Nonalcoholic Fatty Liver Disease

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

Esterbauer, H., Schaur, R. J., & Zollner, H. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90192-6 · Cited by 6,672

Steatohepatitis: A tale of two “hits”?

Day, C. P., & James, O. F. W. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70599-2 · Cited by 4,285

Nonalcoholic Steatohepatitis: A Proposal for Grading and Staging The Histological Lesions

Brunt, E. M., Janney, C. G., Di Bisceglie, A. M., Neuschwander-Tetri, B. A., & Bacon, B. R. (1999) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01377.x · Cited by 3,907

Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity.

MATTEONI, C., YOUNOSSI, Z., GRAMLICH, T., BOPARAI, N., LIU, Y., & MCCULLOUGH, A. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70506-8 · Cited by 3,345

Overweight and obesity in the United States: prevalence and trends, 1960–1994

Flegal, K., Carroll, M., Kuczmarski, R., & Johnson, C. (1998) · International Journal of Obesity · doi:10.1038/sj.ijo.0800541 · Cited by 3,045

The Prevalence of Hepatitis C Virus Infection in the United States, 1988 through 1994

Alter, M. J., Kruszon‐Moran, D., Nainan, O. V., McQuillan, G. M., Gao, F., Moyer, L. A., Kaslow, R. A., & Margolis, H. S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199908193410802 · Cited by 2,973

Nonalcoholic Steatohepatitis

Ludwig, J., Viggiano, T. R., McGill, D. B., & Ott, B. J. (1980) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(24)00530-5 · Cited by 2,903

Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988–1994

Harris, M. I., Flegal, K. M., Cowie, C. C., Eberhardt, M. S., Goldstein, D. E., Little, R. R., Wiedmeyer, H.-M., & Byrd-Holt, D. D. (1998) · Diabetes Care · doi:10.2337/diacare.21.4.518 · Cited by 2,703

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630

Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities

Sanyal, A. J., Campbell–Sargent, C., Mirshahi, F., Rizzo, W. B., Contos, M. J., Sterling, R. K., Luketic, V. A., Shiffman, M. L., & Clore, J. N. (2001) · Gastroenterology · doi:10.1053/gast.2001.23256 · Cited by 2,078

World Gastroenterology Organisation Global Guidelines

LaBrecque, D. R., Abbas, Z., Anania, F. A., Ferenci, P., Khan, A. G., Goh, K., Hamid, S. S., Va, I., Lizarzábal, M., Peñaranda, M. M., et al. (2014) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000116 · Cited by 524

Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients

Videla, L. A., Rodrigo, R., Myriam Orellana, B., Fernández, V., Tapia, G., Quiñones, L. A., Varela, N., CONTRERAS, J., Lazarte, R. A., Csendes, A., et al. (2004) · Clinical Science · doi:10.1042/cs20030285 · Cited by 522

Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: A prospective study

Loomba, R. S., Wolfson, T. J., Ang, B., Hooker, J. C., Behling, C. A., Peterson, M. R., Valasek, M. A., Lin, G., Brenner, D. A., Gamst, A. C., et al. (2014) · Hepatology · doi:10.1002/hep.27362 · Cited by 517

Risk Factors for Intrahepatic and Extrahepatic Cholangiocarcinoma in the United States: A Population-Based Case-Control Study

Welzel, T. M., Graubard, B. I., El‐Serag, H. B., Shaib, Y. H., Hsing, A. W., Davila, J. A., & McGlynn, K. A. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.05.020 · Cited by 514

Long term prognosis of fatty liver: risk of chronic liver disease and death

Dam‐Larsen, S., Franzmann, M., Andersen, I. B., Christoffersen, P., Jensen, L. B., Sørensen, T. I. A., Becker, U., & Bendtsen, F. (2004) · Gut · doi:10.1136/gut.2003.019984 · Cited by 511

