C., Hosokawa, Y., Jardine, J., Kane, S. F., LaBotz, M., Lemieux, R. S., et al. (2018) · Prehospital Emergency Care · doi:10.1080/10903127.2017.1392666 · Cited by 167

Super‐Absorbent Polymer Valves and Colorimetric Chemistries for Time‐Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin‐Mounted Soft Microfluidics

Kim, S. B., Zhang, Y., Won, S. M., Bandodkar, A. J., Sekine, Y., Xue, Y., Koo, J., Harshman, S. W., Martin, J. A., Park, J. M., et al. (2018) · Small · doi:10.1002/smll.201703334 · Cited by 170

Estimating the mortality effect of the July 2006 California heat wave

Ostro, B. D., Roth, L. A., Green, R., & Basu, R. (2009) · Environmental Research · doi:10.1016/j.envres.2009.03.010 · Cited by 162

Short-term effects of air temperature on mortality and effect modification by air pollution in three cities of Bavaria, Germany: A time-series analysis

Breitner, S., Wolf, K., Devlin, R. B., Díaz-Sánchez, D., Peters, A., & Schneider, A. E. (2014) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2014.03.048 · Cited by 160

Sex differences in mortality after heat waves: are elderly women at higher risk?

van Steen, Y., Ntarladima, A.-M., Grobbee, R., Karssenberg, D., & Vaartjes, I. C. H. (2018) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-018-1360-1 · Cited by 163

Drug-Induced Hyperhidrosis and Hypohidrosis

Cheshire, W. P., & Fealey, R. D. (2008) · Drug Safety · doi:10.2165/00002018-200831020-00002 · Cited by 159

Heat stress induces apoptosis through transcription-independent p53-mediated mitochondrial pathways in human umbilical vein endothelial cell

Gu, Z., Wang, H., Li, L., Liu, Y. S., Deng, X. B., Huo, S., Yuan, F., Liu, Z. F., Tong, H., & Su, L. (2014) · Scientific Reports · doi:10.1038/srep04469 · Cited by 161

Climate change threats to population health and well-being: the imperative of protective solutions that will last

Kjellstrom, T., & McMichael, A. J. (2013) · Global Health Action · doi:10.3402/gha.v6i0.20816 · Cited by 158

Heat stress induces a biphasic thermoregulatory response in mice

Leon, L. R., DuBose, D. A., & Mason, C. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00046.2004 · Cited by 158

Pattern and determinants of hospitalization during heat waves: an ecologic study

Mastrangelo, G., Fedeli, U., Visentin, C., Milan, G., Fadda, E., & Spolaore, P. (2007) · BMC Public Health · doi:10.1186/1471-2458-7-200 · Cited by 157

Pediatric Thermoregulation: Considerations in the Face of Global Climate Change

Smith, C. J. (2019) · Nutrients · doi:10.3390/nu11092010 · Cited by 177

Time course of cytokine, corticosterone, and tissue injury responses in mice during heat strain recovery

Leon, L. R., Blaha, M. D., & DuBose, D. A. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01040.2005 · Cited by 156

Extreme heat, preterm birth, and stillbirth: A global analysis across 14 lower-middle income countries

McElroy, S., Ilango, S. D., Dimitrova, A., Gershunov, A., & Benmarhnia, T. (2021) · Environment International · doi:10.1016/j.envint.2021.106902 · Cited by 181

Mapping Human Vulnerability to Extreme Heat: A Critical Assessment of Heat Vulnerability Indices Created Using Principal Components Analysis

Conlon, K. C., Mallen, E. S., Gronlund, C. J., Berrocal, V. J., Larsen, L. S., & O’Neill, M. S. (2020) · Environmental Health Perspectives · doi:10.1289/ehp4030 · Cited by 165

Cooling Methods in Heat Stroke

Gaudio, F. G., & Grissom, C. K. (2015) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2015.09.014 · Cited by 153

