Cited by 5,228Liver Disease Diagnosis and TreatmentAlcohol Consumption and Health EffectsLiver physiology and pathology

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Nonalcoholic Fatty Liver Disease

Angulo, Paul·2002·New England Journal of Medicine

DOI 10.1056/nejmra011775

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Abstract

Alcohol abuse is the most common cause of fatty liver disease, but it is now apparent that fat deposition in the liver, and its consequences, may occur without alcohol abuse. The principal risk factors are obesity, non-insulin-dependent diabetes mellitus, and hyperlipidemia. The disorder has a wide clinical spectrum, ranging from asymptomatic steatosis to steatohepatitis, fibrosis, and cirrhosis. This article provides a broad overview of this increasingly recognized liver disease.

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Authors: Angulo, P.
Affiliations: Mayo Clinic (US)
Corresponding author: Angulo, Paul
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2002-04-18
Volume: 346
Issue: 16
Pages: 1221-1231
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmra011775
OpenAlex: W2040109162
Cited by: 5,228
References: 90
Citations by year: 2026: 38 · 2025: 80 · 2024: 102 · 2023: 171 · 2022: 155 · 2021: 191 · 2020: 246 · 2019: 228 · 2018: 222 · 2017: 264 · 2016: 275 · 2015: 339 · 2014: 368 · 2013: 319 · 2012: 309
FWCI: 23.15
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords: non-alcoholic fatty liver disease, hepatic steatosis, steatohepatitis, liver fibrosis, liver cirrhosis, obesity, type 2 diabetes, hyperlipidemia, risk factors, alcohol abuse
MeSH terms: Biopsy, Fatty Liver, Humans, Liver, Liver Function Tests, Radiography, Risk Factors, Ultrasonography, Weight Loss, Prevalence

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