Feasibility and Diagnostic Performance of the Fibroscan XL Probe for Liver Stiffness Measurement in Overweight and Obese Patients

Myers, R. P., Pomier–Layrargues, G., Kirsch, R., Pollett, A. F., Duarte‐Rojo, A., Wong, D., Beaton, M. D., Levstik, M. A., Crotty, P., & Elkashab, M. (2011) · Hepatology · doi:10.1002/hep.24624 · Cited by 511

Interobserver and Intraobserver Variability in the Sonographic Assessment of Fatty Liver

Strauss, S., Gavish, E., Gottlieb, P., & Katsnelson, L. (2007) · American Journal of Roentgenology · doi:10.2214/ajr.07.2123 · Cited by 510

Obesity and Inflammation: Epidemiology, Risk Factors, and Markers of Inflammation

Rodríguez-Hernández, H., Simental‐Mendía, L. E., Ramírez, G. R., & Reyes-Romero, M. A. (2013) · International Journal of Endocrinology · doi:10.1155/2013/678159 · Cited by 509

Mechanisms of Disease: mechanisms of hepatic fibrosis and therapeutic implications

Friedman, S. L. (2004) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep0055 · Cited by 508

ACC/AHA/NHLBI clinical advisory on the use and safety of statins11When citing this document, the American College of Cardiology, American Heart Association, and National Heart, Lung and Blood Institute would appreciate the following citation format: Pasternak RC, Smith SC, Jr., Bairey-Merz CN, Grundy SM, Cleeman JI, Lenfant C. ACC/AHA/NHLBI Advisory on the Use and Safety of Statins. J Am Coll Cardiol 2002;40:568–73.22This document is available on the Web sites of the ACC (www.acc.org), the AHA (www.americanheart.org), and the NHLBI (www.nhlbi.nih.gov/guidelines/cholesterol).

Pasternak, R. C., Smith, S. C., Merz, C. N. B., Grundy, S. M., Cleeman, J. I., & Lenfant, C. J. M. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02030-2 · Cited by 507

Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease

Ratziu, V., Massard, J., Charlotte, F., Messous, D., Imbert‐Bismut, F., Bonyhay, L., Tahiri, M., Munteanu, M., Thabut, D., Cadranel, J. F. D., et al. (2006) · BMC Gastroenterology · doi:10.1186/1471-230x-6-6 · Cited by 504

AMP‐activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives

Viollet, B., Guigas, B., Leclerc, J., Hébrard, S., Lantier, L., Mounier, R., Andréelli, F., & Foretz, M. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01970.x · Cited by 498

Obesity, insulin resistance, and other clinicopathological correlates of pediatric nonalcoholic fatty liver disease

Schwimmer, J. B., Deutsch, R., Rauch, J. B., Behling, C. A., Newbury, R., & Lavine, J. E. (2003) · The Journal of Pediatrics · doi:10.1067/s0022-3476(03)00325-1 · Cited by 495

Mechanisms of Disease Progression in Nonalcoholic Fatty Liver Disease

Jou, J. H., Choi, S. S., & Diehl, A. M. (2008) · Seminars in Liver Disease · doi:10.1055/s-0028-1091981 · Cited by 494

Insulin resistance, inflammation, and non-alcoholic fatty liver disease

Tilg, H., & Moschen, A. R. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.08.005 · Cited by 484

The Association of Genetic Variability in Patatin-Like Phospholipase Domain-Containing Protein 3 (PNPLA3) with Histological Severity of Nonalcoholic Fatty Liver Disease†

Rotman, Y., Koh, C., Zmuda, J. M., Kleiner, D. E., & Liang, J. T. (2010) · Hepatology · doi:10.1002/hep.23759 · Cited by 479

Steatosis and hepatitis C virus: Mechanisms and significance for hepatic and extrahepatic disease

Lonardo, A., Adinolfi, L. E., Loria, P., Carulli, N., Ruggiero, G., & Day, C. P. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.020 · Cited by 473