Decreased ADAMTS-13 (A disintegrin-like and metalloprotease with thrombospondin type 1 repeats) is associated with a poor prognosis in sepsis-induced organ failure*

Martin, K., Borgel, D., Lerolle, N., Feys, H. B., Trinquart, L., Vanhoorelbeke, K., Deckmyn, H., Legendre, P., Diehl, J., & Baruch, D. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000284508.05247.b3 · Cited by 153

Development of an early-warning system for site work in hot and humid environments: A case study

Yi, W., Chan, A. P. C., Wang, X., & Wang, J. (2015) · Automation in Construction · doi:10.1016/j.autcon.2015.11.003 · Cited by 157

A Large Change in Temperature between Neighbouring Days Increases the Risk of Mortality

Guo, Y., Barnett, A. G., Yu, W., Pan, X., Ye, X., Huang, C., & Tong, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016511 · Cited by 149

Heat Stroke in Dogs: A Retrospective Study of 54 Cases (1999–2004) and Analysis of Risk Factors for Death

Bruchim, Y., Klement, E., Saragusty, J., Finkeilstein, E., Kass, P. H., & Aroch, I. (2006) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.2006.tb02821.x · Cited by 149

Ambient temperature and added heat wave effects on hospitalizations in California from 1999 to 2009

Sherbakov, T., Malig, B. J., Guirguis, K. J., Gershunov, A., & Basu, R. (2017) · Environmental Research · doi:10.1016/j.envres.2017.08.052 · Cited by 148

The Changing Climate and Pregnancy Health

Ha, S. (2022) · Current Environmental Health Reports · doi:10.1007/s40572-022-00345-9 · Cited by 145

Predictors of multi-organ dysfunction in heatstroke

Varghese, G. M. (2005) · Emergency Medicine Journal · doi:10.1136/emj.2003.009365 · Cited by 145

Public Health Impact of Heat-Related Illness Among Migrant Farmworkers

Fleischer, N. L., Tiesman, H. M., Sumitani, J., Mize, T., Amarnath, K. K., Bayakly, A. R., & Murphy, M. W. (2013) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2012.10.020 · Cited by 144

Is planned adaptation to heat reducing heat-related mortality and illness? A systematic review

Boeckmann, M., & Rohn, I. (2014) · BMC Public Health · doi:10.1186/1471-2458-14-1112 · Cited by 146

Fever as an adverse event following immunization: case definition and guidelines of data collection, analysis, and presentation

Marcy, S. M., Kohl, K. S., Dagan, R., Nalin, D. R., Blum, M., Jones, M. C., Hansen, J. R., Labadie, J., Lee, L., Martin, B. L., et al. (2003) · Vaccine · doi:10.1016/j.vaccine.2003.09.007 · Cited by 144

Association of Summer Temperatures With Hospital Admissions for Renal Diseases in New York State: A Case-Crossover Study

Fletcher, B. A. S., Lin, S., Fitzgerald, E. F., & Hwang, S. (2012) · American Journal of Epidemiology · doi:10.1093/aje/kwr417 · Cited by 141

Effects of temperature on mortality in Chiang Mai city, Thailand: a time series study

Guo, Y., Punnasiri, K., & Tong, S. (2012) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.1186/1476-069x-11-36 · Cited by 141

Effects of heat stress on carbohydrate and lipid metabolism in growing pigs

Sanz-Fernandez, M. V., Johnson, J. S., Abuajamieh, M., Stoakes, S. K., Seibert, J. T., Cox, L., Kahl, S., Elsasser, T. H., Ross, J. W., Isom, S. C., et al. (2015) · Physiological Reports · doi:10.14814/phy2.12315 · Cited by 140

Association Between Exercise-Induced Hyperthermia and Intestinal Permeability: A Systematic Review

