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Risks of testosterone-replacement therapy and recommendations for monitoring.

Rhoden, Ernani Luis, Morgentaler, Abraham·2004·New England Journal of Medicine

DOI 10.1056/nejmra022251

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Abstract

Although some reports suggest that testosterone-replacement therapy may provide benefits for aging men, considerable controversy remains regarding indications for its use. Neither large-scale nor long-term studies have been initiated, in part because of theoretical concern regarding the risks associated with testosterone therapy, especially the possible stimulation of prostate cancer. This article discusses what is known (and not known) about the risks of testosterone-replacement therapy and provides recommendations for monitoring men who are receiving testosterone.

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Authors: Rhoden, E. L., & Morgentaler, A.
Affiliations: Beth Israel Deaconess Medical Center (US)
ORCID: Morgentaler, Abraham
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2004-01-29
Volume: 350
Issue: 5
Pages: 482-492
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmra022251
OpenAlex: W2120158027
Cited by: 705
References: 77
Citations by year: 2026: 5 · 2025: 7 · 2024: 12 · 2023: 10 · 2022: 7 · 2021: 16 · 2020: 18 · 2019: 21 · 2018: 19 · 2017: 20 · 2016: 22 · 2015: 36 · 2014: 30 · 2013: 35 · 2012: 44
FWCI: 9.78
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords: testosterone replacement therapy, risk, prostate cancer, older men, monitoring, androgen therapy, hypogonadism
MeSH terms: Cardiovascular Diseases, Humans, Hypogonadism, Lipids, Male, Polycythemia, Prostatic Diseases, Risk Factors, Testosterone, Drug Monitoring, Prostate-Specific Antigen, Age Distribution, Hormone Replacement Therapy

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Risks of testosterone-replacement therapy and recommendations for monitoring.

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