Hepatocyte-Specific Disruption of CD36 Attenuates Fatty Liver and Improves Insulin Sensitivity in HFD-Fed Mice

Wilson, C. G., Tran, J. L., Erion, D. M., Vera, N. B., Febbraio, M., & Weiss, E. J. (2015) · Endocrinology · doi:10.1210/en.2015-1866 · Cited by 473

Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo-controlled Trial

Rahmani, S., Asgary, S., Askari, G., Keshvari, M., Hatamipour, M., Feizi, A., & Sahebkar, A. (2016) · Phytotherapy Research · doi:10.1002/ptr.5659 · Cited by 472

Bariatric Surgery: A Review of Procedures and Outcomes

Elder, K. A., & Wolfe, B. M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.057 · Cited by 470

Orlistat for overweight subjects with nonalcoholic steatohepatitis: A randomized, prospective trial†‡§

Harrison, S. A., Fecht, W., Brunt, E. M., & Neuschwander‐Tetri, B. A. (2009) · Hepatology · doi:10.1002/hep.22575 · Cited by 470

The role of AMP-activated protein kinase in the action of ethanol in the liver

You, M., Matsumoto, M., Pacold, C. M., Cho, W. K., & Crabb, D. W. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.09.049 · Cited by 469

Pathology of Nonalcoholic Fatty Liver Disease

Yeh, M. M., & Brunt, E. M. (2007) · American Journal of Clinical Pathology · doi:10.1309/rtpm1py6ygbl2g2r · Cited by 469

Survival, liver failure, and hepatocellular carcinoma in obesity-related cryptogenic cirrhosis

Ratziu, V., Bonyhay, L., Martino, V. D., Charlotte, F., Cavallaro, L. G., Sayegh-Tainturier, M.-H., Giral, P., Grimaldi, A., Opolon, P., & Poynard, T. (2002) · Hepatology · doi:10.1053/jhep.2002.33324 · Cited by 465

Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C

Miquilena-Colina, M. E., Lima‐Cabello, E., Sánchez‐Campos, S., García‐Mediavilla, M. V., Fernández‐Bermejo, M., Lozano-Rodríguez, T., Vargas‐Castrillón, J., Buqué, X., Ochoa, B., Aspichueta, P., et al. (2011) · Gut · doi:10.1136/gut.2010.222844 · Cited by 461

Liver-Specific Inhibition of ChREBP Improves Hepatic Steatosis and Insulin Resistance in ob/ob Mice

Dentin, R., Benhamed, F., Hainault, I., Fauveau, V., Foufelle, F., Dyck, J. R. B., Girard, J. R., & Postic, C. (2006) · Diabetes · doi:10.2337/db06-0200 · Cited by 461

Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis

Yokohama, S., Yoneda, M., Haneda, M., Okamoto, S., Okada, M., Aso, K., Hasegawa, T., Tokusashi, Y., Miyokawa, N., & Nakamura, K. (2004) · Hepatology · doi:10.1002/hep.20420 · Cited by 459

Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition

Charlton, M., Krishnan, A., Viker, K., Sanderson, S. O., Cazanave, S. C., McConico, A. L., Masuoko, H., & Gores, G. J. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00145.2011 · Cited by 455

Macrophages and lipid metabolism

Remmerie, A., & Scott, C. L. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.01.020 · Cited by 451

The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: An international collaborative study

Bhala, N. B., Angulo, P., van der Poorten, D., Lee, E., Hui, J. M., Saracco, G. M., Adams, L. A., Charatcharoenwitthaya, P., Topping, J. H., Bugianesi, E., et al. (2011) · Hepatology · doi:10.1002/hep.24491 · Cited by 450

Beneficial Effects of a Probiotic VSL#3 on Parameters of Liver Dysfunction in Chronic Liver Diseases