Pires, W., Veneroso, C. E., Wanner, S. P., Pacheco, D. A. S., Vaz, G. C., Amorim, F. T., Tonoli, C., Soares, D. D., & Coimbra, C. C. (2016) · Sports Medicine · doi:10.1007/s40279-016-0654-2 · Cited by 141

Fever in the critically ill medical patient

Laupland, K. B. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181aa6117 · Cited by 139

Ambient temperature and preterm birth: A retrospective study of 32 million US singleton births

Sun, S., Weinberger, K. R., Spangler, K. R., Eliot, M., Braun, J. M., & Wellenius, G. A. (2019) · Environment International · doi:10.1016/j.envint.2019.02.023 · Cited by 139

Cocaine Intoxication

Zimmerman, J. L. (2012) · Critical Care Clinics · doi:10.1016/j.ccc.2012.07.003 · Cited by 139

Individual-level and community-level effect modifiers of the temperature–mortality relationship in 66 Chinese communities

Huang, Z., Lin, H., Liu, Y., Zhou, M., Liu, T., Xiao, J., Zeng, W., Li, X., Zhang, Y., Ebi, K. L., et al. (2015) · BMJ Open · doi:10.1136/bmjopen-2015-009172 · Cited by 138

Fever in Children: Pearls and Pitfalls

Barbi, E., Marzuillo, P., Neri, E., Naviglio, S., & KRAUSS, B. S. (2017) · Children · doi:10.3390/children4090081 · Cited by 136

Heat Stroke

Yeo, T. P. (2004) · AACN Clinical Issues Advanced Practice in Acute & Critical Care · doi:10.1097/00044067-200404000-00013 · Cited by 136

Recognition and management of complications of new recreational drug use

Ricaurte, G. A., & McCann, U. D. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66737-2 · Cited by 134

Health of the Homeless and Climate Change

Ramin, B., & Svoboda, T. J. (2009) · Journal of Urban Health · doi:10.1007/s11524-009-9354-7 · Cited by 137

Ambient temperature and coronary heart disease mortality in Beijing, China: a time series study

Tian, Z., Li, S., Zhang, J., Jaakkola, J. J. K., & Guo, Y. (2012) · Environmental Health · doi:10.1186/1476-069x-11-56 · Cited by 134

First aid cooling techniques for heat stroke and exertional hyperthermia: A systematic review and meta-analysis

Douma, M. J., Aves, T., Allan, K. S., Bendall, J., Berry, D. C., Chang, W., Epstein, J. L., Hood, N. A., Singletary, E. M., Zideman, D. A., et al. (2020) · Resuscitation · doi:10.1016/j.resuscitation.2020.01.007 · Cited by 130

Greatly enhanced risk to humans as a consequence of empirically determined lower moist heat stress tolerance

Vecellio, D. J., Kong, Q., Kenney, W. L., & Huber, M. S. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2305427120 · Cited by 154

Physical activity: the health benefits outweigh the risks

Melzer, K., Kayser, B., & Pichard, C. (2004) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200411000-00009 · Cited by 130

Interaction Effects of Temperature and Ozone on Lung Function and Markers of Systemic Inflammation, Coagulation, and Fibrinolysis: A Crossover Study of Healthy Young Volunteers

Kahle, J. J., Neas, L., Devlin, R. B., Case, M., Schmitt, M. T., Madden, M. C., & Díaz-Sánchez, D. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1307986 · Cited by 128

Heat shock proteins and the heat shock response during hyperthermia and its modulation by altered physiological conditions

Horowitz, M., & Robinson, S. D. M. (2007) · Progress in brain research · doi:10.1016/s0079-6123(06)62021-9 · Cited by 128

Ryanodine Receptor Physiology and Its Role in Disease

Lanner, J. T. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2888-2_9 · Cited by 121

Use of scopoletin to inhibit the production of inflammatory cytokines through inhibition of the IκB/NF-κB signal cascade in the human mast cell line HMC-1