Loguercio, C., Federico, A., Tuccillo, C., Terracciano, F., D’Auria, M. V., Simone, C. D., & Blanco, C. D. V. (2005) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000165671.25272.0f · Cited by 450

Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease

Targher, G., Bertolini, L., Scala, L., CIGOLINI, M., Zenari, L., Falezza, G., & Arcaro, G. (2006) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.04.002 · Cited by 449

NAFLD and liver transplantation: Current burden and expected challenges

Pais, R., Barritt, A. S., Calmus, Y., Scatton, O., Runge, T. M., Lebray, P., Poynard, T., Ratziu, V., & Conti, F. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.07.033 · Cited by 445

New insights into the pathophysiology of dyslipidemia in type 2 diabetes

Taskinen, M.-R., & Borén, J. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.01.039 · Cited by 440

Sex differences in body composition and association with cardiometabolic risk

Haines, M. S., Dichtel, L. E., Gerweck, A. V., Valera, R., Torriani, M., Miller, K. K., & Bredella, M. A. (2018) · Biology of Sex Differences · doi:10.1186/s13293-018-0189-3 · Cited by 439

Fatty Liver: Imaging Patterns and Pitfalls

Hamer, O. W., Aguirre, D. A., Casola, G., Lavine, J. E., Woenckhaus, M., & Sirlin, C. B. (2006) · Radiographics · doi:10.1148/rg.266065004 · Cited by 438

Early Detection of Nonalcoholic Steatohepatitis in Patients with Nonalcoholic Fatty Liver Disease by Using MR Elastography

Chen, J., Talwalkar, J. A., Yin, M., Glaser, K. J., Sanderson, S. O., & Ehman, R. L. (2011) · Radiology · doi:10.1148/radiol.11101942 · Cited by 434

Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis†

Nobili, V., Vizzutti, F., Arena, U., Abraldeṣ, J. G., Marra, F., Pietrobattista, A., Fruhwirth, R., Marcellini, M., & Pinzani, M. (2008) · Hepatology · doi:10.1002/hep.22376 · Cited by 433

Impact of steatosis on perioperative outcome following hepatic resection

Kooby, D. A., Fong, Y., Suriawinata, A. A., Gönen, M., Allen, P. J., Klimstra, D. S., DeMatteo, R. P., D'Angelica, M. I., Blumgart, L. H., & Jarnagin, W. R. (2003) · Journal of Gastrointestinal Surgery · doi:10.1016/j.gassur.2003.09.012 · Cited by 430

Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis

Wieckowska, A., McCullough, A. J., & Feldstein, A. E. (2007) · Hepatology · doi:10.1002/hep.21768 · Cited by 428

Prevalence and risk factors of non‐alcoholic fatty liver disease among Korean adults

PARK, S. H., Jeon, W. K., KIM, S. H., Kim, H. J., Park, D. I., Cho, Y. K., Sung, I. K., Sohn, C. I., Keum, D. K., & KIM, B. I. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2005.04086.x · Cited by 428

Endoplasmic reticulum stress in liver diseases

Ajoolabady, A., Kaplowitz, N., Lebeaupin, C., Kroemer, G., Kaufman, R. J., Malhi, H., & Ren, J. T. (2022) · Hepatology · doi:10.1002/hep.32562 · Cited by 428

Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis

Marra, F., Gastaldelli, A., Svegliati‐Baroni, G., Tell, G., & Tiribelli, C. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.12.003 · Cited by 427

Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: A comprehensive review

Palomba, S., Falbo, A., Zullo, F., & Orio, F. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0030 · Cited by 426

Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance

Kelley, D. E., McKolanis, T. M., Hegazi, R. A. F., Kuller, L. H., & Kalhan, S. C. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00117.2003 · Cited by 426

Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with nonalcoholic fatty liver disease (NAFLD)

Yoneda, M., Yoneda, M., Mawatari, H., Fujita, K., Endo, H., Iida, H., Nozaki, Y., Yonemitsu, K., Higurashi, T., Takahashi, H., et al. (2007) · Digestive and Liver Disease · doi:10.1016/j.dld.2007.10.019 · Cited by 426

Effect of body mass index and alcohol consumption on liver disease: analysis of data from two prospective cohort studies

Hart, C. L., Morrison, D. S., Batty, G. D., Mitchell, R. J., & Davey Smith, G. (2010) · BMJ · doi:10.1136/bmj.c1240 · Cited by 422

Comparative review of diets for the metabolic syndrome: implications for nonalcoholic fatty liver disease

Zivkovic, A. M., German, J. B., & Sanyal, A. J. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.2.285 · Cited by 422

Total fecal microbiota transplantation alleviates high-fat diet-induced steatohepatitis in mice via beneficial regulation of gut microbiota

Zhou, D., Pan, Q., Shen, F., Cao, H.-X., Ding, W.-J., Chen, Y.-W., & Fan, J.-G. (2017) · Scientific Reports · doi:10.1038/s41598-017-01751-y · Cited by 421

Characteristics of Patients With Nonalcoholic Steatohepatitis Who Develop Hepatocellular Carcinoma

Yasui, K., Hashimoto, E., Komorizono, Y., Koike, K., Arii, S., Imai, Y., Shima, T., Kanbara, Y., Saibara, T., Mori, T., et al. (2011) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2011.01.023 · Cited by 420

Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease

Rotman, Y., & Sanyal, A. J. (2016) · Gut · doi:10.1136/gutjnl-2016-312431 · Cited by 420

Hepatic Steatosis: Quantification by Proton Density Fat Fraction with MR Imaging versus Liver Biopsy

İdilman, İ. S., Aniktar, H., Idılman, R., Kabaçam, G., Savaş, B., Elhan, A. H., Çelik, A., Bahar, K., & Karçaaltıncaba, M. (2013) · Radiology · doi:10.1148/radiol.13121360 · Cited by 419

Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice

Lin, C., Zhang, H., Li, M., Xiong, X., Chen, X., Chen, X., Dong, X. C., & Yin, X. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.01.011 · Cited by 418

Redox mechanisms in hepatic chronic wound healing and fibrogenesis

Novo, E., & Parola, M. (2008) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-1-5 · Cited by 417

Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression

Sekiya, M., Yahagi, N., Matsuzaka, T., Najima, Y., Nakakuki, M., Nagai, R., Ishibashi, S., Osuga, J.-I., Yamada, N., & Shimano, H. (2003) · Hepatology · doi:10.1016/j.hep.2003.09.028 · Cited by 415

Hepatic Lipid Partitioning and Liver Damage in Nonalcoholic Fatty Liver Disease

Li, Z.-Z., Berk, M. P., McIntyre, T. M., & Feldstein, A. E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807616200 · Cited by 414

ER stress induces NLRP3 inflammasome activation and hepatocyte death

Lebeaupin, C., Proïcs, E., de Bieville, C.-H. D., Rousseau, D., Bonnafous, S., Patouraux, S., Adam, G., Lavallard, V., Rovère, C., Thuc, O. L., et al. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.248 · Cited by 413

Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal

Alkhouri, N., Dixon, L. J., & Feldstein, A. E. (2009) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.09.32 · Cited by 413

Prolonged n‐3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non‐alcoholic fatty liver disease: a pilot study

Capanni, M., Calella, F., Biagini, M. R., Genise, S., Raimondi, L., Bedogni, G., Svegliati‐Baroni, G., Sofi, F., Milani, S., Abbate, R., et al. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02885.x · Cited by 412

Synbiotic supplementation in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled pilot study

Eslamparast, T., Poustchi, H., Zamani, F., Sharafkhah, M., Malekzadeh, R., & Hekmatdoost, A. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.068890 · Cited by 412

STEATOSIS IN CHRONIC HEPATITIS C: WHY DOES IT REALLY MATTER?