Moon, P., Lee, B.-H., Jeong, H., An, H., Park, S., Kim, H., Ko, S., Um, J., Hong, S., & Kim, H. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.10.021 · Cited by 126

Associations between risk perception, spontaneous adaptation behavior to heat waves and heatstroke in Guangdong province, China

Liu, T., Xu, Y. J., Zhang, Y. H., Yan, Q. H., Song, X. L., Xie, H. Y., Luo, Y., Rutherford, S., Chu, C. M.-Y., Lin, H. L., et al. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-913 · Cited by 125

Heat stress and inadequate sanitary facilities at workplaces – an occupational health concern for women?

Venugopal, V., Shanmugam, R., Krishnamoorthy, M., Latha, P. K., Vishwanathan, V., Ganesan, N., Perumal, K., & Chinnadurai, J. (2016) · Global Health Action · doi:10.3402/gha.v9.31945 · Cited by 130

Controversies in exertional heat stroke diagnosis, prevention, and treatment

Laitano, O., Leon, L. R., Roberts, W. O., & Sawka, M. N. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00452.2019 · Cited by 125

Exertional heat injury and gene expression changes: a DNA microarray analysis study

Sonna, L. A., Wenger, C. B., Flinn, S. D., Sheldon, H. K., Sawka, M. N., & Lilly, C. M. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00886.2003 · Cited by 125

Pathophysiological factors underlying heatstroke

Yan, Y., Zhao, Y., Wang, H., & Fan, M. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2005.12.048 · Cited by 125

Assessing Heat Health Risk for Sustainability in Beijing’s Urban Heat Island

Dong, W., Liu, Z., Zhang, L., Tang, Q., Liao, H., & Li, X. (2014) · Sustainability · doi:10.3390/su6107334 · Cited by 124

Heat stroke and cytokines

Leon, L. R. (2007) · Progress in brain research · doi:10.1016/s0079-6123(06)62024-4 · Cited by 127

Role of circulating cytokines and chemokines in exertional heatstroke

Lu, K., Wang, J., Lin, S., Chu, P., & Lin, Y. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000108884.74110.d9 · Cited by 123

A glossary for biometeorology

Gosling, S. N., Bryce, E., Dixon, P., Gabriel, K. M. A., Gosling, E. Y., Hanes, J. M., Hondula, D. M., Liang, L., Mac-Lean, P. A. B., Muthers, S., et al. (2014) · International Journal of Biometeorology · doi:10.1007/s00484-013-0729-9 · Cited by 125

Effects of Vitamin C or E on the Pro-inflammatory Cytokines, Heat Shock Protein 70 and Antioxidant Status in Broiler Chicks under Summer Conditions

Jang, I.-S., Ko, Y.-H., Moon, Y.-S., & Sohn, S. H. (2014) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2013.13852 · Cited by 122

Why do older patients die in a heatwave?

Flynn, A., McGreevy, C., & Mulkerrin, E. C. (2005) · QJM · doi:10.1093/qjmed/hci025 · Cited by 122

Between Extremes: Health Effects of Heat and Cold

Seltenrich, N. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.123-a275 · Cited by 121

The influence of climate change on human cardiovascular function

Gostimirović, M., Novaković, R., Rajković, J., Djokic, V., Terzić, D., Putnik, S. M., & Gojković‐Bukarica, L. (2020) · Archives of Environmental & Occupational Health · doi:10.1080/19338244.2020.1742079 · Cited by 121

Brain Damage After Heat Stroke

Bazille, C., Mégarbane, B., Bensimhon, D., Lavergne‐Slove, A., Baglin, A. C., Loirat, P., Woimant, F., Mikol, J., & Gray, F. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000186924.88333.0d · Cited by 121

Effects of apparent temperature on daily mortality in Lisbon and Oporto, Portugal

Almeida, S., Casimiro, E., & Calheiros, J. M. (2010) · Environmental Health · doi:10.1186/1476-069x-9-12 · Cited by 121

Leukocyte activation: The link between inflammation and coagulation during heatstroke. A study of patients during the 2003 heat wave in Paris*

Huisse, M., Pease, S., Hurtado-Nédelec, M., Arnaud, B., Malaquin, C., Wolff, M., Gougerot‐Pocidalo, M., Kermarrec, N., Bezeaud, A., Guillin, M., et al. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e318180dd43 · Cited by 119

Heat-related illness in China, summer of 2013

Gu, S., Huang, C., Bai, L., Chu, C. M.-Y., & Liu, Q. (2015) · International Journal of Biometeorology · doi:10.1007/s00484-015-1011-0 · Cited by 120

Global, Regional, and Megacity Trends in the Highest Temperature of the Year: Diagnostics and Evidence for Accelerating Trends

Papalexiou, S. M., AghaKouchak, A., Trenberth, K. E., & Foufoula‐Georgiou, E. (2018) · Earth s Future · doi:10.1002/2017ef000709 · Cited by 122

Brain hyperthermia as physiological and pathological phenomena

Kiyatkin, E. A. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.04.001 · Cited by 120

Temperature change between neighboring days and mortality in United States: A nationwide study

Zhan, Z., Zhao, Y. K., Pang, S., Zhong, X. Y., Wu, C., & Ding, Z. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.01.177 · Cited by 122

Syndromic surveillance and heat wave morbidity: a pilot study based on emergency departments in France

Josseran, L., Caillère, N., BRUN-NEY, D., Rottner, J., Filleul, L., Brücker, G., & Astagneau, P. (2009) · BMC Medical Informatics and Decision Making · doi:10.1186/1472-6947-9-14 · Cited by 119

Anesthetic‐and heat‐induced sudden death in calsequestrin‐1‐knockout mice

Dainese, M., Quarta, M., Lyfenko, A. D., Paolini, C., Canato, M., Reggiani, C., Dirksen, R. T., & Protasi, F. (2009) · The FASEB Journal · doi:10.1096/fj.08-121335 · Cited by 119

Sympathetic regulation during thermal stress in human aging and disease

Greaney, J. L., Kenney, W. L., & Alexander, L. M. (2015) · Autonomic Neuroscience · doi:10.1016/j.autneu.2015.11.002 · Cited by 117

ORAL GLUTAMINE ENHANCES HEAT SHOCK PROTEIN EXPRESSION AND IMPROVES SURVIVAL FOLLOWING HYPERTHERMIA

Singleton, K. D., & Wischmeyer, P. E. (2006) · Shock · doi:10.1097/01.shk.0000196548.10634.02 · Cited by 118

Temperature Changes between Neighboring Days and Mortality in Summer: A Distributed Lag Non-Linear Time Series Analysis

Lin, H., Zhang, Y., Xu, Y., Xu, X., Liu, T., Luo, Y., Xiao, J., Wu, W., & Ma, W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066403 · Cited by 117

Prediction of human core body temperature using non-invasive measurement methods

Niedermann, R., Wyss, E., Annaheim, S., Psikuta, A., Davey, S., & Rossi, R. M. (2013) · International Journal of Biometeorology · doi:10.1007/s00484-013-0687-2 · Cited by 117

Cytokine induction during exertional hyperthermia is abolished by core temperature clamping: neuroendocrine regulatory mechanisms

Rhind, S. G., Gannon, G. A., Shephard, R. J., Buguet, A., Shek, P. N., & Radomski, M. W. (2004) · International Journal of Hyperthermia · doi:10.1080/02656730410001670651 · Cited by 119

AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation

Lanner, J. T., Georgiou, D. K., Dagnino-Acosta, A., Ainbinder, A., Cheng, Q., Joshi, A., Chen, Z., Yarotskyy, V., Oakes, J. M., Lee, C. S., et al. (2012) · Nature Medicine · doi:10.1038/nm.2598 · Cited by 121