Asselah, T., Rubbia-Brandt, L., Marcellin, P., & Negro, F. (2005) · Gut · doi:10.1136/gut.2005.069757 · Cited by 410

Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: A systematic review

Sookoian, S. C., & Pirola, C. J. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.06.012 · Cited by 407

Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: From “two hit theory” to “multiple hit model”

Fang, Y., Chen, H., Wang, C., & Liang, L. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i27.2974 · Cited by 407

Metformin in the treatment of patients with non‐alcoholic steatohepatitis

Uygun, A., Kadayıfçı, A., Işık, A. T., Ozgurtas, T., Deveci, S., Tüzün, A., Yeşilova, Z., Gülşen, M., & Dağalp, K. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.01888.x · Cited by 406

Persistent Organic Pollutant Exposure Leads to Insulin Resistance Syndrome

Ruzzin, J., Petersen, R. K., Meugnier, E., Madsen, L., Lock, E., Lillefosse, H. H., Ma, T., Pesenti, S., Sonne, S. B., Marstrand, T. T., et al. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0901321 · Cited by 405

Relations Between Carotid Artery Wall Thickness and Liver Histology in Subjects With Nonalcoholic Fatty Liver Disease

Targher, G., Bertolini, L., Padovani, R., Rodella, S., Zoppini, G., Zenari, L., CIGOLINI, M., Falezza, G., & Arcaro, G. (2006) · Diabetes Care · doi:10.2337/dc06-0135 · Cited by 405

Metabolic syndrome and hepatocellular carcinoma: Two growing epidemics with a potential link

Siegel, A. B., & Zhu, A. X. (2009) · Cancer · doi:10.1002/cncr.24687 · Cited by 399

Non-alcoholic fatty liver disease: The diagnosis and management

El-Kader, S. M. A. (2015) · World Journal of Hepatology · doi:10.4254/wjh.v7.i6.846 · Cited by 398

Prevalence of and Risk Factors for Hepatic Steatosis and Nonalcoholic Fatty Liver Disease in People With Type 2 Diabetes: the Edinburgh Type 2 Diabetes Study

Williamson, R. M., Price, J. F., Glancy, S., Perry, E., Nee, L. D., Hayes, P. C., Frier, B. M., Look, L. A. F. V., Johnston, G. I., Reynolds, R. M., et al. (2011) · Diabetes Care · doi:10.2337/dc10-2229 · Cited by 398

How common is non‐alcoholic fatty liver disease in the Asia–Pacific region and are there local differences?

Amarapurkar, D. N., Hashimoto, E., Lesmana, L. A., Sollano, J. D., Chen, P., Goh, K., & NAFLD, F. T. A. W. P. O. (2007) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05042.x · Cited by 397

Hepatic steatosis as a potential risk factor for major hepatic resection

Behrns, K. E., Tsiotos, G. G., DeSouza, N. F., Krishna, M. K., Ludwig, J., & Nagorney, D. M. (1998) · Journal of Gastrointestinal Surgery · doi:10.1016/s1091-255x(98)80025-5 · Cited by 396

Oxidative Stress as a Critical Factor in Nonalcoholic Fatty Liver Disease Pathogenesis

Spahis, S., DELVIN, E. E., Borys, J.-M., & Levy, E. H. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6776 · Cited by 394

A new perspective on NAFLD: Focusing on lipid droplets

Scorletti, E., & Carr, R. M. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.11.009 · Cited by 394

Nonalcoholic Fatty Liver Disease: Cytokine-Adipokine Interplay and Regulation of Insulin Resistance

Tilg, H., & Hotamışlıgil, G. S. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.05.054 · Cited by 391

Statin use and non-alcoholic steatohepatitis in at risk individuals

Dongiovanni, P., Petta, S., Mannisto, V., Mancina, R. M., Pipitone, R., Karja, V., Maggioni, M., Kakela, P., Wiklund, O., Mozzi, E., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.05.006 · Cited by 390