Fundamental Concepts of Human Thermoregulation and Adaptation to Heat: A Review in the Context of Global Warming

Lim, C. L. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17217795 · Cited by 137

Calsequestrin‐1: a new candidate gene for malignant hyperthermia and exertional/environmental heat stroke

Protasi, F., Paolini, C., & Dainese, M. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.171967 · Cited by 114

A methodological assessment of extreme heat mortality modeling and heat vulnerability mapping in Dallas, Texas

Mallen, E. S., Stone, B., & Lanza, K. (2019) · Urban Climate · doi:10.1016/j.uclim.2019.100528 · Cited by 113

European Resuscitation Council Guidelines 2021: First aid

Zideman, D. A., Singletary, E. M., Borra, V., Cassan, P., Cimpoesu, C. D., Buck, E. D. J. D., Djärv, T., Handley, A. J., Klaassen, B., Meyrán, D., et al. (2021) · Resuscitation · doi:10.1016/j.resuscitation.2021.02.013 · Cited by 126

Non-communicable health risks during mass gatherings

Steffen, R. J., Bouchama, A., Johansson, A., Dvořák, J., Isla, N., Smallwood, C. A. H., & Memish, Z. A. (2012) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(11)70293-6 · Cited by 112

Heat Sepsis Precedes Heat Toxicity in the Pathophysiology of Heat Stroke—A New Paradigm on an Ancient Disease

Lim, C. L. (2018) · Antioxidants · doi:10.3390/antiox7110149 · Cited by 112

Excess mortality and morbidity during the July 2006 heat wave in Porto, Portugal

Monteiro, A., Carvalho, V., Oliveira, T., & Sousa, C. (2012) · International Journal of Biometeorology · doi:10.1007/s00484-012-0543-9 · Cited by 111

Heat-related mortality in residents of nursing homes

Klenk, J., Becker, C., & Rapp, K. (2010) · Age and Ageing · doi:10.1093/ageing/afp248 · Cited by 110

Exercising in Environmental Extremes

Walsh, N. P., & Whitham, M. (2006) · Sports Medicine · doi:10.2165/00007256-200636110-00003 · Cited by 114

Early organ dysfunction course, cooling time and outcome in classic heatstroke

Pease, S., Bouadma, L., Kermarrec, N., Schortgen, F., Regnier, B., & Wolff, M. (2009) · Intensive Care Medicine · doi:10.1007/s00134-009-1500-x · Cited by 110

Does temperature enhance acute mortality effects of ambient particle pollution in Tianjin City, China

Li, G., Zhou, M., Cai, Y., Zhang, Y., & Pan, X. (2011) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2011.02.005 · Cited by 109

ACSM Expert Consensus Statement on Exertional Heat Illness: Recognition, Management, and Return to Activity

Roberts, W. O., Armstrong, L. E., Sawka, M. N., Yeargin, S. W., Heled, Y., & O’Connor, F. G. (2023) · Current Sports Medicine Reports · doi:10.1249/jsr.0000000000001058 · Cited by 109

Heat Stroke

Hadad, E., Rav-Acha, M., Heled, Y., Epstein, Y., & Moran, D. S. (2004) · Sports Medicine · doi:10.2165/00007256-200434080-00002 · Cited by 109

Climate Change and Extreme Heat Events: How Health Systems Should Prepare

Patel, L. H., Conlon, K. C., Sorensen, C. J., McEachin, S., Nadeau, K. C., Kakkad, K. M., & Kizer, K. W. (2022) · NEJM Catalyst · doi:10.1056/cat.21.0454 · Cited by 119

Public Health Preparedness for Extreme Heat Events

Hess, J. J., Errett, N. A., McGregor, G. R., Isaksen, T. B., Wettstein, Z. S., Wheat, S., & Ebi, K. L. (2023) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-071421-025508 · Cited by 122

Natural history of exertional rhabdomyolysis: A population‐based analysis

Alpers, J. P., & Jones, L. K. (2010) · Muscle & Nerve · doi:10.1002/mus.21740 · Cited by 106

Effect of dietary butyric acid on performance, intestinal morphology, microflora composition and intestinal recovery of heat-stressed broilers

Abdelqader, A., & Al-Fataftah, A.-R. A. (2015) · Livestock Science · doi:10.1016/j.livsci.2015.11.026 · Cited by 106

Potential indicators for the effect of temperature steps on human health and thermal comfort

Xiong, J., Lian, Z., Zhou, X., You, J., & Lin, Y. (2015) · Energy and Buildings · doi:10.1016/j.enbuild.2015.12.031 · Cited by 106

Heat stress-induced neuroinflammation and aberration in monoamine levels in hypothalamus are associated with temperature dysregulation

Chauhan, N. R., Kapoor, M., Singh, L. P., Gupta, R. K., Meena, R. C., Tulsawani, R., Nanda, S., & Singh, S. B. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.06.023 · Cited by 106

Indoor overheating: A review of vulnerabilities, causes, and strategies to prevent adverse human health outcomes during extreme heat events

Kenny, G. P., Tetzlaff, E. J., Journeay, W. S., Henderson, S. B., & O’Connor, F. K. (2024) · Temperature · doi:10.1080/23328940.2024.2361223 · Cited by 118

Dietary supplementation of enzymatically treated Artemisia annua could alleviate the intestinal inflammatory response in heat-stressed broilers

Song, Z., Cheng, K., Zhang, L., & Wang, T. (2017) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2017.07.015 · Cited by 102

Heat, infant mortality, and adaptation: Evidence from India

Banerjee, R., & Maharaj, R. (2019) · Journal of Development Economics · doi:10.1016/j.jdeveco.2019.102378 · Cited by 105

Thermal discomfort and health: protecting the susceptible from excess cold and excess heat in housing

Ormandy, D., & Ezratty, V. (2015) · Advances in Building Energy Research · doi:10.1080/17512549.2015.1014845 · Cited by 107

Humidity May Modify the Relationship between Temperature and Cardiovascular Mortality in Zhejiang Province, China

Zeng, J., Zhang, X., Yang, J., Bao, J., Xiang, H., Dear, K. B. G., Liu, Q., Lin, S., Lawrence, W. R., Lin, A., et al. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph14111383 · Cited by 101

High and low temperatures aggravate airway inflammation of asthma: Evidence in a mouse model

Deng, L., Ma, P., Wu, Y., Ma, Y., Yang, X., Li, Y., & Deng, Q. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.113433 · Cited by 101

Molecular Mechanisms of Heatstroke: Pathophysiology and Cell Death Pathways

Ferrer, R., & Iba, T. (2025) · Juntendō Igaku/Juntendo igaku · doi:10.14789/ejmj.jmj25-0023-p · Cited by 7

Heat stroke: Pathogenesis, diagnosis, and current treatment

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Histopathological and molecular mechanisms of multi-organ damage in heat stroke: Endothelial failure, immune crosstalk, and regulated cell death pathways.

Shin, M. C., Jung, B. H., Moon, J., Ahn, J. H., Cho, J. H., Yoo, K., & Won, M.-H. (2026) · PubMed · doi:10.14670/hh-25-076 · Cited by 2

Inflammation, coagulation, and cellular injury in heat-induced shock

Iba, T., Helms, J., Levi, M. M., & Levy, J. H. (2023) · Inflammation Research · doi:10.1007/s00011-022-01687-8 · Cited by 57

The pathogenesis and therapeutic strategies of heat stroke-induced liver injury

Wang, F., Zhang, Y., Li, J., Xia, H., Zhang, D., & Yao, S. (2022) · Critical Care · doi:10.1186/s13054-022-04273-w · Cited by 75