Altered Fecal Microbiota Correlates with Liver Biochemistry in Nonobese Patients with Non-alcoholic Fatty Liver Disease

Wang, B., Jiang, X., Cao, M., Ge, J., Bao, Q., Tang, L., Chen, Y., & Li, L. (2016) · Scientific Reports · doi:10.1038/srep32002 · Cited by 390

Controlled attenuation parameter (CAP) for the diagnosis of steatosis: A prospective study of 5323 examinations

de Lédinghen, V., Vergniol, J., Capdepont, M., Chermak, F., Hiriart, J., Cassinotto, C., Merrouche, W., Foucher, J., & Brigitte, L. B. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.12.018 · Cited by 389

Relationship Between Sarcopenia and Nonalcoholic Fatty Liver Disease: The Korean Sarcopenic Obesity Study

Hong, H. C., Hwang, S. Y., Choi, H. Y., Yoo, H. J., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., Choi, D. S., & Choi, K. M. (2014) · Hepatology · doi:10.1002/hep.26716 · Cited by 385

JNK1 but not JNK2 promotes the development of steatohepatitis in mice

Schattenberg, J. M., Singh, R., Wang, Y., Lefkowitch, J. H., Rigoli, R. M., Scherer, P. E., & Czaja, M. J. (2006) · Hepatology · doi:10.1002/hep.20999 · Cited by 384

Nonalcoholic Fatty Liver Disease Is Associated With Carotid Atherosclerosis

Brea, Á., Mosquera, D., Martin‐Solana, E., Arizti, A., Cordero, J. L., & Ros, E. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000160613.57985.18 · Cited by 384

Expression of miR-33 from an SREBP2 Intron Inhibits Cholesterol Export and Fatty Acid Oxidation*

Gerin, I., Clerbaux, L.-A., Haumont, O., Lanthier, N., Das, A. K., Burant, C. F., Leclercq, I. A., MacDougald, O. A., & Bommer, G. T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.152090 · Cited by 382

PPARγ2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes

Schadinger, S. E., Bucher, N. L. R., Schreiber, B. M., & Farmer, S. R. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00513.2004 · Cited by 382

Reversal of Hepatic Fibrosis — Fact or Fantasy?

Friedman, S. L., & Bansal, M. B. (2006) · Hepatology · doi:10.1002/hep.20974 · Cited by 380

Plasma fetuin-A levels and the risk of type 2 diabetes

Stefan, N., Fritsche, A., Weikert, C., Boeing, H., Joost, H.-G., Häring, H.-U., & Schulze, M. B. (2008) · Diabetes · doi:10.2337/db08-0538 · Cited by 379

Alanine aminotransferase as a marker of non‐alcoholic fatty liver disease in relation to type 2 diabetes mellitus and cardiovascular disease

Schindhelm, R. K., Diamant, M., Dekker, J. M., Tushuizen, M. E., Teerlink, T., & Heine, R. J. (2006) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.666 · Cited by 376

Metformin in the treatment of non-alcoholic steatohepatitis: a pilot open label trial

Nair, S., Diehl, A. M., Wiseman, M., Farr, G. H., & Perrillo, R. P. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02025.x · Cited by 369

Alanine Aminotransferase Levels and Fatty Liver in Childhood Obesity: Associations with Insulin Resistance, Adiponectin, and Visceral Fat

Burgert, T. S., Taksali, S. E., Dziura, J. D., Goodman, T. R., Yeckel, C. W., Papademetris, X., Constable, R. T., Weiss, R., Tamborlane, W. V., Savoye, M., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1010 · Cited by 369

Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH

Caballero, F., Fernández, A., De Lacy, A. M., Fernández-Checa, J. C., Caballería, J., & García-Ruiz, C. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2008.12.016 · Cited by 368

Long-Term Efficacy of Rosiglitazone in Nonalcoholic Steatohepatitis: Results of the Fatty Liver Improvement by Rosiglitazone Therapy (Flirt 2) Extension Trial

Ratziu, V., Charlotte, F., Bernhardt, C., Giral, P., Halbron, M., Naour, G. L., Hartemann–Heurtier, A., Bruckert, É., & Poynard, T. (2009) · Hepatology · doi:10.1002/hep.23270 · Cited by 366

Iron in fatty liver and in the metabolic syndrome: A promising therapeutic target

Dongiovanni, P., Fracanzani, A. L., Fargion, S. R., & Valenti, L. V. C. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.05.008 · Cited by 364

Racial and ethnic distribution of nonalcoholic fatty liver in persons with newly diagnosed chronic liver disease†

Weston, S. R., Leyden, W. A., Murphy, R., Bass, N. M., Bell, B. P., Manos, M. M., & Terrault, N. A. (2005) · Hepatology · doi:10.1002/hep.20554 · Cited by 362

Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: A manifestation of lipotoxicity?

Chitturi, S., Farrell, G. C., Frost, L., Kriketos, A. D., Lin, R., Liddle, C., Samarasinghe, D., & George, J. (2002) · Hepatology · doi:10.1053/jhep.2002.34738 · Cited by 362

Role of cytokines and chemokines in non-alcoholic fatty liver disease

Braunersreuther, V. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i8.727 · Cited by 359

A murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma

Fujii, M., Shibazaki, Y., Wakamatsu, K., Honda, Y., Kawauchi, Y., Suzuki, K., Arumugam, S., Watanabe, K., Ichida, T., Asakura, H., et al. (2013) · Medical Molecular Morphology · doi:10.1007/s00795-013-0016-1 · Cited by 355

Microbiome-modulated metabolites at the interface of host immunity

Blacher, E., Levy, M., Tatirovsky, E., & Elinav, E. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601247 · Cited by 354

Mediterranean diet and nonalcoholic fatty liver disease

Anania, C., Perla, F. M., Olivero, F., Pacifico, L., & Chiesa, C. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i19.2083 · Cited by 353

Noninvasive Measures of Liver Fibrosis

Rockey, D. C., & Bissell, M. D. (2006) · Hepatology · doi:10.1002/hep.21046 · Cited by 353

The changing epidemiology of liver diseases in the Asia–Pacific region

Wong, M. C. S., Huang, J. L. W., George, J., Huang, J., Leung, C., Eslam, M., Chan, H. L., & Ng, S. C. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0055-0 · Cited by 353

Pathological Features of Fatty Liver Disease

Yeh, M. M., & Brunt, E. M. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.07.056 · Cited by 352

NAFLD in children: A prospective clinical-pathological study and effect of lifestyle advice

Nobili, V., Marcellini, M., Vito, R. D., Ciampalini, P., Piemonte, F., Comparcola, D., Sartorelli, M. R., & Angulo, P. (2006) · Hepatology · doi:10.1002/hep.21262 · Cited by 351

Non‐alcoholic fatty liver disease: Further expression of the metabolic syndrome

Tarantino, G., Saldalamacchia, G., Conca, P., & Arena, A. (2007) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.04824.x · Cited by 184

Nonalcoholic fatty liver disease is associated with hyperlipidemia and obesity

Sharabi, Y., & Eldad, A. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(00)00434-4 · Cited by 41

Non alcoholic fatty liver disease : original

Coetzee, A., & Ascott-Evans, B. (2015) · South African Journal of Diabetes

Nonobese Nonalcoholic Fatty Liver Disease: An Important Clinical Entity

Zaman, A. (2016) · Journal watch · doi:10.1056/nejm-jw.na42300

Nicht alkoholische Fettleberkrankheit (NAFLK)

Keller, K. (2004) · Monatsschrift Kinderheilkunde · doi:10.1007/s00112-004-0995-z · Cited by 1